pyrazines has been researched along with Myocardial Ischemia in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shan, L; Sun, Y; Wang, Y; Xu, C; Yu, P; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Deng, H; Hu, H; Luo, J; Shan, L; Wang, Y; Yu, P; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Chen, B; Huang, DD; Huang, HH; Li, DG; Yang, Q; Yuan, CL; Zhang, LM | 1 |
| Asche, CV; Eurich, DT; McAlister, FA; Sandhu-Minhas, JK; Senthilselvan, A; Simpson, S | 1 |
| Franz, WM; Hiergeist, L; Kozlik-Feldmann, R; Mechea, A; Netz, H; Theisen, D; Zaruba, MM | 1 |
| Bond, SJ; Dutka, DP; Hoole, SP; Kydd, AC; McCormick, LM; Read, PA; Ring, LS | 1 |
| Ando, K; Cao, X; Enkhsaikhan, A; Izumi-Nakaseko, H; Kishie, T; Nakamura, Y; Sugiyama, A; Wada, T; Xu, B; Zhu, B | 1 |
| Ban, K; Drucker, DJ; Henkelman, RM; Husain, M; Momen, MA; Sauvé, M; Zhou, YQ | 1 |
| He, Z; Liu, H; Liu, J; Liu, X; Zeng, Z; Zhou, W | 1 |
| Cheng, Y; Gong, JB; Jiang, SS; Lv, L; Xu, J | 1 |
| Battagliese, A; Bucciarelli Ducci, C; Celotto, A; De Luca, L; Fedele, F; Palombaro, GL; Proietti, P | 1 |
| Deng, HW; Deng, PY; Hu, CP; Li, YJ; Zhou, Y | 1 |
| Dunn, ST; Garrett, MW; Huang, S; Kaufman, KM; Kem, DC; Metcalf, JP; Patterson, E; Yu, X; Zhu, M | 1 |
| Chen, SY; Cheng, PY; Hsiao, G; Hwang, HR; Lee, YM | 1 |
| De Aos, I; Garrett, MW; Huang, S; Kem, DC; Patterson, E; Yu, X | 1 |
| MacKenzie, I; Saville, VL; Waterfall, JF | 1 |
| Henderson, C; Kane, K; Tweedie, D | 1 |
| Curtis, MJ; Rees, SA | 1 |
| Jing, Z; Pu, Z; Zeng, Z; Zhu, W; Zuo, W | 1 |
| Gasser, R; Grisold, M; Köppel, H | 1 |
| Feng, J; Tang, S; Wu, G | 1 |
| Auguet, M; Auvin, S; Bigg, D; Chabrier, PE; Cornet, S; Demerlé-Pallardy, C; Gillard-Roubert, V; Guilmard-Favre, C; Marin, JG; Moncada, S; Pignol, B; Roussillot-Charnet, C; Schulz, J; Spinnewyn, B; Viossat, I | 1 |
| Gwilt, M; Henderson, CG; Orme, J; Rourke, JD | 1 |
1 review(s) available for pyrazines and Myocardial Ischemia
| Article | Year |
|---|---|
New positive inotropic agents in the treatment of left ventricular dysfunction.
Topics: Cardiotonic Agents; Diastole; Heart Failure; Humans; Hydrazones; Milrinone; Myocardial Ischemia; Phosphodiesterase Inhibitors; Pyrazines; Pyridazines; Quinolines; Simendan; Ventricular Dysfunction, Left; Ventricular Function, Left | 2004 |
1 trial(s) available for pyrazines and Myocardial Ischemia
| Article | Year |
|---|---|
Chronic dipeptidyl peptidase-4 inhibition with sitagliptin is associated with sustained protection against ischemic left ventricular dysfunction in a pilot study of patients with type 2 diabetes mellitus and coronary artery disease.
Topics: Aged; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Echocardiography, Doppler; Echocardiography, Stress; Electrocardiography; Female; Follow-Up Studies; Glucagon-Like Peptide 1; Heart Ventricles; Humans; Male; Myocardial Ischemia; Pilot Projects; Pyrazines; Sitagliptin Phosphate; Stroke Volume; Treatment Outcome; Triazoles; Ventricular Dysfunction, Left | 2014 |
21 other study(ies) available for pyrazines and Myocardial Ischemia
| Article | Year |
|---|---|
Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Lactates; Male; Molecular Structure; Myocardial Ischemia; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship | 2017 |
A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway.
Topics: Animals; Cell Line; Cell Survival; Free Radicals; Heme Oxygenase-1; Iodoacetic Acid; Lactates; Ligusticum; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; NF-E2-Related Factor 2; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Salvia miltiorrhiza; tert-Butylhydroperoxide; Up-Regulation | 2017 |
Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway.
Topics: Animals; Cytokines; Glycogen Synthase Kinase 3 beta; Inflammation; Isoproterenol; Male; Myocardial Ischemia; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Comparative safety and effectiveness of sitagliptin in patients with type 2 diabetes: retrospective population based cohort study.
Topics: Comparative Effectiveness Research; Confounding Factors, Epidemiologic; Diabetes Complications; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Hospitalization; Humans; Hypoglycemic Agents; Insurance, Health; Male; Middle Aged; Myocardial Ischemia; Practice Guidelines as Topic; Propensity Score; Proportional Hazards Models; Pyrazines; Retrospective Studies; Sitagliptin Phosphate; Time Factors; Treatment Outcome; Triazoles; United States | 2013 |
First treatment of a child suffering from severe ischemic cardiomyopathy with G-CSF and sitagliptin.
Topics: Cardiomyopathies; Combined Modality Therapy; Dipeptidyl-Peptidase IV Inhibitors; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Myocardial Ischemia; Pyrazines; Severity of Illness Index; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2013 |
Assessment of the Anti-anginal Effect of Tetramethylpyrazine Using Vasopressin-Induced Angina Model Rats.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Heart Rate; Male; Myocardial Ischemia; Pyrazines; Rats; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins | 2016 |
Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice.
Topics: Animals; Cardiovascular System; Coronary Vessels; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Gene Deletion; Heart; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Ischemia; Pyrazines; Reference Values; Reperfusion; Sitagliptin Phosphate; Survivors; Triazoles | 2010 |
Pharmacokinetics of ligustrazine ethosome patch in rats and anti-myocardial ischemia and anti-ischemic reperfusion injury effect.
Topics: Animals; Area Under Curve; Blood Viscosity; Chi-Square Distribution; Fibrinolytic Agents; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyrazines; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tissue Distribution; Transdermal Patch | 2011 |
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.
Topics: Animals; Apoptosis; Cardiotonic Agents; Caspase 3; Enzyme Inhibitors; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction | 2012 |
The protective effects of ligustrazine on ischemia-reperfusion and DPPH free radical-induced myocardial injury in isolated rat hearts.
Topics: Animals; Biphenyl Compounds; Cardiotonic Agents; Ligusticum; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Phytotherapy; Picrates; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2004 |
Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction.
Topics: Animals; Boronic Acids; Bortezomib; Death, Sudden, Cardiac; Dogs; Electrocardiography; G-Protein-Coupled Receptor Kinase 5; Immunoblotting; Ligation; Male; Microscopy, Confocal; Microscopy, Fluorescence; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pericardium; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Tachycardia, Ventricular | 2005 |
Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats.
Topics: Animals; Arrhythmias, Cardiac; Chemotaxis; Fibrinolytic Agents; Gene Expression; Heme Oxygenase-1; Humans; Ligusticum; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Respiratory Burst; Superoxides | 2006 |
Proteasome inhibition 1 h following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a model of myocardial infarction.
Topics: Animals; Blotting, Western; Boronic Acids; Bortezomib; Catecholamines; Chymotrypsin; Coronary Vessels; Death, Sudden, Cardiac; Dogs; Electrocardiography; Electrophysiology; G-Protein-Coupled Receptor Kinase 3; Heart Ventricles; HSP72 Heat-Shock Proteins; Ligation; Male; Myocardial Infarction; Myocardial Ischemia; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Tachycardia; Trypsin | 2008 |
Differential class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia/ischaemia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Microelectrodes; Myocardial Ischemia; Papillary Muscles; Piperidines; Potassium Channels; Pyrazines; Pyridines; Sotalol | 1993 |
Glibenclamide, but not class III drugs, prevents ischaemic shortening of the refractory period in guinea-pig hearts.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Electrocardiography; Glyburide; Guinea Pigs; Heart; Male; Myocardial Ischemia; Phenethylamines; Phentolamine; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sulfonamides; Temperature | 1993 |
Selective IK blockade as an antiarrhythmic mechanism: effects of UK66,914 on ischaemia and reperfusion arrhythmias in rat and rabbit hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Heart; Hemodynamics; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium; Pyrazines; Pyridines; Rabbits; Rats; Rats, Wistar; Ventricular Fibrillation | 1993 |
[Effect of tetramethyl pyrazine on coronary vasoconstriction induced by endothelin-1 in dogs].
Topics: Animals; Coronary Angiography; Coronary Vessels; Dogs; Endothelin-1; Heart Rate; Male; Myocardial Ischemia; Pyrazines; Vasoconstriction; Vasodilator Agents | 1996 |
First description of the effect of a non-sulfonylurea compound, tetramethylpyrazine, on coronary response to desoxyglucose-induced ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Deoxyglucose; Flavoring Agents; Guinea Pigs; Myocardial Ischemia; Organ Culture Techniques; Perfusion; Potassium Channels; Pyrazines; Sweetening Agents; Vasodilation | 1998 |
The effects of tetramethylpyrazine on the incidence of arrhythmias and the release of PGI2 and TXA2 in the ischemic rat heart.
Topics: Animals; Arrhythmias, Cardiac; Epoprostenol; Heart; Male; Myocardial Ischemia; Pyrazines; Rats; Rats, Sprague-Dawley; Thromboxane A2 | 1999 |
BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy.
Topics: Animals; Aorta; Brain Injuries; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gerbillinae; Inhibitory Concentration 50; Kinetics; Lipid Peroxidation; Male; Mice; Myocardial Ischemia; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Organ Culture Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors | 1999 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation | 1992 |