pyrazines has been researched along with Hypertension in 132 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 102 (77.27) | 18.7374 |
| 1990's | 8 (6.06) | 18.2507 |
| 2000's | 5 (3.79) | 29.6817 |
| 2010's | 13 (9.85) | 24.3611 |
| 2020's | 4 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, JR; Byrd, JC; Ferrajoli, A; Furman, RR; Ghia, P; Hillmen, P; Jurczak, W; Kuptsova-Clarkson, N; Moslehi, J; Pagel, JM; Patel, P; Sharman, JP; Stephens, DM; Sun, C; Tao, L | 1 |
| Baggett, MV; Rhee, EP; Shepard, JO; Sise, ME; Stevens, JS | 1 |
| Lamanna, N; Lipsky, A | 1 |
| Ambrosino, I; Barbagelata, E; Ciarambino, T; Corbi, G; Moretti, AM; Politi, C | 1 |
| Chen, YC; Chen, YJ; Hsu, MI; Huang, JH; Kao, YH; Lee, TI | 1 |
| Kost, CK; Li, S; Li, Y; Martin, DS; Wang, X | 1 |
| Abd El Motteleb, DM; Elshazly, SM | 1 |
| Gao, Y; Huang, Y; Lau, CW; Liu, J; Liu, L; Ng, CF; Tian, XY; Wong, WT; Xu, A; Xu, G; Yao, X | 1 |
| Boutley, H; Karcher, G; Lacolley, P; Lhuillier, M; Louis, H; Marie, PY; Maskali, F; Poussier, S; Thornton, SN | 1 |
| Nistala, R; Rao, A | 1 |
| Abdo, S; Chan, JS; Chenier, I; Filep, JG; Ghosh, A; Ingelfinger, JR; Lo, CS; Otoukesh, A; Shi, Y; Zhang, SL | 1 |
| Gillespie, DG; Jackson, EK; Mi, Z; Tofovic, SP | 1 |
| Acker, BA; Benson, AG; Blevis-Bal, RM; Bond, BR; Brown, DL; Cubbage, JW; Fobian, YM; Freskos, JN; Heasley, SE; Hughes, RO; Jacobsen, EJ; Macinnes, A; Maddux, TM; Mischke, BV; Molyneaux, JM; Moon, JB; Owen, DR; Rogier, DJ; Rumsey, JM; Stallings, WC; Tollefson, MB; Walker, JK; Williams, JM; Yu, Y; Zheng, Y | 1 |
| Bilan, VP; Jackson, EK; Tofovic, DS | 1 |
| Couto, GK; Crajoinas, RO; Davel, AP; Girardi, AC; Lessa, LM; Pacheco, BP; Rossoni, LV | 1 |
| Ishiki, M; Ito, S; Mori, T; Nako, K; Ogawa, S; Okamura, M; Senda, M | 1 |
| Chen, ZY; Huang, Y; Lam, KS; Lau, CW; Liu, J; Liu, L; Ng, CF; Pu, Y; Tian, XY; Wang, YX; Wong, WT; Xu, A; Xu, G; Yao, X; Zhu, Z | 1 |
| Drouet, C; Graffin, B; Hosotte, M; Kanny, G; Landy, C; Millot, I; Nadaud, J; Plancade, D; Ragot, C | 1 |
| Berg, T | 1 |
| Wang, XF; Zhao, MQ | 1 |
| Davies, MJ; Gottesdiener, KM; Herman, GA; Lasseter, KC; Maes, AL; Mistry, GC; Wagner, JA | 1 |
| Franz, IW | 1 |
| Albertazzi, A; Cappelli, P; Del Rosso, G; Di Paolo, B; Di Vito, R; Palmieri, PF; Spisni, C | 1 |
| Auvinen, J; Gordin, A; Saraste, K; Seppälä, T; Tarkiainen, A | 1 |
| Banderali, G; Carnovali, M; Crespi, E; Missaglia, A; Ponti, GB | 1 |
| Hilewitz, H; Rogel, S; Weinstein, M | 1 |
| Albanesi, FM; Cantarelli, EL; da Cunha, GP; Wajngarten, M | 1 |
| Cepelák, V; Mayer, O; Suchová, H | 1 |
| Bolzano, K; Krempler, F; Sandhofer, F | 1 |
| Lehtonen, A; Lindroos, M | 1 |
| Dean, S; Spencer-Mills, L | 1 |
| Thomas, JP; Thomson, WH | 1 |
| Aylett, MJ | 1 |
| Barr, J; Chan, L; Maronde, RF; Spencer, CA; Vlachakis, ND | 1 |
| Currie, WJ; Isitt, VL; VandenBurg, MJ; Young, JH | 1 |
| Arr, SM; Wight, L; Woollard, ML; Young, JH | 1 |
| Dige-Petersen, H; Giese, J; Ibsen, H; Leth, A; Nielsen, MD; Rasmussen, S; Svendsen, UG | 1 |
| Obel, AO | 1 |
| Schneider, H | 1 |
| Ferrara, LA; Galletti, F; Siani, A; Strazzullo, P | 1 |
| Bentivoglio, M; Corea, L; Verdecchia, P | 1 |
| Cooper, WD; Currie, WJ; Vandenburg, MJ | 1 |
| Morse, BM; Stern, RS; Strykers, PH | 1 |
| Andersson, PO; H-Andersen, H; Hagman, A; Henning, R | 1 |
| Knauf, H; Steim, H | 1 |
| Gould, BA; Hornung, RS; Kieso, H; Raftery, EB | 1 |
| Arr, S; Parry, EE; Tait, D | 1 |
| Chan, L; Maronde, RF; Milgrom, M; Vlachakis, ND | 1 |
| Brown, JL; Chrysant, SG; Hagstrom, D | 1 |
| Drayer, JI; Hoefnagels, WH; Kloppenborg, PW; Smals, AG | 1 |
| van Soeren, F | 1 |
| Burns, DG; Pittaway, D | 1 |
| Pittaway, D | 1 |
| Andersson, PO; Henning, R; Karlberg, BE; Lins, LE; Nilsson, OR; Odar-Cederlöf, I; Tolagen, K | 1 |
| Gillies, A; Morgan, TO; Myers, JB; Waga, S | 1 |
| Hwang, IK; Moncloa, F; Muccilli, AC | 1 |
| Leary, WP; Reyes, AJ | 1 |
| Ballo, M; Cospite, M; Ferrara, F; Lo Presti, T; Meli, F; Milio, G; Raimondi, F | 1 |
| Campbell, N; Fernandez, PG; Galway, AB; Gill, V; Granter-Button, S; Kim, BK; MacDonald, J; Sharma, JN; Snedden, W | 1 |
| Aurecchia, SA; Cole, AG; Griffing, GT; Komanicky, P; Melby, JC; Sindler, BH | 1 |
| Grimshaw, JJ; Jaffé, G; Vallé-Jones, JC; Warnock, JM | 1 |
| Salonen, JT; Ylitalo, P | 1 |
| Della Marchina, MM; Renzi, G; Serofilli, S | 1 |
| Boehringer, K; Meier, A; Mordasini, R; Riesen, W; Schiffl, H; Weidmann, P | 1 |
| Anderson, PO; Colvin, CL; Macfie, HL | 1 |
| Enenkel, W; Nobis, H; Pollak, H; Prachar, H | 1 |
| Albanesi Filho, FM; Brandão, AP; Oigman, W | 1 |
| Fraser, R; Hettiarachchi, J; Morton, JJ; Ramsay, LE | 1 |
| Pedersen, TR | 1 |
| Frewin, DB; Penhall, RK | 1 |
| Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L | 1 |
| Rosenfeld, JB | 1 |
| Beyer, KH; Chambers, CE; Demers, LM; Passananti, GT; Seaton, TD; Vesell, ES | 1 |
| Kwan, CY | 1 |
| Halterman, TJ; Howe, BB; Kau, ST; Li, JH; Schwartz, JA; Yochim, CL | 1 |
| Do, ML; Donahue, JY; Halterman, TJ; Howe, BB; Kau, ST; Keith, RA; Schwartz, JA | 1 |
| Doggrell, SA; Surman, AJ | 1 |
| Barnett, CW; Doggrell, SA; Petcu, EB | 1 |
| Beyer, KH; Vesell, ES | 1 |
| Mikkelsen, E; Pedersen, OL | 2 |
| Lederballe Pedersen, O | 1 |
| Castenfors, H | 1 |
| Amadeo, A; Currò, F; de Pasquale, C | 1 |
| Boddy, K; Brown, JJ; Davies, DL; Fraser, R; Kremer, D; Lever, AF; Morton, JJ; Robertson, JI | 2 |
| Overlack, A; Stumpe, KO | 1 |
| Fraser, R; Hettiarachchi, J; Morton, JJ; Ramsay, LE; Shelton, J | 1 |
| Eisalo, A; Kohvakka, A; Manninen, V | 1 |
| Simpson, FO; Waal-Manning, HJ | 1 |
| Berg, KJ | 1 |
| Ambrosioni, E; Magnani, B; Melandri, G; Pasetti, L; Tartagni, F | 1 |
| Bergis, K | 1 |
| Bernardi, P; Bobba, P; Croce, L; Dalla Torre, M; Di Benedetto, A; Galassi, A; Lombardo, M; Masacci, E; Montemartini, C; Mussari, A; Ricciardi, S; Santucci, F | 1 |
| Chappin, JJ; Henquet, JW; Hintzen, AH; Slagboom, G | 1 |
| Alberti, E; Alessi, A; Antognetti, R; Baraldini, L; Bastagli, L; Bellomo, G; Bernardi, P; Buscarini, L; Camarri, E; Camerini, F; Cazzin, R; Dal Canton, A; De Piccoli, B; Del Favero, A; Fontana, G; Forattini, C; Furlanello, F; Giorgi-Pierfranceschi, D; Lechi, A; Lenzi, S; Malamani, V; Migone, L; Nava, S; Pallumeri, E; Passeri, M; Pecoraro, F; Perin, S; Piccolo, E; Scardi, S; Scarpioni, L; Vergara, G | 1 |
| Antcliff, AC; Beevers, DG; Hamilton, M; Pearce, VR | 1 |
| Benvenuti, C; Sanguigni, D | 1 |
| Corvol, P; Milliez, P; Thibonnier, M | 1 |
| Baumann, JC; Braun, HD | 1 |
| Brailovsky, D | 1 |
| Agabiti-Rosei, E; Alicandri, C; Ambrosioni, E; Magnani, B; Miele, N; Muiesan, G | 1 |
| Bielecki, A; Piwowarska, W | 1 |
| Burge, PS; Montuschi, E | 1 |
| Vorburger, C | 1 |
| Adornato, E; Tassone, F | 1 |
| Das, AM; Harris, DA | 1 |
| Beyer, KH; Chambers, CE; Helm, C; Passananti, GT; Vesell, ES | 1 |
| Lindsay, RM; Spence, JD; Wong, DG | 1 |
| Brachfeld, J; Itskovitz, H; Lunn, JA; Maxwell, MH; Moser, M; Zawada, ET | 1 |
| Larochelle, P; Logan, AG | 1 |
| Dzúrik, R; Dzúriková, V; Krechnáková, A; Szalayová, V | 1 |
| Bühring, KU; Leopold, G; Pabst, J; Simane, Z; Ungethüm, W | 1 |
| Ferrara, LA; Gagliardi, R; Mancini, M; Scillitani, A; Strazzullo, P | 1 |
| Breckenridge, AM; Dollery, CT; George, CF | 1 |
| Nash, DT | 1 |
| Beevers, DG; Brown, JJ; Davies, DL; Ferriss, JB; Fraser, R; Kremer, D; Lever, AF; Robertson, JI | 1 |
| Degaute, JP; Demanet, JC; Fichefet, JP; Hubert, C; Paduart, P | 1 |
| Hintzen, AH | 1 |
| Blatrix, C | 1 |
| Brown, JJ; Davies, DL; Fraser, R; Kremer, D; Lever, AF; Robertson, JI | 1 |
| Falase, AO; Salako, LA | 1 |
| Naidoo, DN; Seedat, YK | 1 |
| Antcliff, AC; Beevers, DG; Hamilton, M; Harpur, JE | 1 |
| Meyer, P; Milliez, P | 1 |
| Yorifuji, S | 1 |
| Koshikawa, S; Sasaoka, T | 1 |
| Sanjo, T | 1 |
| Freis, ED; Gombos, EA; Moghadam, A | 1 |
4 review(s) available for pyrazines and Hypertension
| Article | Year |
|---|---|
Managing toxicities of Bruton tyrosine kinase inhibitors.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Aged; Animals; Arrhythmias, Cardiac; Arthralgia; Benzamides; Diarrhea; Hemorrhage; Humans; Hypertension; Infection Control; Infections; Male; Piperidines; Protein Kinase Inhibitors; Pyrazines | 2020 |
Is there a role for the incretin system in blood pressure regulation?
Topics: Animals; Blood Pressure; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Humans; Hypertension; Incretins; Oxidative Stress; Peptides; Pyrazines; Renin-Angiotensin System; Sitagliptin Phosphate; T-Lymphocytes, Regulatory; Triazoles; Venoms | 2014 |
Studies on pyrazinoylguanidine: a novel antihypertensive, hypoglycemic and lipolytic drug intended for adjunctive use in hypertensive patients with type 2 diabetes mellitus.
Topics: Animals; Antihypertensive Agents; Biological Transport, Active; Diabetes Mellitus, Type 2; Guanidines; Humans; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Kidney Diseases; Pyrazines; Rats | 2000 |
[Importance of the continuity of anti-hypertension treatment in prevention of ischemic cardiovascular diseases: preliminary note. Controlled study of hypertensive patients treated with amiloride associated with hydrochlorothiazide and chlorthalidone].
Topics: Adult; Aged; Amiloride; Chlorthalidone; Coronary Disease; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines | 1978 |
52 trial(s) available for pyrazines and Hypertension
| Article | Year |
|---|---|
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Humans; Hypertension; Hypoglycemic Agents; Male; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2011 |
Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Over Studies; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2008 |
A controlled study of the antihypertensive effect of carteolol, a new beta-adrenergic receptor blocking drug, in combination with hydrochlorothiazide and amiloride.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Carteolol; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines | 1981 |
[Treatment of arterial hypertension with a combination of hydrochlorothiazide and hydrochloride amiloride].
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Sodium | 1983 |
[Report on the clinical evaluation of the antihypertensive effects of Urandil A VUFB].
Topics: Adult; Aged; Amiloride; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hypertension; Isoindoles; Male; Middle Aged; Pyrazines | 1984 |
[A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension].
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Creatinine; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Placebos; Posture; Pulse; Pyrazines; Urea; Uric Acid | 1984 |
Timolol and a hydrochlorothiazide-amiloride combination in the treatment of essential hypertension in young and middle-aged patients: a comparative study with once-daily administration.
Topics: Adult; Amiloride; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Random Allocation; Timolol | 1984 |
Hydrochlorothiazide in combination with potassium-sparing agents in the treatment of hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Random Allocation; Triamterene | 1984 |
Comparison of thiazides and amiloride in treatment of moderate hypertension.
Topics: Adult; Aged; Amiloride; Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Metoprolol; Middle Aged; Potassium; Pyrazines | 1983 |
Comparison of a fixed ratio combination of hydrochlorothiazide, amiloride and timolol ('Moducren') given once versus twice daily in mild to moderate hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Administration Schedule; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Time Factors; Timolol | 1984 |
Efficacy and tolerance of a fixed ratio combination of hydrochlorothiazide, amiloride and timolol, taken before or after food, in the treatment of hypertension.
Topics: Adult; Aged; Amiloride; Drug Combinations; Female; Food; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Timolol | 1984 |
Effects of amiloride on plasma and total body potassium, blood pressure, and the renin-angiotensin-aldosterone system in thiazide-treated hypertensive patients.
Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Random Allocation; Renin-Angiotensin System | 1983 |
A comparison of timolol plus hydrochlorothiazide plus amiloride and methyldopa in essential hypertension in Black Africans.
Topics: Adult; Amiloride; Antihypertensive Agents; Black People; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Kenya; Male; Methyldopa; Middle Aged; Pyrazines; Random Allocation; Timolol | 1983 |
Long term treatment with tienilic acid or thiazides: comparison of antihypertensive and metabolic effects.
Topics: Adult; Amiloride; Blood Pressure; Female; Glycolates; Humans; Hydrochlorothiazide; Hypertension; Liver Function Tests; Male; Middle Aged; Potassium; Pyrazines; Random Allocation; Ticrynafen; Uric Acid | 1983 |
Potassium sparing by amiloride during thiazide therapy in hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines | 1984 |
A general practice study of timolol/hydrochlorothiazide/amiloride ('Moducren'), a new therapy for hypertension, and the doctor's influence on management.
Topics: Adult; Aged; Amiloride; Blood Pressure; Drug Combinations; Family Practice; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Patient Compliance; Propanolamines; Pyrazines; Timolol | 1983 |
Response of thiazide-induced hypokalemia to amiloride.
Topics: Aldosterone; Amiloride; Bicarbonates; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Potassium; Pyrazines | 1983 |
The antihypertensive and biochemical effects of hydrochlorothiazide/amiloride (Moduretic) versus chlorthalidone.
Topics: Adult; Aged; Amiloride; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Pyrazines | 1980 |
Combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A multicentre trial.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Maleates; Middle Aged; Placebos; Potassium; Propanolamines; Pyrazines; Timolol; Urate Oxidase | 1980 |
Evaluation of a fixed combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A long-term multicentre trial.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Diastole; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Patient Compliance; Potassium; Propanolamines; Pulse; Pyrazines; Systole; Time Factors; Timolol; Uric Acid | 1980 |
Timolol and hydrochlorothiazide-amiloride in primary hypertension.
Topics: Adult; Amiloride; Blood Pressure; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Renin; Timolol | 1980 |
Effect of tienilic acid and amiloride in healthy volunteers and in hypertensives with normal renal function.
Topics: Adolescent; Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Electrolytes; Female; Glycolates; Humans; Hydrochlorothiazide; Hypertension; Kidney; Male; Middle Aged; Pyrazines; Ticrynafen; Uric Acid | 1980 |
Multiclinic evaluation of the antihypertensive effect of a methyldopa, hydrochlorothiazine, and amiloride combination.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Potassium; Pyrazines; Random Allocation; Time Factors | 1980 |
Multiclinic comparison of amiloride, hydrochlorothiazide, and hydrochlorothiazide plus amiloride in essential hypertension. Multicenter Diuretic Cooperative Study Group.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines | 1981 |
Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride.
Topics: Adult; Aged; Amiloride; Blood Proteins; Blood Urea Nitrogen; Cholesterol; Clinical Trials as Topic; Creatinine; Drug Combinations; Electrolytes; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Time Factors | 1981 |
Amiloride--a potassium-sparing diuretic.
Topics: Amiloride; Clinical Trials as Topic; Heart Failure; Humans; Hypertension; Hypokalemia; Pyrazines | 1981 |
Potassium conservation with amiloride/hydrochlorothiazide ("Moduret') in thiazide-induced hypokalaemia in hypertension.
Topics: Amiloride; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Potassium; Pyrazines | 1982 |
Antihypertensive, saluretic and hypokalaemic effects of cyclothiazide in comparison with hydrochlorthiazide with amiloride supplement.
Topics: Adult; Amiloride; Antihypertensive Agents; Benzothiadiazines; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Middle Aged; Natriuresis; Pyrazines | 1982 |
[The effect of hydrochlorothiazide/amiloride alone or in combination with alpha-methyldopa on serum lipoproteins].
Topics: Adult; Amiloride; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins; Male; Methyldopa; Pyrazines | 1981 |
[Hypertension treated with hydrochlorothiazide/amilorid and timolol maleate].
Topics: Adult; Amiloride; Blood Pressure; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Propanolamines; Pyrazines; Timolol | 1980 |
Beta-blockers and uric-acid excretion.
Topics: Amiloride; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Timolol; Uric Acid | 1978 |
[Treatment of mild to moderate essential arterial hypertension with timolol alone and in combination with hydrochlorothiazide + amiloride. A multicenter, double-blind, cross-over study].
Topics: Amiloride; Clinical Trials as Topic; Creatinine; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Placebos; Potassium; Propanolamines; Pyrazines; Timolol | 1977 |
Long term effect of timolol and hydrochlorothiazide, or hydrochlorothiazide and amiloride, in essential hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pulse; Pyrazines; Time Factors; Timolol | 1977 |
Amiloride in the treatment of primary hyperaldosteronism and essential hypertension.
Topics: Adult; Amiloride; Blood Pressure; Clinical Trials as Topic; Electrolytes; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Pyrazines | 1978 |
[Antihypertensive effect of a fixed beta-receptor blockader-diuretic combination during a single daily administration].
Topics: Adult; Amiloride; Clinical Trials as Topic; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Placebos; Propanolamines; Pyrazines; Timolol | 1978 |
The relative potency of amiloride and spironolactone in bendrofluazide-treated hypertensive patients [proceedings].
Topics: Amiloride; Bendroflumethiazide; Clinical Trials as Topic; Humans; Hypertension; Pyrazines; Spironolactone | 1978 |
Maintenance of potassium balance during diuretic therapy.
Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Placebos; Potassium; Potassium Chloride; Pyrazines; Spironolactone; Triamterene | 1979 |
Individual factors influencing the response to a beta-adrenergic blocking agent given alone and in combination with a diuretic on arterial hypertension.
Topics: Adult; Aging; Amiloride; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Time Factors; Timolol | 1979 |
One year follow-up of hyperuricaemic hypertensive patients treated with tienilic acid or a diuretic with or without uric acid-lowering drugs.
Topics: Alkaline Phosphatase; Amiloride; Aspartate Aminotransferases; Bilirubin; Blood Pressure; Clinical Trials as Topic; Cyclopenthiazide; Diuretics; Female; Follow-Up Studies; Glycolates; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Pyrazines; Sodium Chloride Symporter Inhibitors; Ticrynafen; Uric Acid | 1979 |
[Potassium-saving saluretic treatment of hypertension and edematous heart decompensation with Moduretik].
Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Edema, Cardiac; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines | 1976 |
The use of timolol maleate alone and with diuretic in the treatment of essential hypertension.
Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Placebos; Potassium; Propanolamines; Pyrazines; Timolol | 1976 |
Evaluation of the effect of timolol alone and in combination with hydrochlorothiazide and amiloride in the treatment of mild to moderate arterial hypertension: a double-blind, controlled study.
Topics: Adult; Amiloride; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1976 |
[The anti-hypertensive effect of timolol maleate (blocadren) in gradated combination with a diuretic].
Topics: Amiloride; Benzothiadiazines; Diuretics; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Sodium Chloride Symporter Inhibitors; Timolol | 1976 |
Pyrazinoylguanidine: antihypertensive, hypocholesterolemic, and renin effects.
Topics: Aged; Blood Pressure; Cholesterol; Dose-Response Relationship, Drug; Female; Guanidines; Heart Rate; Humans; Hypercholesterolemia; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Pyrazines; Renin-Angiotensin System; Single-Blind Method | 1992 |
Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.
Topics: Amiloride; Clinical Trials as Topic; Crystallization; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Kidney Calculi; Male; Middle Aged; Nephritis, Interstitial; Pyrazines; Random Allocation; Triamterene | 1985 |
Blood pressure lowering and potassium conservation by triamterene-hydrochlorothiazide and amiloride-hydrochlorothiazide in hypertension.
Topics: Adult; Aged; Amiloride; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Random Allocation; Triamterene | 1985 |
Hydrochlorothiazide-amiloride versus hydrochlorothiazide alone for essential hypertension: effects on blood pressure and serum potassium level.
Topics: Adolescent; Adult; Age Factors; Aged; Amiloride; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pulse; Pyrazines; Random Allocation | 1985 |
[Esmaloride--a new potassium neutral diuretic combination. Clinical pharmacologic properties].
Topics: Aldosterone; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Drug Combinations; Female; Heart Rate; Humans; Hypertension; Male; Potassium; Pyrazines; Trichlormethiazide; Triglycerides; Uric Acid; Water-Electrolyte Balance | 1985 |
Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients.
Topics: Adult; Amiloride; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Muzolimine; Potassium; Pyrazines; Pyrazoles | 1985 |
Comparison of the potassium- retaining effects of amiloride and spironolactone in hypertensive patients with thiazide-induced hypokalaemia.
Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Pyrazines; Sodium; Spironolactone; Time Factors; Urea | 1973 |
Amiloride hydrochloride combined with hydrochlorothiazide in the control of hypertension and plasma potassium levels.
Topics: Alanine Transaminase; Amiloride; Aspartate Aminotransferases; Diuretics; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Pyrazines; Urea; Uric Acid | 1972 |
[Treatment of the hypertensive patient. Value of Amiloride during saldiuretic treatment].
Topics: Adult; Amiloride; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Kidney Function Tests; Male; Middle Aged; Natriuresis; Potassium; Pyrazines; Spironolactone; Water-Electrolyte Balance | 1972 |
76 other study(ies) available for pyrazines and Hypertension
| Article | Year |
|---|---|
Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients.
Topics: Aged; Atrial Fibrillation; Benzamides; Humans; Hypertension; Leukemia, Lymphocytic, Chronic, B-Cell; Protein Kinase Inhibitors; Pyrazines | 2022 |
Case 17-2020: A 68-Year-Old Man with Covid-19 and Acute Kidney Injury.
Topics: Acute Kidney Injury; Adenosine Monophosphate; Aged; Alanine; Amides; Anti-Inflammatory Agents; Anticoagulants; Antiviral Agents; Betacoronavirus; Continuous Renal Replacement Therapy; Coronavirus Infections; COVID-19; Creatinine; Humans; Hypertension; Lung; Male; Obesity; Pandemics; Pneumonia, Viral; Pyrazines; Radiography, Thoracic; SARS-CoV-2 | 2020 |
Gender differences in treatment of Coronavirus Disease-2019.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Amides; Antimalarials; Antiviral Agents; Cardiovascular Diseases; Chloroquine; Clinical Trials as Topic; Combined Modality Therapy; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; Diabetes Complications; Female; Humans; Hypertension; Immunity; Immunization, Passive; Immunoglobulins; Lopinavir; Male; Middle Aged; Mortality; Pandemics; Pyrazines; Ritonavir; SARS-CoV-2; Sex Characteristics | 2020 |
The dipeptidyl peptidase-4 inhibitor-sitagliptin modulates calcium dysregulation, inflammation, and PPARs in hypertensive cardiomyocytes.
Topics: Action Potentials; Animals; Blood Pressure; Calcium; Cardiotonic Agents; Dipeptidyl-Peptidase IV Inhibitors; Electrocardiography; Heart Ventricles; Hypertension; Inflammation; Interleukin-6; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor for Advanced Glycation End Products; Receptor, Angiotensin, Type 1; Receptors, Immunologic; Sitagliptin Phosphate; Triazoles; Tumor Necrosis Factor-alpha | 2013 |
Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats.
Topics: Angiotensin II; Animals; Aorta; Boronic Acids; Bortezomib; Cell Proliferation; Extracellular Matrix; Gene Expression Regulation; Hypertension; Male; Proteasome Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vascular Cell Adhesion Molecule-1 | 2013 |
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor.
Topics: Animals; Blood Glucose; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutathione Peroxidase; Hypertension; Hypertension, Renal; Hypoglycemic Agents; Kidney; Lipid Peroxidation; Male; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrazines; Rats; Rats, Wistar; Receptors, Glucagon; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles | 2013 |
Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
Topics: Animals; Cyclooxygenase 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Exenatide; Gene Expression Regulation; Humans; Hypertension; Ion Channels; Male; Mice; Mitochondria; Mitochondrial Proteins; Models, Biological; Oxidative Stress; Peptides; Pyrazines; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Renal Artery; Sitagliptin Phosphate; Triazoles; Uncoupling Protein 2; Vasoconstriction; Venoms | 2014 |
Assessment of the early stage of cardiac remodeling of spontaneously hypertensive heart failure rats using the quantitative 3-dimensional analysis provided by acipimox-enhanced FDG-PET.
Topics: Animals; Arterial Pressure; Cardiac Catheterization; Disease Models, Animal; Fibrosis; Fluorodeoxyglucose F18; Heart Failure; Heart Ventricles; Hypertension; Imaging, Three-Dimensional; Lipid Metabolism; Male; Positron-Emission Tomography; Predictive Value of Tests; Pyrazines; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke Volume; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2014 |
Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice.
Topics: Acute Kidney Injury; Angiotensinogen; Animals; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Gene Expression; Hypertension; Kidney Tubules, Proximal; Mice; Mice, Transgenic; NF-E2-Related Factor 2; NF-kappa B; Pyrazines; Reverse Transcriptase Inhibitors; Signal Transduction; Thiones; Thiophenes | 2014 |
Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Hypertension; Male; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2015 |
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Topics: Administration, Oral; Aminopyridines; Animals; Chemistry, Pharmaceutical; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Humans; Hydrogen-Ion Concentration; Hypertension; Microsomes; Models, Chemical; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility | 2009 |
Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with metabolic syndrome.
Topics: Angiotensin II; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Hypertension; Kidney; Male; Metabolic Syndrome; Proteinuria; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Sitagliptin Phosphate; Triazoles; Vasoconstriction; Vasoconstrictor Agents | 2010 |
Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats.
Topics: Aging; Animals; Blood Pressure; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Hypertension; Kidney; Kidney Tubules, Proximal; Male; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sitagliptin Phosphate; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Triazoles | 2011 |
Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism.
Topics: Aged; Aged, 80 and over; Animals; Blood Pressure; Cells, Cultured; Cyclic AMP; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypertension; In Vitro Techniques; Kidney; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide; Peptides; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Glucagon; Regional Blood Flow; Renal Artery; Signal Transduction; Sitagliptin Phosphate; Triazoles; Venoms | 2012 |
Treatment of a life-threatening laryngeal bradykinin angio-oedema precipitated by dipeptidylpeptidase-4 inhibitor and angiotensin-I converting enzyme inhibitor with prothrombin complex concentrates.
Topics: Aged; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Blood Coagulation Factors; Bradykinin; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypertension; Laryngeal Diseases; Male; Perindopril; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2012 |
The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.
Topics: 4-Aminopyridine; Adrenalectomy; Adrenergic Antagonists; Amifampridine; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indomethacin; Losartan; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Potassium Channel Blockers; Prazosin; Protein Kinase C; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Staurosporine; Sulfonamides; Vascular Resistance; Vasoconstriction | 2003 |
[Ligustrazine and Salvia miltiorrhiza injection solution in complementary therapy of pregnancy-induced hypertension: clinical analysis of 60 cases].
Topics: Adult; Female; Humans; Hypertension; Injections; Phytotherapy; Pregnancy; Pregnancy Complications, Cardiovascular; Pyrazines; Salvia miltiorrhiza; Solutions | 2003 |
Differential antihypertensive effect of acebutolol and hydrochlorothiazide/amiloride hydrochloride combination on elevated exercise blood pressures in hypertensive patients.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Amiloride; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Therapy, Combination; Exercise Test; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Sodium Chloride Symporter Inhibitors | 1980 |
[Physiopathological basis for a tailored management of essential hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Amiloride; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Locomotion; Male; Middle Aged; Potassium; Pyrazines; Renin; Sodium | 1981 |
[Efficacy of the association of atenolol with an amiloride-hydrochlorothiazide combination in the treatment of persistent arterial hypertension].
Topics: Adult; Aged; Amiloride; Atenolol; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Retrospective Studies | 1984 |
The effect of single-dose methyldopa and diuretic on BP and left ventricular mass.
Topics: Adult; Aged; Amiloride; Blood Pressure; Cardiomegaly; Drug Therapy, Combination; Echocardiography; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Pyrazines; Stroke Volume; Time Factors | 1984 |
Thiazides and amiloride in treatment of moderate hypertension.
Topics: Amiloride; Benzothiadiazines; Diuretics; Humans; Hypertension; Pyrazines; Sodium Chloride Symporter Inhibitors | 1983 |
Comparison of thiazides and amiloride in treatment of moderate hypertension.
Topics: Amiloride; Blood Glucose; Humans; Hydrochlorothiazide; Hypertension; Pyrazines | 1983 |
Oral potassium chloride and amiloride in hydrochlorothiazide-induced potassium loss.
Topics: Administration, Oral; Adult; Aldosterone; Amiloride; Biological Availability; Creatinine; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Kinetics; Male; Middle Aged; Potassium; Pyrazines; Sodium | 1984 |
[Current aspects of hypertension treatment. Symposium 10 years Moduretic, Budapest 9-12 June 1983].
Topics: Amiloride; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Pyrazines | 1983 |
Effects of hydrochlorothiazide combined with amiloride in atenolol-resistant hypertensive patients.
Topics: Adult; Amiloride; Atenolol; Blood Pressure; Drug Combinations; Drug Resistance; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines | 1983 |
Do elderly patients respond differently to treatment with Moducren?
Topics: Adult; Age Factors; Aged; Amiloride; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Timolol | 1984 |
Hyponatremia induced by a combination of amiloride and hydrochlorothiazide.
Topics: Aged; Amiloride; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Hyponatremia; Pyrazines | 1984 |
[Reliable lowering of blood pressure with one tablet of Moducrin daily (author's transl)].
Topics: Amiloride; Blood Pressure; Circadian Rhythm; Drug Combinations; Drug Evaluation; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Timolol | 1980 |
[Therapy of hypertension with timolol, hydrochlorothiazide and amiloride].
Topics: Amiloride; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Timolol | 1983 |
Antihypertensive and metabolic effects of hydrochlorothiazide, amiloride-hydrochlorothiazide, and timolol.
Topics: Amiloride; Antihypertensive Agents; Blood Pressure; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Lipids; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Timolol | 1983 |
Spironolactone and amiloride in hypertensive patients with and without aldosterone excess.
Topics: Adult; Amiloride; Blood Pressure; Body Weight; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Renin; Spironolactone; Urea | 1980 |
[Antihypertensive effects of timolol and of the combination timolol, amiloride and hydrochlorothiazide].
Topics: Adult; Amiloride; Blood Pressure; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Renin; Sodium; Timolol | 1981 |
Amiloride in primary hyperaldosteronism.
Topics: Adult; Aged; Amiloride; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Prospective Studies; Pyrazines | 1982 |
A comparative study of Moducren and Moduretic and their effect on plasma potassium in essential hypertension.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Body Weight; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Random Allocation; Timolol | 1982 |
[Diuretic therapy in the aged. A clinical comparison between two diuretic compounds].
Topics: Aged; Amiloride; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Pyrazines; Quinazolines; Sulfonamides | 1981 |
New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme).
Topics: Amiloride; Half-Life; Humans; Hypertension; Kinetics; Potassium; Pyrazines | 1981 |
[Moducrin--a new combined preparation in the treatment of hypertension (author's transl)].
Topics: Adult; Amiloride; Antihypertensive Agents; Blood Pressure; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Prospective Studies; Pyrazines; Timolol | 1981 |
[Treatment of arterial hypertension: comparative study of atenolol + chlorthalidone vs. timolol maleate-hydrochlorthiazide-amiloride association].
Topics: Adult; Aged; Amiloride; Atenolol; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1981 |
Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients.
Topics: Adult; Aldosterone; Amiloride; Angiotensin II; Bendroflumethiazide; Bicarbonates; Blood Pressure; Diuretics; Female; Humans; Hypertension; Hypokalemia; Male; Middle Aged; Placebos; Potassium; Potassium Chloride; Pyrazines; Sodium; Sodium Chloride Symporter Inhibitors; Spironolactone | 1980 |
Plasma potassium levels in hypertensive patients receiving fixed-combination diuretic therapy.
Topics: Adult; Aged; Amiloride; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Potassium; Pyrazines | 1980 |
A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension.
Topics: Adolescent; Adult; Aged; Amiloride; Blood Chemical Analysis; Blood Pressure; Body Weight; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Hydrochlorothiazide; Hyperglycemia; Hypertension; Male; Middle Aged; Pyrazines; Uric Acid | 1980 |
[Comparative evaluation of the anti-hypertensive effect of moduretic and thiazides].
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines; Sodium Chloride Symporter Inhibitors | 1980 |
Pyrazinoylguanidine downregulates the glucose fatty-acid cycle in hypertensive, hyperinsulinemic diabetic patients.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Fatty Acids; Female; Glucose Tolerance Test; Guanidines; Humans; Hypertension; Male; Middle Aged; Pyrazines | 1994 |
Plant-derived drugs acting on cellular Ca2+ mobilization in vascular smooth muscle: tetramethylpyrazine and tetrandrine.
Topics: Alkaloids; Benzylisoquinolines; Calcium; Humans; Hypertension; Medicine, Chinese Traditional; Muscle, Smooth, Vascular; Plants, Medicinal; Pyrazines; Vascular Diseases | 1994 |
Diuretic and antihypertensive activity of ZENECA ZM224,832: a novel eukalemic diuretic with calcium channel blocking activity.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Calcium Channel Blockers; Diuresis; Diuretics; Dogs; Hypertension; Male; Muscle, Smooth, Vascular; Nephrectomy; Potassium; Pyrazines; Rats; Rats, Inbred SHR | 1994 |
ICI 206,970: a novel calcium channel blocker with eukalemic diuretic activity.
Topics: Animals; Aorta; Calcium Channel Blockers; Cardiomegaly; Coronary Circulation; Diuretics; Dogs; Electrocardiography; Hypertension; In Vitro Techniques; Male; Pyrazines; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley | 1993 |
Loss of maximum attenuation and receptor reserve for isoprenaline at the beta 2-adrenoceptors of the portal veins of hypertensive rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Animals; Hypertension; Hypertrophy; Isoproterenol; Male; Nitroprusside; Portal Vein; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Vasodilator Agents; Verapamil | 1995 |
Affinity constants and beta-adrenoceptor reserves for isoprenaline on cardiac tissue from normotensive and hypertensive rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alprenolol; Animals; Female; Heart; Heart Atria; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Isoproterenol; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta | 1998 |
[Use and abuse of potassium-saving diuretics].
Topics: Amiloride; Humans; Hypertension; Pyrazines; Spironolactone; Substance-Related Disorders | 1979 |
Total body potassium and long-term treatment with amiloride HCL and/or hydrochlorothiazide.
Topics: Amiloride; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Potassium; Pyrazines; Time Factors | 1979 |
[Results of a field study with Moducrin in 12596 hypertensive patients].
Topics: Amiloride; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1979 |
[The combination of hydrochlorothiazide, amiloride and alpha-methyldopa in the treatment of arterial hypertension. Clinical evaluation of a multicentric study].
Topics: Amiloride; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Pyrazines | 1979 |
Concomitant administration of timolol and hydrochlorothiazide/amiloride in hypertensive patients. Results of a titration study.
Topics: Adult; Aged; Amiloride; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1978 |
[Long-term treatment of hypertension with the combination of hydrochlorothiazine and amiloride. Results of a multi-center study of 277 patients].
Topics: Adult; Aged; Amiloride; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines | 1978 |
Total exchangeable potassium in response to amiloride.
Topics: Amiloride; Body Weight; Carbon Dioxide; Humans; Hypertension; Hypokalemia; Potassium; Pyrazines; Time Factors | 1978 |
[Comparison of spironolactone and amiloride combined with hydrochlorothiazide in the treatment of slight or moderate hypertension].
Topics: Amiloride; Blood Glucose; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Spironolactone; Uric Acid | 1978 |
[Spirolactones and potassium-sparing diuretics].
Topics: Amiloride; Edema; Humans; Hyperaldosteronism; Hypertension; Pyrazines; Spironolactone; Triamterene | 1978 |
Amiloride in the treatment of primary hyperaldosteronism and essential hypertension.
Topics: Adult; Aged; Amiloride; Angiotensin II; Electrolytes; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Pyrazines; Renin | 1977 |
[Moduretic in ambulatory treatment of hypertension].
Topics: Adult; Amiloride; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines | 1977 |
Long-term effects of an amiloride/hydrochlorothiazide combination ('Moduretic') on electrolyte balance.
Topics: Adult; Aged; Amiloride; Drug Combinations; Electrolytes; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines | 1976 |
[Combination of amiloride chlorhydrate and hydrochlorothiazide in the ambulatory treatment of mild and moderate hypertension].
Topics: Adult; Ambulatory Care; Amiloride; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines | 1976 |
Mitochondrial ATP synthase regulation in heart: defects in hypertension are restored after treatment with captopril.
Topics: Animals; Captopril; Cardiotonic Agents; Cells, Cultured; Electric Stimulation; Hypertension; Isoproterenol; Male; Mitochondria, Heart; Multienzyme Complexes; Myocardium; NADH, NADPH Oxidoreductases; Proton-Translocating ATPases; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ruthenium Red; Verapamil | 1992 |
[Combination of methyldopa and diuretics in the treatment of hypertensive disease].
Topics: Aged; Amiloride; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Pyrazines | 1985 |
A clinical study of Co-hydroDiuril a combination of an antikaliuretic (amiloride) and hydrochlorothiazide.
Topics: Adult; Aged; Amiloride; Blood Pressure; Blood Urea Nitrogen; Body Weight; Diuretics; Drug Combinations; Drug Eruptions; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Urinary Incontinence; Vertigo | 1972 |
Spironolactone and amiloride in the treatment of low renin hyperaldosteronism and related syndromes.
Topics: Adrenocortical Hyperfunction; Amiloride; Angiotensin II; Body Water; Corticosterone; Diuretics; Extracellular Space; Humans; Hyperaldosteronism; Hypertension; Plasma Volume; Potassium; Pyrazines; Renin; Secretory Rate; Sodium; Spironolactone; Urea | 1973 |
Tolerance and side-effects of the association hydrochlorothiazide-amiloride in long-term treatment of arterial hypertension.
Topics: Adult; Aged; Amiloride; Calcium; Creatinine; Drug Combinations; Drug Tolerance; Humans; Hydrochlorothiazide; Hypercalcemia; Hypertension; Hypocalcemia; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea; Uric Acid | 1974 |
Some aspects of the use of Moduretic in the treatment of patients with mild hypertension.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pyrazines | 1973 |
[Diuretic treatment of arterial hypertension. Value of potassium sparing].
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines | 1972 |
Amiloride in primary hyperaldosteronism with chronic peptic ulceration.
Topics: Aged; Amiloride; Bicarbonates; Blood Pressure; Body Water; Chlorides; Chronic Disease; Diuretics; Female; Humans; Hyperaldosteronism; Hypertension; Peptic Ulcer; Potassium; Pyrazines; Sodium; Spironolactone; Urea | 1973 |
A comparison of moduretic and hydrochlorothiazide in the treatment of hypertension in African patients.
Topics: Adult; Aged; Amiloride; Blood Pressure; Diuretics; Electrolytes; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium Chloride; Pyrazines; Urea; Uric Acid | 1973 |
Evaluation of amiloride combined with hydrochlorothiazide (Moduretic) in the treatment of hypertension.
Topics: Adult; Aged; Amiloride; Benzothiadiazines; Diuretics; Drug Combinations; Female; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Potassium; Propranolol; Pyrazines; Urea; Uremia | 1973 |
Sodium and hypertension.
Topics: Aldosterone; Amidines; Aorta; Depression, Chemical; Diuretics; Epinephrine; Heart Atria; Heart Ventricles; Humans; Hypertension; Potassium; Pyrazines; Sodium; Stimulation, Chemical | 1971 |
Clinical evaluations of a combined application of amiloride (MK-870) and thiazide.
Topics: Adult; Blood Pressure; Diuretics; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Kidney Function Tests; Liver Cirrhosis; Male; Middle Aged; Nephrotic Syndrome; Potassium; Pyrazines; Sodium | 1969 |
[New diuretics--amiloride].
Topics: Animals; Chemical Phenomena; Chemistry; Diuretics; Heart Diseases; Humans; Hypertension; Kidney Diseases; Liver Cirrhosis; Pyrazines | 1970 |
Effects of MK-870 in normal subjects and hypertensive patients.
Topics: Adult; Aged; Amidines; Blood Urea Nitrogen; Creatine; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Natriuresis; Potassium; Pyrazines; Sodium; Uric Acid | 1966 |