Page last updated: 2024-08-21

pyrazines and Sensitivity and Specificity

pyrazines has been researched along with Sensitivity and Specificity in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (11.27)	18.2507
2000's	34 (47.89)	29.6817
2010's	24 (33.80)	24.3611
2020's	5 (7.04)	2.80

Authors

Authors	Studies
Chen, M; Du, L; Han, J; Hou, R; Jiao, W; Lei, Z; Ma, A; Wang, K; Zhao, X	1
Habib, AA; Hammad, SF; Kamal, AH; Megahed, SM	1
Abraham, I; Al-Jedai, A; Alajami, HN; Alali, AH; Alamer, A; Alfaifi, M; AlHassar, F; Alkharji, F; Almulhim, AS; Almutairi, M; Almutairi, W; Alosaimi, B; Alrashed, AA; Alsaeed, A; Baredhwan, AA; Howaidi, J; Mohzari, Y; Sulaiman, T	1
Amara Babu, NLA; Koganti, K; Palakeeti, B; Rao, KP; Srinivas, KSV	1
Abusoglu, S; Eryavuz Onmaz, D; Onmaz, M; Unlu, A; Yerlikaya, FH	1
Chen, J; Fu, C; Huang, J; Liu, X; Pei, Q; Tan, H; Wang, J; Xiang, Y; Yang, G; Yang, S	1
Choulwar, S; Deshpande, A; Giri, S; Paul, D; Pokharkar, S; Satheeshkumar, N; Surendran, S	1
Du, M; Song, L; Wu, J; Xu, X; Zhao, H	1
Cabañas, C; Cardeñes, B; López-Martín, S; Morales, S; Toribio, V; Yáñez-Mó, M	1
Gillet, JP; Gottesman, MM; Varma, S	1
Brandstetter, M; Engelhard, K; Förster, CY; Neuhaus, W; Schaible, EV; Scheffer, D; Thal, SC; Wunder, C	1
Chen, L; Kong, L; Liu, H; Liu, X; Wei, C; Wei, X; Zhang, X	1
Bordignon-Luiz, MT; Burin, VM; de Revel, G; Marchand, S	1
Abildgaard, N; Hansen, CT; Nielsen, LC; Pedersen, PT	1
Chai, C; Cheng, D; Cui, XB; Kang, B; Li, W; Shan, CX; Wang, TL; Wen, HM; Zhou, Y	1
Chagovets, V; Chen, H; Ding, J; Frankevich, V; Kononikhin, A; Starodubtseva, N	1
Ba, W; Fan, W; Guo, Z; Li, Z; Liao, F; Liao, W; Wang, D; Wang, L; Wu, Y; Yu, J	1
Ferguson, PD; Jiang, Z; Smith, NW; Taylor, MR	1
Han, QB; Li, CY; Wu, TS; Xu, HX	1
Drake, MA; Miracle, RE; Neta, ER; Sanders, TH	1
Gujer, W; Neumann, MB; von Gunten, U	1
Inglis, D; Karthik, A; Ker, K; Pickering, GJ; Sears, M	1
Bergman, AJ; Bloomfield, DM; Ghosh, K; Gottesdiener, KM; Gutierrez, MJ; Herman, GA; Hickey, L; Hreniuk, D; Krishna, R; Miller, J; Stoltz, R; Wagner, JA	1
Ahrén, B	1
Decaux, O; Karras, A	1
Brodoefel, H; Claussen, CD; Fenchel, M; Horger, M; Konaktchieva, M; Kraus, S; Weisel, K	1
Constanzer, M; Woolf, EJ; Xu, Y; Zeng, W	1
Huang, QJ; Yan, YL; Ye, Y; Zhou, LL	1
Cacho, J; Ferrreira, V; Gracia-Moreno, E; López, R	1
Denn, M; Gallagher, RT; Peter, RM; Swales, JG	1
Chen, J; Deng, X; Liang, G; Qi, M; Xie, P	1
Djamali, A; Kim, J; Lorentzen, D; Mohamed, MA	1
Jin, QR; Kim, CY; Kim, DG; Lee, GW; Lee, JH; Lee, KR; Lim, H; Noh, HJ; Park, DH; Woo, YA	1
Nogueira, JM; Portugal, FC; Rodrigues, C	1
Chen, F; Han, JZ; Hu, JH; Liu, JY; Sun, J; Zhu, QG	1
Burugula, L; Kandhagatla, R; Lodagala, DS; Makula, A; Mullangi, R; Pilli, NR	1
Asano, T; Ito, K; Sato, A	1
Alasalvar, C; Cadwallader, KR; Shahidi, F	1
Majumdar, TK; Tse, FL; Vedananda, S	1
Cardoso, F; Durbecq, V; Picart, MJ; Ross, JS; Sotiriou, C	1
Chapman, DM; Ebeler, SE; Guinard, JX; Matthews, MA; Thorngate, JH	1
Anzai, J; Hoshi, T; Kashiwagi, Y; Li, G; Sun, Z; Zheng, X	1
Fang, L; Jin, X; Qi, M; Wang, P	1
Chu, H; Kensler, TW; Muñoz, A	1
Allen, M; Marriott, P; Ryan, D; Smith, J; Watkins, P	1
Chu, H; Cole, SR; Nie, L	1
Ding, H; Wu, F; Zhang, Z	1
Bagheri, H; Barceló, D; Lacorte, S; Salemi, A	1
Belloni, D; Caligaris-Cappio, F; Cangi, MG; Ferrarini, M; Ferrero, E; Foglieni, C; Veschini, L	1
Cai, L; Koziel, JA; O'Neal, ME	1
Bocchia, M; Cerase, A; Fabbri, A; Gozzetti, A; Lauria, F; Pirrotta, MT; Tarantino, A	1
Bönisch, H; Brüss, M; Combrink, S; Göthert, M; Niesler, B; Walstab, J	1
Barlogie, B; Garg, TK; Kellum, RE; Malaviarachchi, PA; Mulder, A; Shaughnessy, JD; Shi, J; Storrie, B; Szmania, SM; Tricot, GJ; van Rhee, F	1
Checińska, A; Giaccone, G; Voortman, J	1
Chen, L; Fisher, AL; Musson, DG; Schwartz, MS; Wang, AQ; Woolf, EJ; Zeng, W	1
Blake, AJ; Brindle, ID; Chen, X; Inglis, D; Kotseridis, YS; Pickering, GJ; Sears, M; Soleas, G; Spink, M	1
Bargmann, CI; Chou, JH; Sengupta, P	1
Badminton, MN; Campbell, AK; Kendall, JM; Rembold, CM; Sala-Newby, GB	1
Bax, JJ; Cornel, JH; Fioretti, PM; Krenning, EP; Poldermans, D; Rambaldi, R; Valkema, R; van Lingen, A; Visser, FC	1
Shimomura, O; Teranishi, K	1
Markoglou, N; Wainer, IW	1
Chen, CF; Hong, CY; Liang, CC; Tsai, TH	1
Gu, X; Lo, MW; Riffel, K; Song, H; Yan, K	1
Adams, J; Chau, V; Elliott, PJ; Lightcap, ES; McCormack, TA; Pien, CS	1
Busto, O; Guasch, J; Martí, MP; Mestres, M; Sala, C	1
Gu, X; Lo, MW; Riffel, KA; Song, H; Yan, K	1
Chen, QY; Li, DH; Xu, JG; Yang, HH; Zhu, QZ	1
Bennett, JL; Bennink, M; Crowell, J; Dimitrov, NV; Gardiner, J; Hawk, E; Leece, CM; Nashawaty, M; Seymour, E; Tompkins, ER	1
Teyssier, L	1
Hori, K; Koga, S; Nakano, M; Uehara, K	1
Hara, M; Kato, M; Kimura, H; Kuroiwa, M; Nakano, M; Totsune, K; Yoshikawa, T	1

Reviews

4 review(s) available for pyrazines and Sensitivity and Specificity

Article	Year
Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin--diabetes control and potential adverse events. Best practice & research. Clinical endocrinology & metabolism, 2009, Volume: 23, Issue:4 Topics: Adamantane; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemia; Insulin; Metformin; Nitriles; Pioglitazone; Pyrazines; Pyrrolidines; Sensitivity and Specificity; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Triazoles; Vildagliptin	2009
Desensitization across the HLA barrier in kidney transplantaion. Frontiers in bioscience (Scholar edition), 2011, 06-01, Volume: 3, Issue:3 Topics: Antibodies, Monoclonal, Murine-Derived; Boronic Acids; Bortezomib; Desensitization, Immunologic; Female; Flow Cytometry; HLA Antigens; Humans; Immunoglobulins, Intravenous; Kidney Transplantation; Male; Plasmapheresis; Pyrazines; Rituximab; Sensitivity and Specificity; Sex Factors; Treatment Outcome	2011
Targeting the ubiquitin-proteasome pathway in breast cancer. Clinical breast cancer, 2004, Volume: 5, Issue:2 Topics: Animals; Boronic Acids; Bortezomib; Breast Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cysteine Endopeptidases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Mice; Molecular Biology; Multienzyme Complexes; Neoplasm Transplantation; NF-kappa B; Proteasome Endopeptidase Complex; Protein Transport; Pyrazines; Risk Factors; Sensitivity and Specificity; Survival Rate; Treatment Outcome; Ubiquitin	2004
FDG SPECT in the assessment of myocardial viability. Comparison with dobutamine echo. European heart journal, 1997, Volume: 18 Suppl D Topics: Cardiotonic Agents; Deoxyglucose; Dobutamine; Echocardiography; Exercise Test; Fluorodeoxyglucose F18; Glucose; Humans; Hypolipidemic Agents; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Predictive Value of Tests; Pyrazines; Radiopharmaceuticals; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon	1997

Trials

5 trial(s) available for pyrazines and Sensitivity and Specificity

Article	Year
Evaluation of the serum free light chain (sFLC) analysis in prediction of response in symptomatic multiple myeloma patients: rapid profound reduction in involved FLC predicts achievement of VGPR. European journal of haematology, 2014, Volume: 93, Issue:5 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cyclophosphamide; Dexamethasone; Drug Monitoring; Female; Half-Life; Humans; Immunoglobulin Light Chains; Lenalidomide; Male; Melphalan; Middle Aged; Multiple Myeloma; Myeloma Proteins; Prednisone; Prospective Studies; Pyrazines; Sensitivity and Specificity; Thalidomide; Treatment Outcome	2014
A thorough QTc study to assess the effect of sitagliptin, a DPP4 inhibitor, on ventricular repolarization in healthy subjects. Journal of clinical pharmacology, 2009, Volume: 49, Issue:8 Topics: Adolescent; Adult; Aza Compounds; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Fluoroquinolones; Humans; Male; Middle Aged; Models, Biological; Moxifloxacin; Pyrazines; Quinolines; Sensitivity and Specificity; Sitagliptin Phosphate; Time Factors; Triazoles; Young Adult	2009
Assessing the effect of interventions in the context of mixture distributions with detection limits. Statistics in medicine, 2005, Jul-15, Volume: 24, Issue:13 Topics: Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; China; Double-Blind Method; Humans; Likelihood Functions; Liver Neoplasms; Models, Statistical; Placebos; Pyrazines; Sensitivity and Specificity; Thiones; Thiophenes	2005
Determination of the anticancer agent CI-980 in plasma by achiral liquid chromatography on a Pirkle-type stationary phase. Journal of chromatography. B, Biomedical sciences and applications, 1997, Jun-06, Volume: 693, Issue:2 Topics: Antineoplastic Agents; Carbamates; Child; Chromatography, Liquid; Humans; Neoplasms; Pyrazines; Pyridines; Sensitivity and Specificity; Stereoisomerism	1997
Oltipraz concentrations in plasma, buccal mucosa cells, and lipids: pharmacological studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:3 Topics: Administration, Oral; Adult; Anticarcinogenic Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Lipid Metabolism; Lung Neoplasms; Male; Middle Aged; Mouth Mucosa; Probability; Pyrazines; Risk Assessment; Sensitivity and Specificity; Smoking; Statistics, Nonparametric; Thiones; Thiophenes; Tissue Distribution	2001

Other Studies

62 other study(ies) available for pyrazines and Sensitivity and Specificity

Article	Year
Pharmacokinetic study of tanshinol and ligustrazine in rat plasma after intravenous administration of tanshinol and Danshen Chuanxiongqin Injection. Biomedical chromatography : BMC, 2020, Volume: 34, Issue:9 Topics: Administration, Intravenous; Animals; Caffeic Acids; Chromatography, High Pressure Liquid; Female; Linear Models; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Salvia miltiorrhiza; Sensitivity and Specificity; Tandem Mass Spectrometry	2020
Experimental design approach for development of spectrofluorimetric method for determination of favipiravir; a potential therapeutic agent against COVID-19 virus: Application to spiked human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Mar-15, Volume: 249 Topics: Amides; Antiviral Agents; Blood Chemical Analysis; COVID-19; COVID-19 Drug Treatment; Humans; Limit of Detection; Pyrazines; SARS-CoV-2; Sensitivity and Specificity; Spectrometry, Fluorescence	2021
Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: a retrospective study with propensity score matching sensitivity analysis. Current medical research and opinion, 2021, Volume: 37, Issue:7 Topics: Amides; Antiviral Agents; COVID-19; Critical Illness; Humans; Propensity Score; Pyrazines; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Saudi Arabia; Sensitivity and Specificity	2021
Development of an efficient stability-indicating LC-MS/MS method for the analysis of selexipag and characterization of its degradation products. Biomedical chromatography : BMC, 2021, Volume: 35, Issue:10 Topics: Acetamides; Chromatography, High Pressure Liquid; Drug Contamination; Linear Models; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2021
Development and validation of a sensitive, fast and simple LC-MS / MS method for the quantitation of favipiravir in human serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Jun-30, Volume: 1176 Topics: Amides; Antiviral Agents; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Drug Stability; Humans; Limit of Detection; Pyrazines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2021
Simultaneous determination of Pyragrel, a novel anti-thrombotic agent, and its two primary metabolites in plasma by HPLC-MS/MS. Journal of pharmaceutical and biomedical analysis, 2018, Jul-15, Volume: 156 Topics: Cerebral Infarction; Chromatography, High Pressure Liquid; Clinical Trials, Phase I as Topic; Female; Fibrinolytic Agents; Healthy Volunteers; Humans; Male; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Thromboxane-A Synthase	2018
Novel Bruton tyrosine kinase inhibitor acalabrutinib quantification by validated LC-MS/MS method: An application to pharmacokinetic study in Sprague Dawley rats. Journal of pharmaceutical and biomedical analysis, 2019, Feb-05, Volume: 164 Topics: Administration, Oral; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Benzamides; Chromatography, High Pressure Liquid; Drug Stability; Male; Models, Animal; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Therapeutic Equivalency	2019
Dispersive liquid-liquid microextraction for rapid and inexpensive determination of tetramethylpyrazine in vinegar. Food chemistry, 2019, Jul-15, Volume: 286 Topics: Acetic Acid; Chromatography, High Pressure Liquid; Food Analysis; Limit of Detection; Liquid Phase Microextraction; Pyrazines; Sensitivity and Specificity	2019
Development of a quantitative method to measure EV uptake. Scientific reports, 2019, 07-19, Volume: 9, Issue:1 Topics: Biological Transport; Breast Neoplasms; Cell Line, Tumor; Extracellular Vesicles; Female; Genes, Reporter; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Imidazoles; Luciferases, Renilla; Luminescent Measurements; Nanoparticles; Pyrazines; Recombinant Fusion Proteins; Sensitivity and Specificity; Subcellular Fractions; Tetraspanin 29; Tetraspanin 30	2019
The clinical relevance of cancer cell lines. Journal of the National Cancer Institute, 2013, Apr-03, Volume: 105, Issue:7 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Profiling; Humans; Molecular Targeted Therapy; Multiple Myeloma; Neoplasms; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Transcriptome; Translational Research, Biomedical; Xenograft Model Antitumor Assays	2013
Inhibition of proteasomal glucocorticoid receptor degradation restores dexamethasone-mediated stabilization of the blood-brain barrier after traumatic brain injury. Critical care medicine, 2013, Volume: 41, Issue:5 Topics: Animals; Blood Gas Analysis; Blood-Brain Barrier; Blotting, Western; Boronic Acids; Bortezomib; Brain Edema; Brain Injuries; Dexamethasone; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Multivariate Analysis; Proteasome Endopeptidase Complex; Pyrazines; Random Allocation; Real-Time Polymerase Chain Reaction; Receptors, Glucocorticoid; Reference Values; RNA, Messenger; Sensitivity and Specificity; Statistics, Nonparametric	2013
Pharmacokinetics of a new tetramethylpyrazine analogue CXC195 in rats. Drug research, 2013, Volume: 63, Issue:7 Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Female; Half-Life; Injections, Intraperitoneal; Limit of Detection; Male; Models, Biological; Neuroprotective Agents; Piperazines; Pyrazines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity	2013
Development and validation of method for heterocyclic compounds in wine: optimization of HS-SPME conditions applying a response surface methodology. Talanta, 2013, Dec-15, Volume: 117 Topics: Factor Analysis, Statistical; Furans; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Maillard Reaction; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Microextraction; Temperature; Thiazoles; Thiophenes; Wine	2013
Identification, Characterization, Synthesis and Quantification of Related Impurities of Liguzinediol. Journal of chromatographic science, 2015, Volume: 53, Issue:8 Topics: Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Linear Models; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Signal-To-Noise Ratio	2015
Letter: Comparison of pyridine and pyrazine derivatives distributions in exhaled breath and exhaled breath condensate after smoking. European journal of mass spectrometry (Chichester, England), 2015, Volume: 21, Issue:6 Topics: Breath Tests; Exhalation; Humans; Pyrazines; Pyridines; Reproducibility of Results; Sensitivity and Specificity; Smoking; Spectrometry, Mass, Electrospray Ionization	2015
Microdialysis combined with UPLC-MS/MS method for determination of tetramethylpyrazine and ferulic acid in striatum of awake and anesthetic rats subjected to cerebral ischemia. Journal of pharmaceutical and biomedical analysis, 2016, Sep-05, Volume: 128 Topics: Animals; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Corpus Striatum; Coumaric Acids; Drug Synergism; Limit of Detection; Male; Microdialysis; Pyrazines; Rats; Reperfusion Injury; Sensitivity and Specificity; Tandem Mass Spectrometry	2016
Mixed-mode reversed-phase and ion-exchange monolithic columns for micro-HPLC. Journal of separation science, 2008, Volume: 31, Issue:15 Topics: Acrylates; Amitriptyline; Aniline Compounds; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Diltiazem; Hydrogen-Ion Concentration; Ketones; Methacrylates; Microchemistry; Molecular Structure; Particle Size; Phenols; Polycyclic Aromatic Hydrocarbons; Polymers; Porosity; Pyrazines; Quinine; Reproducibility of Results; Sensitivity and Specificity; Stearates; Surface Properties; Time Factors; Verapamil	2008
Quality assessment of Radix Codonopsis by quantitative nuclear magnetic resonance. Journal of chromatography. A, 2009, Mar-13, Volume: 1216, Issue:11 Topics: Alkaloids; Codonopsis; Drugs, Chinese Herbal; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Pyrazines; Quaternary Ammonium Compounds; Sensitivity and Specificity; Solid Phase Extraction	2009
Characterization of alkylmethoxypyrazines contributing to earthy/bell pepper flavor in farmstead cheddar cheese. Journal of food science, 2008, Volume: 73, Issue:9 Topics: Capsicum; Cheese; Consumer Behavior; Earth, Planet; Gas Chromatography-Mass Spectrometry; Humans; North Carolina; Odorants; Penicillium; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Taste	2008
Global sensitivity analysis for model-based prediction of oxidative micropollutant transformation during drinking water treatment. Water research, 2009, Volume: 43, Issue:4 Topics: Bezafibrate; Carcinogens; Ciprofloxacin; Methyl Ethers; Naphthols; Ozone; Predictive Value of Tests; Probability; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Water Pollutants, Chemical; Water Supply	2009
Detection thresholds for 2-isopropyl-3-methoxypyrazine in Concord and Niagara grape juice. Journal of food science, 2008, Volume: 73, Issue:6 Topics: Animals; Beverages; Coleoptera; Food Contamination; Humans; Odorants; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Taste; Vitis; Volatilization	2008
[Update in multiple myeloma: international criteria for treatment response and renal complications]. La Revue de medecine interne, 2009, Volume: 30, Issue:12 Topics: Antineoplastic Agents; Biomarkers; Boronic Acids; Bortezomib; France; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Immunologic Factors; International Cooperation; Kidney Diseases; Multiple Myeloma; Practice Guidelines as Topic; Prevalence; Pyrazines; Renal Dialysis; Renal Insufficiency; Sensitivity and Specificity; Societies, Medical	2009
Early response assessment in patients with multiple myeloma during anti-angiogenic therapy using arterial spin labelling: first clinical results. European radiology, 2010, Volume: 20, Issue:12 Topics: Aged; Angiogenesis Inhibitors; Boronic Acids; Bortezomib; Female; Humans; Lenalidomide; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Myeloma; Pilot Projects; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Spin Labels; Thalidomide; Treatment Outcome	2010
Determination of sitagliptinin human plasma using protein precipitation and tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Jul-01, Volume: 878, Issue:21 Topics: Chemical Precipitation; Dipeptidyl-Peptidase IV Inhibitors; Drug Stability; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Least-Squares Analysis; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Sitagliptin Phosphate; Solid Phase Extraction; Tandem Mass Spectrometry; Temperature; Triazoles	2010
[Determination of plasma protein binding rate of tetramethylpyrazine phosphate by ultrafiltration]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2010, Volume: 33, Issue:8 Topics: Animals; Apiaceae; Blood Proteins; Chromatography, High Pressure Liquid; Humans; Phosphates; Protein Binding; Pyrazines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Ultrafiltration; Vasodilator Agents	2010
Development of a mixed-mode solid phase extraction method and further gas chromatography mass spectrometry for the analysis of 3-alkyl-2-methoxypyrazines in wine. Journal of chromatography. A, 2011, Feb-11, Volume: 1218, Issue:6 Topics: Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Linear Models; Odorants; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Wine	2011
Simultaneous quantitation of metformin and sitagliptin from mouse and human dried blood spots using laser diode thermal desorption tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2011, Jun-01, Volume: 55, Issue:3 Topics: Animals; Blood Stains; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Drug Storage; Humans; Hypoglycemic Agents; Lasers, Semiconductor; Metformin; Mice; Mice, Inbred C57BL; Molecular Structure; Pyrazines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Sitagliptin Phosphate; Species Specificity; Specimen Handling; Tandem Mass Spectrometry; Temperature; Triazoles	2011
Simultaneous determination of eight common odors in natural water body using automatic purge and trap coupled to gas chromatography with mass spectrometry. Journal of chromatography. A, 2011, Jun-17, Volume: 1218, Issue:24 Topics: Adsorption; Aldehydes; Camphanes; Diterpenes; Eutrophication; Fresh Water; Gas Chromatography-Mass Spectrometry; Naphthols; Norisoprenoids; Odorants; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Sulfides; Temperature	2011
Quantification of oltipraz using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in rat plasma. Journal of pharmaceutical and biomedical analysis, 2011, Nov-01, Volume: 56, Issue:3 Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Pyrazines; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Thiones; Thiophenes	2011
Static headspace analysis using polyurethane phases--application to roasted coffee volatiles characterization. Talanta, 2012, Jan-30, Volume: 89 Topics: Adsorption; Coffee; Dimethylpolysiloxanes; Furans; Gas Chromatography-Mass Spectrometry; Ketones; Polyurethanes; Pyrazines; Pyrroles; Sensitivity and Specificity; Solid Phase Microextraction; Volatile Organic Compounds	2012
A modified LC-MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home-made linear probes. Biomedical chromatography : BMC, 2012, Volume: 26, Issue:10 Topics: Abdomen; Analysis of Variance; Animals; Calibration; Chromatography, Liquid; Drug Stability; Electrodes, Implanted; Equipment Design; Linear Models; Male; Microdialysis; Pyrazines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Subcutaneous Tissue; Tandem Mass Spectrometry	2012
Simultaneous determination of sitagliptin and simvastatin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Biomedical chromatography : BMC, 2013, Volume: 27, Issue:1 Topics: Administration, Oral; Chromatography, Liquid; Dipeptidyl-Peptidase IV Inhibitors; Drug Stability; Humans; Least-Squares Analysis; Liquid-Liquid Extraction; Male; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Simvastatin; Sitagliptin Phosphate; Tandem Mass Spectrometry; Triazoles	2013
Vorinostat and bortezomib synergistically cause ubiquitinated protein accumulation in prostate cancer cells. The Journal of urology, 2012, Volume: 188, Issue:6 Topics: Animals; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Hydroxamic Acids; Male; Mice; Mice, Nude; Molecular Targeted Therapy; Prostatic Neoplasms; Pyrazines; Random Allocation; RNA, Small Interfering; Sensitivity and Specificity; Ubiquitinated Proteins; Vorinostat; Xenograft Model Antitumor Assays	2012
Comparison of natural and roasted Turkish tombul hazelnut (Corylus avellana L.) volatiles and flavor by DHA/GC/MS and descriptive sensory analysis. Journal of agricultural and food chemistry, 2003, Aug-13, Volume: 51, Issue:17 Topics: Aldehydes; Chromatography, Gas; Corylus; Gas Chromatography-Mass Spectrometry; Hot Temperature; Ketones; Odorants; Pyrazines; Seeds; Sensitivity and Specificity; Taste; Volatilization	2003
Rapid analysis of MMI270B, an inhibitor of matrix metalloproteases in human plasma by liquid chromatography-tandem mass spectrometry: matrix interference in patient samples. Biomedical chromatography : BMC, 2004, Volume: 18, Issue:2 Topics: Chromatography, Liquid; Humans; Hydroxamic Acids; Mass Spectrometry; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides	2004
Yield effects on 2-methoxy-3-isobutylpyrazine concentration in cabernet sauvignon using a solid phase microextraction gas chromatography/mass spectrometry method. Journal of agricultural and food chemistry, 2004, Aug-25, Volume: 52, Issue:17 Topics: Gas Chromatography-Mass Spectrometry; Odorants; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Wine	2004
The electrochemistry and determination of Ligustrazine hydrochloride. Analytical and bioanalytical chemistry, 2004, Volume: 380, Issue:3 Topics: Animals; Electrochemistry; Hydrogen-Ion Concentration; Molecular Structure; Pyrazines; Rabbits; Sensitivity and Specificity	2004
Liquid chromatography-mass spectrometry method for determination of tetramethylpyrazine and its metabolite in dog plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Dec-25, Volume: 813, Issue:1-2 Topics: Animals; Chromatography, Liquid; Dogs; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2004
Analysis of methoxypyrazines in wine using headspace solid phase microextraction with isotope dilution and comprehensive two-dimensional gas chromatography. Journal of separation science, 2005, Volume: 28, Issue:9-10 Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Pyrazines; Sensitivity and Specificity; Wine	2005
Sample size and statistical power assessing the effect of interventions in the context of mixture distributions with detection limits. Statistics in medicine, 2006, Aug-15, Volume: 25, Issue:15 Topics: Aflatoxin M1; Cohort Studies; Computer Simulation; Drug Evaluation; Food Contamination; Humans; Models, Statistical; Monte Carlo Method; Pyrazines; Randomized Controlled Trials as Topic; Sample Size; Sensitivity and Specificity; Thiones; Thiophenes	2006
Simple high-performance liquid chromatographic method for the determination of tetramethylpyrazine phosphate in very small volumes of dog plasma: application to a pharmacokinetic study. Journal of chromatographic science, 2006, Volume: 44, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Female; Male; Pyrazines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet	2006
Automated trace determination of earthy-musty odorous compounds in water samples by on-line purge-and-trap-gas chromatography-mass spectrometry. Journal of chromatography. A, 2006, Dec-15, Volume: 1136, Issue:2 Topics: Anisoles; Automation; Camphanes; Gas Chromatography-Mass Spectrometry; Naphthols; Odorants; Online Systems; Pyrazines; Sensitivity and Specificity; Water	2006
Hypoxia-inducible transcription factor-1 alpha determines sensitivity of endothelial cells to the proteosome inhibitor bortezomib. Blood, 2007, Mar-15, Volume: 109, Issue:6 Topics: Apoptosis; Boronic Acids; Bortezomib; Cells, Cultured; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; NF-kappa B; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Sensitivity and Specificity; Up-Regulation	2007
Determination of characteristic odorants from Harmonia axyridis beetles using in vivo solid-phase microextraction and multidimensional gas chromatography-mass spectrometry-olfactometry. Journal of chromatography. A, 2007, Apr-13, Volume: 1147, Issue:1 Topics: Animals; Calibration; Coleoptera; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Odorants; Pheromones; Pyrazines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Smell; Solid Phase Microextraction; Volatilization	2007
Multiple myeloma involving the cavernous sinus: a report of 3 cases and response to bortezomib. Clinical lymphoma & myeloma, 2007, Volume: 7, Issue:5 Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cavernous Sinus; Fatal Outcome; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Myeloma; Neoplasm Staging; Pyrazines; Recurrence; Sensitivity and Specificity; Treatment Outcome	2007
Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization. Analytical biochemistry, 2007, Sep-15, Volume: 368, Issue:2 Topics: Aequorin; Calcium; Cells, Cultured; Humans; Imidazoles; Ligands; Luminescent Agents; Luminescent Measurements; Pyrazines; Receptors, Serotonin, 5-HT3; Reproducibility of Results; Sensitivity and Specificity; Transfection	2007
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood, 2008, Feb-01, Volume: 111, Issue:3 Topics: Boronic Acids; Bortezomib; Cell Membrane; Cell Survival; Down-Regulation; Histocompatibility Antigens Class I; Humans; Killer Cells, Natural; Multiple Myeloma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Receptors, KIR; Sensitivity and Specificity; Tumor Cells, Cultured	2008
The proteasomal and apoptotic phenotype determine bortezomib sensitivity of non-small cell lung cancer cells. Molecular cancer, 2007, Nov-17, Volume: 6 Topics: Apoptosis; Boronic Acids; Bortezomib; Carcinoma, Non-Small-Cell Lung; Catalytic Domain; Cell Line, Tumor; Humans; Lung Neoplasms; Proteasome Endopeptidase Complex; Pyrazines; Sensitivity and Specificity	2007
Determination of sitagliptin in human urine and hemodialysate using turbulent flow online extraction and tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2008, Feb-13, Volume: 46, Issue:3 Topics: Calibration; Chromatography, Liquid; Drug Stability; Hemodialysis Solutions; Humans; Pyrazines; Sensitivity and Specificity; Sitagliptin Phosphate; Tandem Mass Spectrometry; Triazoles	2008
Quantitative analysis of 3-alkyl-2-methoxypyrazines in juice and wine using stable isotope labelled internal standard assay. Journal of chromatography. A, 2008, May-09, Volume: 1190, Issue:1-2 Topics: Beverages; Calibration; Isotopes; Magnetic Resonance Spectroscopy; Pyrazines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Wine	2008
odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell, 1996, Mar-22, Volume: 84, Issue:6 Topics: Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans; Chemotaxis; Diacetyl; Gene Expression Regulation; Genes, Helminth; Helminth Proteins; Male; Molecular Sequence Data; Mutation; Olfactory Receptor Neurons; Pyrazines; Receptors, Odorant; Sensitivity and Specificity; Signal Transduction	1996
Recombinant apoaequorin acting as a pseudo-luciferase reports micromolar changes in the endoplasmic reticulum free Ca2+ of intact cells. The Biochemical journal, 1996, Sep-01, Volume: 318 ( Pt 2) Topics: Adenosine Triphosphate; Aequorin; Apoproteins; Calcium; Endoplasmic Reticulum; HeLa Cells; Humans; Imidazoles; Ionomycin; Kinetics; Luciferases; Luminescent Measurements; Pyrazines; Recombinant Proteins; Sensitivity and Specificity; Time Factors	1996
Coelenterazine analogs as chemiluminescent probe for superoxide anion. Analytical biochemistry, 1997, Jun-15, Volume: 249, Issue:1 Topics: Aequorin; Firefly Luciferin; Hypoxanthine; Imidazoles; Luminescent Measurements; Molecular Structure; Pyrazines; Sensitivity and Specificity; Solubility; Structure-Activity Relationship; Superoxides; Xanthine Oxidase	1997
Measurement and pharmacokinetic study of tetramethylpyrazine in rat blood and its regional brain tissue by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1999, Mar-19, Volume: 724, Issue:2 Topics: Animals; Brain; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tissue Distribution	1999
Determination of a novel thrombin inhibitor in human plasma and urine utilizing liquid chromatography with tandem mass spectrometric and ultraviolet detection. Journal of chromatography. B, Biomedical sciences and applications, 2000, Jan-28, Volume: 738, Issue:1 Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Pyrazines; Pyridines; Reproducibility of Results; Sensitivity and Specificity; Solvents; Thrombin	2000
Proteasome inhibition measurements: clinical application. Clinical chemistry, 2000, Volume: 46, Issue:5 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cysteine Endopeptidases; Humans; In Vitro Techniques; Kinetics; Male; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence	2000
Headspace solid-phase microextraction method for determining 3-alkyl-2-methoxypyrazines in musts by means of polydimethylsiloxane-divinylbenzene fibres. Journal of chromatography. A, 2000, Jun-02, Volume: 880, Issue:1-2 Topics: Osmolar Concentration; Pyrazines; Reference Standards; Sensitivity and Specificity; Wine	2000
Simultaneous determination of a novel thrombin inhibitor and its two metabolites in human plasma by liquid chromatography/tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2000, Aug-15, Volume: 23, Issue:2-3 Topics: Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Pyrazines; Pyridines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Thrombin	2000
Application of magdala red as a fluorescence probe in the determination of nucleic acids. Fresenius' journal of analytical chemistry, 2000, Volume: 366, Issue:3 Topics: Adenine; Animals; Cattle; Cytosine; DNA; Fluorescent Dyes; Guanine; Indicators and Reagents; Naphthalenes; Proteins; Pyrazines; Reproducibility of Results; RNA; RNA, Fungal; Saccharomyces cerevisiae; Salmon; Sensitivity and Specificity; Spectrometry, Fluorescence; Thymine; Thymus Gland	2000
Higher activity of morphazinamide over pyrazinamide against intracellular. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2001, Volume: 5, Issue:4 Topics: Antitubercular Agents; Humans; Isoniazid; Macrophages; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazinamide; Pyrazines; Sensitivity and Specificity	2001
Highly sensitive chemiluminescence method for determining myeloperoxidase in human polymorphonuclear leukocytes. Analytical biochemistry, 1991, Volume: 199, Issue:2 Topics: Deferoxamine; Free Radicals; Humans; Hydrogen Peroxide; Imidazoles; Neutrophils; Oxygen; Peroxidase; Pyrazines; Sensitivity and Specificity; Subcellular Fractions; Substrate Specificity; Superoxide Dismutase	1991
A highly sensitive method for determining both Mn- and Cu-Zn superoxide dismutase activities in tissues and blood cells. Analytical biochemistry, 1990, Volume: 187, Issue:2 Topics: Animals; Erythrocytes; Imidazoles; Luminescent Measurements; Male; Organ Specificity; Pyrazines; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Superoxide Dismutase	1990