pyrazines has been researched along with Liver Dysfunction in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Izumi, R; Kuo, H; Kwan, A; Madere, J; Marbury, T; Nguyen, H; Podoll, T; Preston, RA; Sharma, S; Slatter, JG; Smith, W; Vishwanathan, K; Ware, JA; Xu, Y | 1 |
| Fujita, T; Inoue, K; Ishii, D; Itou, M; Kakuyama, H; Takagaki, T; Uchida, N | 1 |
| Azuma, T; Furumoto, A; Haku, T; Hidaka, M; Himeji, D; Ikeda, K; Ishida, M; Ishimaru, T; Kadowaki, N; Kakihana, Y; Kamikokuryo, C; Kaneko, M; Kawamura, M; Kurosu, T; Ohge, H; Saijo, M; Sakabe, S; Shimojima, M; Suemori, K; Takahashi, T; Takenaka, K; Taniguchi, T; Yamanaka, A; Yasukawa, M; Yoshikawa, T | 1 |
| Chen, YG; Huang, LL; Liu, B; Tao, XG; Wang, JQ; Wei, L; Zhang, L | 1 |
| Abedi, M; Blazar, BR; Chen, M; Hagino, T; Hsiao, HH; Mall, C; Monjazeb, A; Murphy, WJ; Pai, CC; Sun, K; Tellez, J | 1 |
| Cruz, HG; Dingemanse, J; Halabi, A; Kaufmann, P; Krause, A; Ulč, I | 1 |
| Bailey, KW; Furuta, Y; Gowen, BB; Hall, JO; Jung, KH; Morrey, JD; Smee, DF; Stevens, JR; Wong, MH | 1 |
| Brooks, JS; Brooks, SC; Kim, SG; Lee, MG; Lee, WH | 1 |
| Bladé, J; Cakana, A; Comenzo, RL; Dubrey, SW; Elsayed, Y; Enny, C; Fermand, JP; Hassoun, H; Heffner, LT; Hegenbart, U; Liu, X; Merlini, G; Mortimer, S; Palladini, G; Ramaswami, P; Reece, DE; Sanchorawala, V; Van De Velde, H; Vescio, RA | 1 |
| Dowlati, A; Esseltine, DL; Hamilton, A; Ivy, P; LoRusso, PM; Mani, S; Mulkerin, D; Neuwirth, R; Ramanathan, RK; Rudek, MA; Sarantopoulos, J; Shibata, SI; Takimoto, CH; Venkatakrishnan, K | 1 |
| Ren, ZP; Sun, LP; Tong, QX | 1 |
| Hughes, M; Micallef-Eynaud, P | 1 |
| Farombi, EO; Surh, YJ | 1 |
| Sato, N; Uehara, M | 1 |
| Curphey, TJ; Kensler, TW; Maxuitenko, YY; Roebuck, BD | 1 |
| Lin, CC; Lin, SC; Liu, CF; Ng, LT | 1 |
| Cleres-Kaiser, I | 1 |
| Ford, EJ | 1 |
| Richard, JL | 1 |
| Hillenbrand, P; Sherlock, S | 1 |
| Adlung, J; Fricke, G; Schmid, E; Stoffels, G | 1 |
4 review(s) available for pyrazines and Liver Dysfunction
| Article | Year |
|---|---|
Therapeutic potential of dithiolethiones for hepatic diseases.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Fatty Liver; Glutathione Transferase; Humans; Inactivation, Metabolic; Insulin Resistance; Liver; Liver Cirrhosis; Liver Diseases; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Protein Kinases; Pyrazines; Receptors, Aryl Hydrocarbon; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Thiones; Thiophenes; TOR Serine-Threonine Kinases | 2009 |
[Advanced in studies of proteasome inhibitor bortezomib and hepatic disease].
Topics: Boronic Acids; Bortezomib; Humans; Liver Diseases; Proteasome Inhibitors; Pyrazines | 2012 |
Heme oxygenase-1 as a potential therapeutic target for hepatoprotection.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Garlic; Heme Oxygenase-1; Humans; Liver; Liver Diseases; Metals, Heavy; Pyrazines; Signal Transduction; Thiones; Thiophenes | 2006 |
Mycotoxin photosensitivity.
Topics: Animal Feed; Animals; Cattle; Cattle Diseases; Chemical and Drug Induced Liver Injury; Cholestasis; Eczema; Indoles; Liver Diseases; Medicago sativa; Mitosporic Fungi; Mycotoxins; Photosensitivity Disorders; Pyrazines; Pyrroles; Sheep; Sheep Diseases; United States | 1973 |
5 trial(s) available for pyrazines and Liver Dysfunction
| Article | Year |
|---|---|
Pharmacokinetics and Safety of Ranirestat in Patients With Hepatic Impairment.
Topics: Adult; Aged; Area Under Curve; Diabetic Neuropathies; Enzyme Inhibitors; Female; Healthy Volunteers; Humans; Liver Diseases; Male; Middle Aged; Protein Binding; Pyrazines; Spiro Compounds | 2020 |
Pharmacokinetics of the novel oral prostacyclin receptor agonist selexipag in subjects with hepatic or renal impairment.
Topics: Acetamides; Acetates; Adult; Aged; Antihypertensive Agents; Area Under Curve; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Liver Diseases; Male; Middle Aged; Prospective Studies; Pyrazines; Receptors, Epoprostenol; Severity of Illness Index | 2016 |
Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects.
Topics: Aged; Amyloidosis; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Diseases; Humans; Kidney Diseases; Liver Diseases; Male; Maximum Tolerated Dose; Middle Aged; Paraproteinemias; Peripheral Nervous System Diseases; Prospective Studies; Pyrazines; Treatment Outcome | 2011 |
Pharmacokinetics and safety of bortezomib in patients with advanced malignancies and varying degrees of liver dysfunction: phase I NCI Organ Dysfunction Working Group Study NCI-6432.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Boronic Acids; Bortezomib; Drug Dosage Calculations; Female; Humans; Liver; Liver Diseases; Male; Middle Aged; Neoplasms; Pyrazines | 2012 |
[Treatment of cardiac and hepatic edemas using the potassium-sparing diuretic Moduretic].
Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Edema; Female; Heart Diseases; Humans; Hydrochlorothiazide; Liver Diseases; Male; Middle Aged; Pyrazines | 1975 |
12 other study(ies) available for pyrazines and Liver Dysfunction
| Article | Year |
|---|---|
Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment.
Topics: Adult; Area Under Curve; Benzamides; Humans; Liver Diseases; Pyrazines | 2022 |
A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome.
Topics: Adult; Aged; Aged, 80 and over; Amides; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Japan; Liver Diseases; Male; Middle Aged; Phlebovirus; Pyrazines; RNA, Viral; Severe Fever with Thrombocytopenia Syndrome; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Viral Load | 2021 |
Tetramethylpyrazine upregulates the aquaporin 8 expression of hepatocellular mitochondria in septic rats.
Topics: Animals; Aquaporins; Calcium Channel Blockers; Disease Models, Animal; Hepatocytes; Liver Diseases; Male; Mitochondria, Liver; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels.
Topics: Acute Disease; Animals; Antibodies, Neutralizing; Antineoplastic Agents; Boronic Acids; Bortezomib; CD8-Positive T-Lymphocytes; Disease Models, Animal; Female; Graft vs Host Disease; Interleukin-6; Liver Diseases; Mice; Organ Specificity; Pyrazines; Skin Diseases | 2014 |
Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin.
Topics: Absorption; Administration, Oral; Alanine Transaminase; Amides; Animals; Arenaviridae Infections; Aspartate Aminotransferases; Cricetinae; Disease Models, Animal; Disease Progression; Female; Hemorrhagic Fevers, Viral; Interferon Type I; Liver Diseases; Mesocricetus; Pichinde virus; Pyrazines; Ribavirin; Survival Analysis; Treatment Outcome; Viral Load | 2008 |
Bortezomib in relapsed multiple myeloma complicated by extramedullary plasmacytomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Humans; Immunohistochemistry; Liver Diseases; Male; Middle Aged; Multiple Myeloma; Pancreatic Neoplasms; Pyrazines; Tomography, X-Ray Computed | 2006 |
Impaired ability of neutrophils to produce oxygen-derived free radicals in patients with chronic liver disease and hepatocellular carcinoma.
Topics: Alanine Transaminase; Bilirubin; Carcinoma, Hepatocellular; Chronic Disease; Female; Free Radicals; Hepatitis, Chronic; Humans; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Luminescent Measurements; Luminol; Male; Middle Aged; Neutrophils; Oxygen; Prothrombin Time; Pyrazines; Serum Albumin | 1994 |
Protection against aflatoxin B1-induced hepatic toxicity as short-term screen of cancer chemopreventive dithiolethiones.
Topics: Aflatoxin B1; Animals; Chemoprevention; Liver; Liver Diseases; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1996 |
Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Dose-Response Relationship, Drug; Econazole; Ferrous Compounds; Free Radical Scavengers; Lipid Peroxidation; Liver; Liver Diseases; Male; Malondialdehyde; Pyrazines; Rats; Rats, Wistar; Silymarin; Superoxides; Vitamin E | 2002 |
Activity of gamma-glutamyl transpeptidase and other enzymes in the serum of sheep with liver or kidney damage.
Topics: Alcohol Oxidoreductases; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Indoles; Intestine, Small; Kidney; Kidney Diseases; Ligation; Liver; Liver Diseases; Male; Mercury Poisoning; Muscles; Mycotoxins; Myocardium; Pancreas; Pyrazines; Pyrroles; Sheep; Sheep Diseases; Urea | 1974 |
Use of metolazone in the treatment of ascites due to liver disease.
Topics: Adult; Ascites; Chlorides; Chronic Disease; Diuretics; Female; Hepatic Encephalopathy; Humans; Hypokalemia; Hyponatremia; Ketones; Liver Diseases; Male; Middle Aged; Nitrogen; Pyrazines; Quinazolines; Spironolactone; Sulfonamides; Uremia | 1971 |
[Clinico-pharmacological studies on drug absorption in liver diseases].
Topics: Diuretics; Humans; Intestinal Absorption; Liver Diseases; Nitrofurantoin; Pyrazines | 1968 |