pyrazines has been researched along with Reperfusion Injury in 76 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (5.26) | 18.2507 |
| 2000's | 27 (35.53) | 29.6817 |
| 2010's | 38 (50.00) | 24.3611 |
| 2020's | 7 (9.21) | 2.80 |
| Authors | Studies |
|---|---|
| Acar, E; Altunrende, F; Can, O; Canat, L; Eraldemir, FC; Otunctemur, A; Sonmez, K; Yildirim, F | 1 |
| Fang, BY; Gao, G; Hu, J; Liu, F; Meng, XB; Sun, GB; Sun, XB; Wang, H; Wu, Y; Zhang, SX; Zhu, T | 1 |
| Chen, J; Dong, L; Dong, Y; Fu, X; Guo, T; Liu, M; Mao, Y; Qiao, C; Yang, Y; Zhang, J; Zhang, X; Zhao, Y | 1 |
| Fan, X; Tang, W; Wang, S; Zhang, H; Zhang, J | 1 |
| Du, P; Han, H; Hou, Y; Jiang, G; Meng, X; Sun, W; Wang, L; Xin, R; Yuan, W; Zhang, L | 1 |
| Dong, M; Du, P; Li, A; Qi, F; Sun, W; Sun, X; Wang, L; Wang, Z; Zhang, Y | 1 |
| Cai, JY; Du, HY; Jian, YL; Li, JL; Luo, H; Wang, R; Xie, XY; Yan, R | 1 |
| Chai, H; Huang, Z; Lei, Z; Liu, Y; Qin, X; Wu, Z | 1 |
| Deng, H; Hu, H; Luo, J; Shan, L; Wang, Y; Yu, P; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Gao, F; Li, P; Luo, L; Shen, M; Teng, F; Tu, J; Yeh, CK; Zhang, C; Zhang, D | 1 |
| Du, S; He, G; Sun, Z; Wu, Y; Zhang, X; Zhao, Y; Zhou, L; Zhou, P; Zhuo, LH | 1 |
| Jing, G; Jinmin, Z; Li, Z; Min, L; Xinyong, L; Yaqing, J; Yulei, J | 1 |
| Chen, Q; Gao, L; Gong, P; Han, S; Li, M; Liao, J; Tian, Q; Xu, Z; Zhang, Z; Zou, Y | 1 |
| Cao, W; Chen, W; Ding, M; Guo, H; Lin, T; Wang, T; Wei, H; Yu, H; Zhang, C; Zhao, S; Zhao, X | 1 |
| Chen, FT; Yang, CH; Yang, CM | 1 |
| Gál, P; Guzy, J; Pekárová, T; Tomečková, V; Tóth, Š; Varga, J; Veselá, J | 1 |
| Chang, G; Duan, Q; Lu, K; Qin, S; Wang, Y; Ye, L; Zhang, D; Zhang, P; Zheng, A | 1 |
| Chen, L; Li, S; Liu, H; Liu, X; Wei, X; Zhang, X | 1 |
| Abdennebi, HB; Bardag-Gorce, F; Bejaoui, M; Carbonell, T; Folch-Puy, E; Oliva, J; Pantazi, E; Rimola, A; Roselló-Catafau, J; Zaouali, MA | 1 |
| Chang, CL; Chang, HW; Chang, LT; Chen, HH; Chen, YL; Chen, YT; Leu, S; Sun, CK; Sung, PH; Tsai, TH; Yang, CC; Yip, HK; Zhen, YY | 1 |
| Anderson, CD; Busch, RA; Chapman, WC; Dines, JN; Gunter, KL; Jia, J; Knolhoff, BL; Mohanakumar, T; Ramachandran, S; Sarma, NJ; Tiriveedhi, V; Upadhya, GA | 1 |
| Chen, L; Hou, Y; Li, S; Liu, H; Liu, X; Sun, B; Wei, X | 1 |
| Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY | 1 |
| Teng, F; Tu, J; Zhang, C; Zhang, D | 1 |
| Chen, L; Cheng, L; Kong, L; Liu, H; Liu, X; Wei, X; Yan, S; Zhang, X | 1 |
| Chang, HW; Chang, MW; Chen, CH; Chen, YC; Chen, YT; Chiang, HJ; Ko, SF; Leu, S; Sung, PH; Tsai, TH; Wu, YC; Yang, CC; Yip, HK; Zhen, YY | 1 |
| Ain-Shoka, AA; Attia, AS; El-Sahar, AE; Safar, MM; Zaki, HF | 1 |
| Polat, H; Türk, Ö; Uysal, O; Yaşar, B | 1 |
| Hu, DH; Lu, CY; Peng, XM; Xi, L; Zheng, ZX | 1 |
| Guo, M; Liu, Y; Shi, D | 1 |
| Chen, ML; Cui, YJ; He, GW; Liu, B; Wu, YL; Xu, SH; Yang, D; Yin, MS; Zhou, PP | 1 |
| Ba, W; Fan, W; Guo, Z; Li, Z; Liao, F; Liao, W; Wang, D; Wang, L; Wu, Y; Yu, J | 1 |
| Gao, Q; Huang, W; Su, M; Yang, Y; Zeng, Z; Zhu, B | 1 |
| Chan, CC; Chang, Y; Chao, FP; Chao, HM; Chi, CW; Ho, LT; Hsu, WM; Kuo, CD; Lee, FL; Lee, SM; Lin, DE; Liu, TY; Lui, WY; Pan, WH | 1 |
| Chen, SY; Gong, G; Hu, S; Liu, ZG; Ma, X; Wang, Q; Xiong, LZ; Zhu, XL; Zhu, ZH | 1 |
| Hu, X; Tian, M; Wan, H; Yang, J; Zhang, H; Zhao, C; Zhu, H | 1 |
| Guo, QC; Hu, YS; Jia, J; Li, NN; Wang, QZ; Wu, CQ; Wu, Y; Yu, HX; Zhang, X | 1 |
| Jang, HS; Kim, KM; Oh, KJ; Park, JW; Rhyu, IJ | 1 |
| Agrawal, A; Cohen, S; Jacobsen, J; Romero-Perez, D; Thomas, R; Villarreal, F; Yan, Y | 1 |
| Eller, K; Heininger, D; Huber, JM; Mayer, G; Rosenkranz, AR; Tagwerker, A | 1 |
| Bouskela, E; Cordi, A; De Wael, F; Jeanjot, P; Marchand-Brynaert, J; Moens, C; Rees, JF; Verbeuren, T | 1 |
| Cheng, F; Feng, L; Guo, Y; Ke, N; Li, Q; Li, S; Li, Y | 1 |
| Bhalodia, Y; Manek, R; Sheth, N; Vaghasiya, J | 1 |
| Jiang, DM; Liang, Y; Yang, QH; Yu, XD | 1 |
| Duan, GX; Men, XL; Peng, J | 1 |
| Chen, RJ; Chen, XW; Fang, ZX; Hao, ML; Wang, FY; Wang, WT; Wang, XY | 1 |
| Li, D; Lin, LN; Wang, WT; Xu, ZJ | 1 |
| Ni, SR; Wang, WT; Xu, ZJ; Zhou, WB | 1 |
| Dang, X; Die, J; Fan, L; Shi, Z; Wang, C; Wang, K | 1 |
| Li, JH; Wan, HT; Zhu, ZH | 1 |
| Li, J; Lu, J; Wan, H; Yang, J; Zhang, Y; Zhu, Z | 1 |
| Chapman, WC; Csontos, K; Glasgow, SC; Jia, J; Liaw, JM; Liu, W; Mohanakumar, T; Ramachandran, S; Upadhya, GA | 1 |
| Ding, Y; Li, J; Li, S; Liang, X; Liao, X; Luo, Y; Min, W; Sun, G; Yang, C; Zhou, H | 1 |
| Bardag-Gorce, F; Bartrons, R; Bonaccorsi-Riani, E; Boncompagni, E; Carbonell, T; French, SW; Oliva, J; Padrissa-Altés, S; Roselló-Catafau, J; Zaouali, MA | 1 |
| Huang, Z; Luo, ZL; Ren, JD; Tang, LJ; Tian, FZ; Wan, H; Wang, T; Yan, HT | 1 |
| Chen, L; Ding, Y; Hou, X; Li, H; Tang, Y; Zhao, S; Zheng, Y; Zhou, H | 1 |
| Bardag-Gorce, F; Bejaoui, M; Ben Abdennebi, H; Carbonell, T; Oliva, J; Pantazi, E; Rimola, A; Roselló-Catafau, J; Zaouali, MA | 1 |
| Li, Y; Shi, J; Sun, L; Wang, X | 1 |
| Fukuuchi, Y; Itoh, Y; Uematsu, D; Watanabe, S; Yamaguchi, K | 1 |
| Arrault, A; Bouskela, E; Cordi, A; Dubuisson, M; Gharbi, S; Marchand, C; Marchand-Brynaert, J; Rees, JF; Rupin, A; Verbeuren, T | 1 |
| Boehncke, WH; Elliott, PJ; Zollner, TM | 1 |
| Chen, JL; Chen, NW; Chen, WX; Wu, YL; Zhang, MJ; Zhou, T; Zhu, JS | 1 |
| Cheng, F; Feng, L; Li, S; Li, Y; Xiong, Y; Zhang, L | 1 |
| Hu, Z; Lin, LN; Wang, WT; Wu, JZ; Xie, K | 1 |
| Chen, CH; Chen, TH; Chu, YL; Hou, CC; Hsu, YH; Juan, SH; Lin, H; Sue, YM | 1 |
| Chen, XL; Liu, Y; Qi, CF; Tian, YM; Xiao, XL; Zhang, JF; Zhang, JS; Zhang, PB | 1 |
| Chen, XL; Liu, Y; Qi, CF; Qiu, F; Tian, YM; Xiao, XL; Zhang, JS; Zhang, PB | 1 |
| Gao, S; Kong, LH; Mao, JJ; Su, FR; Sun, GJ | 1 |
| Cai, Y; Chen, LE; Park, JW; Qi, WN; Urbaniak, JR | 1 |
| Qiu, F; Wu, W | 1 |
| Ma, XL | 1 |
| Phillis, JW | 1 |
| Auguet, M; Chabrier, PE; Cornet, S; Demerlé-Pallardy, C; Marin, JG; Spinnewyn, B | 1 |
| Maehara, K; Maruyama, Y; Midorikawa, J; Ohtani, H; Ushiroda, S; Watanabe, T; Yaoita, H | 1 |
| Birraux, G; Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Stutzmann, JM; Vuilhorgne, M; Wahl, F | 1 |
| Shao, GF | 1 |
4 review(s) available for pyrazines and Reperfusion Injury
| Article | Year |
|---|---|
Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors.
Topics: Animals; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Kidney; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Reperfusion Injury; Sitagliptin Phosphate; Triazoles; Up-Regulation | 2015 |
Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; Calcium; China; Humans; Pinellia; Pyrazines; Reperfusion Injury; Rhizome | 2016 |
Proteasome inhibition: a new anti-inflammatory strategy.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Asthma; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Inflammation; Lysine; Models, Biological; Models, Chemical; Multienzyme Complexes; Multiple Sclerosis; Neoplasms; NF-kappa B; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Psoriasis; Pyrazines; Reperfusion Injury | 2003 |
[Protection of Chinese medicinal herb extracts against cerebral ischemia-reperfusion injury].
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Drugs, Chinese Herbal; Ginsenosides; Pyrazines; Reperfusion Injury; Saponins | 1993 |
1 trial(s) available for pyrazines and Reperfusion Injury
| Article | Year |
|---|---|
[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury].
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Drug Therapy, Combination; Female; Humans; Lipid Peroxides; Liver; Liver Neoplasms; Male; Middle Aged; Propofol; Pyrazines; Reperfusion Injury; Superoxide Dismutase | 2006 |
71 other study(ies) available for pyrazines and Reperfusion Injury
| Article | Year |
|---|---|
Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study.
Topics: Humans; Ischemia; Male; Malondialdehyde; Pyrazines; Rats; Reperfusion Injury; Spermatic Cord Torsion; Testis; Thiones; Thiophenes | 2022 |
Folium
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ginkgo biloba; Infarction, Middle Cerebral Artery; Inflammasomes; Ischemic Stroke; Male; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
Hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites for ischemic stroke.
Topics: Animals; Apigenin; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Neurons; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats; Reperfusion Injury; Stroke | 2019 |
Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF-κB Signaling Pathways.
Topics: Animals; Anti-Inflammatory Agents; Brain; Cell Adhesion Molecules; Cell Hypoxia; Cell Line; Cytokines; Endothelial Cells; Glucose; Inflammation; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Platelet Adhesiveness; Pyrazines; Reperfusion Injury; Signal Transduction | 2020 |
Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation.
Topics: Acute Kidney Injury; Animals; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Immunohistochemistry; In Situ Nick-End Labeling; Male; Nod2 Signaling Adaptor Protein; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction | 2020 |
Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF‑1α and apoptosis.
Topics: Acute Kidney Injury; Animals; Case-Control Studies; Cell Line; Cell Survival; Down-Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Injections, Intraperitoneal; Kidney Tubules, Proximal; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2020 |
Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway.
Topics: Animals; Apoptosis; Autophagy; Cell Survival; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Reperfusion Injury; Retinal Ganglion Cells; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Tetramethylpyrazine inhibits neutrophil extracellular traps formation and alleviates hepatic ischemia/reperfusion injury in rat liver transplantation.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cell-Free Nucleic Acids; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Extracellular Traps; In Situ Nick-End Labeling; Liver; Liver Transplantation; Male; NADPH Oxidases; Neutrophils; Onium Compounds; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome | 2021 |
A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway.
Topics: Animals; Cell Line; Cell Survival; Free Radicals; Heme Oxygenase-1; Iodoacetic Acid; Lactates; Ligusticum; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; NF-E2-Related Factor 2; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Salvia miltiorrhiza; tert-Butylhydroperoxide; Up-Regulation | 2017 |
Ultrasound-Enhanced Protective Effect of Tetramethylpyrazine via the ROS/HIF-1A Signaling Pathway in an in Vitro Cerebral Ischemia/Reperfusion Injury Model.
Topics: Animals; Brain Ischemia; Cell Survival; Cells, Cultured; Flow Cytometry; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Polymerase Chain Reaction; Pyrazines; Rats; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Ultrasonic Waves; Vasodilator Agents | 2018 |
Tetramethylpyrazine‑2'O‑sodium ferulate provides neuroprotection against neuroinflammation and brain injury in MCAO/R rats by suppressing TLR-4/NF-κB signaling pathway.
Topics: Animals; Brain Edema; Brain Injuries; Chemokine CCL2; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2019 |
Protective effects of tetramethylpyrazine analogue Z-11 on cerebral ischemia reperfusion injury.
Topics: Animals; Brain; Glutathione; Heme Oxygenase (Decyclizing); Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neuroprotective Agents; NF-E2-Related Factor 2; Pyrazines; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2019 |
Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia/reperfusion injury through the JAK/STAT signaling pathway.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Infarction; Cytoprotection; JNK Mitogen-Activated Protein Kinases; Neurons; Pyrazines; Rats; Reperfusion Injury; Signal Transduction; STAT Transcription Factors; Tyrphostins; Water | 2019 |
Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis.
Topics: Acute Kidney Injury; Animals; Antioxidants; Fibrosis; Mice; Nanoparticles; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrazines; Reperfusion Injury; Thiones; Thiophenes; Time Factors; Tissue Distribution; Treatment Outcome | 2019 |
The protective effects of the proteasome inhibitor bortezomib (velcade) on ischemia-reperfusion injury in the rat retina.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Boronic Acids; Bortezomib; Cell Count; Chymotrypsin; Gene Expression Regulation; Inflammation Mediators; Male; NF-kappa B; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Ganglion Cells; RNA, Messenger | 2013 |
Intravenous administration of tetramethylpyrazine reduces intestinal ischemia-reperfusion injury in rats.
Topics: Administration, Intravenous; Animals; Apoptosis; Disease Models, Animal; Goblet Cells; Intestinal Mucosa; Jejunum; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Paneth Cells; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents | 2013 |
Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model.
Topics: Animals; Apoptosis; Body Weight; Cardiotonic Agents; Creatine Kinase, MB Form; Disease Models, Animal; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glutathione Peroxidase; Heart; Heart Ventricles; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocytes, Cardiac; Organ Size; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles | 2013 |
Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion injury in the rat by an antioxidant action via inhibition of NADPH oxidase and iNOS expression.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Brain; Brain Ischemia; Glutathione Peroxidase; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Piperazines; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2013 |
Bortezomib enhances fatty liver preservation in Institut George Lopez-1 solution through adenosine monophosphate activated protein kinase and Akt/mTOR pathways.
Topics: AMP-Activated Protein Kinases; Animals; Boronic Acids; Bortezomib; Fatty Liver; Liver; Organ Preservation; Organ Preservation Solutions; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Zucker; Reperfusion Injury; Solutions; TOR Serine-Threonine Kinases | 2014 |
Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction.
Topics: Animals; Biomarkers; Creatinine; Exenatide; Inflammation; Kidney; Male; Oxidative Stress; Peptides; Proteinuria; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Sitagliptin Phosphate; Triazoles; Venoms | 2013 |
Protective role of bortezomib in steatotic liver ischemia/reperfusion injury through abrogation of MMP activation and YKL-40 expression.
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Chitinase-3-Like Protein 1; Enzyme Activation; Extracellular Matrix Proteins; Fatty Liver; Gene Expression Regulation; Glycoproteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pyrazines; Rats; Rats, Zucker; Reperfusion Injury | 2014 |
Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Neuroprotective Agents; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinase; Piperazines; Pyrazines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2014 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Microdialysis; Molecular Structure; Neurotransmitter Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine; Time Factors | 2014 |
Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury.
Topics: Animals; bcl-2-Associated X Protein; Brain Ischemia; Glutamic Acid; High-Energy Shock Waves; Interleukin-8; Ligusticum; Medicine, Chinese Traditional; Microscopy, Electron, Scanning; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2014 |
Tetramethylpyrazine analogue CXC195 ameliorates cerebral ischemia-reperfusion injury by regulating endothelial nitric oxide synthase phosphorylation via PI3K/Akt signaling.
Topics: Animals; Brain Ischemia; Humans; Male; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Piperazines; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2015 |
Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: implication of the oxidative-inflammatory-apoptotic pathway.
Topics: Animals; Brain Ischemia; Caspase 3; Cytochromes c; Diabetes Complications; Diabetes Mellitus, Experimental; Hippocampus; Hypoglycemic Agents; Interleukin-10; Male; Neuroprotective Agents; Neutrophil Infiltration; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Sitagliptin Phosphate; Triazoles | 2015 |
[The effect of ligustrazin in intestinal ischemia reperfusion injury generated on rats].
Topics: Animals; Disease Models, Animal; Ileum; Jejunum; Male; Mesenteric Ischemia; Pyrazines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents | 2015 |
[Protective effects of perfluorocarbon combined with ligustrazine against lung ischemia-reperfusion injury in rats].
Topics: Animals; Cytokines; Fluorocarbons; Lung Injury; Malondialdehyde; Peroxidase; Protective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
Tetramethylpyrazine-2'-O-sodium ferulate attenuates blood-brain barrier disruption and brain oedema after cerebral ischemia/reperfusion.
Topics: Animals; Aquaporin 4; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; Cell Adhesion Molecules; Coumaric Acids; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Occludin; Pyrazines; Rats, Sprague-Dawley; Reperfusion Injury | 2017 |
Microdialysis combined with UPLC-MS/MS method for determination of tetramethylpyrazine and ferulic acid in striatum of awake and anesthetic rats subjected to cerebral ischemia.
Topics: Animals; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Corpus Striatum; Coumaric Acids; Drug Synergism; Limit of Detection; Male; Microdialysis; Pyrazines; Rats; Reperfusion Injury; Sensitivity and Specificity; Tandem Mass Spectrometry | 2016 |
Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Coronary Occlusion; Coronary Vessels; Creatine Kinase; Gene Expression Regulation; Humans; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats; Reperfusion Injury; Salvia miltiorrhiza; Signal Transduction | 2016 |
Ferulic acid, but not tetramethylpyrazine, significantly attenuates retinal ischemia/reperfusion-induced alterations by acting as a hydroxyl radical scavenger.
Topics: Animals; Coumaric Acids; Electroretinography; Free Radical Scavengers; Hydroxyl Radical; Immunohistochemistry; Ischemia; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Retina; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats.
Topics: Analysis of Variance; Animals; Brain Infarction; Disease Models, Animal; Ischemic Attack, Transient; Male; Neurologic Examination; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Thioredoxins; Time Factors; Vasodilator Agents | 2009 |
Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia.
Topics: Animals; Antioxidants; Brain; Gene Expression Regulation; Glucose; Infarction, Middle Cerebral Artery; Interleukin-1; Ischemic Attack, Transient; Isoflavones; Male; Malondialdehyde; Nervous System Diseases; Neuroprotective Agents; Nitric Oxide; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Synaptophysin; Tetrazolium Salts | 2008 |
Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism.
Topics: Animals; Apoptosis; Brain Ischemia; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thioredoxin Reductase 1; Thioredoxins | 2009 |
Proteasome inhibition promotes functional recovery after peripheral nerve reperfusion injury.
Topics: Animals; Boronic Acids; Bortezomib; Female; Injections, Intravenous; Isometric Contraction; Locomotion; Muscle, Skeletal; Muscular Atrophy; Nerve Compression Syndromes; Premedication; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retrograde Degeneration; Sciatic Nerve; Synaptic Transmission | 2009 |
Effects of novel semiselective matrix metalloproteinase inhibitors on ex vivo cardiac structure-function.
Topics: Animals; Coronary Circulation; Hydroxamic Acids; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Myocardial Contraction; Myocardial Stunning; Oligopeptides; Pyrazines; Pyridones; Pyrones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides | 2009 |
The proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Boronic Acids; Bortezomib; CD4 Lymphocyte Count; Creatinine; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Necrosis; Nephritis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Reperfusion Injury; Time Factors | 2009 |
In vitro and in vivo studies of 6,8-(diaryl)imidazo[1,2-a]pyrazin-3(7H)-ones as new antioxidants.
Topics: Amines; Animals; Antioxidants; Capillary Permeability; Chromatography, High Pressure Liquid; Cricetinae; Imidazoles; Ischemia; Male; Oxidation-Reduction; Pyrazines; Reperfusion Injury | 2009 |
The protective mechanism of ligustrazine against renal ischemia/reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Disease Models, Animal; Gene Expression; Intercellular Adhesion Molecule-1; Kidney; Kidney Diseases; Kidney Transplantation; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxidative Stress; Peroxidase; Pyrazines; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2011 |
Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes.
Topics: Animals; Apoptosis; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Fragmentation; Female; Glutathione; Glutathione Peroxidase; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles; Xanthine Oxidase | 2011 |
Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Deferoxamine; Disease Models, Animal; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Siderophores; Spinal Cord Ischemia | 2011 |
[The effects of tetramethylpyrazine on lung injury induced by brain ischemia/reperfusion].
Topics: Animals; Blood Gas Analysis; Brain Ischemia; Lung Injury; Male; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury | 2006 |
[Effect of ligustrazine on expression of Fas/FasL in pulmonary injury induced by ischemia/reperfusion in rabbits].
Topics: Animals; Apoptosis; Fas Ligand Protein; fas Receptor; Lung; Lung Injury; Pyrazines; Rabbits; Reperfusion Injury; RNA, Messenger | 2007 |
[Effects of ligustrazin on lipid peroxidation during hepatic ischemia reperfusion injury].
Topics: Alanine Transaminase; Animals; Female; Lipid Peroxidation; Liver; Male; Malondialdehyde; Pyrazines; Rabbits; Reperfusion Injury; Superoxide Dismutase; Xanthine Oxidase | 2002 |
[Effect of ligustrazine on the expression and activity of heme oxygenase-1 in the pulmonary ischemia/reperfusion injury in rabbits].
Topics: Animals; Disease Models, Animal; Heme Oxygenase-1; Lung; Pyrazines; Rabbits; Reperfusion Injury | 2005 |
Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Male; Neurologic Examination; Neuroprotective Agents; Neutrophil Infiltration; NF-kappa B; Peroxidase; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Interleukin-1beta; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger; Saponins; Triterpenes | 2011 |
Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.
Topics: Animals; Astragalus Plant; Cardiovascular Agents; Caspase 3; Disease Models, Animal; Drug Synergism; Glucose; Hippocampus; Ischemic Attack, Transient; Male; Malondialdehyde; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Positron-Emission Tomography; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Saponins; Superoxide Dismutase; Triterpenes | 2012 |
Ischemia-reperfusion injury in rat steatotic liver is dependent on NFκB P65 activation.
Topics: Animals; Boronic Acids; Bortezomib; Chemokine CXCL2; Disease Models, Animal; Fatty Liver; Humans; Inflammation Mediators; Interleukin-1beta; Liver; Proteasome Inhibitors; Pyrazines; Rats; Rats, Zucker; Reperfusion Injury; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2012 |
TMP prevents retinal neovascularization and imparts neuroprotection in an oxygen-induced retinopathy model.
Topics: Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Ligusticum; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nerve Tissue Proteins; Neuroprotective Agents; Oxygen; Pyrazines; Reperfusion Injury; Retinal Neovascularization; Retinal Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vasodilator Agents | 2012 |
The use of a reversible proteasome inhibitor in a model of Reduced-Size Orthotopic Liver transplantation in rats.
Topics: Animals; Boronic Acids; Bortezomib; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); HSP70 Heat-Shock Proteins; Liver Regeneration; Liver Transplantation; Male; Mitochondria, Liver; Nitric Oxide Synthase Type III; Organ Size; Oxidative Stress; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
[Protective effect of Ligustrazine preconditioning on hepatic energy metabolism in ischemia/reperfusion injury of rat].
Topics: Animals; Energy Metabolism; Ischemic Preconditioning; Liver; Male; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury | 2012 |
Protective action of tetramethylpyrazine on the medulla oblongata in rats with chronic hypoxia.
Topics: Animals; Apoptosis; Atmosphere Exposure Chambers; bcl-2-Associated X Protein; Gene Expression Regulation; Hypoxia; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Lipid Peroxidation; Male; Medulla Oblongata; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2013 |
Proteasome inhibitors protect the steatotic and non-steatotic liver graft against cold ischemia reperfusion injury.
Topics: Adiponectin; Animals; Boronic Acids; Bortezomib; Cold Ischemia; Cysteine Proteinase Inhibitors; Cytoprotection; Fatty Liver; Interleukin-1; Leupeptins; Liver Transplantation; Mitochondria, Liver; Organ Preservation; Organ Preservation Solutions; Oxidative Stress; Proteasome Inhibitors; Pyrazines; Rats; Rats, Zucker; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2013 |
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
Topics: Animals; Disease Models, Animal; Endothelin-1; Free Radical Scavengers; Kidney; Kidney Diseases; Malondialdehyde; Pyrazines; Random Allocation; Rats; Rats, Wistar; Renal Artery; Reperfusion Injury; Superoxide Dismutase | 2002 |
In vivo measurement of superoxide in the cerebral cortex during anoxia-reoxygenation and ischemia-reperfusion.
Topics: Animals; Cats; Cerebral Cortex; Hemodynamics; Imidazoles; Luminescent Measurements; Oxygen; Photons; Pyrazines; Reperfusion Injury; Superoxides; Time Factors | 2002 |
Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury.
Topics: Amidines; Animals; Antioxidants; Capillary Permeability; Cricetinae; Firefly Luciferin; Imidazoles; Lipid Peroxidation; Microcirculation; Protective Agents; Pyrazines; Reperfusion Injury; Structure-Activity Relationship | 2003 |
Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.
Topics: Animals; Disease Models, Animal; Free Radical Scavengers; Kidney; Liver; Male; P-Selectin; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury | 2003 |
Effect of ligustrazine on ischemia-reperfusion injury in murine kidney.
Topics: Animals; Blood Urea Nitrogen; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Nephrectomy; Pyrazines; Renal Circulation; Reperfusion Injury; Superoxide Dismutase; Vasodilator Agents | 2004 |
Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Cytochromes c; Disease Models, Animal; DNA; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression; Gentamicins; In Situ Nick-End Labeling; Kidney Tubules, Proximal; Ligusticum; Male; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2007 |
[Effect of ligustrazine on nNOS expression and neuranagenesis in adult rats after cerebral ischemia-reperfusion injury].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain; Brain Ischemia; Cell Proliferation; Cerebral Ventricles; Dentate Gyrus; Immunohistochemistry; Male; Nerve Regeneration; Nitric Oxide Synthase Type I; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2007 |
[Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury].
Topics: Animals; Blotting, Western; Brain Ischemia; Cell Proliferation; Cerebral Ventricles; Infarction, Middle Cerebral Artery; Male; Nitric Oxide Synthase Type I; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors | 2007 |
[Effects of acupoint-embedding of medicinal thread and electroacupuncture on contents of TNF-alpha and IL-6 of hippocampus tissue in rats with focal cerebral ischemia-reperfusion injury].
Topics: Acupuncture Points; Animals; Brain Ischemia; Collagen; Electroacupuncture; Female; Hippocampus; Interleukin-6; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2007 |
Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation.
Topics: Animals; Blood Vessels; Boronic Acids; Bortezomib; Drug Evaluation, Preclinical; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Laser-Doppler Flowmetry; Male; Mice; Microscopy, Video; Muscle, Skeletal; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Protease Inhibitors; Proteasome Inhibitors; Proteins; Pyrazines; Random Allocation; Reperfusion Injury; Surgical Flaps; Tyrosine | 2007 |
Experimental study on ischemia and reperfusion injury of rat liver and effects of ligustrazine and salvia compound.
Topics: Adenosine Triphosphate; Animals; Drugs, Chinese Herbal; Free Radical Scavengers; Free Radicals; Ischemia; Liver; Male; Plant Extracts; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Salvia miltiorrhiza | 1994 |
The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil.
Topics: Animals; Behavior, Animal; Caffeine; Carotid Arteries; Cerebral Cortex; Cerebrovascular Disorders; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Locomotion; Male; Purinergic P1 Receptor Antagonists; Pyrazines; Reperfusion Injury; Xanthines | 1995 |
BN 80933 inhibits F2-isoprostane elevation in focal cerebral ischaemia and hypoxic neuronal cultures.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Dinoprost; Enzyme Inhibitors; F2-Isoprostanes; Hypoxia, Brain; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Thiophenes | 2000 |
Continuous observation of superoxide generation in an in-situ ischemia-reperfusion rat lung model.
Topics: Animals; Arterial Occlusive Diseases; Disease Models, Animal; Free Radical Scavengers; Imidazoles; Kinetics; Luminescent Measurements; Lung; Male; Pulmonary Artery; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Superoxides | 2001 |
9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): selective anticonvulsive and neuroprotective AMPA antagonist.
Topics: Animals; Anticonvulsants; Brain Injuries; Brain Ischemia; Disease Models, Animal; Gerbillinae; Imidazoles; Male; Neuroprotective Agents; Oocytes; Protein Binding; Pyrazines; Radioligand Assay; Rats; Receptors, AMPA; Reperfusion Injury; Seizures; Spinal Cord Compression; Synapses; Xenopus | 2002 |
[Changes in gerbil brain tissue following cerebral ischemia and postischemic reperfusion and studies of the effects of the Chinese drugs].
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cerebrovascular Circulation; Drugs, Chinese Herbal; Female; Gerbillinae; Glucose; Lactates; Male; Plant Extracts; Pyrazines; Reperfusion Injury; Salvia miltiorrhiza | 1992 |