Page last updated: 2024-08-21

pyrazines and Leukemia

pyrazines has been researched along with Leukemia in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	19 (50.00)	29.6817
2010's	18 (47.37)	24.3611
2020's	1 (2.63)	2.80

Authors

Authors	Studies
Chubinskiy-Nadezhdin, V; Morachevskaya, E; Negulyaev, Y; Sudarikova, A; Vasileva, V	1
Bagiński, M; Bieszczad, B; Czajkowska, J; Mieczkowski, A; Mroczkowska, M; Psurski, M; Trzybiński, D; Wietrzyk, J; Wilczek, M; Woźniak, K	1
Abdallah, AO; Bailey, C; Barlogie, B; Chauhan, N; Cottler-Fox, M; Crowley, J; Epstein, J; Heuck, CJ; Hoering, A; Johann, D; Muzaffar, J; Petty, N; Rosenthal, A; Sawyer, J; Sexton, R; Singh, Z; Usmani, SZ; van Rhee, F; Waheed, S; Yaccoby, S	1
Gao, L; Shi, J; Tao, Y; Wang, H; Wu, X; Yang, G; Zhan, F	1
Bertomeu, T; Bucur, O; Dewar, R; Goganau, I; Khosravi-Far, R; Pennarun, B; Petrescu, SM; Stancu, AL	1
Arai, S; Iwakura, Y; Kagoya, Y; Kataoka, K; Kobayashi, H; Kumano, K; Kurokawa, M; Nakagawa, M; Saito, T; Yoshimi, A	1
Anderl, JL; Assaraf, YG; Cloos, J; Jansen, G; Kale, AJ; Kaspers, GJ; Moore, BS; Niewerth, D; Riethoff, LF; van Meerloo, J; Zweegman, S	1
Chudej, J; Chudý, P; Dobrota, D; Hatok, J; Kliková, K; Pilchová, I; Račay, P; Štefaniková, A	1
Amaravadi, RK; Boyiadzis, M; Johnson, DE; Konig, H; Lotze, MT; Sehgal, AR; Tang, D	1
Chen, HX; Wang, XJ; Xu, YH; Yang, GC; Zhang, P	1
Crawford, LJ; Irvine, AE; Walker, B	1
Birgens, H; Brown, Pde N; Dalseg, AM; Dufva, IH; Hasselbalch, HC; Jensen, MK; Vangsted, A	1
Bachmann, AS	1
Li, J; Liu, P; Lu, H; Xu, B	1
Chen, L; Chen, Z; Han, F; Li, J; Lü, S; Wang, J; Xu, X; Yang, J; Zhou, H	1
Fuchs, O; Kuzelova, K; Marinov, I; Provaznikova, D; Spicka, I	1
Dewar, MR; Ghaffari, S; Grassian, A; Jagani, Z; Khosravi-Far, R; Kutok, JL; Melet, A; Miller, K; Ren, R; Rodin, HY; Santos, T; Song, K; Wu, C; Yeckes-Rodin, H	1
Chen, SM; Cui, XY; Han, XF; Ling, Z; Shao, M; Sun, L; Wang, F; Zhang, H	1
Budunova, IV; Kirsanov, KI; Lesovaya, EA; Yakubovskaya, MG; Yemelyanov, AY	1
Gong, Y; Shan, Q; Yang, X; Zheng, B; Zhou, R	1
Chen, SJ; Chen, YL; Chen, Z; Cheng, X; Fang, HT; Feng, TT; Gao, L; Hu, ZG; Liu, Z; Ma, L; Pan, XF; Sheng, GQ; Xie, J; Yang, Y; Yu, XJ; Zhang, B; Zhang, FX; Zhao, HX; Zhen, T; Zhou, GB	1
Kim, WS; Lee, SJ; Park, C; Yeom, SY	1
Chen, KF; Chen, MH; Huang, HP; Kuo, HY; Liu, CY; Shiau, CW; Tzeng, CH	1
Arzeni, D; Astolfi, D; Catavitello, C; D'Antonio, D; Farina, C; Favaro, M; Fazii, P; Fontana, C; Hendrickx, M; Masciarelli, G; Pitzurra, L; Polilli, E; Savini, V; Sisti, M; Stubbe, D	1
Chen, WM; Chen, ZZ; Shang, J; Wei, TN; Wu, WB	1
Kato, M; Kimura, H; Kobayashi, Y; Kozawa, K; Kuroiwa, M; Minakami, H; Morikawa, A; Oshima, S	1
Dent, P; Grant, S; Rahmani, M; Yu, C	1
Berg, SL; Blaney, SM; D'Argenio, DZ; Gannavarapu, A; Horton, TM; Plon, SE	1
Furukawa, Y; Ishii, H; Kano, Y; Kobayashi, Y; Ozawa, K; Sutheesophon, K; Takatoku, MA	1
Jaehde, U; Scheulen, ME; Simons, S	1
Cloos, J; Kaspers, GJ; Vink, J	1
Beck, A; Berkers, CR; Burg, D; Driessen, C; Gogel, J; Kammer, W; Kraus, M; Ovaa, H; Overkleeft, H; Reich, M; Rückrich, T	1
Adamson, PC; Blaney, SM; Bomgaars, LR; Brockman, AH; Horton, TM; Ingle, AM; Pati, D; Paton, M; Plon, SE; Thompson, PA; Wright, J	1
Chen, GQ; Li, D; Liu, W; Wang, Y; Wang, YC; Wu, YL; Yan, H	1
Lü, SQ; Wang, JM; Yang, JM	1
Cai, YX; Fu, YB; Li, L; Meng, FY; Sun, QX	1
Ames, E; Barao, I; Hallett, WH; Hudig, D; Motarjemi, M; Murphy, WJ; Sayers, TJ; Shanker, A; Tamang, DL	1
Irvine, AE; McCloskey, SM; McMullin, MF; Walker, B	1

Reviews

8 review(s) available for pyrazines and Leukemia

Article	Year
You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia. Leukemia, 2015, Volume: 29, Issue:3 Topics: Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Cell Survival; Clinical Trials as Topic; Drug Resistance, Neoplasm; Gene Expression; HMGB1 Protein; Humans; Hydroxychloroquine; Leukemia; Leukocytes; Lysosomes; Phagosomes; Pyrazines; Sirolimus	2015
Proteasome inhibitors: a therapeutic strategy for haematological malignancy. Frontiers in bioscience : a journal and virtual library, 2008, May-01, Volume: 13 Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Nucleus; Cytoplasm; Hematologic Neoplasms; Humans; Leukemia; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Ubiquitin	2008
[Novel medical treatment modalities in hematology]. Ugeskrift for laeger, 2008, Jun-09, Volume: 170, Issue:24 Topics: Aminoglycosides; Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Benzamides; Benzoates; Boronic Acids; Bortezomib; Carbazoles; Carrier Proteins; Cyclophosphamide; Dasatinib; Furans; Gemtuzumab; Hematologic Diseases; Humans; Hydrazines; Imatinib Mesylate; Immunologic Factors; Indoles; Lenalidomide; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Piperazines; Purpura, Thrombocytopenic; Pyrazines; Pyrazoles; Pyrimidines; Receptors, Fc; Recombinant Fusion Proteins; Rituximab; Thalidomide; Thiazoles; Thrombopoietin; Vidarabine	2008
Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells. Cardiovascular & hematological disorders drug targets, 2009, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Lactones; Leukemia; Oligopeptides; Protease Inhibitors; Pyrazines; Pyrroles	2009
[Bortezomib]. Deutsche medizinische Wochenschrift (1946), 2006, Feb-03, Volume: 131, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Division; Humans; Kidney Neoplasms; Leukemia; Lymphoma, Non-Hodgkin; Male; Multiple Myeloma; Prostatic Neoplasms; Protease Inhibitors; Pyrazines	2006
Proteasome inhibition as novel treatment strategy in leukaemia. British journal of haematology, 2006, Volume: 134, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Clinical Trials, Phase I as Topic; Forecasting; Humans; Leukemia; NF-kappa B; Protease Inhibitors; Pyrazines; Ubiquitin	2006
[Effects of proteasome inhibitors on leukemias]. Zhongguo shi yan xue ye xue za zhi, 2007, Volume: 15, Issue:4 Topics: Animals; Boronic Acids; Bortezomib; Humans; Leukemia; Multiple Myeloma; Protease Inhibitors; Proteasome Inhibitors; Pyrazines	2007
The therapeutic potential of the proteasome in leukaemia. Hematological oncology, 2008, Volume: 26, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Clinical Trials as Topic; Gene Expression Regulation, Leukemic; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Medical Oncology; Models, Biological; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Recurrence	2008

Trials

1 trial(s) available for pyrazines and Leukemia

Article	Year
A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Mar-01, Volume: 13, Issue:5 Topics: Adolescent; Antineoplastic Agents; Boronic Acids; Bortezomib; Child; Child, Preschool; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; I-kappa B Kinase; Immunoblotting; Infant; Leukemia; Male; Maximum Tolerated Dose; NF-kappa B; Proteasome Endopeptidase Complex; Pyrazines	2007

Article

Year

A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Mar-01, Volume: 13, Issue:5

Topics: Adolescent; Antineoplastic Agents; Boronic Acids; Bortezomib; Child; Child, Preschool; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; I-kappa B Kinase; Immunoblotting; Infant; Leukemia; Male; Maximum Tolerated Dose; NF-kappa B; Proteasome Endopeptidase Complex; Pyrazines

2007

Other Studies

29 other study(ies) available for pyrazines and Leukemia

Article	Year
Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis. International journal of molecular sciences, 2021, Jul-22, Volume: 22, Issue:15 Topics: Cell Membrane; Humans; Ion Channels; Leukemia; Mechanotransduction, Cellular; Pyrazines; Single-Cell Analysis; Thiadiazoles	2021
Novel (S)-1,3,4,12a-tetrahydropyrazino[2,1-c][1,4]benzodiazepine-6,12(2H,11H)-dione derivatives: Selective inhibition of MV-4-11 biphenotypic B myelomonocytic leukemia cells' growth is accompanied by reactive oxygen species overproduction and apoptosis. Bioorganic & medicinal chemistry letters, 2018, 02-15, Volume: 28, Issue:4 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepinones; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Humans; Leukemia; Mice; Pyrazines; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; Stereoisomerism; Structure-Activity Relationship	2018
Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma. Blood, 2013, Jun-06, Volume: 121, Issue:23 Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Chromosome Aberrations; Female; Follow-Up Studies; Humans; Incidence; Lenalidomide; Leukemia; Male; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Prognosis; Pyrazines; Risk Factors; Thalidomide; Young Adult	2013
Down-regulation of 11β-hydroxysteroid dehydrogenase type 2 by bortezomib sensitizes Jurkat leukemia T cells against glucocorticoid-induced apoptosis. PloS one, 2013, Volume: 8, Issue:6 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Apoptosis; Boronic Acids; Bortezomib; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Leukemic; Glucocorticoids; Humans; Hydrocortisone; Jurkat Cells; Leukemia; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyrazines; Receptors, Glucocorticoid; RNA, Messenger	2013
Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells. PloS one, 2013, Volume: 8, Issue:10 Topics: Benzamides; Boronic Acids; Bortezomib; Caspases; Cell Death; Cell Line, Tumor; Dasatinib; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Fusion Proteins, bcr-abl; Heterocyclic Compounds, 2-Ring; Humans; Imatinib Mesylate; JNK Mitogen-Activated Protein Kinases; Leukemia; Mitosis; Models, Biological; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pteridines; Pyrazines; Pyrimidines; Signal Transduction; STAT5 Transcription Factor; Thiazoles	2013
Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity. The Journal of clinical investigation, 2014, Volume: 124, Issue:2 Topics: Active Transport, Cell Nucleus; Adult; Aged; Animals; Bone Marrow Cells; Boronic Acids; Bortezomib; Disease Progression; Female; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Middle Aged; NF-kappa B; Phenotype; Proteasome Endopeptidase Complex; Pyrazines; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha	2014
Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). Molecular pharmacology, 2014, Volume: 86, Issue:1 Topics: Actinobacteria; Boronic Acids; Bortezomib; Catalysis; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Lactones; Leukemia; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Up-Regulation	2014
Differential impact of bortezomib on HL-60 and K562 cells. General physiology and biophysics, 2015, Volume: 34, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Gene Expression Regulation, Leukemic; Heat-Shock Proteins; HL-60 Cells; HSP90 Heat-Shock Proteins; Humans; K562 Cells; Leukemia; Proteasome Endopeptidase Complex; Pyrazines; Time Factors	2015
[Study on effect of tetramethylpyrazine on proliferation and apoptosis of leukemic U937 cells and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:11 Topics: Apoptosis; Cell Cycle; Cell Proliferation; Cyclin-Dependent Kinase 2; Humans; Leukemia; Proto-Oncogene Proteins c-bcl-2; Pyrazines; U937 Cells	2015
Proteasome inhibitors in pediatric cancer treatment. Hawaii medical journal, 2008, Volume: 67, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Child; Humans; Leukemia; Neoplasms; Protease Inhibitors; Pyrazines	2008
BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis. FEBS letters, 2009, Jan-22, Volume: 583, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Caspase 3; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Gene Silencing; Humans; Leukemia; Mice; Proteasome Inhibitors; Pyrazines; RNA, Small Interfering	2009
The effects of proteasome inhibitor bortezomib on a P-gp positive leukemia cell line K562/A02. International journal of laboratory hematology, 2010, Volume: 32, Issue:1 Pt 1 Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Boronic Acids; Bortezomib; Chymotrypsin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia; Pyrazines	2010
Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors. Cancer research, 2009, Aug-15, Volume: 69, Issue:16 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Boronic Acids; Bortezomib; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Female; Forkhead Transcription Factors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; Leukemia; Mice; Mice, Nude; Piperazines; Proteasome Inhibitors; Pyrazines; Pyrimidines; Remission Induction; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2009
[Effect of proteasome inhibitor bortezomib on proliferation, apoptosis and XIAP expression in K562 cells]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2011, Volume: 32, Issue:3 Topics: Apoptosis; Boronic Acids; Bortezomib; Cell Proliferation; Humans; K562 Cells; Leukemia; Pyrazines; X-Linked Inhibitor of Apoptosis Protein	2011
Antitumor effect of non-steroid glucocorticoid receptor ligand CpdA on leukemia cell lines CEM and K562. Biochemistry. Biokhimiia, 2011, Volume: 76, Issue:11 Topics: Acetates; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cytostatic Agents; Fluocinolone Acetonide; Humans; K562 Cells; Leukemia; Ligands; NF-kappa B; Pyrazines; Receptors, Glucocorticoid; Tacrolimus Binding Proteins; Transcription Factor AP-1; Tyramine	2011
Proteasome inhibitor bortezomib overcomes P-gp-mediated multidrug resistance in resistant leukemic cell lines. International journal of laboratory hematology, 2012, Volume: 34, Issue:3 Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Humans; K562 Cells; Leukemia; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines	2012
Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells. Proceedings of the National Academy of Sciences of the United States of America, 2012, Feb-14, Volume: 109, Issue:7 Topics: Apoptosis; Boronic Acids; Bortezomib; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Humans; Leukemia; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-kit; Pyrazines; Translocation, Genetic	2012
Rad knockdown induces mitochondrial apoptosis in bortezomib resistant leukemia and lymphoma cells. Leukemia research, 2012, Volume: 36, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Jurkat Cells; K562 Cells; Leukemia; Lymphoma; Mitochondria; Pyrazines; ras Proteins; RNA, Small Interfering; Up-Regulation	2012
Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells. Haematologica, 2013, Volume: 98, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Autoantigens; Boronic Acids; Bortezomib; Cell Line, Tumor; DNA Replication; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; K562 Cells; Leukemia; Membrane Proteins; Mice; Proteasome Endopeptidase Complex; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Pyrazines; Transcription, Genetic; Xenograft Model Antitumor Assays	2013
An atypical, pigment-producing Metschnikowia strain from a leukaemia patient. Medical mycology, 2013, Volume: 51, Issue:4 Topics: Amphotericin B; Antifungal Agents; Base Sequence; DNA, Fungal; DNA, Ribosomal; Fluconazole; Humans; Italy; Leukemia; Male; Metschnikowia; Microbial Sensitivity Tests; Molecular Sequence Data; Mycoses; Phylogeny; Pigments, Biological; Pyrazines; Sequence Analysis, DNA; Sputum; Voriconazole	2013
[Proliferation-inhibiting and multidrug-resistant reversing effect of bortezomib on human HL-60 cells]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2012, Volume: 33, Issue:11 Topics: Boronic Acids; Bortezomib; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Leukemia; NF-kappa B; Pyrazines; RNA, Messenger	2012
Superoxide radical generation and Mn- and Cu-Zn superoxide dismutases activities in human leukemic cells. Hematological oncology, 2003, Volume: 21, Issue:1 Topics: Adult; Anions; Child; Humans; Imidazoles; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocytes; Manganese; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Oxidative Stress; Oxygen; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrazines; Sodium Dodecyl Sulfate; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Zymosan	2003
The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib. Experimental cell research, 2004, May-01, Volume: 295, Issue:2 Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; MAP Kinase Signaling System; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Protease Inhibitors; Pyrazines; Pyridines; Reactive Oxygen Species; Signal Transduction; U937 Cells	2004
Bortezomib interactions with chemotherapy agents in acute leukemia in vitro. Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:1 Topics: Adolescent; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Drug Interactions; Heat-Shock Proteins; Histone Deacetylase Inhibitors; Humans; Infant; Inhibitory Concentration 50; Leukemia; Male; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Tumor Cells, Cultured	2006
Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib. Acta haematologica, 2006, Volume: 115, Issue:1-2 Topics: 14-3-3 Proteins; Antibiotics, Antineoplastic; Antigens, Nuclear; Apoptosis; bcl-2-Associated X Protein; Boronic Acids; Bortezomib; Caspase 9; Caspase Inhibitors; Caspases; Cytochromes c; Depsipeptides; DNA-Binding Proteins; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; HL-60 Cells; Humans; K562 Cells; Ku Autoantigen; Leukemia; Mitochondria; Mitochondrial Membranes; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Transport; Pyrazines	2006
Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia, 2007, Volume: 21, Issue:1 Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Catalytic Domain; Cell Line, Tumor; Drug Screening Assays, Antitumor; Hematologic Neoplasms; Humans; Leukemia; Mice; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines	2007
Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cdelta. Leukemia, 2007, Volume: 21, Issue:7 Topics: Adult; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Synergism; Enzyme Activation; Humans; Leukemia; Middle Aged; Mitogen-Activated Protein Kinases; Oxides; Protease Inhibitors; Protein Kinase C-delta; Pyrazines; Tumor Cells, Cultured	2007
[Effect of bortezomib used alone or in combination with arsenic trioxide on HL-60 cell xenograft in nude mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:10 Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Proliferation; Disease Models, Animal; HL-60 Cells; Humans; Leukemia; Male; Mice; Mice, Nude; Oxides; Pyrazines; Random Allocation; Xenograft Model Antitumor Assays	2007
Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition. Journal of immunology (Baltimore, Md. : 1950), 2008, Jan-01, Volume: 180, Issue:1 Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Combined Modality Therapy; Cytotoxicity, Immunologic; Fas Ligand Protein; Immunotherapy; Killer Cells, Natural; Leukemia; Mice; Mice, Inbred Strains; Neoplasms; Perforin; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand	2008