pyrazines has been researched along with Infarction, Middle Cerebral Artery in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (43.33) | 29.6817 |
| 2010's | 16 (53.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, BY; Gao, G; Hu, J; Liu, F; Meng, XB; Sun, GB; Sun, XB; Wang, H; Wu, Y; Zhang, SX; Zhu, T | 1 |
| Chen, J; Dong, L; Dong, Y; Fu, X; Guo, T; Liu, M; Mao, Y; Qiao, C; Yang, Y; Zhang, J; Zhang, X; Zhao, Y | 1 |
| Alexander, JC; Candelario-Jalil, E; DeMars, KM; Febo, M; Yang, C | 1 |
| Gu, J; Li, C; Liu, W; Long, C; Shan, L; Sun, Y; Wang, Y; Wu, L; Xu, L; Yang, X; Zhang, G; Zhang, T; Zhang, Z; Zhou, X | 1 |
| Du, S; He, G; Sun, Z; Wu, Y; Zhang, X; Zhao, Y; Zhou, L; Zhou, P; Zhuo, LH | 1 |
| Jing, G; Jinmin, Z; Li, Z; Min, L; Xinyong, L; Yaqing, J; Yulei, J | 1 |
| Chu, L; Li, L; Li, T; Ren, C; Sun, S; Wang, J; Yin, Y | 1 |
| Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY | 1 |
| Kong, X; Lin, N; Liu, C; Qin, Q; Shang, H; Su, H; Su, X; Wan, H; Wu, J; Zhang, Y; Zhong, M | 1 |
| Chen, ML; Cui, YJ; He, GW; Liu, B; Wu, YL; Xu, SH; Yang, D; Yin, MS; Zhou, PP | 1 |
| Hu, X; Tian, M; Wan, H; Yang, J; Zhang, H; Zhao, C; Zhu, H | 1 |
| Edvinsson, L; Maddahi, A | 1 |
| Chen, X; Liu, Y; Qi, C; Qiu, F; Xiao, X; Yang, P; Zhang, J | 1 |
| Cheng, Y; Sun, J; Wang, H; Yang, C; Zhang, S | 1 |
| Sun, Y; Wang, L; Wang, Y; Yu, P; Zhai, Z; Zhang, G; Zhong, H | 1 |
| Liu, HW; Yan, YL; Zhou, LL | 1 |
| Han, R; Li, J; Luo, Q; Shen, J; Tang, Q; Xiao, H | 1 |
| Cao, R; Chu, T; Jin, H; Li, H; Li, Q; Mao, SJ | 1 |
| Chabrier, PE; Croci, N; Ding-Zhou, L; Marchand-Verrecchia, C; Margaill, I; Palmier, B; Plotkine, M | 1 |
| Bai, M; Jiang, AH; Ma, KL; Wang, QM; Wang, YJ | 1 |
| Chen, SY; Hu, S; Huan, Y; Liu, YH; Wei, MQ; Xiong, LZ | 1 |
| Bouley, J; Fisher, M; Henninger, N; Sicard, KM; Stagliano, NE | 1 |
| Chopp, M; Hozeska, A; Liu, X; Lu, M; Riordan, W; Stagliano, N; Zhang, L; Zhang, ZG | 1 |
| Chen, YC; Chou, DS; Hsiao, G; Lin, CH; Lin, JH; Lin, KH; Sheu, JR | 1 |
| Liu, Y; Qi, CF; Qian, YH; Qiu, F; Tian, YF; Zhao, JJ | 1 |
| Liu, Y; Qi, CF; Qiu, F; Tian, YF; Xiao, XL; Yang, J; Zhang, PB; Zhao, JJ | 1 |
| Chen, XL; Kang, QY; Liu, Y; Qi, CF; Qiu, F; Tian, YF; Zhang, PB; Zhao, JJ | 1 |
| Edvinsson, L; Henriksson, M; Jamali, R; Maddahi, A; Stenman, E | 1 |
| Chen, XL; Liu, Y; Qi, CF; Qiu, F; Tian, YM; Xiao, XL; Zhang, JS; Zhang, PB | 1 |
| Auguet, M; Chabrier, PE; Cornet, S; Demerlé-Pallardy, C; Marin, JG; Spinnewyn, B | 1 |
30 other study(ies) available for pyrazines and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Folium
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ginkgo biloba; Infarction, Middle Cerebral Artery; Inflammasomes; Ischemic Stroke; Male; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
Hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites for ischemic stroke.
Topics: Animals; Apigenin; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Neurons; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats; Reperfusion Injury; Stroke | 2019 |
Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog.
Topics: Acetates; Age Factors; Animals; Brain Ischemia; Epoprostenol; Infarction, Middle Cerebral Artery; Male; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Stroke | 2017 |
Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium; Cell Hypoxia; Cells, Cultured; Drug Evaluation, Preclinical; Free Radical Scavengers; Glucose; Glutamic Acid; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Mitochondria; Motor Activity; Nerve Tissue Proteins; Neuroprotective Agents; Nitrogen Oxides; Patch-Clamp Techniques; Protein Kinase Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Tetramethylpyrazine‑2'O‑sodium ferulate provides neuroprotection against neuroinflammation and brain injury in MCAO/R rats by suppressing TLR-4/NF-κB signaling pathway.
Topics: Animals; Brain Edema; Brain Injuries; Chemokine CCL2; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2019 |
Protective effects of tetramethylpyrazine analogue Z-11 on cerebral ischemia reperfusion injury.
Topics: Animals; Brain; Glutathione; Heme Oxygenase (Decyclizing); Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neuroprotective Agents; NF-E2-Related Factor 2; Pyrazines; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2019 |
Enhanced Migration of Bone Marrow-Derived Mesenchymal Stem Cells with Tetramethylpyrazine and Its Synergistic Effect on Angiogenesis and Neurogenesis After Cerebral Ischemia in Rats.
Topics: Animals; Bone Marrow Cells; Cell Movement; Cells, Cultured; Chemokine CXCL12; Infarction, Middle Cerebral Artery; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neovascularization, Physiologic; Neurogenesis; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Vasodilator Agents | 2019 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Microdialysis; Molecular Structure; Neurotransmitter Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine; Time Factors | 2014 |
Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway.
Topics: Animals; Brain Infarction; Cell Movement; Chemokine CXCL12; Infarction, Middle Cerebral Artery; Male; Mitogen-Activated Protein Kinases; Models, Biological; Neural Stem Cells; Phosphatidylinositol 3-Kinase; Phosphorylation; Pyrazines; Rats, Sprague-Dawley; Signal Transduction; Wound Healing | 2016 |
Tetramethylpyrazine-2'-O-sodium ferulate attenuates blood-brain barrier disruption and brain oedema after cerebral ischemia/reperfusion.
Topics: Animals; Aquaporin 4; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; Cell Adhesion Molecules; Coumaric Acids; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Occludin; Pyrazines; Rats, Sprague-Dawley; Reperfusion Injury | 2017 |
Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia.
Topics: Animals; Antioxidants; Brain; Gene Expression Regulation; Glucose; Infarction, Middle Cerebral Artery; Interleukin-1; Ischemic Attack, Transient; Isoflavones; Male; Malondialdehyde; Nervous System Diseases; Neuroprotective Agents; Nitric Oxide; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Synaptophysin; Tetrazolium Salts | 2008 |
Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway.
Topics: Animals; Brain; Butadienes; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Male; MAP Kinase Kinase Kinases; Neurologic Examination; Nitric Oxide Synthase Type II; Nitriles; Pyrazines; Rats; Rats, Wistar; Signal Transduction; Sulfonamides; Time Factors | 2010 |
Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia.
Topics: Adult Stem Cells; Aging; Animals; Body Water; Brain; Brain Infarction; Brain Ischemia; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurogenesis; Neurons; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Stem Cell Niche | 2010 |
Neuroprotective effects of NKN on focal cerebral ischemia in rats.
Topics: Abietanes; Acetophenones; Animals; Benzoates; Brain Ischemia; Bridged-Ring Compounds; Drug Combinations; Endothelin-1; Glucosides; Immunohistochemistry; In Situ Hybridization; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neurologic Examination; Neurons; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stroke; Superoxide Dismutase | 2012 |
Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function | 2012 |
[Comparison of the brain pharmacokinetics of nasal tetramethylpyrazine phosphate pH-sensitive in situ gel in normal rats and model rats].
Topics: Administration, Intranasal; Animals; Area Under Curve; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Gels; Hydrogen-Ion Concentration; Infarction, Middle Cerebral Artery; Male; Microdialysis; Phosphates; Pyrazines; Rats; Rats, Sprague-Dawley | 2012 |
Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2012 |
Development of 2-hydroxymethyl-3,5,6-trimethylpyrazine palmitate-loaded lipid emulsion: formulation, optimization, characterization, pharmacokinetics, biodistribution and pharmacodynamics.
Topics: Animals; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Emulsions; Half-Life; Infarction, Middle Cerebral Artery; Male; Mice; Palmitates; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2013 |
Neuroprotective effects of (S)-N-[4-[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl]-2-thiophenecarboximid-amide (BN 80933), an inhibitor of neuronal nitric-oxide synthase and an antioxidant, in model of
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Infarction; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Mice; Nervous System Diseases; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Peroxidase; Pyrazines; Thiophenes | 2003 |
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
Topics: Animals; Brain Ischemia; Endothelin-1; Female; Infarction, Middle Cerebral Artery; Insulin; Insulin Resistance; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2003 |
[Experimental study of evaluation on neuroprotective effect for tetramethylpyrazine against focal cerebral ischemic injury with diffusion-weighted magnetic resonance imaging].
Topics: Animals; Diffusion Magnetic Resonance Imaging; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Phytotherapy; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley | 2005 |
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia.
Topics: Animals; Boronic Acids; Bortezomib; Brain Infarction; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Intracranial Embolism; Male; Neuroprotective Agents; Proteasome Inhibitors; Pyrazines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley | 2006 |
Treatment of embolic stroke in rats with bortezomib and recombinant human tissue plasminogen activator.
Topics: Animals; Anti-Inflammatory Agents; Boronic Acids; Bortezomib; Brain; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Fibrinolytic Agents; Humans; Infarction, Middle Cerebral Artery; Intracranial Embolism; Male; NF-kappa B; Nitric Oxide Synthase Type III; Platelet Aggregation; Protease Inhibitors; Pyrazines; Rats; Rats, Wistar; Recombinant Proteins; Stroke; Time Factors; Tissue Plasminogen Activator; Vascular Patency | 2006 |
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Ligusticum; Male; Neuroprotective Agents; Neutrophils; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Wistar; Respiratory Burst; Telencephalon; Tyrosine | 2006 |
[Effect of ligustrazine on cell proliferation in subventricular zone of lateral cerebral ventricle after adult rat suffering from focal cerebral ischemia].
Topics: Animals; Cell Proliferation; Cerebral Ventricles; Doublecortin Domain Proteins; Doublecortin Protein; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Male; Microtubule-Associated Proteins; Neuropeptides; Phytotherapy; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Stem Cells | 2006 |
[Effects of ligustrazine on hippocampal dentate gyrus cell proliferation after focal cerebral ischemia in adult rats].
Topics: Animals; Cell Proliferation; Dentate Gyrus; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Male; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
[The effect of ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult rats].
Topics: Animals; Apiaceae; Brain Ischemia; Cell Count; Cell Proliferation; Cerebral Cortex; Corpus Striatum; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Male; Plants, Medicinal; Pyrazines; Rats; Rats, Sprague-Dawley | 2006 |
Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Drug Synergism; Endothelin A Receptor Antagonists; Infarction, Middle Cerebral Artery; Male; Pyrazines; Rats; Rats, Wistar; Sulfonamides; Tetrazoles | 2007 |
[Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury].
Topics: Animals; Blotting, Western; Brain Ischemia; Cell Proliferation; Cerebral Ventricles; Infarction, Middle Cerebral Artery; Male; Nitric Oxide Synthase Type I; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors | 2007 |
BN 80933 inhibits F2-isoprostane elevation in focal cerebral ischaemia and hypoxic neuronal cultures.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Dinoprost; Enzyme Inhibitors; F2-Isoprostanes; Hypoxia, Brain; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Thiophenes | 2000 |