pyrazines has been researched along with Inflammation in 103 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.94) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (11.65) | 29.6817 |
| 2010's | 65 (63.11) | 24.3611 |
| 2020's | 24 (23.30) | 2.80 |
| Authors | Studies |
|---|---|
| Bockelmann, W; Ebsen, M; Fölster-Holst, R; Frahm, SO; Ghadimi, D; Heller, KJ; Röcken, C; Schwiertz, A | 1 |
| Le, G; Lin, X; Zhu, Y | 1 |
| Bian, Y; He, J; Hu, S; Wang, S | 1 |
| Ai, Z; Almuttaqi, H; Berthold, DL; Bonham, S; Bullers, S; Corbin, AL; Eames, HL; Fischer, R; Jostins-Dean, L; Kessler, BM; Khoyratty, T; Pearson, C; Ryzhakov, G; Travis, SPL; Udalova, IA; Zec, K | 1 |
| Chen, M; Chen, X; Jiang, R; Liu, J; Wang, Y; Xu, J; Yin, M; Zhang, Y | 1 |
| Chen, H; Li, C; Liang, Y; Qiu, Y; Shen, Y; Xu, M | 1 |
| Gao, J; Liu, J; Ma, X; Ren, J; Shi, D; Song, L; Zhang, Y | 1 |
| Apta, BHR; Davies, JE; Harper, MT; Lin, Z; Lopresto, D; Ma, W | 1 |
| He, Y; Li, Q; Sun, H; Wang, S; Wang, Y; Xing, W; Xu, X | 1 |
| Fan, X; Tang, W; Wang, S; Zhang, H; Zhang, J | 1 |
| Du, J; Jiao, Y; Zhang, J; Zhang, S | 1 |
| Alharbi, KS; Alotaibi, BS; Alotaibi, MR; Alotaibi, NH; Alotaibi, NM; Alruwaili, NK; Alzarea, AI; Bukhari, SNA | 1 |
| Dong, J; Fu, Y; Jing, F; Li, G; Liu, S; Pan, R; Tang, H; Wang, H; Wang, Y; Yan, X | 1 |
| An, W; Duan, Y; Wang, J; Wu, Y | 1 |
| Chong, EA; Davids, MS; Mato, AR; Roeker, LE; Schuster, SJ; Shadman, M | 1 |
| Guo, Z; He, S; Hu, Z; Jiang, K; Lin, C; Su, H; Yuan, G; Zeng, Y; Zhong, F | 1 |
| Cui, L; Gong, L; Hou, G; Hou, Y; Jiang, P; Lu, X; Zhang, H; Zhang, L; Zhao, W | 1 |
| Baselga, J; Chung, KK; Collen, J; Desai, JV; Goy, A; Hamdy, A; Izumi, R; Lionakis, MS; Monticelli, MA; Roschewski, M; Rose, K; Roshon, M; Roswarski, J; Sharman, JP; Staudt, LM; Wilson, WH; Wright, GW; Wrzesinski, SH; Zarakas, MA | 1 |
| Ali, M; Bonay, M; Deramaudt, TB; Vanhee, V; Vinit, S | 1 |
| Evans, R; Raubo, P; Willis, P | 1 |
| Gong, S; Li, B; Li, Y; Pan, J; Qian, J; Qu, H; Wang, Y; Xiong, D; Ye, T; Zhang, L | 1 |
| Dong, Z; Li, P; Liu, J; Yuan, C; Zhang, Q | 1 |
| Huang, H; Kong, L; Luan, S; Qi, C; Wu, F | 1 |
| Chang, Y; Chen, Y; Li, J; Li, L; Li, Y; Wang, H; Wang, Q; Yang, D; Yu, B; Zhai, J; Zhang, H; Zhang, P; Zhao, X | 1 |
| Hull-Ryde, EA; Kato, T; Martino, MEB; Minges, JT; Norris-Drouin, JL; Ribeiro, CMP | 1 |
| Ambarkhane, A; Bellenie, BR; Bracher, M; Bruce, I; Chinn, C; Coote, J; Cullen, E; Culshaw, A; Hall, E; Hollingworth, GJ; Lal, A; Marshall, S; McDonald, S; Neef, J; Nicklin, P; Rosner, E; Spendiff, M; Tessier, C; Thomas, M; Wallis, G; Wuersch, K | 1 |
| Agostinis, P; Alexopoulos, LG; de Witte, PA; Derua, R; Dewaele, M; Finotello, F; Garg, AD; Janssens, S; Korovesis, D; Rožanc, J; Rufo, N; Sauter, T; Sinkkonen, L; Van Eygen, S; Vara-Perez, M; Verhelst, SHL | 1 |
| Chen, L; Liu, J; Liu, T; Wang, Q | 1 |
| Conrad, BL; Furuta, Y; Gowen, BB; Hickerson, BT; Jung, KH; Li, R; Miao, J; Nielson, S; Reynolds, ES; Rigas, JD; Thangamani, S; Van Wettere, AJ; Wang, Z; Westover, JB | 1 |
| Gao, P; Hao, X; Liu, X; Xu, H; Zhan, P; Zou, J | 1 |
| Hayashi, T; Kittaka, M; Kondo, T; Reichenberger, EJ; Ueki, Y; Yoshimoto, T | 1 |
| Jin, H; Qu, J; Wang, Y; Yu, T | 1 |
| Bai, XY; Cao, Z; Du, PC; Hou, Y; Wang, XF; Zhang, LS | 1 |
| Du, S; He, G; Sun, Z; Wu, Y; Zhang, X; Zhao, Y; Zhou, L; Zhou, P; Zhuo, LH | 1 |
| Jessen, N; Johannsen, M; Jørgensen, JO; Møller, AB; Møller, N; Rittig, N; Thomsen, HH | 1 |
| Bonhaus, D; Khan, A; Koike, MA; Masliah, E; Price, DL; Rockenstein, E; Wrasidlo, W | 1 |
| Chávez-Riveros, A; Hernández-Vázquez, E; Miranda, LD; Nieto-Camacho, A | 1 |
| Li, Y; Zhang, T; Zhou, Y; Zhu, Z | 1 |
| Choi, J; Chung, SH; Ham, YJ; Jang, SY; Kang, SJ; Kim, YH; Lee, JW; Min, KH; Suh, KH | 1 |
| Chen, B; Huang, DD; Huang, HH; Li, DG; Yang, Q; Yuan, CL; Zhang, LM | 1 |
| Lin, L; Liu, N; Wang, JP; Wang, JQ; Zhang, FK | 1 |
| Fu, X; Hao, B; Lei, B; Lin, R; Liu, J; Qiu, Y; Yang, L; Yu, P | 1 |
| Ahonen, TJ; Alakurtti, S; Haavikko, R; Hämäläinen, M; Mäki-Opas, I; Moilanen, E; Moilanen, LJ; Moreira, VM; Muraki, K; Yli-Kauhaluoma, J | 1 |
| Chen, J; Chen, Y; Fan, Y; Gao, C; Li, W; Liu, D; Pan, S; Wang, H | 1 |
| Ambrosio, CE; Araujo, KP; Belizario, JE; Bonuccelli, G; Duarte, CN; Feder, D; Gaiad, TP; Lisanti, MP; Miglino, MA; Moreira, DF | 1 |
| Bruce, SS; Connolly, ES; Heyer, EJ; Mergeche, JL | 1 |
| Chen, YC; Chen, YJ; Hsu, MI; Huang, JH; Kao, YH; Lee, TI | 1 |
| Babina, M; Mudnakudu Nagaraju, KK; Worm, M | 1 |
| Chang, CL; Chang, HW; Chang, LT; Chen, HH; Chen, YL; Chen, YT; Leu, S; Sun, CK; Sung, PH; Tsai, TH; Yang, CC; Yip, HK; Zhen, YY | 1 |
| Kim, SY; Min, S; Yeom, GG | 1 |
| Barreiro, E; Chacon-Cabrera, A; de Kier Joffé, ED; Diament, MJ; Fermoselle, C; Mateu-Jimenez, M; Sandri, M; Urtreger, AJ | 1 |
| Ambrósio, AF; Fernandes, R; Gonçalves, A; Leal, E; Marques, C; Reis, F; Ribeiro, CF | 1 |
| Fernandes, R; Fontes-Ribeiro, C; Gonçalves, A; Marques, C; Mega, C; Reis, F; Rodrigues-Santos, P; Teixeira, F; Teixeira-Lemos, E | 1 |
| Choi, YK; Jang, BK; Jung, GS; Jung, YA; Kim, HS; Kim, JG; Kim, MK; Lee, IK; Park, KG; Seo, HY | 1 |
| Chen, YJ; Gong, JY; Huang, CS; Pan, ZH; Wang, F | 1 |
| Cai, J; Chen, YJ; Huang, L; Liu, A; Ouyang, Y; Tu, Q; Wang, Y; Xiao, D; Yan, W; Zeng, X; Zeng, Z | 1 |
| Canu, T; De Cobelli, F; Del Maschio, A; Esposito, A; Fragasso, G; Lattuada, G; Manzoni, G; Margonato, A; Perseghin, G; Salerno, A | 1 |
| Alexander, T; Bokarewa, M; Brisslert, M; Dörner, T; Dürr, M; Engelmann, R; Frölich, D; Giesecke, C; Grün, JR; Kühl, AA; Luda, K; Mei, HE; Perka, C; Radbruch, A; Scheel, T; Schmidt, S; Wirries, I | 1 |
| Agdauletova, S; Daiber, A; Hausding, M; Klein, T; Kröller-Schön, S; Li, H; Mader, M; Mikhed, Y; Münzel, T; Oelze, M; Pfeffer, A; Schulz, E; Stamm, P; Steven, S; Sudowe, S; Welschof, P; Zinßius, E | 1 |
| Lian, N; Lu, C; Lu, Y; Wu, X; Xiong, X; Zhang, F; Zheng, S | 1 |
| Best, C; Laciny, E; Reeds, DN; Royal, M; Struthers, H; Yarasheski, KE | 1 |
| Ishibashi, Y; Kato, H; Matsui, T; Matsumoto, T; Yamagishi, S | 1 |
| Allanore, Y; Bruni, C; Distler, O; Gabrielli, A; Iannone, F; Matucci-Cerinic, M; Praino, E | 1 |
| Jang, J; Jho, EH; Jung, Y; Kim, Y; Yoon, Y | 1 |
| Jimenez, SA; Roman-Blas, JA | 1 |
| Littlehales, C | 1 |
| Luo, YC; Wang, Q; Xiang, QW | 1 |
| Lupfer, C; Pastey, MK; Patton, KM | 1 |
| Dong, X; Gao, SL; Jiang, RY; Peng, JP; Wang, J; Wu, YL; Xie, QP; Zhan, YC | 1 |
| Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Franzetti, IG; Gadaleta, G; Maffioli, P; Piccinni, MN; Querci, F; Ragonesi, PD; Salvadeo, SA | 1 |
| Blackwell, TS; Kalomenidis, I; Karabela, SP; Kollintza, A; Magkouta, S; Moschos, C; Psallidas, I; Roussos, C; Sherrill, TP; Stathopoulos, GT; Theodoropoulou, P | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X | 1 |
| Gong, F; Gong, Q; Gu, H; Jin, X; Li, X; Yin, H; Yuan, B; Zhang, B; Zheng, F; Zhu, J | 1 |
| Du, Z; Fan, M; Gu, W; Jiao, Y; Kim, JG; Nosrat, CA; Pavicevic, Z; Pfeffer, LM; Rao, SK; Rosebush, M; Samant, S | 1 |
| Anagnostopoulos, A; Athanasiou, E; Bougiouklis, D; Kaloyannidis, P; Palladas, P; Papadopoulou, A; Paraskeva, A; Yannaki, E; Yiangou, M | 1 |
| Resmi, H | 1 |
| Coben, J; Dobrian, AD; Galkina, EV; Leone, KA; Lindsay, JW; Ma, K; Ma, Q; Nadler, JL | 1 |
| Blake, J; Brandner, S; D'Sa, S; Elliott, KJ; Lunn, MP; Rabin, N; Reilly, MM; Saifee, TA; Yong, KL | 1 |
| Bergamini, E; Bertolotto, M; Dallegri, F; Delrio, A; Franciosi, U; Lenglet, S; Mach, F; Minetti, S; Montecucco, F; Ottonello, L; Pelli, G; Pende, A; Puddu, A; Quercioli, A; Viviani, GL; Vuilleumier, N | 1 |
| Czyz, M; Duechler, M; Wilczynski, J | 1 |
| Dagli, F; Isik, A; Koca, SS; Ozercan, IH; Ozgen, M; Sahin, K; Tuzcu, M | 1 |
| Cheng, T; Mao, X; Pan, X; Zhang, X | 1 |
| Chen, XB; Hao, J; Jin, BL; Wang, SQ; Wu, HJ | 1 |
| Chai, J; Choudhury, RP; Digby, JE; Greaves, DR; Jefferson, A; Martinez, F; Ruparelia, N; Wamil, M | 1 |
| Cheng, T; Mao, X; Pan, X; Peng, X; Zhang, X; Zhao, S | 1 |
| Cheng, T; Mao, X; Pan, X; Peng, X; Zhang, X | 1 |
| Barbieri, M; Marfella, R; Paolisso, G; Rizzo, MR | 1 |
| El-Agamy, DS; El-Awady, MS; Nader, MA; Shalaby, AA | 1 |
| Isogawa, A; Iwamoto, M; Koike, K; Ohki, T; Ohsugi, M; Omata, M; Tagawa, K; Toda, N; Yoshida, H | 1 |
| Hasegawa, K; Iguchi, A; Kono, S; Nakagawachi, R; Odori, S; Sasaki, Y; Satoh-Asahara, N; Shimatsu, A; Tochiya, M; Wada, H | 1 |
| Hu, JZ; Huang, JH; Li, JH; Li, XM; Lu, HB; Xiao, ZM | 1 |
| Barbieri, M; Boccardi, V; Esposito, A; Marfella, R; Pansini, A; Paolisso, G; Rizzo, MR | 1 |
| Boehncke, WH; Elliott, PJ; Zollner, TM | 1 |
| Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K | 1 |
| Durrance, A | 1 |
| Ahsan, MH; Purchio, AF; Sambucetti, LC; West, DB; Zhang, N; Zhu, L | 1 |
| Cho, CS; Eom, KS; Kim, CC; Kim, YJ; Lee, JW; Lee, S; Min, CK; Min, WS; Park, G | 1 |
| Fujita, M; Harada, E; Ikegame, S; Inoshima, I; Nakanishi, Y; Ouchi, H; Ye, Q | 1 |
| Janssen, JJ; Lokhorst, HM; Zweegman, S | 1 |
| Adams, W; Adedoyin, A; Barry, A; Cummons, TA; Harrison, J; Jones, PG; Leventhal, L; Lu, P; Piesla, MJ; Ramdass, R; Schantz, J; Smith, VA; Spangler, TB; Strassle, BW; Sullivan, NR; Sun, SC; Uveges, AJ; Whiteside, GT | 1 |
| Eisendle, K; Fritsch, P; Linder, D; Philipp, W; Piza, H; Ratzinger, G; Schmuth, M; Zelger, B | 1 |
| Bonardi, G; Coppi, G; Vidi, A | 1 |
| Fumagalli, G | 1 |
5 review(s) available for pyrazines and Inflammation
| Article | Year |
|---|---|
Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Bacteria; Cardiovascular Diseases; Humans; Inflammation; Molecular Structure; Neoplasms; Neuroprotective Agents; Pyrazines | 2018 |
Use of biologics and other novel therapies for the treatment of systemic sclerosis.
Topics: Abatacept; Acetamides; Antibodies, Monoclonal, Humanized; Biological Products; Clinical Trials as Topic; Fibrinolytic Agents; Fibrosis; Humans; Hypertension, Pulmonary; Indoles; Inflammation; Joints; Lisuride; Lung; PubMed; Pyrazines; Pyrazoles; Pyrimidines; Scleroderma, Systemic; Skin | 2017 |
Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Boronic Acids; Bortezomib; Humans; Immunosuppression Therapy; Inflammation; Mice; NF-kappa B; Nuclear Localization Signals; Oligodeoxyribonucleotides; Pyrazines; Rats; Signal Transduction | 2008 |
Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part I.
Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; Cytokines; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Inflammation; Mice; Models, Biological; Neoplasms; NF-kappa B; Pyrazines; Signal Transduction; Transcription Factors; Tumor Suppressor Protein p53 | 2011 |
Proteasome inhibition: a new anti-inflammatory strategy.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Asthma; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Inflammation; Lysine; Models, Biological; Models, Chemical; Multienzyme Complexes; Multiple Sclerosis; Neoplasms; NF-kappa B; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Psoriasis; Pyrazines; Reperfusion Injury | 2003 |
9 trial(s) available for pyrazines and Inflammation
| Article | Year |
|---|---|
Effect of DLT-SML on Chronic Stable Angina Through Ameliorating Inflammation, Correcting Dyslipidemia, and Regulating Gut Microbiota.
Topics: Adult; Aged; Angina, Stable; Anti-Inflammatory Agents; Bacteria; Biomarkers; China; Cytokines; Drug Therapy, Combination; Drugs, Chinese Herbal; Dysbiosis; Dyslipidemias; Female; Gastrointestinal Microbiome; Humans; Hypolipidemic Agents; Inflammation; Inflammation Mediators; Lipids; Male; Methylamines; Middle Aged; Pyrazines; Time Factors; Treatment Outcome | 2021 |
Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies.
Topics: 3-Hydroxybutyric Acid; Adult; Biomarkers; Blotting, Western; Fatty Acids, Nonesterified; Glucose Clamp Technique; Humans; Hypolipidemic Agents; Inflammation; Insulin Resistance; Ketone Bodies; Kinetics; Lipopolysaccharides; Male; Muscle Proteins; Muscle, Skeletal; Phosphorylation; Protein Biosynthesis; Proteolysis; Pyrazines; Ribosomal Protein S6 Kinases; Signal Transduction; Young Adult | 2018 |
[Effect of ligustrazine hydrochloride on coagulation reaction and inflammation reaction in single valve replacement patients with rheumatic heart disease undergoing cardiopulmonary bypass].
Topics: Blood Coagulation; C-Reactive Protein; Cardiopulmonary Bypass; Humans; Inflammation; Interleukin-10; Interleukin-6; Pyrazines; Rheumatic Heart Disease | 2014 |
Sitagliptin Reduces Inflammation and Chronic Immune Cell Activation in HIV+ Adults With Impaired Glucose Tolerance.
Topics: Adipokines; Adult; Chemokines; Endothelial Progenitor Cells; Female; Glucose Intolerance; HIV Infections; HIV-1; Humans; Hypoglycemic Agents; Inflammation; Lymphocyte Activation; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Triazoles | 2015 |
Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients.
Topics: Adiponectin; Blood Glucose; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Humans; Hypoglycemic Agents; Inflammation; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Pioglitazone; Pyrazines; Resistin; Sitagliptin Phosphate; Thiazolidinediones; Triazoles; Tumor Necrosis Factor-alpha | 2010 |
Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome.
Topics: Administration, Oral; Adult; Algorithms; Cells, Cultured; Down-Regulation; Female; Humans; Hypolipidemic Agents; Inflammation; Insulin; Male; Metabolic Syndrome; Middle Aged; Neutrophils; Pyrazines; Time Factors | 2011 |
Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition.
Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Glycated Hemoglobin; Humans; Inflammation; Interleukin-18; Interleukin-6; Male; Metformin; Middle Aged; Nitriles; Oxidative Stress; Postprandial Period; Prospective Studies; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Vildagliptin | 2012 |
A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients.
Topics: Blood Glucose; C-Reactive Protein; Cholesterol; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Glucagon-Like Peptide 1; Humans; Inflammation; Interleukin-10; Interleukin-6; Leukocytes, Mononuclear; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Pyrazines; Regression Analysis; Serum Amyloid A Protein; Sitagliptin Phosphate; Triazoles; Tumor Necrosis Factor-alpha | 2013 |
Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors.
Topics: Adamantane; Atherosclerosis; Blood Glucose; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cytokines; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Inflammation; Nitriles; Oxidative Stress; Prospective Studies; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Tyrosine; Vildagliptin | 2013 |
89 other study(ies) available for pyrazines and Inflammation
| Article | Year |
|---|---|
Effects of ad libitum Free-Choice Access to Freshly Squeezed Domestic White Asparagus Juice on Intestinal Microbiota Composition and Universal Bio-Markers of Immuno-Metabolic Homeostasis and General Health in Middle-Aged Female and Male C57BL/6 Mice.
Topics: Animals; Bacteria; Biomarkers; Butyrates; Dysbiosis; Fatty Acids, Volatile; Female; Gastrointestinal Microbiome; Homeostasis; Inflammation; Male; Mice; Mice, Inbred C57BL; Polyphenols; Propionates; Pyrazines; Sulfur; Water | 2022 |
Tetramethylpyrazine Alleviates Tight Junction Disruption of Bronchial Mucosal Epithelial Cells Caused by Interleukin-17 via Inhibiting Nuclear Factor-κB-p65/Tumor Necrosis Factor-α Signaling Pathway.
Topics: Acute Lung Injury; Bronchi; Cell Line; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Inflammation; Interleukin-17; Mucous Membrane; Pyrazines; Signal Transduction; Tight Junctions; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2021 |
Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes.
Topics: Animals; Apoptosis; Chondrocytes; Endoplasmic Reticulum Stress; Extracellular Matrix; Gene Expression; Gene Expression Regulation; Heat-Shock Proteins; Inflammation; Interleukin-1beta; Male; Osteoarthritis; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Transcription Factor CHOP | 2022 |
Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Topics: Animals; Benzamides; Cells, Cultured; Colitis; Cytokines; Focal Adhesion Kinase 2; Gene Expression Profiling; HEK293 Cells; Humans; Inflammation; Interferon Regulatory Factors; Intestines; Macrophages; Male; Mice; Mice, Inbred C57BL; Mutation; Phosphorylation; Pyrazines; RAW 264.7 Cells; Sulfonamides | 2021 |
Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte.
Topics: Inflammation; Keratinocytes; Ligusticum; NF-kappa B; Psoriasis; Pyrazines; Signal Transduction; TNF Receptor-Associated Factor 6 | 2022 |
Selexipag Improves Lipopolysaccharide-Induced ARDS on C57BL/6 Mice by Modulating the cAMP/PKA and cAMP/Epac1 Signaling Pathways.
Topics: Acetamides; Animals; Inflammation; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Pyrazines; Respiratory Distress Syndrome; Signal Transduction | 2022 |
Ligustrazine prevents coronary microcirculation dysfunction in rats via suppression of miR-34a-5p and promotion of Sirt1.
Topics: Animals; Heart Diseases; Inflammation; Microcirculation; MicroRNAs; Pyrazines; Rats; Sirtuin 1 | 2022 |
Using Yoda-1 to mimic laminar flow in vitro: A tool to simplify drug testing.
Topics: Antibiotics, Antineoplastic; Cell Survival; Doxorubicin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Piezosurgery; Pyrazines; Stress, Mechanical; Thiadiazoles | 2019 |
RETRACTED: Tetramethylpyrazine alleviates lipopolysaccharide-induced damage in ATDC5 cells via down-regulating MyD88.
Topics: Animals; Apoptosis; Cells, Cultured; Chondrocytes; Inflammation; Lipopolysaccharides; Mice; Myeloid Differentiation Factor 88; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyrazines; Signal Transduction; Vasodilator Agents | 2019 |
Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF-κB Signaling Pathways.
Topics: Animals; Anti-Inflammatory Agents; Brain; Cell Adhesion Molecules; Cell Hypoxia; Cell Line; Cytokines; Endothelial Cells; Glucose; Inflammation; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Platelet Adhesiveness; Pyrazines; Reperfusion Injury; Signal Transduction | 2020 |
Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus.
Topics: Administration, Oral; Animals; Diabetes, Gestational; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Female; Inflammation; Mice; Mice, Inbred C57BL; Oxidative Stress; Placenta; Pregnancy; Pyrazines | 2019 |
Pharmacological appraisal of ligustrazine based cyclohexanone analogs as inhibitors of inflammatory markers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanones; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Inflammation; Lipoxygenase Inhibitors; Pyrazines; Structure-Activity Relationship | 2020 |
Ligustrazine ameliorates lipopolysaccharide‑induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway.
Topics: Animals; Apoptosis; Autophagy; Down-Regulation; Female; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Neurocognitive Disorders; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Tetramethylpyrazine reduces inflammation levels and the apoptosis of LPS‑stimulated human periodontal ligament cells via the downregulation of miR‑302b.
Topics: Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Down-Regulation; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; MicroRNAs; NF-kappa B; Osteogenesis; Periodontal Ligament; Periodontitis; Pyrazines; Signal Transduction; Stem Cells; Tumor Necrosis Factor-alpha | 2020 |
BTK Inhibitors in Cancer Patients with COVID-19: "The Winner Will be the One Who Controls That Chaos" (Napoleon Bonaparte).
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Anti-Inflammatory Agents; Antineoplastic Agents; Benzamides; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Inflammation; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Macrophages; Pandemics; Piperidines; Pneumonia, Viral; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; SARS-CoV-2 | 2020 |
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Chromones; Chronic Disease; Fibrinolytic Agents; Hepatic Stellate Cells; Inflammation; Liver Cirrhosis; Male; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-кB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice.
Topics: Animals; Brain; Cell Polarity; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Endothelial Cells; Female; Humans; Inflammation; Interferon-gamma; Mice, Inbred C57BL; Microglia; Microvessels; Neuroprotection; NF-kappa B; Phenotype; Pyrazines; Signal Transduction; Spinal Cord; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein | 2021 |
Inhibition of Bruton tyrosine kinase in patients with severe COVID-19.
Topics: Agammaglobulinaemia Tyrosine Kinase; Aged; Aged, 80 and over; Benzamides; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Critical Illness; Female; Follow-Up Studies; Humans; Inflammation; Interleukin-6; Male; Middle Aged; Monocytes; Pandemics; Pneumonia, Viral; Prospective Studies; Pyrazines; Respiration, Artificial; SARS-CoV-2; Treatment Outcome | 2020 |
Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in an in vitro macrophage infection model.
Topics: Anti-Inflammatory Agents; Antioxidants; Dimethyl Fumarate; Escherichia coli; Escherichia coli Infections; Flavanones; Humans; Inflammation; Isothiocyanates; Leukocytes, Mononuclear; Macrophage Activation; Macrophages; NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Staphylococcal Infections; Staphylococcus aureus; Sulfoxides; Thiones; Thiophenes; THP-1 Cells | 2020 |
The discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors.
Topics: Administration, Inhalation; Alkanes; Amines; Animals; Anti-Inflammatory Agents; Benzamides; Dogs; Drug Evaluation, Preclinical; Humans; Inflammation; Mitogen-Activated Protein Kinase 14; Models, Molecular; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazines; Quinazolines; Rats; Structure-Activity Relationship | 2020 |
Combination of Danshen and ligustrazine has dual anti-inflammatory effect on macrophages and endothelial cells.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; Pyrazines; Salvia miltiorrhiza | 2021 |
Effects of Floium ginkgo extract and tertram ethypyrazine sodium chloride injection on expression of inflammatory cytokines and cerebral infarction.
Topics: Aged; Brain Ischemia; Cerebral Infarction; Cytokines; Female; Ginkgo biloba; Humans; Inflammation; Male; Plant Extracts; Proteins; Pyrazines; Sodium Chloride | 2020 |
Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway.
Topics: Animals; Becaplermin; Cell Cycle; Cell Proliferation; China; Disease Models, Animal; Inflammation; Male; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pyrazines; Rats; Rats, Sprague-Dawley | 2021 |
IRE1α Is a Therapeutic Target for Cystic Fibrosis Airway Inflammation.
Topics: Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytokines; Endoribonucleases; Epithelium; Humans; Imidazoles; Inflammation; Lung; Models, Biological; Molecular Targeted Therapy; Naphthalenes; Protein Serine-Threonine Kinases; Pyrazines; RNA, Messenger; Up-Regulation; X-Box Binding Protein 1 | 2021 |
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Class Ib Phosphatidylinositol 3-Kinase; Female; Humans; Inflammation; Molecular Structure; No-Observed-Adverse-Effect Level; Protein Kinase Inhibitors; Pyrazines; Rats, Sprague-Dawley; Structure-Activity Relationship | 2021 |
Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting.
Topics: Endoplasmic Reticulum; Endoribonucleases; Humans; Imidazoles; Immunogenic Cell Death; Inflammation; Naphthalenes; Protein Serine-Threonine Kinases; Pyrazines | 2022 |
Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspartate Aminotransferases; Cartilage; Curcumin; Cytokines; Drug Combinations; Edema; Female; Inflammation; Joints; Kidney; Liver; Male; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Pyrazines; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2017 |
Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir.
Topics: Amides; Animal Structures; Animals; Antiviral Agents; Bunyaviridae Infections; Chemoprevention; Cricetinae; Disease Models, Animal; Inflammation; Interferon Type I; Pyrazines; STAT2 Transcription Factor; Treatment Outcome | 2017 |
Second-Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bone and Bones; Cherubism; Disease Models, Animal; Indazoles; Inflammation; Mice; Protein Kinase Inhibitors; Pyrazines; Syk Kinase | 2018 |
Ligustrazine protects chondrocyte against IL-1β induced injury by regulation of SOX9/NF-κB signaling pathway.
Topics: Aged; Cells, Cultured; Chondrocytes; Female; Humans; Inflammation; Interleukin-1beta; Male; Middle Aged; NF-kappa B; Protective Agents; Pyrazines; Signal Transduction; SOX9 Transcription Factor | 2018 |
Tetramethylpyrazine ameliorates experimental autoimmune encephalomyelitis by modulating the inflammatory response.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Inflammation; Mice; Mice, Inbred C57BL; Pyrazines | 2018 |
Tetramethylpyrazine‑2'O‑sodium ferulate provides neuroprotection against neuroinflammation and brain injury in MCAO/R rats by suppressing TLR-4/NF-κB signaling pathway.
Topics: Animals; Brain Edema; Brain Injuries; Chemokine CCL2; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2019 |
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cerebral Cortex; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; Lewy Body Disease; Mice; Mice, Transgenic; Multiple System Atrophy; Neurons; Parkinson Disease; Piperidines; Protein Aggregation, Pathological; Protein Folding; Pyrazines; Pyrimidines; Retina | 2018 |
A Two-Step Multicomponent Synthetic Approach and Anti-inflammatory Evaluation of N-Substituted 2-Oxopyrazines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Ear; Edema; Inflammation; Male; Mice; Molecular Structure; Pyrazines; Structure-Activity Relationship | 2019 |
Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-κB and Nrf-2/HO-1 pathways.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Heme Oxygenase (Decyclizing); Inflammation; Injections, Subcutaneous; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Sirtuin 1; Structure-Activity Relationship | 2019 |
Synthesis and anti-tumor activity of imidazopyrazines as TAK1 inhibitors.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Heterografts; Humans; Inflammation; MAP Kinase Kinase Kinases; Mice; Neoplasms; Protein Kinase Inhibitors; Pyrazines | 2019 |
Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway.
Topics: Animals; Cytokines; Glycogen Synthase Kinase 3 beta; Inflammation; Isoproterenol; Male; Myocardial Ischemia; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Tetramethylpyrazine supplementation reduced Salmonella Typhimurium load and inflammatory response in broilers.
Topics: Animal Feed; Animals; Body Weight; Chickens; Diet; Gastrointestinal Contents; Inflammation; Male; Permeability; Poultry Diseases; Pyrazines; Salmonella Infections, Animal; Salmonella typhimurium | 2019 |
Retinal Transcriptome Analysis in the Treatment of Endotoxin-Induced Uveitis with Tetramethylpyrazine Eye Drops.
Topics: Animals; Endotoxins; Female; Inflammation; Mice; Mice, Inbred BALB C; Ophthalmic Solutions; Protective Agents; Pyrazines; Retina; Transcriptome; Uveitis | 2019 |
Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo.
Topics: Animals; Anti-Inflammatory Agents; HEK293 Cells; Humans; Inflammation; Mice; Pyrazines; Triterpenes; TRPA1 Cation Channel | 2019 |
Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs by inhibiting Rho/ROCK pathway.
Topics: Acute Lung Injury; Amides; Apoptosis; Cell Survival; Cell-Derived Microparticles; Cytokines; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Platelet Endothelial Cell Adhesion Molecule-1; Protective Agents; Pyrazines; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases | 2019 |
Bortezomib (PS-341) treatment decreases inflammation and partially rescues the expression of the dystrophin-glycoprotein complex in GRMD dogs.
Topics: Animals; Boronic Acids; Bortezomib; Chymotrypsin; Collagen; Dogs; Dystroglycans; Dystrophin-Associated Protein Complex; Gene Expression; Immunohistochemistry; Inflammation; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Proteasome Endopeptidase Complex; Pyrazines | 2013 |
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hypoglycemic Agents; Inflammation; Logistic Models; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Triazoles | 2013 |
The dipeptidyl peptidase-4 inhibitor-sitagliptin modulates calcium dysregulation, inflammation, and PPARs in hypertensive cardiomyocytes.
Topics: Action Potentials; Animals; Blood Pressure; Calcium; Cardiotonic Agents; Dipeptidyl-Peptidase IV Inhibitors; Electrocardiography; Heart Ventricles; Hypertension; Inflammation; Interleukin-6; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor for Advanced Glycation End Products; Receptor, Angiotensin, Type 1; Receptors, Immunologic; Sitagliptin Phosphate; Triazoles; Tumor Necrosis Factor-alpha | 2013 |
Opposing effects on immune function and skin barrier regulation by the proteasome inhibitor bortezomib in an allergen-induced eczema model.
Topics: Animals; Boronic Acids; Bortezomib; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dermatitis, Atopic; Disease Models, Animal; Eczema; Female; Immune System; Immunoglobulin E; Immunohistochemistry; Inflammation; Mice; Mice, Inbred BALB C; Organ Culture Techniques; Proteasome Inhibitors; Pyrazines; Skin | 2013 |
Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction.
Topics: Animals; Biomarkers; Creatinine; Exenatide; Inflammation; Kidney; Male; Oxidative Stress; Peptides; Proteinuria; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Sitagliptin Phosphate; Triazoles; Venoms | 2013 |
2,3,5,6-Tetramethylpyrazine of Ephedra sinica regulates melanogenesis and inflammation in a UVA-induced melanoma/keratinocytes co-culture system.
Topics: Animals; Cell Line; Cell Line, Tumor; Coculture Techniques; Cytokines; Ephedra sinica; Humans; Inflammation; Keratinocytes; Melanins; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Nitric Oxide; Pyrazines; Ultraviolet Rays | 2014 |
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness.
Topics: Animals; Autophagy; Boronic Acids; Bortezomib; Butadienes; Cachexia; Cell Line, Tumor; Inflammation; Lung Neoplasms; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; NF-kappa B; Nitriles; Oxidation-Reduction; Proteolysis; Pyrazines; Signal Transduction; Sulfasalazine; Tyrosine; Weight Gain | 2014 |
Dipeptidyl peptidase-IV inhibition prevents blood-retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats.
Topics: Animals; Apoptosis; Biomarkers; Blood-Retinal Barrier; Blotting, Western; Cell Death; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Enzyme-Linked Immunosorbent Assay; Immunoenzyme Techniques; Inflammation; Male; Neurons; Pyrazines; Rats; Rats, Wistar; Retina; Sitagliptin Phosphate; Triazoles | 2014 |
Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Inflammation; Kidney; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Triazoles; Tumor Necrosis Factor-alpha | 2014 |
Sitagliptin attenuates methionine/choline-deficient diet-induced steatohepatitis.
Topics: Animals; Biomarkers; Blotting, Western; Choline Deficiency; Diet; Dipeptidyl-Peptidase IV Inhibitors; Endoplasmic Reticulum Stress; Fatty Liver; Immunoenzyme Techniques; Inflammation; Lipid Peroxidation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sitagliptin Phosphate; Triazoles; Triglycerides | 2014 |
CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-κB and MAPK pathway.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Inflammation; Lipopolysaccharides; Liver Neoplasms; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Myeloid Differentiation Factor 88; NF-kappa B; Piperazines; Pyrazines; Toll-Like Receptor 4 | 2015 |
Effects of short-term manipulation of serum FFA concentrations on left ventricular energy metabolism and function in patients with heart failure: no association with circulating bio-markers of inflammation.
Topics: Adipokines; Adult; Aged; Biomarkers; Energy Metabolism; Fatty Acids, Nonesterified; Heart Failure; Heart Ventricles; Humans; Hypolipidemic Agents; Inflammation; Insulin; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pyrazines; Tumor Necrosis Factor-alpha; Ventricular Function, Left | 2015 |
A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow.
Topics: Antigens, CD19; Antilymphocyte Serum; Bone Marrow Cells; Boronic Acids; Bortezomib; Cell Differentiation; Cell Survival; Diphtheria-Tetanus Vaccine; Humans; Immunity, Humoral; Immunoglobulin G; Immunologic Memory; Inflammation; Lymphocyte Depletion; Models, Immunological; Mutation; Phenotype; Plasma Cells; Pyrazines; V(D)J Recombination | 2015 |
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.
Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endotoxemia; Glucagon-Like Peptide 1; Inflammation; Linagliptin; Lipopolysaccharides; Liraglutide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Purines; Pyrazines; Quinazolines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles | 2015 |
Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway.
Topics: Animals; Carrier Proteins; Caspase 1; Cytokines; Hepatocytes; Inflammasomes; Inflammation; Inflammation Mediators; Liver Cirrhosis; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Platelet-Derived Growth Factor; Pyrazines; Rats; Rats, Sprague-Dawley | 2015 |
Ranirestat has a stronger inhibitory activity on aldose reductase and suppresses inflammatory reactions in high glucose-exposed endothelial cells.
Topics: Aldehyde Reductase; Anti-Inflammatory Agents; Cell Line, Tumor; Chromatography, Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Rhodanine; Sorbitol; Spiro Compounds; Superoxides; Tandem Mass Spectrometry; Thiazolidines; Vascular Cell Adhesion Molecule-1 | 2016 |
LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974.
Topics: Anti-Inflammatory Agents; Cell Line; Cytokines; Epithelial Cells; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Inflammation; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; NF-kappa B; Protein Binding; Pyrazines; Pyridines; Wnt Proteins; Wnt Signaling Pathway | 2017 |
Deborah Dunsire.
Topics: Anti-Inflammatory Agents; Biopharmaceutics; Biotechnology; Boronic Acids; Bortezomib; Drug Industry; Entrepreneurship; History, 21st Century; Humans; Inflammation; Neoplasms; Organizational Objectives; Pyrazines | 2008 |
[Effect of ligustrazine on expression of RhoA mRNA, ROCK-II protein in the lung and airway inflammation of allergic asthma model mice].
Topics: Animals; Asthma; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Pyrazines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger | 2008 |
Treatment of human respiratory syncytial virus infected Balb/C mice with the proteasome inhibitor bortezomib (Velcade, PS-341) results in increased inflammation and mortality.
Topics: Animals; Antiviral Agents; Boronic Acids; Bortezomib; Chlorocebus aethiops; Cytokines; Enzyme Inhibitors; Inflammation; Mice; Mice, Inbred BALB C; Proteasome Inhibitors; Pyrazines; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Vero Cells; Virus Replication | 2010 |
The potential effect of proteasome inhibitor PS-341 on severe acute pancreatitis detected by positron emission tomography in ICR mice.
Topics: Amylases; Animals; Apoptosis; Boronic Acids; Bortezomib; C-Reactive Protein; Ceruletide; Female; Inflammation; Interleukin-1beta; L-Lactate Dehydrogenase; Mice; Mice, Inbred ICR; Pancreatitis; Positron-Emission Tomography; Protease Inhibitors; Pyrazines; Radiography | 2010 |
Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study.
Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Inflammation; Inflammation Mediators; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Neovascularization, Pathologic; NF-kappa B; Pleural Effusion, Malignant; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines | 2010 |
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2010 |
Heme oxygenase-1 upregulation improves lipopolysaccharide-induced acute lung injury involving suppression of macrophage migration inhibitory factor.
Topics: Acute Lung Injury; Animals; Cell Line; Cell Movement; Gene Expression Regulation; Heme Oxygenase-1; Inflammation; Intramolecular Oxidoreductases; Lipopolysaccharides; Macrophage Migration-Inhibitory Factors; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Pyrazines; Pyrroles; RNA, Small Interfering; Specific Pathogen-Free Organisms; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Up-Regulation | 2010 |
Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Biomarkers; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Profiling; Humans; Inflammation; Interleukin-8; Microarray Analysis; Mouth Neoplasms; NF-kappa B; Pyrazines; RNA, Small Interfering | 2010 |
The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant-induced arthritis in rats.
Topics: Analysis of Variance; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Diseases; Boronic Acids; Bortezomib; Cell Proliferation; Cytokines; Flow Cytometry; Immunohistochemistry; Inflammation; Joints; Pyrazines; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Synovial Membrane; Toll-Like Receptors; Treatment Outcome | 2010 |
The combination of bortezomib and resveratrol may prevent muscle wasting in diabetes.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Boronic Acids; Bortezomib; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Inflammation; Models, Biological; Muscular Atrophy; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Rats; Resveratrol; Stilbenes | 2011 |
Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice.
Topics: Adipocytes; Adipose Tissue; Adiposity; Animals; Anti-Inflammatory Agents; Body Weight; Cytokines; Dipeptidyl-Peptidase IV Inhibitors; Flow Cytometry; Glucose; Glucose Intolerance; Glucose Tolerance Test; Immunohistochemistry; Inflammation; Insulin; Islets of Langerhans; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Neutrophil Infiltration; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles | 2011 |
Bortezomib-induced inflammatory neuropathy.
Topics: Boronic Acids; Bortezomib; Humans; Inflammation; Inflammation Mediators; Male; Middle Aged; Multiple Myeloma; Neural Conduction; Peripheral Nervous System Diseases; Pyrazines | 2010 |
Proteasome inhibition prevents development of experimental dermal fibrosis.
Topics: Actins; Animals; Bleomycin; Boronic Acids; Bortezomib; Collagen Type I; Female; Fibrosis; Inflammation; Interleukin-4; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 8; NF-kappa B; Proteasome Inhibitors; Pyrazines; Random Allocation; Scleroderma, Localized; Skin; Transforming Growth Factor beta1 | 2012 |
Therapeutic potential of the proteasome inhibitor Bortezomib on titanium particle-induced inflammation in a murine model.
Topics: Animals; Boronic Acids; Bortezomib; Female; I-kappa B Kinase; Inflammation; Inflammation Mediators; Joint Prosthesis; Mice; Mice, Inbred BALB C; NF-kappa B; Osteolysis; Prosthesis Failure; Proteasome Inhibitors; Pyrazines; Random Allocation; Titanium; Tumor Necrosis Factor-alpha | 2012 |
Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.
Topics: Autoimmunity; Biomarkers; Chaperonin 60; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Nitric Oxide; Pyrazines; Tumor Necrosis Factor-alpha | 2012 |
Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms.
Topics: Anti-Inflammatory Agents; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Cyclooxygenase 2 Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Kinase; Inflammation; Inflammation Mediators; Integrin alpha4beta1; Interleukin-6; Lipopolysaccharides; Monocytes; Niacin; Phosphorylation; Pyrazines; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Nicotinic; Receptors, Prostaglandin; RNA Interference; Toll-Like Receptor 2; Toll-Like Receptor 4; Transcription Factor RelA; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2012 |
Protection against titanium particle-induced inflammatory osteolysis by the proteasome inhibitor bortezomib in vivo.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Arthroplasty, Replacement; Boronic Acids; Bortezomib; Female; Inflammation; Mice; Mice, Inbred BALB C; Osteolysis; Osteoprotegerin; Prosthesis Failure; Proteasome Inhibitors; Pyrazines; Random Allocation; RANK Ligand; Titanium; TNF Receptor-Associated Factor 6; Vascular Endothelial Growth Factors | 2012 |
Inhibition of titanium particle-induced inflammation by the proteasome inhibitor bortezomib in murine macrophage-like RAW 264.7 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Boronic Acids; Bortezomib; Cell Line; Cell Survival; Chemokine CCL2; Cyclooxygenase 2; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Macrophage Inflammatory Proteins; Macrophages; Mice; Nitric Oxide Synthase Type II; Proteasome Inhibitors; Pyrazines; Titanium; Tumor Necrosis Factor-alpha | 2012 |
Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Inflammation; Lung; Male; Mice; Nitric Oxide Synthase Type II; Ovalbumin; Pyrazines; RNA, Messenger; Sitagliptin Phosphate; Triazoles | 2012 |
The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone.
Topics: Adult; Alanine Transaminase; Blood Glucose; Body Weight; Comorbidity; Diabetes Mellitus, Type 2; Drug Evaluation; Drug Therapy, Combination; Fatty Liver; Female; Follow-Up Studies; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Inflammation; Liraglutide; Liver Cirrhosis; Logistic Models; Male; Middle Aged; Multivariate Analysis; Non-alcoholic Fatty Liver Disease; Odds Ratio; Pioglitazone; Platelet Count; Pyrazines; Retrospective Studies; Sitagliptin Phosphate; Thiazolidinediones; Treatment Outcome; Triazoles | 2012 |
Tetramethylpyrazine accelerates the function recovery of traumatic spinal cord in rat model by attenuating inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cytokines; Hindlimb; I-kappa B Proteins; Immunohistochemistry; Inflammation; Macrophage Migration-Inhibitory Factors; Male; Motor Activity; Neutrophil Infiltration; NF-kappa B; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries | 2013 |
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Proteinase inhibitors - IBC's Third International Conference. New approaches, new discoveries, new targets.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Boronic Acids; Bortezomib; Cathepsins; Drug Evaluation, Preclinical; Endopeptidases; Humans; Inflammation; Peptide Library; Protease Inhibitors; Pyrazines | 2004 |
NF-kappaB and not the MAPK signaling pathway regulates GADD45beta expression during acute inflammation.
Topics: Animals; Antigens, Differentiation; Apoptosis; Arsenites; Blotting, Northern; Blotting, Western; Boronic Acids; Bortezomib; Dexamethasone; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Female; Gene Library; Genetic Vectors; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Luciferases; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Promoter Regions, Genetic; Proteasome Inhibitors; Protein Binding; Pyrazines; RNA, Messenger; Signal Transduction; Sodium Compounds; Thalidomide; Time Factors; Tissue Distribution; Tumor Necrosis Factor-alpha | 2005 |
Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; association with pro-inflammatory cytokines.
Topics: Boronic Acids; Bortezomib; Cytokines; Humans; Inflammation; Male; Middle Aged; Multiple Myeloma; Pyrazines; Skin; Vasculitis, Leukocytoclastic, Cutaneous | 2006 |
Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Doxycycline; Drug Resistance, Bacterial; Hydroxamic Acids; Immunologic Factors; Inflammation; Lipopolysaccharides; Lung; Lung Diseases; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Neutrophils; Pulmonary Alveoli; Pyrazines; Streptococcus pneumoniae; Sulfonamides | 2007 |
Immune-modulatory effects of bortezomib in GVHD.
Topics: Antineoplastic Agents; Bone Marrow Cells; Boronic Acids; Bortezomib; Cytokines; Graft vs Host Disease; Humans; Immune System; Inflammation; Multiple Myeloma; NF-kappa B; Plasmacytoma; Pyrazines; Spleen; Stem Cell Transplantation; T-Lymphocytes; Transplantation, Homologous | 2007 |
Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.
Topics: Animals; Biological Availability; Bridged-Ring Compounds; Chronic Disease; Disease Models, Animal; Inflammation; Inhibitory Concentration 50; Muscarinic Agonists; Pain; Pyrazines; Rats; Receptors, Muscarinic | 2007 |
Inflammation and lipid accumulation in xanthoma disseminatum: Therapeutic considerations.
Topics: Adult; Histiocytosis, Non-Langerhans-Cell; Humans; Inflammation; Lipid Metabolism; Male; Pyrazines; Rosiglitazone; Simvastatin; Thiazolidinediones | 2008 |
Effects of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370, fenilprenazone) on lysosomes.
Topics: Acid Phosphatase; Animals; Anti-Inflammatory Agents; Inflammation; Kaolin; Lysosomes; Membranes; Phenylbutazone; Pyrazines; Rats | 1973 |
[Experimental research on the anti-inflammatory and anti-exudative action of morphazinamide].
Topics: Animals; Antitubercular Agents; Exudates and Transudates; Inflammation; Pyrazines; Rats | 1965 |