pyrazines has been researched along with Nerve Pain in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 20 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, D; Liu, D; Ma, X; Sun, M; Xu, D; Yu, H | 1 |
| Bartolucci, G; Buccioni, M; Catarzi, D; Ceni, C; Colotta, V; Dal Ben, D; Di Cesare Mannelli, L; Falsini, M; Ghelardini, C; Lucarini, E; Marucci, G; Menicatti, M; Varano, F; Volpini, R | 1 |
| Han, Y; Hu, L; Jiang, L; Liu, BQ; Liu, L; Liu, WT; Pan, CL; Qu, JW; Wang, CY; Yang, Y | 1 |
| Leánez, S; Pol, O; Redondo, A; Riego, G | 1 |
| Guo, S; Li, A; Wang, S | 1 |
| Gao, T; Jiang, JD; Li, T; Shi, T; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Bennett, GJ; Bryant, L; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Ryerse, J; Salvemini, D | 1 |
| Aylı, M; Cevik, C; Mandıroğlu, S | 1 |
| Bianchi, E; Cerretani, D; Ghelardini, C; Menicacci, C | 1 |
| Chu, SH; Cleeland, CS; Geng, Y; Lee, ES; Lee, YJ; Wang, XS | 1 |
| Bujalska-Zadrożny, M; Dawidowski, M; de Cordé, A; Kleczkowska, P; Kogut, E | 1 |
| Gao, Y; Liang, S; Mu, S; Wan, F; Wang, Y; Xu, C; Zhang, A | 1 |
| Corso, A; Lazzarino, M; Mangiacavalli, S; Pascutto, C; Varettoni, M; Zappasodi, P | 1 |
| Alfonsi, E; Corso, A; De Amici, M; Lazzarino, M; Lozza, A; Mangiacavalli, S; Varettoni, M | 1 |
| Mashimo, T; Nakae, A; Nakai, K; Oba, S; Ueda, K | 1 |
| Antonio, B; Atkinson, RN; Chapman, ML; Drizin, I; Faltynek, CR; Gregg, RJ; Honore, P; Jarvis, MF; Johnson, MS; Joshi, S; Knox, A; Kort, ME; Krafte, DS; Krambis, MJ; Liu, D; Liu, Y; Marron, BE; Marsh, KC; Scanio, MJ; Shi, L; Shieh, CC; Simler, GH; Thomas, JB; Werness, S; Zhang, X | 1 |
| Farquhar-Smith, P | 1 |
| Borsini, W; Di Stasi, V; Donadio, V; Giannoccaro, MP; Gomis Pèrez, C; Liguori, R | 1 |
| Hervera, A; Leánez, S; Motterlini, R; Negrete, R; Pol, O | 1 |
| Gao, XM; Leng, YF; Wang, SX; Xing, YH | 1 |
| Collet, P; Marotte, H; Nizeica, V | 1 |
| Goto, F; Obata, H; Saito, S; Sakurazawa, S; Sasaki, M; Usui, T | 1 |
| Briggs, MA; Bruton, G; Calver, AR; Chessell, I; Crook, B; Davis, JB; Davis, RP; Foley, AG; Heslop, T; Hirst, WD; Medhurst, AD; Medhurst, SJ; Ociepka, S; Orlek, B; Ray, A; Regan, CM; Sargent, B; Schogger, J; Stean, TO; Trail, BK; Upton, N; White, T; Wilson, DM | 1 |
| Gaillarde, B; Nove-Josserand, G; Ortonne, JP; Philippe, LP; Plauchu, M; Pugiat, M | 1 |
| Gaillarde, B; Ortonne, JP; Plauchu, M; Pugeat, M | 1 |
2 review(s) available for pyrazines and Nerve Pain
| Article | Year |
|---|---|
Current use of drugs affecting the central nervous system for chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Carbamazepine; Central Nervous System; Cyclohexanols; Duloxetine Hydrochloride; Epothilones; Humans; Neoplasms; Neuralgia; Oxcarbazepine; Peripheral Nervous System Diseases; Pyrazines; Taxoids; Thalidomide; Thiophenes; Venlafaxine Hydrochloride; Vinca Alkaloids | 2015 |
Chemotherapy-induced neuropathic pain.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Neuralgia; Pyrazines; Thalidomide | 2011 |
2 trial(s) available for pyrazines and Nerve Pain
| Article | Year |
|---|---|
Bortezomib-induced peripheral neuropathy in multiple myeloma: a comparison between previously treated and untreated patients.
Topics: Activities of Daily Living; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Multiple Myeloma; Neoadjuvant Therapy; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Risk Factors | 2010 |
Emergent T-helper 2 profile with high interleukin-6 levels correlates with the appearance of bortezomib-induced neuropathic pain.
Topics: Aged; Antineoplastic Agents; Boronic Acids; Bortezomib; Female; Humans; Interleukin-6; Male; Middle Aged; Multiple Myeloma; Neuralgia; Prospective Studies; Pyrazines; Th2 Cells | 2010 |
21 other study(ies) available for pyrazines and Nerve Pain
| Article | Year |
|---|---|
Inhibition of TRPA1 and IL-6 signal alleviates neuropathic pain following chemotherapeutic bortezomib.
Topics: Acetanilides; Analgesics; Animals; Bortezomib; Disease Models, Animal; Ganglia, Spinal; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Proteasome Inhibitors; Purines; Pyrazines; Quinoxalines; Rats, Sprague-Dawley; Receptors, Interleukin-6; Sensory Receptor Cells; Signal Transduction; TRPA1 Cation Channel | 2019 |
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-
Topics: Analgesics; Animals; Antioxidants; Cell Survival; CHO Cells; Cricetulus; Crystallography, X-Ray; Cyclic AMP; Humans; Microglia; Molecular Docking Simulation; Neuralgia; Oxaliplatin; Oxidative Stress; Pain Management; Phenol; Purinergic P1 Receptor Antagonists; Pyrazines; Rats; Receptor, Adenosine A2A; Triazoles | 2019 |
Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats.
Topics: Animals; Astrocytes; Cells, Cultured; Injections, Spinal; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neuralgia; Pyrazines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2017 |
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
Topics: Animals; Carbon Monoxide; Central Nervous System; Gene Expression Regulation; Heme Oxygenase-1; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Organometallic Compounds; Pyrazines; Pyrroles; Sciatic Nerve; Signal Transduction | 2018 |
Ligustrazine attenuates neuropathic pain by inhibition of JAK/STAT3 pathway in a rat model of chronic constriction injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Constriction, Pathologic; Cytokines; Hot Temperature; Male; Neuralgia; Pain Threshold; Pyrazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Signal Transduction; Spinal Cord; STAT3 Transcription Factor | 2016 |
Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Gabapentin; Male; Mice; Mice, Inbred C57BL; Morphinans; Neuralgia; Peripheral Nerve Injuries; Pyrazines; Spinal Cord Injuries | 2019 |
Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Axons; Boronic Acids; Bortezomib; Energy Metabolism; Hyperalgesia; Male; Mitochondria; Neoplasm Transplantation; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Peripheral Nerves; Peroxynitrous Acid; Physical Stimulation; Protein Processing, Post-Translational; Pyrazines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Superoxide Dismutase | 2013 |
Acupuncture for neuropathic pain due to bortezomib in a patient with multiple myeloma.
Topics: Acupuncture Therapy; Aged; Boronic Acids; Bortezomib; Humans; Male; Multiple Myeloma; Neuralgia; Pyrazines | 2014 |
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.
Topics: Analgesics; Animals; Boronic Acids; Bortezomib; Ceftriaxone; Cell Line, Tumor; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hyperalgesia; Injections, Spinal; Male; Neural Conduction; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5 | 2014 |
Antinociceptive activity of intraperitoneally administered novel and potent anticonvulsive compound, CY-PROLL-SS, in animal neuropathic pain models.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Male; Neuralgia; Pain Measurement; Pyrazines; Pyrroles; Rats; Streptozocin | 2016 |
Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states.
Topics: Afferent Pathways; Animals; Calcium Channel Blockers; Constriction; Electrophysiology; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Male; Neuralgia; Neurons; Neurons, Afferent; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Sciatic Nerve; Spinal Cord | 2008 |
5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethylamines; Indoles; Injections, Spinal; Male; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Trigeminal Neuralgia | 2010 |
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Topics: Administration, Oral; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Ganglia, Spinal; Humans; Microsomes; NAV1.8 Voltage-Gated Sodium Channel; Neuralgia; Neurons; Pyrazines; Rats; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship | 2010 |
Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Autonomic Nervous System Diseases; Boronic Acids; Bortezomib; Fluorescent Antibody Technique; Humans; Male; Middle Aged; Multiple Myeloma; Neuralgia; Polyneuropathies; Pyrazines; Skin | 2011 |
Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice.
Topics: Animals; Carbon Monoxide; CD11b Antigen; CD11c Antigen; Enzyme Induction; Ganglia, Spinal; Gene Expression Regulation, Enzymologic; Gene Knockout Techniques; Heme Oxygenase-1; Male; Mice; Microglia; Neuralgia; Nitric Oxide; Nitric Oxide Synthase Type II; Organometallic Compounds; Pyrazines; Pyrroles; Sciatic Nerve; Spinal Cord | 2012 |
Effects of tetramethylpyrazine on neuronal apoptosis in the superficial dorsal horn in a rat model of neuropathic pain.
Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Male; Neuralgia; Neurons; Posterior Horn Cells; Pyrazines; Rats | 2012 |
Bortezomib induced a phrenic palsy in a multiple myeloma patient.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Boronic Acids; Bortezomib; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diagnosis, Differential; Diphosphonates; gamma-Aminobutyric Acid; Humans; Imidazoles; Male; Melphalan; Multiple Myeloma; Nerve Compression Syndromes; Neuralgia; Phrenic Nerve; Prednisone; Pregabalin; Protease Inhibitors; Pyrazines; Respiratory Paralysis; Zoledronic Acid | 2013 |
Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury.
Topics: Amphetamines; Animals; Indoles; Injections, Spinal; Ketanserin; Ligation; Lumbar Vertebrae; Male; Neuralgia; Nociceptors; Piperazines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Nerves; Spiro Compounds; Sulfonamides; Thiophenes | 2004 |
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.
Topics: Analgesics; Animals; Avoidance Learning; Azepines; Benzazepines; Capsaicin; Central Nervous System; Drinking; Histamine Agonists; Histamine Antagonists; Humans; Male; Memory Disorders; Neuralgia; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Scopolamine | 2007 |
[Value of pyrazinobutazone in the treatment of various inflammatory conditions].
Topics: Anti-Inflammatory Agents; Arthritis; Drug Tolerance; Neuralgia; Osteoarthritis; Osteoporosis; Phenylbutazone; Phlebitis; Pyrazines; Rheumatic Diseases; Spondylitis | 1972 |
[Value of pyrazinobutazone in the treatment of different inflammatory states].
Topics: Adult; Aged; Anti-Inflammatory Agents; Female; Humans; Joint Diseases; Male; Middle Aged; Neuralgia; Phenylbutazone; Pyrazines; Rheumatic Diseases | 1972 |