pyrazines has been researched along with Seizures in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, S; Chew, LA; Jiang, Y; Jin, Y; Khanna, R; Ruan, Y; Wen, C; Xu, Z; Yu, J; Zhong, K | 1 |
| Ding, K; Gross, RE; Shiu, FH; Tung, JK | 1 |
| Aizawa, H; Ito, Y; Mitani, A; Shimizu, T; Soma, M; Sugimoto, J; Sugiyama, K; Tanaka, K; Tanaka, M | 1 |
| Carroll, NK; Higgins, GA; Silenieks, LB; Taylor, C; Upton, N; Van Niekerk, A; Van Niekerk, E | 1 |
| Abdel-Hafez, A; Abdel-Zaher, A; El-Kashef, H; Esmail, S; Farghaly, AR | 1 |
| Chońska, J; Dawidowski, M; Mika, W; Turło, J | 1 |
| DESMEDT, JE; LAGRUTTA, V | 1 |
| Eller, M; Foreman, MM; Hanania, T; Stables, JP; Stratton, SC; White, HS; Wilcox, KS | 1 |
| Cugola, A; Donati, D; Micheli, F; Missio, A; Pecunioso, A; Reggiani, A; Tarzia, G | 1 |
| George, FR; Kreifeldt, MJ; O'Dell, LE; Ritz, MC | 1 |
| Bohme, GA; Boireau, A; Cheve, M; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Bohme, GA; Boireau, A; Bouquerel, J; Damour, D; Debono, MW; Genevois-Borella, A; Hardy, JC; Hubert, P; Jimonet, P; Manfré, F; Mignani, S; Nemecek, P; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K | 1 |
| Birraux, G; Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Stutzmann, JM; Vuilhorgne, M; Wahl, F | 1 |
| van Riezen, H | 1 |
| Keyl, AC; Nishie, K; Waiss, AC | 2 |
18 other study(ies) available for pyrazines and Seizures
| Article | Year |
|---|---|
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
Topics: Animals; Anticonvulsants; Anxiety; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels; Convulsants; Disease Progression; Electric Stimulation; Electroshock; Epilepsy, Complex Partial; Excitatory Postsynaptic Potentials; Exploratory Behavior; Ion Transport; Kindling, Neurologic; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Pentylenetetrazole; Pyrazines; Recognition, Psychology; Seizures; Sodium Channels | 2019 |
Chemically activated luminopsins allow optogenetic inhibition of distributed nodes in an epileptic network for non-invasive and multi-site suppression of seizure activity.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Dentate Gyrus; Epilepsy; Imidazoles; Luminescent Agents; Male; Neural Inhibition; Neural Pathways; Opsins; Optogenetics; Pyrazines; Rats, Sprague-Dawley; Seizures | 2018 |
Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Transporter 2; Forkhead Transcription Factors; Homeodomain Proteins; Male; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nuclear Proteins; Pentylenetetrazole; Pyrazines; Receptors, N-Methyl-D-Aspartate; Seizures; Transcription Factors | 2018 |
Evaluation of Selective 5-HT
Topics: Animals; Benzazepines; Disease Models, Animal; Ethylamines; Fenfluramine; Indoles; Mice; Piperazines; Pyrazines; Rats; Receptor, Serotonin, 5-HT2C; Seizures; Serotonin 5-HT2 Receptor Agonists; Treatment Outcome | 2019 |
Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles.
Topics: Animals; Anticonvulsants; Heterocyclic Compounds; Male; Mice; Molecular Structure; Pentylenetetrazole; Pyrazines; Seizures | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2014 |
[OBSERVATIONS ON THE MECHANISM OF ACTION OF A SPINAL CONVULSANT, HEXAHYDRO-2'-METHYLSPIROCYCLOHEXANE-1,8'-(6H)-OXAZINO-(3,4-A)-PYRAZINE OR COP].
Topics: Animals; Birds; Cats; Central Nervous System Stimulants; Convulsants; Guinea Pigs; Pharmacology; Pyrazines; Research; Seizures; Spinal Cord; Toxicology | 1964 |
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Behavior, Animal; Calcium Channel Blockers; Central Nervous System; Disease Models, Animal; Epilepsy; Humans; Kindling, Neurologic; Lamotrigine; Male; Mice; Molecular Structure; Motor Activity; Pyrazines; Rats; Rats, Sprague-Dawley; Seizures; Sodium Channel Blockers; Triazines | 2008 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Mice; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Pyrazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotyped Behavior; Strychnine | 1997 |
Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions.
Topics: Animals; Cocaine; Male; Mice; Mice, Inbred C57BL; Piperazines; Pyrazines; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Seizures; Species Specificity | 1999 |
8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazines: highly potent in vivo AMPA antagonists.
Topics: Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Isoquinolines; Mice; Oocytes; Pyrazines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Tetrazoles; Xenopus laevis | 2000 |
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Cell Membrane; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Agonists; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Inhibitory Concentration 50; Male; Mice; Mice, Inbred DBA; Oocytes; Protein Binding; Pyrazines; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Time Factors; Xenopus | 2000 |
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Disease Models, Animal; Excitatory Amino Acid Antagonists; Imidazoles; Inhibitory Concentration 50; Male; Mice; Oocytes; Pyrazinamide; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Injections, Intraventricular; Male; Mice; Pentobarbital; Picrotoxin; Pyrazines; Seizures; Sleep; Time Factors; Valproic Acid | 2001 |
9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): selective anticonvulsive and neuroprotective AMPA antagonist.
Topics: Animals; Anticonvulsants; Brain Injuries; Brain Ischemia; Disease Models, Animal; Gerbillinae; Imidazoles; Male; Neuroprotective Agents; Oocytes; Protein Binding; Pyrazines; Radioligand Assay; Rats; Receptors, AMPA; Reperfusion Injury; Seizures; Spinal Cord Compression; Synapses; Xenopus | 2002 |
Different central effects of the 5-HT antagonists mianserine and cyproheptadine.
Topics: Animals; Behavior, Animal; Cyproheptadine; Dibenzazepines; Drug Antagonism; Electroshock; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Pilocarpine; Pyrazines; Reserpine; Salivation; Seizures; Serotonin Antagonists; Strychnine; Tremorine | 1972 |
Pharmacology of alkyl and hydroxyalkylpyrazines.
Topics: Animals; Anticonvulsants; Central Nervous System; Glucose; Hypnotics and Sedatives; Imidazoles; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrazines; Reflex; Seizures | 1970 |
Toxicity of methylimidazoles.
Topics: Animals; Anticonvulsants; Chickens; Chlordiazepoxide; Electroencephalography; Heart Rate; Imidazoles; Mice; Motor Activity; Pentobarbital; Pentylenetetrazole; Phenytoin; Pyrazines; Rabbits; Respiration; Respiratory Paralysis; Seizures | 1969 |