Page last updated: 2024-08-21

pyrazines and Muscle Contraction

pyrazines has been researched along with Muscle Contraction in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (30.36)	18.7374
1990's	17 (30.36)	18.2507
2000's	7 (12.50)	29.6817
2010's	14 (25.00)	24.3611
2020's	1 (1.79)	2.80

Authors

Authors	Studies
Accart, N; Alave Reyes-Furrer, A; Bachmann, D; Bono, E; De Andrade, S; Dunbar, A; Jeker, H; Keller, H; Rausch, M; Rimann, M; Steinmann, M	1
Granzier, HL; Hwee, DT; Kolb, J; Lee, EJ; Malik, FI	1
Clozel, M; Gatfield, J; Gnerre, C; Hess, P; Iglarz, M; Menyhart, K; Monnier, L; Morrison, K; Nayler, O; Wanner, D	1
Chang, H; Gao, Y; Goswami, N; Hinghofer-Szalkay, H; Li, G; Li, Y; Ma, X; Wang, H; Zhang, J	1
Cui, YL; Feng, T; Liu, T; Sun, H; Wang, HP; Zhang, Y	1
Barreiro, E; Chacon-Cabrera, A; de Kier Joffé, ED; Diament, MJ; Fermoselle, C; Mateu-Jimenez, M; Sandri, M; Urtreger, AJ	1
Hudson, MB; Kavazis, AN; Nelson, WB; Powers, SK; Smuder, AJ	1
Bartho, L; Bencsik, T; Sandor, Z	1
Chen, L; Chen, YQ; Cheng, D; Li, W; Liu, J; Wang, TL; Wen, HM; Zhu, HH	1
Callahan, LA; Supinski, GS; Vanags, J	1
Horie, S; Hosoya, T; Kurosawa, E; Matsumoto, K; Murayama, T; Priestley, JV; Tashima, K; Terui, H	1
Clozel, M; Ernst, R; Hess, P; Morrison, K; Studer, R	1
Kim, EY; Kim, JH; Rhyu, MR	1
Bartho, L; Benko, R; Illényi, L; Kelemen, D; Papp, A; Papp, R	1
Albertus, DL; Browne, WF; Chen, MM; Claflin, DR; Clarke, D; Collibee, SE; Driscoll, L; Garard, M; Godinez, G; Hansen, R; Hartman, JJ; Hinken, AC; Jia, Z; Kawas, R; Lee, KH; Lu, PP; Malik, FI; Marquez, D; Morgan, BP; Morgans, DJ; Muci, AR; Rodriguez, H; Russell, AJ; Saikali, KG; Schaletzky, J; Vijayakumar, V	1
Agten, A; Cielen, N; Decramer, M; Dekhuijzen, RP; Gayan-Ramirez, G; Maes, K; Thomas, D; Van Hees, HW	1
Gao, Y; Hinghofer-Szalkay, HG; Li, G; Li, S; Wang, H; Yang, Z	1
Benhamú, B; Caicoya, AG; Delgado, M; Fernández-Alfonso, MS; Fuentes, JA; Greciano, V; López-Rodríguez, ML; Manzanares, J; Pozo, MA	1
Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S	1
Chen, J; Fan, L; Liu, J; Wang, T; Xiao, H; Ye, Z; Yin, C	1
Kwan, D; Riveles, K; Roza, R; Talbot, P; Tran, V	1
Akhtar-Khavari, F; Khoyi, MA; Rezaei, E	1
Odebiyi, OO; Ojewole, JA	1
Barnette, M; Grous, M	1
Bonnet, PA; Boucard, M; Chapat, JP; Laurent, F; Michel, A	2
Eckly, AE; Lugnier, C	1
Chen, HM; Lin, CI; Tao, PL; Wei, J; Wu, SL	1
Epand, RM; Kwan, CY; Nie, SQ	1
Advenier, C; Bakdach, H; Bonnet, PA; Cui, YY; Michel, A; Naline, E	1
Chiu, KW; Pang, PK; Shan, JJ	1
Barnes, PJ; Belvisi, MG; Bernareggi, MM; Giembycz, MA; Patel, H	1
Adams, MA; Bennett, BM; Fraser, AB; Ratz, JD; Rees-Milton, KJ	1
Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A	1
Clineschmidt, BV; McGuffin, JC	1
Fontanella, L; Occelli, E; Testa, E	1
Bowen, JM; Cole, RJ; Field, DJ	1
Clineschmidt, BV; Engelhardt, EL; Hartman, RD; Hirschmann, R; Lumma, WC; Saari, WS; Stone, CA; Torchiana, ML	1
Bennett, JL; Fetterer, R; Pax, R	1
Clineschmidt, BV; Mcguffin, JC; Pflueger, AB	1
Chiavarelli, S; Gatta, F; Huidobro-Toro, JP; Zaccari, V	1
Li, YK; Liang, ZJ; Xu, J	1
Ke, J; Lü, AG; Zhang, GQ	1
Bymaster, FP; Honoré, T; Klimkowski, VJ; Lamb, ML; Merritt, L; Mitch, CH; Olesen, PH; Sawyer, B; Shannon, HE; Ward, JS	1
Chen, MC; Cragoe, EJ; Daniel, EE; Gaspar, V; Kwan, CY; Ohta, A; Shi, AG; Wang, ZL	1
Chen, MC; Daniel, EE; Kwan, CY	1
Barer, GR; Barnes, PJ; Cai, YN; Evans, TW; Liu, SF; McCormack, DG	1
Barnes, PJ; Rhoden, KJ	1
Barnette, MS; Grous, M; Ormsbee, HS; Torphy, TJ	1
Chiou, WF; Wu, CC; Yen, MH	1
Clineschmidt, BV; Pettibone, DJ; Reiss, DR; Robinson, JL	1
Fabre, J; Pinon, JF	1
Bonta, IL; Frankhuyzen, AL	1
Nott, MW	1
Bonta, IL; Frankhuijzen, AL	2

Other Studies

56 other study(ies) available for pyrazines and Muscle Contraction

Article	Year
Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses. Communications biology, 2021, 10-14, Volume: 4, Issue:1 Topics: Bioprinting; Caffeine; Collagen; Drug Combinations; Electric Stimulation; Exercise; Humans; Imidazoles; Laminin; Muscle Contraction; Muscle, Skeletal; Printing, Three-Dimensional; Proteoglycans; Pyrazines	2021
Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator International journal of molecular sciences, 2019, Oct-10, Volume: 20, Issue:20 Topics: Animals; Copper Transporter 1; Diaphragm; Disease Models, Animal; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Myopathies, Nemaline; Pyrazines; Troponin	2019
Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:1 Topics: Acetamides; Acetates; Animals; beta-Arrestins; Cell Proliferation; CHO Cells; Contractile Proteins; Cricetinae; Cricetulus; Cyclic AMP; Epoprostenol; Extracellular Matrix; Humans; Hypertension, Pulmonary; Iloprost; Male; Muscle Contraction; Muscle Relaxation; Pyrazines; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Epoprostenol	2017
Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 96 Topics: Animals; Calpain; Dose-Response Relationship, Drug; Female; Hindlimb Suspension; Muscle Contraction; Muscle, Skeletal; Muscular Atrophy; Pyrazines; Rats; Rats, Sprague-Dawley; Vasodilator Agents	2017
[Effects of ligustrazine on the Ca Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2016, Apr-08, Volume: 32, Issue:4 Topics: Animals; Calcium; Carotid Arteries; Female; Muscle Contraction; Muscle, Smooth, Vascular; Pyrazines; Rats; Rats, Sprague-Dawley; Weightlessness Simulation	2016
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness. Journal of cellular physiology, 2014, Volume: 229, Issue:11 Topics: Animals; Autophagy; Boronic Acids; Bortezomib; Butadienes; Cachexia; Cell Line, Tumor; Inflammation; Lung Neoplasms; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; NF-kappa B; Nitriles; Oxidation-Reduction; Proteolysis; Pyrazines; Signal Transduction; Sulfasalazine; Tyrosine; Weight Gain	2014
Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragm. Anesthesiology, 2014, Volume: 121, Issue:1 Topics: Anesthesia; Animals; Antibiotics, Antineoplastic; Atrophy; Blotting, Western; Boronic Acids; Bortezomib; Caspase 3; Diaphragm; DNA, Complementary; Female; Muscle Contraction; Muscle Proteins; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteolysis; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Respiration, Artificial; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Ubiquitin; Ubiquitin-Protein Ligases; Ventilator-Induced Lung Injury	2014
High-Concentration Piperine: Capsaicin-Sensitive and -Insensitive Effects on Isolated Organs. Pharmacology, 2015, Volume: 96, Issue:1-2 Topics: Acetanilides; Alkaloids; Animals; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Piperidines; Polyunsaturated Alkamides; Purines; Pyrazines; Pyridines; Trachea; TRPV Cation Channels; Urinary Bladder	2015
Synthesis and positive inotropic activity evaluation of liguzinediol metabolites. Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3 Topics: Animals; Blood Pressure; Cardiotonic Agents; Heart Failure; Heart Rate; Male; Muscle Contraction; Pyrazines; Rats; Rats, Sprague-Dawley	2016
Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction. American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 296, Issue:6 Topics: Animals; Atrophy; Boronic Acids; Bortezomib; Caspase 3; Cysteine Proteinase Inhibitors; Diaphragm; Endotoxemia; Enzyme Activation; Leupeptins; Male; Muscle Contraction; Muscle Weakness; Oligopeptides; Organ Size; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sepsis; Tyrosine	2009
Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:2 Topics: Animals; Atropine; Capsaicin; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Immunohistochemistry; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurokinin A; Pyrazines; Pyridines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Rectum; Substance P; Tetrodotoxin; Time Factors; TRPV Cation Channels; Ubiquitin Thiolesterase	2009
Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1 Topics: Acetamides; Animals; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Gastric Emptying; Gastrointestinal Transit; Humans; Iloprost; Male; Muscle Contraction; Pulmonary Artery; Pyrazines; Rats; Receptors, Epoprostenol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach	2010
Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta: comparison of a butanolic fraction and tetramethylpyrazine, the main active component of Ligusticum wallichii. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:8 Topics: Animals; Aorta, Thoracic; Butanols; Drugs, Chinese Herbal; Endothelium, Vascular; In Vitro Techniques; Ligusticum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility; Time Factors; Vasoconstrictor Agents; Vasodilation	2010
Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC. European journal of pharmacology, 2012, Jan-05, Volume: 674, Issue:1 Topics: Animals; Capsaicin; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Kidney Pelvis; Male; Mice; Muscle Contraction; Muscle, Smooth; Organ Specificity; Pyrazines; Pyridines; Rats; Trachea; TRPV Cation Channels; Urinary Bladder	2012
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nature medicine, 2012, Feb-19, Volume: 18, Issue:3 Topics: Adenosine Triphosphatases; Animals; Calcium; Cattle; Humans; Imidazoles; Molecular Targeted Therapy; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Myasthenia Gravis; Myosins; Neuromuscular Diseases; Pyrazines; Rabbits; Rats; Troponin; Troponin C	2012
Bortezomib partially protects the rat diaphragm from ventilator-induced diaphragm dysfunction. Critical care medicine, 2012, Volume: 40, Issue:8 Topics: Animals; Boronic Acids; Bortezomib; Calpain; Caspase 3; Diaphragm; Male; Muscle Contraction; Muscular Atrophy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Wistar; Respiration, Artificial	2012
Ligustrazine and the contractile properties of soleus muscle in hindlimb-unloaded rats. Aviation, space, and environmental medicine, 2012, Volume: 83, Issue:11 Topics: Animals; Dose-Response Relationship, Drug; Drinking; Eating; Female; Hindlimb Suspension; Kidney; Liver; Lung; Muscle Contraction; Muscle, Skeletal; Myocardium; Platelet Aggregation Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases	2012
Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors. European journal of pharmacology, 2005, Mar-21, Volume: 511, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Behavior, Animal; Binding, Competitive; Body Temperature Regulation; Bradycardia; Colforsin; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; HeLa Cells; Humans; Hydroxyindoleacetic Acid; Hypothalamus; Ileum; In Vitro Techniques; Male; Membrane Potentials; Mice; Motor Activity; Muscle Contraction; Neurons; Piperazines; Pyrazines; Radioligand Assay; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists; Social Behavior; Transfection	2005
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes. Biochemical and biophysical research communications, 2006, Feb-17, Volume: 340, Issue:3 Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors	2006
Effects of ligustrazine on the contraction of isolated rabbit corpus cavernosum strips. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2005, Volume: 25, Issue:5 Topics: Animals; Calcium Channels; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Penis; Phenylephrine; Potassium Chloride; Pyrazines; Rabbits	2005
Smoke from traditional commercial, harm reduction and research brand cigarettes impairs oviductal functioning in hamsters (Mesocricetus auratus) in vitro. Human reproduction (Oxford, England), 2007, Volume: 22, Issue:2 Topics: Animals; Cilia; Cresols; Cricetinae; Fallopian Tubes; Female; Indoles; Mesocricetus; Muscle Contraction; No-Observed-Adverse-Effect Level; Oocytes; Phenols; Picolines; Pyrazines; Pyridines; Quinolines; Tissue and Organ Harvesting; Tobacco Smoke Pollution	2007
Effects of amiloride on contractions and the release of tritium from rat vas deferens preloaded with [3H]-noradrenaline. British journal of pharmacology, 1981, Volume: 74, Issue:1 Topics: Amiloride; Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Potassium Chloride; Pyrazines; Rats; Tyrosine; Vas Deferens	1981
Neuromuscular and cardiovascular actions of tetramethylpyrazine from the stem of Jatropha podagrica. Planta medica, 1980, Volume: 38, Issue:4 Topics: Animals; Anura; Blood Pressure; Cats; Chickens; Female; Heart Rate; Male; Muscle Contraction; Muscles; Neuromuscular Junction; Plants, Medicinal; Pyrazines; Rats	1980
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle. British journal of pharmacology, 1994, Volume: 111, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram	1994
Evaluation of the relaxant effects of SCA40, a novel charybdotoxin-sensitive potassium channel opener, in guinea-pig isolated trachealis. British journal of pharmacology, 1993, Volume: 108, Issue:3 Topics: Animals; Carbachol; Charybdotoxin; Glyburide; Guinea Pigs; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Potassium Channels; Potassium Chloride; Pyrazines; Scorpion Venoms; Trachea	1993
Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway. British journal of pharmacology, 1994, Volume: 113, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram	1994
The role of cyclic AMP and phosphodiesterase activity in the mechanism of action of tetramethylpyrazine on human and dog cardiac and dog coronary arterial tissues. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:11 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Coronary Vessels; Cyclic AMP; Dogs; Epinephrine; Female; Heart; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardium; Purkinje Fibers; Pyrazines; Theophylline; Vasodilator Agents	1993
Pyrazine derivatives affect membrane fluidity of vascular smooth muscle microsomes in relation to their biological activity. European journal of pharmacology, 1993, Jan-04, Volume: 244, Issue:1 Topics: Animals; Binding Sites; Dogs; Electron Spin Resonance Spectroscopy; Female; Fluorescence Polarization; In Vitro Techniques; Lipid Bilayers; Male; Membrane Fluidity; Microsomes; Muscle Contraction; Muscle, Smooth, Vascular; Pyrazines; Vasodilator Agents	1993
Pharmacological activities of imidazo[1,2-alpha]pyrazine derivatives. Arzneimittel-Forschung, 1995, Volume: 45, Issue:12 Topics: Adenosine; Animals; Calcium; Cardiovascular Agents; Cattle; Diuresis; Guinea Pigs; Heart Atria; Heart Rate; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Phosphodiesterase Inhibitors; Pyrazines; Rabbits; Rats; Rats, Wistar; Theophylline; Trachea	1995
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4 Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds	1996
Tetramethylpyrazine, a calcium antagonist. Planta medica, 1996, Volume: 62, Issue:5 Topics: Animals; Arteries; Blood Pressure; Calcium; Calcium Channel Blockers; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Plants, Medicinal; Pyrazines; Rats; Rats, Sprague-Dawley	1996
Anti-spasmogenic activity of isoenzyme-selective phosphodiesterase inhibitors in guinea-pig trachealis. British journal of pharmacology, 1999, Volume: 128, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholine; Animals; Antihypertensive Agents; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Histamine; In Vitro Techniques; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth; Nitroprusside; Parasympatholytics; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Trachea	1999
Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2 Topics: Animals; Aorta, Thoracic; Binding, Competitive; Biotransformation; Blood Pressure; Cyclic GMP; Drug Tolerance; Endothelin Receptor Antagonists; Endothelin-1; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitroglycerin; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Vasodilator Agents	2000
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle. Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles	1979
Pharmacological differentiation of the central 5-hydroxytryptamine-like actions of MK-212 (6-chloro-2[1-piperazinyl]-pyrazine),p-methoxyamphetamine and fenfluramine in an in vivo model system. European journal of pharmacology, 1978, Aug-15, Volume: 50, Issue:4 Topics: Amphetamines; Animals; Dextroamphetamine; Drug Interactions; Fenclonine; Fenfluramine; Fluoxetine; In Vitro Techniques; Male; Metergoline; Muscle Contraction; Piperazines; Pyrazines; Rats; Serotonin; Time Factors	1978
[Tricyclic homologs of piperazine. III. Synthesis of 4-substituted hexahydro-1H-2,6-methanopyrrolo[1,2a]pyrazines]. Il Farmaco; edizione scientifica, 1978, Volume: 33, Issue:11 Topics: Animals; Cyclization; In Vitro Techniques; Methods; Muscle Contraction; Neuromuscular Nondepolarizing Agents; Pyrazines; Rabbits	1978
Verruculotoxin potentiation of twitch tension in skeletal muscle. Toxicology and applied pharmacology, 1978, Volume: 46, Issue:2 Topics: Action Potentials; Animals; Anura; Caffeine; Cats; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Mycotoxins; Pyrazines; Rana pipiens; Rats; Structure-Activity Relationship; Time Factors	1978
Piperazinylpyrazines with central serotoninmimetic activity. Journal of medicinal chemistry, 1978, Volume: 21, Issue:6 Topics: Animals; Central Nervous System; Female; In Vitro Techniques; Mice; Molecular Conformation; Muscle Contraction; Piperazines; Pyrazines; Quantum Theory; Rats; Receptors, Serotonin; Serotonin; Structure-Activity Relationship; Uterine Contraction	1978
A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum. Naunyn-Schmiedeberg's archives of pharmacology, 1978, Volume: 304, Issue:3 Topics: Animals; Benzodiazepinones; Calcium; Dopamine; Isoquinolines; Muscle Contraction; Muscles; Potassium; Pyrazines; Schistosoma japonicum; Schistosoma mansoni; Schistosomicides; Sodium; Time Factors	1978
Central serotonin-like activity of 6-chloro-2-[1-piperazinyl]-pyrazine (CPP; MK-212). European journal of pharmacology, 1977, Jul-01, Volume: 44, Issue:1 Topics: Animals; Behavior, Animal; Electric Stimulation; Female; Male; Motor Activity; Muscle Contraction; Piperazines; Pyrazines; Rats; Reflex; Serotonin; Serotonin Antagonists; Time Factors	1977
[Pyrazino (1,2-a)- and 1,4-diazepino(1,2-a)indoles. II. Synthesis of 1-substituted 10-phenyl-3,4-dihydropyrazino(1,2-a)indoles and of 11-phenyl-4,5-dihydro-4H-diazepino(1,2-a)indoles]. Il Farmaco; edizione scientifica, 1975, Volume: 30, Issue:1 Topics: Animals; Azepines; Cardiovascular System; Hypnotics and Sedatives; Indoles; Magnetic Resonance Spectroscopy; Male; Mice; Muscle Contraction; Pyrazines	1975
[Effects of tetramethylpyrazine and ferulic acid alone or combined on vascular smooth muscle, blood viscosity and toxicity]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1992, Volume: 17, Issue:11 Topics: Animals; Aorta; Blood Viscosity; Coronary Circulation; Coumaric Acids; Drug Synergism; Female; Guinea Pigs; In Vitro Techniques; Lethal Dose 50; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Pyrazines; Rabbits; Rats; Rats, Sprague-Dawley	1992
[Effects of tetramethylpyrazine on rabbit basilar artery ring and canine vertebroarterial circulation]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:6 Topics: Animals; Basilar Artery; Blood Pressure; Calcium Channel Blockers; Dogs; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Pyrazines; Rabbits; Rats; Regional Blood Flow; Vascular Resistance; Vertebral Artery	1992
Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore. Journal of medicinal chemistry, 1992, Oct-30, Volume: 35, Issue:22 Topics: Animals; Hippocampus; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Pyrazines; Pyridines; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Structure-Activity Relationship	1992
Vascular effects of tetramethylpyrazine: direct interaction with smooth muscle alpha-adrenoceptors. European journal of pharmacology, 1991, May-30, Volume: 198, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amiloride; Animals; Azepines; Binding, Competitive; Dogs; In Vitro Techniques; Microsomes; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Prazosin; Pyrazines; Radioligand Assay; Receptors, Adrenergic, alpha; Vasodilator Agents	1991
Inhibition of vasoconstriction by tetramethylpyrazine: does it act by blocking the voltage-dependent Ca channel? Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:1 Topics: Animals; Calcium; Dogs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Pyrazines; Vasoconstriction	1990
Ligustrazine is a vasodilator of human pulmonary and bronchial arteries. European journal of pharmacology, 1990, Dec-04, Volume: 191, Issue:3 Topics: Animals; Bronchial Arteries; Calcium; Calcium Chloride; Dinoprost; Endothelium, Vascular; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Artery; Pyrazines; Rats; Rats, Inbred Strains; Serotonin; Vasodilator Agents	1990
Potentiation of nonadrenergic neural relaxation in guinea pig airways by a cyclic cAMP phosphodiesterase inhibitor. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Ethylmaleimide; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nitroprusside; Potassium Chloride; Pyrazines; Tetrodotoxin; Trachea; Vasoactive Intestinal Peptide	1990
Activation of cyclic AMP-dependent protein kinase during canine lower esophageal sphincter relaxation. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Electric Stimulation; Enzyme Activation; Esophagogastric Junction; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Protein Kinases; Purinones; Pyrazines	1990
A possible mechanism of action of tetramethylpyrazine on vascular smooth muscle in rat aorta. European journal of pharmacology, 1989, Oct-10, Volume: 169, Issue:2-3 Topics: Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenethylamines; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Theophylline; Vasodilation	1989
Characterization of 5-hydroxytryptamine receptors in rat stomach fundus. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3 Topics: Animals; Binding, Competitive; Brain Chemistry; Gastric Fundus; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Piperazines; Piperidines; Propranolol; Pyrazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium	1985
Inhibition of potassium-induced contracture of the isolated rat aorta by amiloride. Arzneimittel-Forschung, 1985, Volume: 35, Issue:1A Topics: Amiloride; Animals; Aorta; Calcium; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Ouabain; Potassium; Potassium Chloride; Pyrazines; Rats; Rats, Inbred Strains; Sodium	1985
Effect of mianserin, a potent anti-serotonin agent, on the isolated rat stomach fundus preparation. European journal of pharmacology, 1974, Volume: 25, Issue:1 Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Binding Sites; Calcium; Chlorpromazine; Cyproheptadine; Dextroamphetamine; Dibenzazepines; Dioxins; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Methysergide; Morphine; Muscle Contraction; Phenoxybenzamine; Piperidines; Propranolol; Pyrazines; Rats; Receptors, Drug; Scopolamine; Serotonin; Serotonin Antagonists; Stomach; Tryptamines	1974
Interaction between phosphodiesterase inhibitors and catecholamines on contractions of the cat soleus muscle. British journal of pharmacology, 1971, Volume: 42, Issue:4 Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Cats; Cyclic AMP; Electric Stimulation; Muscle Contraction; Phosphoric Monoester Hydrolases; Pyrazines; Tibia	1971
Receptors involved in the action of 5-HT and tryptamine on the isolated rat stomach fundus preparation. European journal of pharmacology, 1974, Volume: 26, Issue:2 Topics: Acetylcholine; Animals; Cyproheptadine; Dibenzazepines; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Pyrazines; Rats; Receptors, Adrenergic; Serotonin; Serotonin Antagonists; Stomach; Sympatholytics; Time Factors; Tryptamines	1974
Serotonin receptor protection experiments on the isolated rat stomach fundus preparation. Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 197, Issue:2 Topics: Alkylation; Animals; Dibenzazepines; Drug Antagonism; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Phenoxybenzamine; Pyrazines; Rats; Receptors, Drug; Serotonin Antagonists; Stomach	1972