pyrazines and Medulloblastoma

Topics: Animals; Blood-Brain Barrier; Brain; Calibration; Cerebellar Neoplasms; Checkpoint Kinase 1; Child; Chromatography, Liquid; Chromatography, Reverse-Phase; Dialysis Solutions; Female; Humans; Limit of Detection; Liquid-Liquid Extraction; Medulloblastoma; Mice; Mice, Nude; Microdialysis; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays

Topics: Antagomirs; Apoptosis Regulatory Proteins; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cerebellar Neoplasms; Humans; Matrix Metalloproteinase 2; Medulloblastoma; MicroRNAs; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation; Vasodilator Agents

Topics: 3T3 Cells; Animals; Antineoplastic Agents; Benzoquinones; Boronic Acids; Bortezomib; Carcinoma, Basal Cell; Cell Line; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Green Fluorescent Proteins; Hedgehog Proteins; Heterocyclic Compounds, 4 or More Rings; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Medulloblastoma; Mice; Mutant Proteins; Pyrazines; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering; Signal Transduction; Smoothened Receptor; Thapsigargin; Ubiquitin-Protein Ligases; Unfolded Protein Response

Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Development; Boronic Acids; Bortezomib; Humans; Intracellular Signaling Peptides and Proteins; Male; Medulloblastoma; Neuroblastoma; Proteasome Inhibitors; Pyrazines

Topics: Animals; Antineoplastic Agents; Apoptosis; Bone Development; Boronic Acids; Bortezomib; Cell Line, Tumor; Chondrocytes; Dose-Response Relationship, Drug; Drug Administration Schedule; Femur; Growth Plate; Heterografts; Humans; Intracellular Signaling Peptides and Proteins; Male; Medulloblastoma; Metatarsal Bones; Mice; Mice, Nude; Neuroblastoma; Proteasome Inhibitors; Pyrazines; Time Factors

Topics: Animals; Antineoplastic Agents; Benzeneacetamides; beta Catenin; Brain Neoplasms; Camptothecin; Celecoxib; Cisplatin; Colorectal Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glucose-6-Phosphate Isomerase; Heterocyclic Compounds, 3-Ring; Humans; Immunoblotting; Immunohistochemistry; Irinotecan; Medulloblastoma; Mice; Neoplasm Transplantation; Neoplasms; Neuroblastoma; Pyrans; Pyrazines; Pyridines; Real-Time Polymerase Chain Reaction; Sulfones; Temozolomide; Triazoles; Tumor Suppressor Proteins; Vincristine; Wnt Proteins; Wnt Signaling Pathway

Topics: Animals; Animals, Newborn; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Cerebellum; Chromosomal Instability; Developmental Disabilities; Female; Gene Deletion; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Isoxazoles; Male; Medulloblastoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Nervous System Malformations; Neurogenesis; Neurons; Pyrazines

Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Disease Models, Animal; Gene Knock-In Techniques; Hedgehog Proteins; Humans; Immunoblotting; Immunoprecipitation; Loss of Heterozygosity; Medulloblastoma; Mice; Mice, Knockout; Patched Receptors; Patched-1 Receptor; PAX7 Transcription Factor; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyrazines; Receptors, Cell Surface

Topics: Animals; Antineoplastic Agents; Ataxia; Boronic Acids; Bortezomib; Cerebellar Neoplasms; Disease Models, Animal; Disease Progression; Drug Screening Assays, Antitumor; Gait Disorders, Neurologic; Lameness, Animal; Magnetic Resonance Imaging; Medulloblastoma; Mice; Mice, Knockout; Patched Receptors; Patched-1 Receptor; Protease Inhibitors; Psychomotor Performance; Pyrazines; Receptors, Cell Surface

Topics: Animals; Boronic Acids; Bortezomib; Cerebellum; Magnetic Resonance Imaging; Medulloblastoma; Mice; Organ Size; Pyrazines; Tumor Burden; User-Computer Interface; X-Ray Microtomography

Topics: Animals; Boronic Acids; Bortezomib; Cell Growth Processes; Cell Line, Tumor; Cerebellar Neoplasms; Curcumin; Ditiocarb; Humans; I-kappa B Proteins; Medulloblastoma; Mice; Mice, Inbred C57BL; Mice, Nude; NF-kappa B; Pyrazines; Pyrrolidines; Signal Transduction; Sulfasalazine; Thiocarbamates; Transgenes; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cells, Cultured; Cerebellar Neoplasms; Gene Expression Profiling; Immunohistochemistry; Medulloblastoma; Mice; Mice, Mutant Strains; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering

Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-Associated Death Protein; Boronic Acids; Bortezomib; Caspase 3; Caspase 9; Cerebellar Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cytochromes c; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Medulloblastoma; NF-kappa B; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Sorafenib; Tumor Cells, Cultured