Page last updated: 2024-08-21

pyrazines and Paraproteinemias

pyrazines has been researched along with Paraproteinemias in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (28.95)	29.6817
2010's	27 (71.05)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cho, YH; Choi, BS; Choi, YJ; Chung, BH; Hong, YA; Kim, YS; Park, CW; Park, GS; Sun, IO; Yang, CW	1
De Maeyer, N; Delforge, M; Dierickx, D; Meersseman, W; Wauters, J	1
Foard, D; Gibbs, SD; Gillmore, JD; Hawkins, PN; Lachmann, HJ; Lane, T; Mahmood, S; Pinney, JH; Rannigan, L; Sachchithanantham, S; Venner, CP; Wechalekar, AD; Whelan, CJ	1
Cheng, J; Lamy, T; Loughran, TP; Malysz, J; Ochmann, M; Talamo, G	1
Bastani, B; Fesler, M; Jasim, S; Mahmud, G	1
Basnayake, K; Talbot, B; Wright, D	1
Cheungpasitporn, W; Fervenza, FC; Gertz, MA; Leung, N; Sethi, S	1
Adamová, D; Bačovský, J; Krejčí, K; Minařík, J; Pika, T; Sčudla, V; Srovnalík, K; Tichý, T; Zadražil, J	1
Takahashi, N	1
Dimopoulos, MA; Kastritis, E; Rajkumar, SV	1
Bladé, J; Cibeira, MT; Fernández de Larrea, C; Lloreta, J; Mascaró, JM; Rovira, M; Serra, N; Solé, M; Torras, A	1
Dimopoulos, MA; Gavriatopoulou, M; Hadjikonstantinou, V; Kastritis, E; Migkou, M; Zirogiannis, P	1
Prommer, EE	1
Eby, C	1
Mitsiades, CS	1
Veselý, K	1
Adam, Z; Cermáková, Z; Feit, J; Hájek, R; Krejcí, M; Mayer, J; Pour, L; Vasků, V	1
Cherem, L; Kahan, BD; Kaposztas, Z; Katz, SM; Van Buren, CT	1
Mehta, AB; Shah, AD; Watts, AJ; Wechalekar, AD	1
Handa, H; Higeta, D; Hirato, J; Karasawa, M; Koiso, H; Mawatari, M; Murakami, H; Nojima, Y; Osaki, Y; Saito, T; Sekigami, T; Tahara, K; Tsukamoto, N; Uchiumi, H; Yokohama, A	1
Adam, Z; Büchler, T; Feit, J; Hájek, R; Krejcí, M; Pour, L	1
Liedtke, M; Medeiros, BC	1
Abraham, J; Bridoux, F; Delbès, S; Desport, E; Fermand, JP; Jaccard, A; Lacotte-Thierry, L; Moumas, E; Touchard, G	1
Kyle, RA; Steensma, DP	1
Henderson, RA; McGhee, CN; Patel, D; Pradhan, MA; Vincent, AL	1
Bladé, J; Cakana, A; Comenzo, RL; Dubrey, SW; Elsayed, Y; Enny, C; Fermand, JP; Hassoun, H; Heffner, LT; Hegenbart, U; Liu, X; Merlini, G; Mortimer, S; Palladini, G; Ramaswami, P; Reece, DE; Sanchorawala, V; Van De Velde, H; Vescio, RA	1
O'Connell, C; Schroyens, W; Sykes, DB	2
Albrecht, P; Braun, SA; Hanneken, S; Methner, A	1
Alexander, MP; Méndez, GP; Nasr, SH; Rennke, HG; Watson, DC	1
Bridoux, F; Delbes, S; Desport, E; Fermand, JP; Jaccard, A; Pourreau, F; Puyade, M; Sirac, C; Touchard, G	1
Juul, JS; Larsen, T; Marcussen, N; Pedersen, EB	1
Korde, N; Kwok, M; Landgren, O	1
Bai, C; Hu, X; Liu, J; Song, X; Wang, J	1
Jimenez-Zepeda, VH; John, R; Trudel, S; Vajpeyi, R	1
Chen, C; Jimenez-Zepeda, VH; Kukreti, V; Reece, DE; Trudel, S; Winter, A	1
Bagot, M; Bezier, M; Cordoliani, F; Delyon, J; Malphettes, M; Rybojad, M; Szalat, R	1
Kyle, RA; Rajkumar, SV	1

Reviews

9 review(s) available for pyrazines and Paraproteinemias

Article	Year
Hyperammonemia, resolved by chemotherapy. Annals of hematology, 2014, Volume: 93, Issue:8 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Coma; Combined Modality Therapy; Cyclophosphamide; Dexamethasone; Diabetes Mellitus, Type 2; Diagnosis, Differential; Female; Humans; Hyperammonemia; Paraproteinemias; Plasmapheresis; Purpura, Thrombotic Thrombocytopenic; Pyrazines; Respiration, Artificial	2014
Treatment of plasma cell dyscrasias with lenalidomide. Leukemia, 2008, Volume: 22, Issue:7 Topics: Amyloidosis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Boronic Acids; Bortezomib; Clinical Trials as Topic; Dexamethasone; Humans; Lenalidomide; Multiple Myeloma; Paraproteinemias; Pyrazines; Renal Insufficiency; Thalidomide; Thromboembolism; Waldenstrom Macroglobulinemia	2008
Pathogenesis and management of bleeding and thrombosis in plasma cell dyscrasias. British journal of haematology, 2009, Volume: 145, Issue:2 Topics: Blood Coagulation Disorders; Blood Platelet Disorders; Boronic Acids; Bortezomib; Hemorrhage; Humans; Immunosuppressive Agents; Paraproteinemias; Protease Inhibitors; Pyrazines; Retrospective Studies; Thalidomide; Thrombosis	2009
[IgA pemphigus accompanying multiple myeloma has disappeared following the treatment with bortezomib (Velcade), cyclophosphamide and dexamethasone. Case study and literature review]. Vnitrni lekarstvi, 2009, Volume: 55, Issue:10 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cyclophosphamide; Dexamethasone; Female; Humans; Immunoglobulin A; Multiple Myeloma; Paraproteinemias; Pemphigus; Pyrazines; Skin Diseases, Vesiculobullous	2009
Plasma cell leukemia: concepts and management. Expert review of hematology, 2010, Volume: 3, Issue:5 Topics: Aged; Antigens, CD20; Antineoplastic Agents; Boronic Acids; Bortezomib; CD56 Antigen; Humans; Lenalidomide; Leukemia, Plasma Cell; Multiple Myeloma; Neoplasms, Second Primary; Palliative Care; Paraproteinemias; Prognosis; Pyrazines; Stem Cell Transplantation; Thalidomide; Transplantation, Autologous; Treatment Outcome	2010
[Current treatment of AL amyloidosis]. Nephrologie & therapeutique, 2011, Volume: 7, Issue:6 Topics: Amyloid; Amyloidosis; Biomarkers; Boronic Acids; Bortezomib; Cardiomyopathies; Consensus Development Conferences as Topic; Dexamethasone; Drug Therapy, Combination; Heart Transplantation; Humans; Immunoglobulin Light Chains; Kaplan-Meier Estimate; Kidney Failure, Chronic; Kidney Transplantation; Lenalidomide; Melphalan; Natriuretic Peptide, Brain; Paraproteinemias; Paraproteins; Peptide Fragments; Prognosis; Pyrazines; Randomized Controlled Trials as Topic; Renal Dialysis; Thalidomide	2011
Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literature. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011, Volume: 58, Issue:4 Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cutis Laxa; Dexamethasone; Diabetic Nephropathies; Erythropoietin; Fatal Outcome; Female; Heavy Chain Disease; Hematuria; Humans; Hypertension, Renal; Immunoglobulin alpha-Chains; Immunoglobulin gamma-Chains; Immunoglobulin mu-Chains; Kidney Glomerulus; Male; Multiple Myeloma; Paraproteinemias; Proteinuria; Pyrazines; Thalidomide; Urticaria; Vasculitis, Leukocytoclastic, Cutaneous	2011
[Renal disorders associated with monoclonal gammopathies: diagnostic and therapeutic progress]. Presse medicale (Paris, France : 1983), 2012, Volume: 41, Issue:3 Pt 1 Topics: Amyloidosis; Biopsy; Boronic Acids; Bortezomib; Dexamethasone; Heart Transplantation; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Kidney; Kidney Diseases; Kidney Transplantation; Melphalan; Paraproteinemias; Plasma Exchange; Pyrazines	2012
Multiple myeloma. The New England journal of medicine, 2004, Oct-28, Volume: 351, Issue:18 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Combined Modality Therapy; Disease Progression; Humans; Lenalidomide; Multiple Myeloma; Paraproteinemias; Protease Inhibitors; Pyrazines; Remission Induction; Stem Cell Transplantation; Thalidomide	2004

Trials

1 trial(s) available for pyrazines and Paraproteinemias

Article	Year
Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects. QJM : monthly journal of the Association of Physicians, 2011, Volume: 104, Issue:11 Topics: Aged; Amyloidosis; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Diseases; Humans; Kidney Diseases; Liver Diseases; Male; Maximum Tolerated Dose; Middle Aged; Paraproteinemias; Peripheral Nervous System Diseases; Prospective Studies; Pyrazines; Treatment Outcome	2011

Article

Year

Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects.

QJM : monthly journal of the Association of Physicians, 2011, Volume: 104, Issue:11

Topics: Aged; Amyloidosis; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Diseases; Humans; Kidney Diseases; Liver Diseases; Male; Maximum Tolerated Dose; Middle Aged; Paraproteinemias; Peripheral Nervous System Diseases; Prospective Studies; Pyrazines; Treatment Outcome

2011

Other Studies

28 other study(ies) available for pyrazines and Paraproteinemias

Article	Year
Plasma cell-rich acute rejection with monoclonal gammopathy in a renal transplant recipient. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2013, Volume: 11, Issue:2 Topics: Acute Disease; Adult; Antineoplastic Agents; Boronic Acids; Bortezomib; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Paraproteinemias; Patient Compliance; Plasma Cells; Pyrazines	2013
Lenalidomide and dexamethasone for systemic AL amyloidosis following prior treatment with thalidomide or bortezomib regimens. British journal of haematology, 2014, Volume: 166, Issue:6 Topics: Aged; Amyloidosis; Boronic Acids; Bortezomib; Cohort Studies; Dexamethasone; Drug Therapy, Combination; Female; Hematologic Agents; Humans; Immunoglobulin Light Chains; Lenalidomide; Male; Middle Aged; Paraproteinemias; Pyrazines; Recurrence; Thalidomide; Treatment Outcome	2014
Report of 6 cases of large granular lymphocytic leukemia and plasma cell dyscrasia. Clinical lymphoma, myeloma & leukemia, 2014, Volume: 14, Issue:5 Topics: Aged; Aged, 80 and over; Anemia; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Causality; Cladribine; Combined Modality Therapy; Cyclophosphamide; Disease Progression; Female; Humans; Lenalidomide; Leukemia, Large Granular Lymphocytic; Male; Melphalan; Methotrexate; Middle Aged; Multiple Myeloma; Neutropenia; Paraproteinemias; Peripheral Blood Stem Cell Transplantation; Prednisone; Protease Inhibitors; Pyrazines; Registries; Retrospective Studies; Thalidomide	2014
Subcutaneous bortezomib for treatment of TEMPI syndrome. Clinical lymphoma, myeloma & leukemia, 2014, Volume: 14, Issue:6 Topics: Boronic Acids; Bortezomib; Edema; Female; Humans; Middle Aged; Paraproteinemias; Polycythemia; Proteasome Inhibitors; Pyrazines; Skin; Telangiectasis; Treatment Outcome	2014
The importance of screening for serum free light chains in suspected cases of multiple myeloma and their impact on the kidney. BMJ case reports, 2014, Oct-17, Volume: 2014 Topics: Aged; Antineoplastic Agents; Biopsy; Bone Marrow; Boronic Acids; Bortezomib; Dexamethasone; Diagnosis, Differential; Electrophoresis; Humans; Immunoglobulin Light Chains; Kidney Diseases; Male; Middle Aged; Multiple Myeloma; Paraproteinemias; Pyrazines; Thalidomide	2014
Refractory atypical hemolytic uremic syndrome with monoclonal gammopathy responsive to bortezomib-based therapy. Clinical nephrology, 2015, Volume: 83, Issue:6 Topics: Acute Kidney Injury; Antibodies, Monoclonal, Humanized; Atypical Hemolytic Uremic Syndrome; Boronic Acids; Bortezomib; Humans; Male; Middle Aged; Paraproteinemias; Pyrazines	2015
[Bortezomib-based therapy in patients with light chain deposition disease]. Vnitrni lekarstvi, 2014, Volume: 60, Issue:10 Topics: Adult; Antineoplastic Agents; Boronic Acids; Bortezomib; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunoglobulin Light Chains; Male; Middle Aged; Paraproteinemias; Pyrazines; Treatment Outcome	2014
[Multiple myeloma and renal impairment]. Nihon rinsho. Japanese journal of clinical medicine, 2015, Volume: 73, Issue:1 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Kidney Diseases; Multiple Myeloma; Paraproteinemias; Prognosis; Pyrazines	2015
Generalized cutis laxa and fibrillar glomerulopathy resulting from IgG Deposition in IgG-lambda Monoclonal Gammopathy: pulmonary hemorrhage during stem cell mobilization and complete hematological response with bortezomib and dexamethasone therapy. European journal of haematology, 2009, Volume: 82, Issue:2 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cutis Laxa; Dexamethasone; Granulocyte Colony-Stimulating Factor; Hemorrhage; Humans; Immunoglobulin G; Kidney Diseases; Kidney Glomerulus; Lung; Male; Middle Aged; Paraproteinemias; Pyrazines	2009
Treatment of light chain deposition disease with bortezomib and dexamethasone. Haematologica, 2009, Volume: 94, Issue:2 Topics: Aged; Boronic Acids; Bortezomib; Dexamethasone; Female; Humans; Male; Middle Aged; Paraproteinemias; Pyrazines; Treatment Outcome	2009
Topical analgesic combinations for bortezomib neuropathy. Journal of pain and symptom management, 2009, Volume: 37, Issue:3 Topics: Administration, Topical; Adrenergic alpha-Agonists; Amines; Analgesics; Boronic Acids; Bortezomib; Clonidine; Cyclohexanecarboxylic Acids; Drug Combinations; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Gels; Humans; Ketamine; Male; Middle Aged; Pain Measurement; Paraproteinemias; Peripheral Nervous System Diseases; Protease Inhibitors; Pyrazines; Walking	2009
Molecular profiles of proteasome inhibition in plasma cell dyscrasias. Journal of the National Comprehensive Cancer Network : JNCCN, 2004, Volume: 2 Suppl 4 Topics: Boronic Acids; Bortezomib; Gene Expression Profiling; Humans; Paraproteinemias; Protease Inhibitors; Proteasome Inhibitors; Pyrazines	2004
[IgA pemphigus accompanying multiple myeloma]. Vnitrni lekarstvi, 2009, Volume: 55, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cyclophosphamide; Dexamethasone; Humans; Immunoglobulin A; Multiple Myeloma; Paraproteinemias; Pemphigus; Proteasome Inhibitors; Pyrazines	2009
Bortezomib successfully reverses early recurrence of light-chain deposition disease in a renal allograft: a case report. Transplantation proceedings, 2009, Volume: 41, Issue:10 Topics: Adult; Antilymphocyte Serum; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Melphalan; Multiple Myeloma; Paraproteinemias; Pyrazines; Recurrence; Stem Cell Transplantation; Transplantation, Autologous; Treatment Outcome	2009
An unusual case of transient dermatological reaction to bortezomib in AL amyloidosis. International journal of hematology, 2010, Volume: 91, Issue:1 Topics: Amyloidosis; Boronic Acids; Bortezomib; Drug Eruptions; Humans; Immunoglobulin Light Chains; Male; Middle Aged; Paraproteinemias; Protease Inhibitors; Pyrazines	2010
[IgM-lambda multiple myeloma presenting with systemic amyloidosis]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2009, Volume: 50, Issue:12 Topics: Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Doxorubicin; Fatal Outcome; Humans; Immunoglobulin M; Male; Middle Aged; Multiple Myeloma; Paraproteinemias; Pyrazines; Vincristine	2009
IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen. Wiener klinische Wochenschrift, 2010, Volume: 122, Issue:9-10 Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cyclophosphamide; Dexamethasone; Female; Humans; IgA Deficiency; Middle Aged; Multiple Myeloma; Paraproteinemias; Pemphigus; Pyrazines; Remission Induction	2010
History of multiple myeloma. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2011, Volume: 183 Topics: Adrenal Cortex Hormones; Alkylating Agents; Bence Jones Protein; Boronic Acids; Bortezomib; History, 19th Century; History, Ancient; Humans; Lenalidomide; Melphalan; Multiple Myeloma; Paraproteinemias; Prednisone; Proteinuria; Pyrazines; Stem Cell Transplantation; Thalidomide; Urethane	2011
Heavy-chain amyloidosis in TGFBI-negative and gelsolin-negative atypical lattice corneal dystrophy. Cornea, 2011, Volume: 30, Issue:10 Topics: Amyloid; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Corneal Dystrophies, Hereditary; Dexamethasone; DNA Mutational Analysis; Extracellular Matrix Proteins; Gelsolin; Glucocorticoids; Humans; Immunoglobulin Heavy Chains; Male; Mass Spectrometry; Melphalan; Microscopy, Confocal; Middle Aged; Mutation; Nephrotic Syndrome; Paraproteinemias; Pyrazines; Sequence Analysis, Protein; Transforming Growth Factor beta	2011
The TEMPI syndrome--a novel multisystem disease. The New England journal of medicine, 2011, Aug-04, Volume: 365, Issue:5 Topics: Adult; Boronic Acids; Bortezomib; Erythropoietin; Female; Humans; Hydronephrosis; Lymphangiectasis; Male; Middle Aged; Paraproteinemias; Polycythemia; Protease Inhibitors; Pyrazines; Syndrome; Telangiectasis	2011
[POEMS syndrome. An interdisciplinary clinical challenge]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2011, Volume: 62, Issue:10 Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Boronic Acids; Bortezomib; Cooperative Behavior; Dexamethasone; Drug Therapy, Combination; Humans; Immunoglobulin lambda-Chains; Interdisciplinary Communication; Male; Middle Aged; Paraproteinemias; POEMS Syndrome; Pyrazines; Vascular Endothelial Growth Factor A	2011
[Improved prognosis in light chain nephropathy due to multiple myeloma]. Ugeskrift for laeger, 2012, Apr-23, Volume: 174, Issue:17 Topics: Acute Kidney Injury; Antineoplastic Agents; Boronic Acids; Bortezomib; Dexamethasone; Female; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Kidney Diseases; Middle Aged; Multiple Myeloma; Paraproteinemias; Prognosis; Pyrazines; Stem Cell Transplantation	2012
Bortezomib to treat the TEMPI syndrome. The New England journal of medicine, 2012, May-10, Volume: 366, Issue:19 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Erythropoietin; Female; Humans; Lymphangiectasis; Middle Aged; Paraproteinemias; Polycythemia; Pyrazines; Syndrome; Telangiectasis	2012
Bortezomib combined with thalidomide and dexamethasone is effective for patient with crystal-storing histiocytosis associated with monoclonal gammopathy of undermined significance. European journal of haematology, 2012, Volume: 89, Issue:2 Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Hormonal; Boronic Acids; Bortezomib; Dexamethasone; Female; Histiocytosis; Humans; Paraproteinemias; Pyrazines; Thalidomide	2012
Light chain deposition disease affecting the gastrointestinal tract in the setting of post-living donor kidney transplantation. International journal of hematology, 2012, Volume: 96, Issue:1 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Dexamethasone; Gastrointestinal Tract; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Kidney Transplantation; Lenalidomide; Male; Middle Aged; Paraproteinemias; Pyrazines; Thalidomide; Treatment Outcome	2012
Autologous stem cell transplant for light chain deposition disease: incorporating bortezomib to the induction therapy. American journal of hematology, 2012, Volume: 87, Issue:8 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Disease-Free Survival; Female; Follow-Up Studies; Humans; Immunoglobulin Light Chains; Male; Paraproteinemias; Pyrazines; Retrospective Studies; Stem Cell Transplantation; Survival Rate; Transplantation, Autologous	2012
Complete and partial responses of the TEMPI syndrome to bortezomib. The New England journal of medicine, 2012, Aug-23, Volume: 367, Issue:8 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Erythropoietin; Female; Humans; Male; Middle Aged; Paraproteinemias; Polycythemia; Pyrazines; Syndrome; Telangiectasis	2012
[Cutaneous manifestations revealing cryofibrinogenaemia associated with monoclonal gammopathy]. Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:1 Topics: Acute Kidney Injury; Adult; Aged, 80 and over; Anti-Inflammatory Agents; Antineoplastic Agents; Biopsy; Boronic Acids; Bortezomib; Cryoglobulinemia; Cryoglobulins; Cyclophosphamide; Dexamethasone; Drug Therapy, Combination; Female; Fibrinogens, Abnormal; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Kidney; Leg Ulcer; Microscopy, Fluorescence; Necrosis; Paraproteinemias; Plasmapheresis; Prednisone; Pyrazines; Skin	2013