Compounds > pyrazines
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pyrazines and Experimental Neoplasms

pyrazines has been researched along with Experimental Neoplasms in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19905 (12.20)18.7374
1990's4 (9.76)18.2507
2000's11 (26.83)29.6817
2010's19 (46.34)24.3611
2020's2 (4.88)2.80

Authors

AuthorsStudies
Du, L; Li, M; Yan, C1
Bolomsky, A; Branstrom, A; Breid, H; Caers, J; Duray, E; Hübl, W; Lejeune, M; Ludwig, H; Muller, J; Pfeiffer, C; Stangelberger, K; Vrancken, L; Weetall, M; Willheim, M; Zojer, N1
Houghton, PJ; Kang, M; Kurmashev, D; Kurmasheva, RT; Reynolds, CP; Smith, MA; Wu, J1
Batra, SK; Dhanasingh, I; Kanteti, R; Kaushik, G; Kindler, HL; Kulkarni, P; Mambetsariev, B; Mirzapoiazova, T; Nasser, MW; Ponnusamy, MP; Riehm, JJ; Salgia, R; Seshacharyulu, P; Wang, J1
Abdelazeem, AH; Abdelgawad, MA; Abdelrahman, MH; Bukhari, SNA; Ibrahim, HM; Mohamed, MFA; Salem, OIA; Treambleau, L; Youssif, BGM1
Cheng, L; Dong, G; Du, L; Han, G; Li, M; Li, X; Tang, C; Yang, X; Zhang, C; Zhou, Y1
Alvarez-Berríos, MP; Castillo, A; Rinaldi, C; Torres-Lugo, M1
Ambati, SR; Chiosis, G; Kosugi, K; Lopes, EC; Meyers, PA; Mony, U; Moore, MA; Moreira, AL; Shah, SK; Taldone, T; Zehir, A1
Baron, R; Basto, P; Bertrand, N; Farokhzad, OC; Ghobrial, IM; Glavey, S; Kamaly, N; Liu, J; Lu, ZN; Manier, S; Memarzadeh, M; Mishima, Y; Moschetta, M; Nagano, K; Reagan, MR; Roccaro, AM; Sacco, A; Seevaratnam, D; Shi, J; Swami, A; Wu, J; Zhang, S; Zhang, Y1
Bodo, J; Chen-Kiang, S; Di Liberto, M; Durkin, L; Elemento, O; Eng, K; Hsi, ED; Shetty, S; Smith, MR; Zhao, X1
Albert, ML; Barreira da Silva, R; Fiette, L; Ingersoll, MA; Laird, ME; Yatim, N1
Ai, Y; Ding, K; Huang, Z; Kang, F; Lai, Y; Li, J; Peng, S; Ren, C; Tian, J; Zhang, Y; Zhu, B1
Boos, A; Chen, B; Fairhurst, RA; Furet, P; Guagnano, V; Jeay, S; Jiang, S; Lu, W; Marsilje, TH; McCarthy, C; Michellys, PY; Niklaus, M; Schnell, C; Stauffer, F; Stutz, S; Vaupel, A1
Akkari, L; Bowman, RL; Holland, EC; Huse, JT; Joyce, JA; Quail, DF; Quick, ML; Schuhmacher, AJ; Sutton, JC1
Hashimoto, K; Hibino, R; Inazuka, M; Ishikawa, T; Kuida, K; Morimoto, M; Smith, PG; Sumi, H; Yabuki, M; Yoshida, S1
Broggini, M; Carrassa, L; Crippa, F; Damia, G; Ganzinelli, M; Tavecchio, M1
Barr, S; Brown, E; Buck, E; Epstein, D; Eyzaguirre, A; Gibson, NW; Haley, JD; Iwata, KK; Ji, QS; Miglarese, M; Mulvihill, M; O'Connor, M; Pachter, J; Rosenfeld-Franklin, M; Thomson, S; Yao, Y1
Anderson, KC; Azab, AK; Azab, F; Burwick, N; Chen, C; Ghobrial, IM; Jia, X; Leleu, X; Melhem, MR; Ngo, HT; Novina, CD; Roccaro, AM; Rollins, BJ; Runnels, J; Sacco, A; Varticovski, L1
Begleiter, A; Bird, RP; Lefas, GM; Maksymiuk, AW; Sivananthan, K1
Blackwell, TS; Kalomenidis, I; Karabela, SP; Kollintza, A; Magkouta, S; Moschos, C; Psallidas, I; Roussos, C; Sherrill, TP; Stathopoulos, GT; Theodoropoulou, P1
Ikeda, D; Inoue, H; Kato, T; Kawada, M; Masuda, T; Ohba, S; Someno, T1
Inoue, Y; Izawa, K; Kiryu, S; Ohtomo, K; Ratanakanit, H; Sheng, F; Tojo, A; Watanabe, M1
Chen, HJ; Chen, KC; Chen, KF; Cheng, AL; Huang, CY; Wei, CC1
Chen, CC; Chen, KC; Chen, KF; Cheng, AL; Lin, YC1
Berenson, JR; Chen, H; Li, J; Li, M; Nichols, CM; Sanchez, E; Wang, C1
Blazar, BR; Brooks, AD; Elliott, PJ; Koh, CY; Ma, W; Murphy, WJ; Raziuddin, A; Sayers, TJ; Seki, N; Zhang, X1
Hattori, K; Nakajima, M; Nakashima, E; Oku, N; Tamura, M; Tsukada, H; Unno, K; Yonezawa, S1
Gudegast, C; Stöckle, M; Tahmatzopoulos, A; Unteregger, G; Wullich, B; Zwergel, T; Zwergel, U1
Ambinder, RF; Chen, J; Chong, JM; Foss, CA; Fox, JJ; Fu, DX; Lemas, V; Pomper, MG; Tanhehco, YC1
Dierlam, L; Lass, A; McConnell, EJ; Nowis, D; Palamarchuk, A; Wójcik, C1
Adamson, DJ; Bowdon, BJ; Temple, CG; Werline, JA; Wheeler, GP1
Adams, GE; Cole, S; Haigh, A; Jenner, T; Naylor, MA; Robertson, N; Siemann, D; Stephens, MA; Stratford, IJ1
Adams, GE; Cole, S; Fielden, EM; Naylor, MA; Reeves, NJ; Stratford, IJ; Sutton, BM1
Helzlsouer, KJ; Kensler, TW1
Furukawa, F; Hirose, M; Ikeda, T; Kasahara, KI; Miyauchi, M; Nakamura, H; Nishikawa, A; Son, HY1
Adams, J; Chen, Z; Crowl Bancroft, C; Dong, G; Elliott, P; Sausville, E; Sunwoo, JB; Van Waes, C; Yeh, N1
Dykes, DJ; Griswold, DP; Harrison, SD; Plowman, J; Waud, WR1
Baker, DC; Hand, ES; Haugwitz, RD; Narayanan, VL; Plowman, J; Rampal, JB; Safavy, A1
Bueding, E; Wattenberg, LW1
Nair, RV; Schmid, FA; Witiak, DT1
Blair, R; Goldschmidt, BM; Katz, C; Melchionne, S; Van Duuren, BL1

Reviews

2 review(s) available for pyrazines and Experimental Neoplasms

ArticleYear
[Proteasome inhibitors: induction of apoptosis as new therapeutic option in prostate cancer].
    Aktuelle Urologie, 2004, Volume: 35, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Prostate-Specific Antigen; Prostatic Neoplasms; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2004
Cancer chemoprotection by oltipraz: experimental and clinical considerations.
    Preventive medicine, 1993, Volume: 22, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Female; Humans; Male; Neoplasms; Neoplasms, Experimental; Pyrazines; Thiones; Thiophenes

1993

Trials

2 trial(s) available for pyrazines and Experimental Neoplasms

ArticleYear
Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma.
    Molecular oncology, 2014, Volume: 8, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzodioxoles; Bone Neoplasms; Boronic Acids; Bortezomib; Cell Line, Tumor; Female; HSP90 Heat-Shock Proteins; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Purines; Pyrazines; Sarcoma, Ewing; Xenograft Model Antitumor Assays

2014
CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells.
    Oral oncology, 2012, Volume: 48, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autoantigens; Blotting, Western; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cell Line, Tumor; Head and Neck Neoplasms; In Vitro Techniques; Male; Membrane Proteins; Mice; Mice, Nude; Neoplasms, Experimental; Polymerase Chain Reaction; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Pyrazines; RNA, Small Interfering; Signal Transduction

2012

Other Studies

37 other study(ies) available for pyrazines and Experimental Neoplasms

ArticleYear
Novel NanoLuc-type substrates with various C-6 substitutions.
    Bioorganic & medicinal chemistry letters, 2020, 05-01, Volume: 30, Issue:9

    Topics: A549 Cells; Animals; Drug Design; Furans; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Luciferases; Luminescent Measurements; Mice; Mice, Nude; Nanotechnology; Neoplasms, Experimental; Pyrazines

2020
The anti-mitotic agents PTC-028 and PTC596 display potent activity in pre-clinical models of multiple myeloma but challenge the role of BMI-1 as an essential tumour gene.
    British journal of haematology, 2020, Volume: 190, Issue:6

    Topics: Animals; Antineoplastic Agents; Benzimidazoles; Female; Humans; Male; Mice; Mitosis; Multiple Myeloma; Neoplasm Proteins; Neoplasms, Experimental; Polycomb Repressive Complex 1; Pyrazines; Xenograft Model Antitumor Assays

2020
Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program.
    Pediatric blood & cancer, 2018, Volume: 65, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Cisplatin; Female; Humans; Isoxazoles; Melphalan; Mice; Mice, SCID; Neoplasms, Experimental; Protein Kinase Inhibitors; Pyrazines; Xenograft Model Antitumor Assays

2018
Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma.
    Cancer biology & therapy, 2018, 04-03, Volume: 19, Issue:4

    Topics: Animals; Benzamides; Carcinoma, Pancreatic Ductal; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Mice, Transgenic; Neoplasms, Experimental; Pancreatic Neoplasms; Phosphorylation; Pleural Neoplasms; Proto-Oncogene Proteins p21(ras); Pyrazines; Quinolones; Sulfonamides; Sulfones

2018
Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production.
    European journal of medicinal chemistry, 2018, Feb-25, Volume: 146

    Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Indoles; Male; Mice; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Polymerization; Proto-Oncogene Proteins B-raf; Pyrazines; Reactive Oxygen Species; Small Molecule Libraries; Structure-Activity Relationship; Tubulin

2018
Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo.
    Organic & biomolecular chemistry, 2018, 07-04, Volume: 16, Issue:26

    Topics: Animals; Imidazoles; Luciferases, Renilla; Luminescent Agents; Luminescent Measurements; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Optical Imaging; Photochemical Processes; Pyrazines; Substrate Specificity; Ultraviolet Rays

2018
Magnetic fluid hyperthermia enhances cytotoxicity of bortezomib in sensitive and resistant cancer cell lines.
    International journal of nanomedicine, 2014, Volume: 9

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Caco-2 Cells; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hyperthermia, Induced; Magnetic Field Therapy; Magnetic Fields; Magnetite Nanoparticles; Neoplasms, Experimental; Pyrazines; Treatment Outcome

2014
Engineered nanomedicine for myeloma and bone microenvironment targeting.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jul-15, Volume: 111, Issue:28

    Topics: Alendronate; Animals; Antineoplastic Agents; Bone Neoplasms; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Delivery Systems; Heterografts; Humans; Lactic Acid; Mice; Mice, Inbred BALB C; Mice, Nude; Multiple Myeloma; Nanoparticles; Neoplasm Transplantation; Neoplasms, Experimental; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrazines; Tumor Microenvironment; Xenograft Model Antitumor Assays

2014
CCMCL1: a new model of aggressive mantle cell lymphoma.
    Blood, 2015, Apr-23, Volume: 125, Issue:17

    Topics: Adenine; Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cell Line, Tumor; Humans; Lymphoma, Mantle-Cell; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Transplantation; Neoplasms, Experimental; Piperidines; Pyrazines; Pyrazoles; Pyrimidines; Rituximab; Tumor Cells, Cultured

2015
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.
    Nature immunology, 2015, Volume: 16, Issue:8

    Topics: Adoptive Transfer; Animals; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Female; Flow Cytometry; Immunotherapy; Lymphocytes; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neoplasms, Experimental; Pyrazines; Receptors, CXCR3; Sitagliptin Phosphate; Triazoles

2015
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
    Journal of medicinal chemistry, 2016, Mar-10, Volume: 59, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Curcumin; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Molecular Structure; Neoplasms, Experimental; Pyrazines; Reactive Oxygen Species; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase

2016
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
    Bioorganic & medicinal chemistry letters, 2016, Apr-15, Volume: 26, Issue:8

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Imidazoles; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; NIH 3T3 Cells; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2016
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas.
    Science (New York, N.Y.), 2016, May-20, Volume: 352, Issue:6288

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzothiazoles; Drug Resistance, Neoplasm; Glioblastoma; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Insulin-Like Growth Factor I; Macrophages; Mice; Mice, Inbred Strains; Neoplasm Recurrence, Local; Neoplasms, Experimental; NFATC Transcription Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Picolinic Acids; Pyrazines; Receptor, IGF Type 1; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Signal Transduction; STAT6 Transcription Factor; Tumor Microenvironment

2016
An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).
    Biochemical and biophysical research communications, 2016, Nov-18, Volume: 480, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclopentanes; Dose-Response Relationship, Drug; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Mice; NEDD8 Protein; Neoplasms, Experimental; Oligopeptides; Pyrazines; Pyrimidines; Treatment Outcome; Ubiquitins

2016
Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Aug-15, Volume: 14, Issue:16

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; Down-Regulation; Doxorubicin; Etoposide; Female; Fluorescent Antibody Technique; Fluorouracil; Genes, p53; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplasms, Experimental; Paclitaxel; Protein Kinases; Pyrazines; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays

2008
Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.
    Cancer research, 2008, Oct-15, Volume: 68, Issue:20

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Feedback, Physiological; Female; Humans; Imidazoles; Insulin Receptor Substrate Proteins; MAP Kinase Signaling System; Mice; Mice, Nude; Neoplasms, Experimental; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrazines; Quinazolines; Receptor, IGF Type 1; Signal Transduction

2008
microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia.
    Blood, 2009, Apr-30, Volume: 113, Issue:18

    Topics: Aged; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Boronic Acids; Bortezomib; Case-Control Studies; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Humans; Lymphocytes; Male; Mice; MicroRNAs; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms, Experimental; NF-kappa B; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Rituximab; RNA, Messenger; Signal Transduction; Waldenstrom Macroglobulinemia

2009
Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
    Oncology reports, 2009, Volume: 21, Issue:6

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Intestinal Mucosa; Male; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Time Factors

2009
Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study.
    Molecular cancer, 2010, Mar-10, Volume: 9

    Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Inflammation; Inflammation Mediators; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Neovascularization, Pathologic; NF-kappa B; Pleural Effusion, Malignant; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines

2010
NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716.
    The Journal of antibiotics, 2010, Volume: 63, Issue:6

    Topics: Animals; Antibiotics, Antineoplastic; Ascomycota; Cell Line, Tumor; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Mice, Nude; Neoplasms, Experimental; Prostatic Neoplasms; Pyrazines

2010
Gaussia luciferase for bioluminescence tumor monitoring in comparison with firefly luciferase.
    Molecular imaging, 2011, Volume: 10, Issue:5

    Topics: Animals; Area Under Curve; Genes, Reporter; HCT116 Cells; Humans; Imidazoles; Kinetics; Luciferases; Mice; Mice, SCID; Neoplasms, Experimental; Pyrazines; Spectrometry, Fluorescence; Statistics, Nonparametric; Whole Body Imaging

2011
Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A.
    Cancer letters, 2012, Apr-01, Volume: 317, Issue:1

    Topics: Animals; Apoptosis; Autoantigens; Boronic Acids; Bortezomib; Cell Line, Tumor; Chemoradiotherapy; Dose-Response Relationship, Drug; Down-Regulation; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Nude; Neoplasms, Experimental; Pyrazines; Radiation-Sensitizing Agents; RNA Interference; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

2012
Anti-myeloma effects of the novel anthracycline derivative INNO-206.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jul-15, Volume: 18, Issue:14

    Topics: Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Doxorubicin; Humans; Hydrazones; Mice; Multiple Myeloma; Neoplasms, Experimental; Neovascularization, Pathologic; Pyrazines

2012
The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP.
    Blood, 2003, Jul-01, Volume: 102, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Bone Marrow Purging; Boronic Acids; Bortezomib; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Disease-Free Survival; Drug Synergism; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Mice; Neoplasms, Experimental; Protease Inhibitors; Pyrazines; TNF-Related Apoptosis-Inducing Ligand; Transplantation, Isogeneic; Treatment Outcome; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2003
In vivo trafficking of endothelial progenitor cells their possible involvement in the tumor neovascularization.
    Life sciences, 2004, Jun-18, Volume: 75, Issue:5

    Topics: Animals; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Endothelium, Vascular; Fluorodeoxyglucose F18; Gamma Rays; Hydroxamic Acids; Metalloendopeptidases; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Pyrazines; Rats; Stem Cells; Sulfonamides; Tomography, Emission-Computed

2004
Virus-associated tumor imaging by induction of viral gene expression.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Mar-01, Volume: 13, Issue:5

    Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Boronic Acids; Bortezomib; Burkitt Lymphoma; Diagnostic Imaging; Gene Expression; Gene Transfer Techniques; Genes, Viral; Herpesvirus 4, Human; Humans; Immunoblotting; Mice; Neoplasms, Experimental; Oncogenic Viruses; Pyrazines; Radionuclide Imaging; Radiopharmaceuticals; Reverse Transcriptase Polymerase Chain Reaction; Thymidine Kinase

2007
TNF potentiates anticancer activity of bortezomib (Velcade) through reduced expression of proteasome subunits and dysregulation of unfolded protein response.
    International journal of cancer, 2007, Jul-15, Volume: 121, Issue:2

    Topics: Alternative Splicing; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line; Cell Line, Tumor; DNA-Binding Proteins; Drug Synergism; Drug Therapy, Combination; Endoplasmic Reticulum; Female; Gene Expression; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Fluorescence; Neoplasms, Experimental; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Folding; Protein Subunits; Pyrazines; Regulatory Factor X Transcription Factors; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha; X-Box Binding Protein 1

2007
Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928).
    Cancer research, 1982, Volume: 42, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; DNA; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Methotrexate; Mice; Mice, Inbred BALB C; Mitosis; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazines

1982
Fused pyrazine mono-N-oxides as bioreductive drugs. III. Characterization of RB 90740 in vitro and in vivo.
    Anti-cancer drugs, 1995, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Survival; Cricetinae; DNA Damage; Female; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Pyrazines; Tumor Cells, Cultured

1995
Pharmacokinetics, metabolism and distribution of 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-A] pyrido [3,2-E] pyrazine-5-oxide in C3H mice.
    International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2

    Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Pyrazines; Tissue Distribution

1994
Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters.
    Cancer letters, 2000, May-29, Volume: 153, Issue:1-2

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; Female; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Organ Size; Pyrazines; Thiones; Thiophenes

2000
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:5

    Topics: Animals; Antineoplastic Agents; Blood Vessels; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cysteine Endopeptidases; Cytokines; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Inbred BALB C; Mice, SCID; Multienzyme Complexes; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; NF-kappa B; Proteasome Endopeptidase Complex; Pyrazines; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2001
Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:6

    Topics: Animals; Antineoplastic Agents; Drug Administration Schedule; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Leukemia L1210; Leukemia P388; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazines

1990
Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).
    Anti-cancer drug design, 1987, Volume: 2, Issue:3

    Topics: Animals; Antineoplastic Agents; Azides; Drug Evaluation, Preclinical; Drug Stability; Female; Half-Life; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pyrazines; Pyrimethamine; Pyrimidines

1987
Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard.
    Carcinogenesis, 1986, Volume: 7, Issue:8

    Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Lung Neoplasms; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Pyrazines; Stomach Neoplasms; Thiones; Thiophenes; Uracil Mustard

1986
Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazines) in the Lewis lung carcinoma model.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Animals; Chemical Phenomena; Chemistry; Female; Magnetic Resonance Spectroscopy; Mice; Morpholines; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazines; Stereoisomerism

1985
Carcinogenicity of isosters of epoxides and lactones: aziridine ethanol, propane sultone, and related compounds.
    Journal of the National Cancer Institute, 1971, Volume: 46, Issue:1

    Topics: Aldehydes; Aniline Compounds; Animals; Azirines; Biological Assay; Carcinogens; Chemical Phenomena; Chemistry; Cycloparaffins; Ethers, Cyclic; Female; Injections, Subcutaneous; Ketones; Lactones; Mice; Neoplasms, Experimental; Pyrazines

1971