Compounds > pyrazines
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pyrazines and Heart Diseases

pyrazines has been researched along with Heart Diseases in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199016 (51.61)18.7374
1990's1 (3.23)18.2507
2000's2 (6.45)29.6817
2010's9 (29.03)24.3611
2020's3 (9.68)2.80

Authors

AuthorsStudies
Gao, J; Liu, J; Ma, X; Ren, J; Shi, D; Song, L; Zhang, Y1
Al Zoubi, S; Chiazza, F; Coldewey, SM; Collino, M; Collotta, D; Martin, L; O'Riordan, CE; Purvis, GSD; Stiehler, L; Thiemermann, C; Wissuwa, B1
Ban, K; Choi, SW; Go, YY; Jung, E; Kim, SJ; Lee, J; Lee, JH; Moon, SH; Park, HJ; Park, SJ; Park, SM; Park, YG; Shin, JS1
Khaheshi, I; Shahrbaf, MA; Tabary, M1
Shang, Z; Wei, J; Xiao, Y; Yin, J1
Aki, T; Funakoshi, T; Uemura, K; Unuma, K; Watanabe, M1
Basset, M; Foli, A; Gillmore, J; Hawkins, P; Lachmann, H; Merlini, G; Milani, P; Palladini, G; Sachchithanantham, S; Wechalekar, AD1
Armstrong, PW; Bethel, MA; Buse, JB; Engel, SS; Garg, J; Green, JB; Holman, RR; Josse, R; Kaufman, KD; Koglin, J; Korn, S; Lachin, JM; McGuire, DK; Pencina, MJ; Peterson, ED; Standl, E; Stein, PP; Suryawanshi, S; Van de Werf, F1
Abramczyk, P; Bil, J; Bugajski, M; Dabrowska-Iwanicka, A; Duszyński, J; Golab, J; Jakóbisiak, M; Kujawa, M; Mackiewicz, U; Maczewski, M; Malinowska, M; Nowis, D; Ratajska, A; Salwa, P; Siński, M; Wieckowski, MR; Wilczyński, GM; Winiarska, M; Wójcik, C1
Hao, H; Hasegawa, S; Hirota, S; Lee-Kawabata, M; Masuyama, T; Naito, Y; Ogawa, H; Tamaki, H; Taniguchi, Y1
Bladé, J; Cakana, A; Comenzo, RL; Dubrey, SW; Elsayed, Y; Enny, C; Fermand, JP; Hassoun, H; Heffner, LT; Hegenbart, U; Liu, X; Merlini, G; Mortimer, S; Palladini, G; Ramaswami, P; Reece, DE; Sanchorawala, V; Van De Velde, H; Vescio, RA1
Benjamin, M; Gibbs, S1
Antonio, S; Daniele, V; Enrico, O; Gabriele, B; Giulia, C; Mario, P; Nadia, C; Sara, G1
Salvatore, C; Schena, FP; Vox, E1
Cleres-Kaiser, I1
Castenfors, H1
Futaki, S; Goto, Y; Hata, K; Kawaguchi, O; Nishioka, T; Saeki, A; Suga, H; Takasago, T1
Chapelle, M; Chiche, P1
Davidson, C; Gillebrand, IM1
Croxson, MS; John, MB; Neutze, JM1
Savoie, LL1
Blascheck, JA; Gardell, C; Kovács, K2
Savoie, L; Selye, H; Somogyi, A1
Sanna, GP1
Grinnell, E; Prioreschi, P; Sullivan, R1
Classen, HG; Solymoss, B; Varga, S2
Sanjo, T1
Counihan, TB; Heffernan, AG1

Reviews

1 review(s) available for pyrazines and Heart Diseases

ArticleYear
Incidence and risk of cardiotoxicity associated with bortezomib in the treatment of cancer: a systematic review and meta-analysis.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Heart Diseases; Humans; Incidence; Neoplasms; Odds Ratio; Pyrazines; Risk

2014

Trials

4 trial(s) available for pyrazines and Heart Diseases

ArticleYear
Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.
    The New England journal of medicine, 2015, Jul-16, Volume: 373, Issue:3

    Topics: Administration, Oral; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Glycated Hemoglobin; Heart Diseases; Heart Failure; Hospitalization; Humans; Hypoglycemic Agents; Kaplan-Meier Estimate; Pyrazines; Sitagliptin Phosphate; Triazoles

2015
Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects.
    QJM : monthly journal of the Association of Physicians, 2011, Volume: 104, Issue:11

    Topics: Aged; Amyloidosis; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Diseases; Humans; Kidney Diseases; Liver Diseases; Male; Maximum Tolerated Dose; Middle Aged; Paraproteinemias; Peripheral Nervous System Diseases; Prospective Studies; Pyrazines; Treatment Outcome

2011
[Effects of a potassium-sparing diuretic in cardiac edema and ascitic cirrhosis].
    La Clinica terapeutica, 1977, Sep-15, Volume: 82, Issue:5

    Topics: Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Edema; Female; Heart Diseases; Humans; Hydrochlorothiazide; Liver Cirrhosis; Male; Middle Aged; Pyrazines

1977
[Treatment of cardiac and hepatic edemas using the potassium-sparing diuretic Moduretic].
    Die Medizinische Welt, 1975, Apr-18, Volume: 26, Issue:16

    Topics: Adult; Aged; Amiloride; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Edema; Female; Heart Diseases; Humans; Hydrochlorothiazide; Liver Diseases; Male; Middle Aged; Pyrazines

1975

Other Studies

26 other study(ies) available for pyrazines and Heart Diseases

ArticleYear
Ligustrazine prevents coronary microcirculation dysfunction in rats via suppression of miR-34a-5p and promotion of Sirt1.
    European journal of pharmacology, 2022, Aug-15, Volume: 929

    Topics: Animals; Heart Diseases; Inflammation; Microcirculation; MicroRNAs; Pyrazines; Rats; Sirtuin 1

2022
Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Benzamides; Cecum; Disease Models, Animal; Heart; Heart Diseases; Inflammasomes; Ligation; Male; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase Inhibitors; Punctures; Pyrazines; Pyrazoles; Pyrimidines; Sepsis

2019
Antiviral activity and safety of remdesivir against SARS-CoV-2 infection in human pluripotent stem cell-derived cardiomyocytes.
    Antiviral research, 2020, Volume: 184

    Topics: Adenosine Monophosphate; Alanine; Amides; Animals; Antimalarials; Antiviral Agents; Chlorocebus aethiops; Chloroquine; COVID-19; COVID-19 Drug Treatment; Electrocardiography; Flow Cytometry; Heart Diseases; Humans; Hydroxychloroquine; Microscopy, Fluorescence; Myocytes, Cardiac; Pluripotent Stem Cells; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Vero Cells; Viral Plaque Assay

2020
Cardiovascular Considerations of Remdesivir and Favipiravir in the Treatment of COVID-19.
    Cardiovascular & hematological disorders drug targets, 2021, Volume: 21, Issue:2

    Topics: Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Heart Diseases; Humans; Pyrazines; SARS-CoV-2

2021
Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis.
    Toxicology, 2014, Aug-01, Volume: 322

    Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Autophagy; Blotting, Western; Boronic Acids; Bortezomib; Heart Diseases; Homeostasis; Immunoprecipitation; Lysosomes; Membrane Potential, Mitochondrial; Mice; Microscopy, Fluorescence; Mitochondria, Heart; Myocytes, Cardiac; Oxides; Proteasome Endopeptidase Complex; Pyrazines; Ubiquitin; Ubiquitin-Protein Ligases; Voltage-Dependent Anion Channel 1

2014
A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis.
    Blood, 2015, Jul-30, Volume: 126, Issue:5

    Topics: Amyloid; Amyloidosis; Boronic Acids; Bortezomib; Cooperative Behavior; Cyclophosphamide; Dexamethasone; Drug Therapy, Combination; Europe; Heart Diseases; Humans; Kidney Diseases; Pyrazines; Treatment Outcome

2015
Cardiotoxicity of the anticancer therapeutic agent bortezomib.
    The American journal of pathology, 2010, Volume: 176, Issue:6

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line; Cell Respiration; Echocardiography; Female; Heart; Heart Diseases; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Myocytes, Cardiac; Protease Inhibitors; Pyrazines; Rats; Rats, Wistar; Ventricular Dysfunction, Left

2010
Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomib.
    International journal of hematology, 2010, Volume: 92, Issue:4

    Topics: Amyloidosis; Antineoplastic Agents; Boronic Acids; Bortezomib; Echocardiography; Heart Diseases; Humans; Immunoglobulin Light Chains; Male; Middle Aged; Multiple Myeloma; Myocardium; Protease Inhibitors; Pyrazines; Stroke Volume; Treatment Outcome

2010
Amyloidosis.
    BMJ (Clinical research ed.), 2011, Nov-16, Volume: 343

    Topics: Aged; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Bone Marrow; Boronic Acids; Bortezomib; Cyclophosphamide; Delayed Diagnosis; Dexamethasone; Dyspnea; Heart Diseases; Humans; Kidney; Kidney Diseases; Male; Narration; Pyrazines; Quality of Life; Serum Amyloid A Protein; Thalidomide

2011
Unexpected cardiotoxicity in haematological bortezomib treated patients.
    British journal of haematology, 2007, Volume: 138, Issue:3

    Topics: Aged; Aged, 80 and over; Boronic Acids; Bortezomib; Female; Heart Diseases; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Protease Inhibitors; Pyrazines

2007
New medications help those with diabetes avoid heart trouble. Drugs mimic the body's natural insulin and glucose controls, but diet and exercise are still keys to controlling the disease.
    Heart advisor, 2007, Volume: 10, Issue:7

    Topics: Diabetes Mellitus; Diabetic Angiopathies; Exenatide; Heart Diseases; Humans; Hypoglycemic Agents; Metformin; Peptides; Pyrazines; Sitagliptin Phosphate; Triazoles; Venoms

2007
[Comparative clinical investigation of furosemide and moduretic in the treatment of cardiac failure].
    Lakartidningen, 1975, Apr-02, Volume: 72, Issue:14

    Topics: Aged; Amiloride; Female; Furosemide; Heart Diseases; Humans; Hydrochlorothiazide; Male; Middle Aged; Potassium; Pyrazines

1975
Left ventricular contractility and energetic cost in disease models--an approach from the pressure-volume diagram.
    Japanese circulation journal, 1992, Volume: 56, Issue:7

    Topics: Animals; Calcium; Disease Models, Animal; Dogs; Epinephrine; Heart Diseases; Myocardial Contraction; Oxygen Consumption; Propranolol; Pyrazines; Quinolines; Rabbits

1992
[Potassium depletion in cardiology. Action of amiloride, a potassium sparing diuretic].
    Acta cardiologica, 1973, Volume: 28, Issue:3

    Topics: Adult; Aged; Amiloride; Arrhythmias, Cardiac; Coronary Disease; Digitalis Glycosides; Diuretics; Female; Heart Diseases; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Potassium Deficiency; Pyrazines

1973
Use of amiloride as a potassium conserving agent in severe cardiac disease.
    British heart journal, 1973, Volume: 35, Issue:4

    Topics: Adult; Aged; Amiloride; Bicarbonates; Chlorides; Diuretics; Female; Furosemide; Heart Diseases; Humans; Male; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea

1973
Exchangeable potassium in heart disease: long-term effects of potassium supplements and amiloride.
    American heart journal, 1972, Volume: 84, Issue:1

    Topics: Adult; Aged; Amiloride; Coronary Disease; Diuretics; Erythrocytes; Female; Furosemide; Heart Diseases; Heart Valve Diseases; Humans; Male; Middle Aged; Potassium; Potassium Isotopes; Pyrazines; Uric Acid

1972
[Role of antikaliuretics and catecholamines in the prevention of cardiac necroses of metabolic origin].
    Pathologia Europaea, 1971, Volume: 6, Issue:4

    Topics: Adrenal Cortex Hormones; Amiloride; Animals; Catecholamines; Digitoxin; Diuretics; Epinephrine; Heart Diseases; Kidney; Magnesium; Metabolic Diseases; Necrosis; Oils; Phenoxybenzamine; Potassium; Potassium Chloride; Propranolol; Pyrazines; Rats; Sodium; Stress, Physiological

1971
[Prevention of electrolyte-steroid cardiopathy with amiloride. Light- and electron microscopic studies].
    Morphologiai es igazsagugyi orvosi szemle, 1971, Volume: 11, Issue:1

    Topics: Amiloride; Animals; Diuretics; Heart; Heart Diseases; Microscopy, Electron; Myocardium; Pyrazines; Rats

1971
Prevention of stress-induced cardiac necrosis by amiloride.
    Angiologica, 1969, Volume: 6, Issue:5

    Topics: Animals; Diuretics; Ethacrynic Acid; Female; Heart Diseases; Hydrochlorothiazide; Immobilization; Myocardial Infarction; Necrosis; Potassium; Pyrazines; Rats; Stress, Physiological

1969
[Modern and rational use of diuretics in cardiology].
    Cardiologia pratica, 1969, Volume: 20, Issue:6

    Topics: Coronary Disease; Diuretics; Ethacrynic Acid; Furosemide; Glucocorticoids; Heart Diseases; Humans; Kidney; Pulmonary Edema; Pyrazines; Sulfonamides; Triamterene; Triazines

1969
Potassium, cardiac necroses and amiloride.
    European journal of pharmacology, 1970, Volume: 10, Issue:3

    Topics: Animals; Blood Chemical Analysis; Diuretics; Female; Heart Diseases; Myocardium; Necrosis; Potassium; Pyrazines; Rats; Sodium; Steroids

1970
Electrocardiographic alterations in metabolic cardiac necrosis and the influence of amiloride on these changes.
    Acta medica Academiae Scientiarum Hungaricae, 1970, Volume: 27, Issue:1

    Topics: Acid-Base Equilibrium; Animals; Arrhythmias, Cardiac; Diuretics; Electrocardiography; Female; Heart; Heart Diseases; Heart Rate; Hydrogen-Ion Concentration; Hypernatremia; Hypocalcemia; Myocardium; Necrosis; Pyrazines; Rats; Water-Electrolyte Balance

1970
[New diuretics--amiloride].
    Nihon rinsho. Japanese journal of clinical medicine, 1970, Volume: 28, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Diuretics; Heart Diseases; Humans; Hypertension; Kidney Diseases; Liver Cirrhosis; Pyrazines

1970
Amiloride and the "electrolyte-eroid-cardiopathy with necrosis". Light and electron microscopic study of protective effects in rats.
    Archives of pathology, 1969, Volume: 88, Issue:2

    Topics: Amides; Amidines; Animals; Coronary Vessels; Female; Fludrocortisone; Heart Diseases; Lipid Metabolism; Microscopy, Electron; Mitochondria, Muscle; Myocardium; Myofibrils; Necrosis; Oils; Phosphates; Pyrazines; Rats; Zea mays

1969
Blood lipids in experimental cardiac necrosis.
    Canadian journal of physiology and pharmacology, 1969, Volume: 47, Issue:8

    Topics: Animals; Cholesterol; Diet; Diuretics; Fatty Acids, Nonesterified; Female; Heart; Heart Diseases; Lipids; Necrosis; Oils; Pyrazines; Rats; Triglycerides; Water-Electrolyte Balance; Zea mays

1969
Long-term studies with the new potassium-sparing diuretic, amiloride ('MK-870').
    Irish journal of medical science, 1969, Volume: 8, Issue:1

    Topics: Adult; Diuretics; Electrolytes; Female; Heart Diseases; Humans; Hydrogen-Ion Concentration; Hypokalemia; Male; Methods; Middle Aged; Pyrazines; Water-Electrolyte Balance

1969