pyrazines has been researched along with Experimental Hepatoma in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 14 (70.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, D; Feng, L; Jiao, Y; Liu, X; Mao, W; Wang, X; Wang, Y; Zhang, D; Zhang, J; Zhao, X | 1 |
| Casale, A; Comolli, R; Mariotti, D | 1 |
| Cameron, IL; Hunter, KE | 1 |
| Cameron, IL; Pool, TB; Smith, NK; Sparks, RL | 1 |
| Egner, PA; Kelloff, GJ; Kensler, TW; Primiano, T; Roebuck, BD; Sutter, TR | 1 |
| Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Kensler, TW; MacMillan, DL; Maxuitenko, YY; Roebuck, BD | 1 |
| Bolton, MG; Groopman, JD; Jacobson, LP; Kensler, TW; Maxuitenko, YY; Muñoz, A; Roebuck, BD | 1 |
| Groopman, JD; Kensler, TW; Musser, SM; Scholl, P | 1 |
| Curphey, TJ; Kensler, TW; Maxuitenko, YY; Roebuck, BD | 1 |
| Baumann, H; Jacob, CO; Kambayashi, T; Lazarus, DD; Strassmann, G; Yato-Kioka, M | 1 |
| Dolan, PM; Egner, PA; Gange, SJ; Groopman, JD; Kensler, TW; Muñoz, A; Roebuck, BD; Rogers, AE | 1 |
| Kim, ND; Kim, SG; Lee, JM; Miller, JA; Park, KK; Sohn, Y; Surh, YJ | 1 |
| Curphey, TJ; Joyner, HH; Kensler, TW; Libby, AH; MacMillan, DL; Maxuitenko, YY; Roebuck, BD | 1 |
| Ha, TG; Jang, JJ; Kim, ND; Kim, SG | 1 |
| Dullaart, RP; van Tol, A | 1 |
| Curphey, TJ; Eaton, DL; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Groopman, JD; Kensler, TW; Liu, YL; Roebuck, BD; Rogers, AE | 1 |
| DeMatos, P; Egner, PA; Groopman, JD; Kensler, TW; Love-Hunt, A | 1 |
| Dolan, PM; Egner, PA; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
1 review(s) available for pyrazines and Experimental Hepatoma
| Article | Year |
|---|---|
Carcinogen-DNA and protein adducts as intermediate biomarkers for human chemoprotection trials.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; DNA; Humans; Liver Neoplasms, Experimental; Neoplasms; Proteins; Pyrazines; Thiones; Thiophenes | 1994 |
19 other study(ies) available for pyrazines and Experimental Hepatoma
| Article | Year |
|---|---|
Pharmacokinetic variations of tetramethylpyrazine phosphate after oral administration in hepatic precancerous mice and its hepatoprotective effects.
Topics: Administration, Oral; Animals; Area Under Curve; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Mice; Phosphates; Precancerous Conditions; Pyrazines | 2014 |
Amiloride and glucose effects on the intracellular pH of Yoshida rat ascites hepatoma AH-130 cells grown in vivo.
Topics: Amiloride; Animals; Ascites; Cell Division; Female; Glucose; Hydrogen-Ion Concentration; Liver Neoplasms, Experimental; Pyrazines; Rats; Rats, Inbred Strains | 1984 |
Effect of cancer cachexia and amiloride treatment on the intracellular sodium content in tissue cells.
Topics: Amiloride; Animals; Cachexia; Chlorine; Duodenum; Liver; Liver Neoplasms, Experimental; Male; Mice; Phosphorus; Potassium; Pyrazines; Sodium | 1983 |
Effects of amiloride on tumor growth and intracellular element content of tumor cells in vivo.
Topics: Adenocarcinoma; Amiloride; Animals; Body Weight; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Liver Neoplasms, Experimental; Male; Mice; Pyrazines; Sodium | 1983 |
Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinogens; Enzyme Induction; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1995 |
Evaluation of the post-initiation effects of oltipraz on aflatoxin B1-induced preneoplastic foci in a rat model of hepatic tumorigenesis.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Body Weight; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes; Time Factors | 1993 |
Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; DNA; DNA Adducts; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1993 |
Inhibition of aflatoxin Ml excretion in rat urine during dietary intervention with oltipraz.
Topics: Aflatoxin B1; Aflatoxin M1; Animals; Anticarcinogenic Agents; Cytochrome P-450 Enzyme System; Diet; Dose-Response Relationship, Drug; Inactivation, Metabolic; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1996 |
Protection against aflatoxin B1-induced hepatic toxicity as short-term screen of cancer chemopreventive dithiolethiones.
Topics: Aflatoxin B1; Animals; Chemoprevention; Liver; Liver Diseases; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1996 |
Vesnarinone inhibits immune-mediated but not Fas (CD95) agonist-mediated hepatic injury.
Topics: Acute-Phase Reaction; Animals; Antibodies, Monoclonal; Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Concanavalin A; fas Receptor; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrazines; Quinolines; Rats; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; Dose-Response Relationship, Drug; Drug Administration Schedule; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1997 |
Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Enzyme Inhibitors; Female; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred ICR; Mutagens; Pyrazines; Rats; Rats, Sprague-Dawley; Urethane | 1998 |
Identification of dithiolethiones with better chemopreventive properties than oltipraz.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Enzyme Induction; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1998 |
2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
Topics: Aflatoxin B1; Animals; Carcinogenicity Tests; DNA Adducts; DNA, Neoplasm; Enzyme Inhibitors; Glutathione Transferase; Hepatectomy; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; RNA | 1999 |
Short-term Acipimox decreases the ability of plasma from Type 2 diabetic patients and healthy subjects to stimulate cellular cholesterol efflux: a potentially adverse effect on reverse cholesterol transport.
Topics: Animals; Apolipoprotein A-I; Body Mass Index; Carrier Proteins; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; High-Density Lipoproteins, Pre-beta; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Liver Neoplasms, Experimental; Male; Membrane Proteins; Middle Aged; Phospholipid Transfer Proteins; Pyrazines; Rats; Reference Values; Tumor Cells, Cultured | 2001 |
Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1992 |
Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.
Topics: Adenoma; Aflatoxin B1; Animals; DNA; gamma-Glutamyltransferase; Growth; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Survival Analysis; Thiones; Thiophenes | 1991 |
Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Biomarkers; DNA; Guanine; Liver Neoplasms, Experimental; Male; Protein Binding; Pyrazines; Rats; Rats, Inbred F344; Serum Albumin; Thiones; Thiophenes | 1992 |
Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antineoplastic Agents; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Heterocyclic Compounds; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 1987 |