Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and Disease Models, Animal

pyrazines has been researched along with Disease Models, Animal in 415 studies

Research

Studies (415)

TimeframeStudies, this research(%)All Research%
pre-19903 (0.72)18.7374
1990's15 (3.61)18.2507
2000's89 (21.45)29.6817
2010's266 (64.10)24.3611
2020's42 (10.12)2.80

Authors

AuthorsStudies
Geng, X; He, J; Huang, H; Jenny Lu, HA; Jia, Y; Jin, W; Li, M; Li, X; Meng, J; Qiu, Z; Shao, G; Wang, L; Wang, S; Xu, Y; Yang, B; Zhang, S; Zhou, H1
Abdelnabi, R; Augustijns, P; Breuer, J; Chatterjee, AK; Coelmont, L; Dallmeier, K; De Jonghe, S; Do, TND; Foo, CS; Heylen, E; Jochmans, D; Kaptein, SJF; Langendries, L; Leyssen, P; Mols, R; Neyts, J; Pang, J; Vangeel, L; Vergote, V; Weynand, B; Williams, R; Zhang, X1
Bengue, M; Choumet, V; de Lamballerie, X; Hamel, R; Liegeois, F; Missé, D; Nougairède, A; Pintong, AR; Pompon, J; Roques, P1
Li, Z; Tong, J; Wang, Y; Zhu, H2
Guo, MQ; He, YJ; Huang, YX; Li, KX; Li, YH; Pan, WY; Qiu, DZ; Wu, HY; Yang, DH1
Begum, R; Garcia-Ocaña, A; Li, Y; Palit, SP; Parmar, N; Patel, R; Rathwa, N1
Du, M; Feng, X; Li, S; Liu, P; Wang, J; Wang, Y1
Jing, M; Sun, Y; Wang, T; Wang, Y; Zhang, T; Zhang, Z1
Egawa, K; Fujii, H; Fukushi, S; Furuta, Y; Harada, S; Komeno, T; Kurosu, T; Lim, CK; Maeki, T; Morikawa, S; Nakajima, N; Saijo, M; Shimojima, M; Takayama-Ito, M; Tani, H; Taniguchi, S; Uda, A; Yamada, S; Yoshikawa, T1
Cai, Q; Huang, G; Li, W; Li, Z; Liu, W; Ma, G; Meng, X; Wang, S; Zhang, Y1
Ang, BT; Chong, YK; Koh, LWH; Lim, SW; Ng, WH; Sandanaraj, E; Tan, MSY; Tan, NS; Tan, P; Tang, C1
Andersson, U; Andreasson, T; Bergström, EL; Björkstrand, E; Bonn, B; Chang, HF; Chapman, D; Davis, AM; Ek, M; Glader, P; Gordon, E; Jiang, F; Johannesson, P; Käck, H; Lundqvist, AJ; Malmberg, A; Munck Af Rosenschöld, M; Nikitidis, A; Nikitidis, G; Pettersen, A; Ripa, L; Rohman, M; Rönn, R; Swedin, L; Tyrchan, C; Ullah, V; Wågberg, F; Zhou, XH1
Gao, D; Liu, D; Ma, X; Sun, M; Xu, D; Yu, H1
Chen, J; Dong, L; Dong, Y; Fu, X; Guo, T; Liu, M; Mao, Y; Qiao, C; Yang, Y; Zhang, J; Zhang, X; Zhao, Y1
Birla, H; Kosuru, R; Prakash, S; Rai, U; Singh, S; Singh, SP; Tiwari, V1
Altamirano-Lagos, MJ; Fernández-Fierro, A; Funes, SC; Gómez-Santander, F; Jara, EL; Kalergis, AM; Mackern-Oberti, JP; Pulgar-Sepúlveda, R; Rebolledo-Zelada, D; Ríos, M; Rivera-Perez, D; Roa, JC; Villarroel, A1
Al Zoubi, S; Chiazza, F; Coldewey, SM; Collino, M; Collotta, D; Martin, L; O'Riordan, CE; Purvis, GSD; Stiehler, L; Thiemermann, C; Wissuwa, B1
Cheng, H; Guo, S; Ke, G; Liu, M; Mao, Y; Mi, Y; Wang, M; Wei, P1
Granzier, HL; Hwee, DT; Kolb, J; Lee, EJ; Malik, FI1
Deng, F; Fang, S; Zhang, B; Zhang, Y1
Chen, Y; Han, Y; Qian, X; Wu, J; Yang, Q; Ying, J; Zhang, Y; Zhu, H1
Du, J; Jiao, Y; Zhang, J; Zhang, S1
Baturevych, A; Clouser, CR; Hause, RJ; Johnstone, TG; Jones, JC; Krejsa, CM; Ponce, R; Ports, MO; Qin, JS; Ragan, SP; Salmon, RA1
Black, SM; Chen, J; Chen, X; Chen, Y; Desai, AA; Duan, X; Garcia, JGN; He, W; Hong, C; Hou, C; Kuang, M; Li, M; Liao, J; Liu, C; Liu, S; Lu, W; Makino, A; Rischard, F; Tang, H; Vanderpool, RR; Wang, J; Wu, X; Yang, K; Yuan, JX; Zhang, J; Zhang, N; Zhang, Z; Zheng, Q; Zhong, N; Zou, G1
Liddle, RA; Liedtke, W; Pandol, SJ; Romac, JM; Shahid, RA; Swain, SM; Vigna, SR1
Barron, S; Barrot, L; Carbonnelle, C; de Lamballerie, X; Duthey, A; Guedj, J; Jacquot, F; Lacarelle, B; Madelain, V; Mentré, F; Mundweiler, S; Raoul, H; Solas, C; Thomas, D; Vallvé, A1
Anglaret, X; Baize, S; de Lamballerie, X; Graw, F; Guedj, J; Günther, S; Laouénan, C; Madelain, V; Malvy, D; Mentré, F; Nguyen, THT; Oestereich, L; Piorkowski, G; Raoul, H1
Bialesova, L; Bouchard, A; Kinsella, BT; Mulvaney, EP; Reid, HM; Salvail, D1
Claus, M; Dauby, N; Dechamps, P; Gérard, M; Günther, S; Konopnicki, D; Mahieu, R; Malvy, D; Martin, C; Martiny, D; Morales, MA; Nasreddine, R; Perandones, C; Roman, A; Schuldt, G; Stevens, E; Swaan, C; Van den Wijngaert, S; Van Praet, S; Vandenberg, O; Veliziotis, I; Vlieghe, E1
Alexopoulos, SJ; Beretta, M; Chen, SY; Garcia, CJ; Hargett, SR; Hoehn, KL; Murray, JH; Olzomer, EM; Salamoun, JM; Santos, WL; Shah, DP; Tucker, SP1
Alexopoulos, SJ; Beretta, M; Brandon, AE; Byrne, FL; Carrive, P; Chen, SY; Cooney, GJ; Garcia, CJ; Hargett, SR; Hoehn, KL; Lackner, C; Lawrence, RT; Lee, B; Olzomer, EM; Philp, A; Philp, AM; Salamoun, JM; Santos, WL; Shah, DP; Sligar, J; Tucker, SP; Turner, N1
Chen, P; Chen, S; Chen, X; Ge, J; Han, X; He, A; He, S; Liu, X; Luo, Q; Qiu, J; Wu, C; Wu, N; Wu, Y; Yang, M; Yang, Y; Yu, K; Zhuang, J1
Feldmann, F; Feldmann, H; Furuta, Y; Gowen, BB; Haddock, E; Hanley, PW; Hawman, DW; Komeno, T; Lovaglio, J; Meade-White, K; Nakajima, N; Nardone, G; Scott, D1
Cao, J; Chen, H; Guo, B; Liu, Z; Sun, Y; Wang, P; Wang, Y; Zha, L; Zhang, G; Zhang, Z1
Alhassan, AB; Anand, R; Babu Boga, S; Bennett, C; Brandish, PE; Cai, J; Duffy, JL; Fischmann, TO; Gao, X; Gao, YD; Garlisi, CG; Guiadeen, D; Hicks, A; Kelly, J; Kim, R; Knemeyer, I; Kozlowski, JA; Krikorian, A; Leccese, E; Liu, J; Liu, S; Maloney, KM; Mansueto, M; Presland, J; Selyutin, O; Stivers, P; Tyagarajan, S; Wang, J; Wu, H; Xu, J; Xu, Z; Yang, C; Yu, W; Yu, Y; Zhang-Hoover, J1
Cao, H; Cheng, Y; Ge, L; Xu, M; Zhang, J1
Abdelnabi, R; Annaert, P; Augustijns, P; Barthelemy, K; Bervoets, L; Boudewijns, R; Breuer, J; Cawthorne, C; Dallmeier, K; De Keyzer, C; Delang, L; Hens, B; Heylen, E; Jacobs, S; Kaptein, SJF; Langendries, L; Liesenborghs, L; Maas, E; Neyts, J; Pang, J; Rocha-Pereira, J; Rymenants, J; Seldeslachts, L; Solas, C; Spriet, I; Ter Horst, S; Thibaut, HJ; Van Buyten, T; Vande Velde, G; Vergote, V; Verougstraete, N; Weynand, B; Williams, R; Wouters, J; Zhang, X1
Fuchikami, C; Honda, Y; Kosugi, K; Kuramoto, K; Kuwano, K; Numakura, Y1
Callender, LA; Coldewey, SM; Collino, M; Collotta, D; Ferreira Alves, G; Greaves, DR; Krieg, N; Mohammad, S; O'Riordan, CE; Purvis, GSD; Sheikh, MH; Thiemermann, C; Wissuwa, B1
Chen, H; Cheng, J; Guo, B; Huang, C; Su, Z; Sun, Y; Wang, Y; Wu, J; Wu, L; Yang, X; Zhang, G; Zhang, Z; Zhu, Z1
Cheng, H; Deng, X; Du, H; Huang, H; Kuang, X; Ling, X; Long, C; Shen, H; Shi, K; Tang, H; Wang, L; Wang, R; Xing, Y; Yan, J; Zhang, H; Zhu, X; Zou, Y1
Huang, H; Kong, L; Luan, S; Qi, C; Wu, F1
Barthélémy, K; Cochin, M; Coutard, B; de Lamballerie, X; Driouich, JS; Guedj, J; Laprie, C; Lingas, G; Moureau, G; Nougairède, A; Petit, PR; Piorkowski, G; Solas, C; Touret, F1
Baillet, N; Baize, S; de Lamballerie, X; Gloaguen, E; Guedj, J; Madelain, V; Mullaert, J; Raoul, H; Reynard, S1
Jiang, SJ; Liu, J; Qin, XH; Wang, J; Wang, LX; Zhang, Q; Zhu, L1
Fukushi, S; Furuta, Y; Kato, H; Kawahara, M; Kitaura, S; Komeno, T; Nakajima, N; Saijo, M; Satoh, M; Takayama-Ito, M; Yoshikawa, T1
Chai, H; Huang, Z; Lei, Z; Liu, Y; Qin, X; Wu, Z1
Berglund, K; Carrasco, D; English, AW; Goebel, K; Gross, RE; Isaacson, R; Mistretta, OC; Wynans, C1
Brasel, T; Comer, JE; Escaffre, O; Freiberg, AN; Ikegami, T; Juelich, TL; Kalveram, B; Massey, S; Neef, N; Perez, D; Smith, J; Smith, JK; Zhang, L1
Arnold, WD; Burghes, AHM; Chugh, D; Kray, KM; McGovern, VL1
Gu, J; Li, N; Sun, Y; Wang, Y; Wu, L; Yu, P; Zhang, G; Zhang, T; Zhang, Z1
Shan, L; Sun, Y; Wang, Y; Xu, C; Yu, P; Zhang, G; Zhang, X; Zhang, Z1
Kaneko, N; Kuromitsu, S; Mori, K; Mori, M; Saito, R; Shimada, I; Tanaka, R; Ueno, Y; Yamada, M1
Chen, SS; Chiorazzi, N; Covey, T; Dadashian, EL; Herman, SEM; Izumi, R; Krantz, F; Lannutti, BJ; Mora-Jensen, HI; Niemann, CU; Ulrich, R; Wiestner, A1
Gao, Y; Guan, S; He, L; Huang, L; Jin, Y; Li, G; Liang, S; Liu, S; Ou, X; Shen, Y; Tan, M; Xiong, W; Xu, C; Xu, H; Yang, G1
Bailey, KW; Furuta, Y; Gowen, BB; Komeno, T; Sefing, EJ; Van Wettere, AJ; Wandersee, L; Westover, JB1
Fan, Y; Wu, Y1
Akerman, S; Goadsby, PJ; Martins-Oliveira, M; Zhao, Y1
Conrad, BL; Furuta, Y; Gowen, BB; Hickerson, BT; Jung, KH; Li, R; Miao, J; Nielson, S; Reynolds, ES; Rigas, JD; Thangamani, S; Van Wettere, AJ; Wang, Z; Westover, JB1
Carrillo-Bustamante, P; Graw, F; Guedj, J; Günther, S; Nguyen, THT; Oestereich, L1
Bian, ZR; Che, XW; Liu, XM; Wang, YB; Wu, Q1
Aizawa, H; Ito, Y; Mitani, A; Shimizu, T; Soma, M; Sugimoto, J; Sugiyama, K; Tanaka, K; Tanaka, M1
Bavari, S; Bixler, SL; Bocan, TM; Cazares, LH; Donnelly, G; Epstein, C; Garza, NL; Giesing, D; Lenk, R; Liang, LF; Soloveva, V; Van Tongeren, SA; Warren, TK; Welch, L; Wells, J; Wetzel, KS1
Bavari, S; Bixler, SL; Bocan, TM; Cazares, LH; Dong, L; Donnelly, G; Epstein, C; Garza, NL; Giesing, D; Koistinen, KA; Lenk, R; Liang, LF; Nuss, J; Soloveva, V; Van Tongeren, SA; Warren, TK; Welch, L; Wells, J; Wetzel, KS1
Banadyga, L; He, S; Qiu, X; Wong, G; Zhang, Z; Zhu, W1
Gong, X; He, X; Sun, M; Sun, Y; Wang, BO; Wang, M; Wang, X; Wang, Z; Wei, X; Yi, F; Zhang, Y; Zhou, Z1
Kitta, T; Kwon, J; Miyake, H; Miyazato, M; Shimizu, T; Sumino, Y; Suzuki, T; Takaoka, E; Yoshikawa, S; Yoshimura, N1
Fan, S; Li, A; Li, Y; Liang, C; Meng, J; Shen, X; Wu, D; Wu, G; Xiao, Q; Xu, Y; Zhang, L; Zhang, X1
Brown, TM; Dorka, N; Hochgeschwender, U; Medendorp, WE; Palmateer, B; Petersen, ED; Prakash, M; Wagner, LM; Zenchak, JR1
Koraka, P; Kycko, A; Marzec, A; Orłowska, A; Osterhaus, ADME; Reichert, M; Smreczak, M; Trębas, P; Żmudziński, JF1
Hayashi, T; Kittaka, M; Kondo, T; Reichenberger, EJ; Ueki, Y; Yoshimoto, T1
Furuta, Y; Gowen, BB; Hickerson, BT; Jung, KH; Komeno, T; Westover, JB1
Dawes, BE; Freiberg, AN; Furuta, Y; Ikegami, T; Juelich, T; Kalveram, B; Komeno, T; Lee, B; Park, A; Smith, JK; Zhang, L1
Chen, P; Ge, J; Qiu, J; Tang, M; Wang, Q; Wu, Y; Xu, Z; Yang, Y; Yu, J; Yu, K; Zhuang, J1
Feldmann, H; Furuta, Y; Gowen, BB; Haddock, E; Hanley, PW; Hawman, DW; Komeno, T; Meade-White, K; Rosenke, K; Williamson, B1
Jin, M; Liu, S; Ma, X; Shao, Z; Shi, H; Wang, X; Wu, P1
Chen, KY; Fagin, JA; Ghossein, R; Knauf, JA; Luckett, KA; Socci, ND; Voza, F1
Du, S; He, G; Sun, Z; Wu, Y; Zhang, X; Zhao, Y; Zhou, L; Zhou, P; Zhuo, LH1
Ahn, BC; Baek, SH; Gangadaran, P; Hong, CM; Jeong, SY; Kalimuthu, SK; Lee, HW; Lee, J; Lee, SW; Li, XJ; Min, OJ; Rajendran, RL; Zhu, L1
Abay, E; Basarab, GS; Brunschwig, C; Chibale, K; Gibhard, L; Lawrence, N; Njoroge, M; Paquet, T; Street, LJ; Taylor, D; Wiesner, L; Wittlin, S1
Baize, S; Barron, S; Carbonnelle, C; de Lamballerie, X; Fizet, A; Guedj, J; Jacquot, F; Lacarelle, B; Madelain, V; Mentré, F; Raoul, H; Reynard, S; Solas, C1
Cardona, DM; Cardones, AR; Chao, NJ; Chen, BJ; Di Paolo, JA; Jia, W; Kim, JY; Perez, VL; Poe, JC; Reyes, NJ; Saban, DR; Sarantopoulos, S; Su, H; Sundy, JS1
Fukuma, A; Fukushi, S; Furuta, Y; Komeno, T; Morikawa, S; Nakajima, N; Saijo, M; Shimojima, M; Tani, H; Taniguchi, S; Uda, A1
Kaptein, SJF; Neyts, J; Segura Guerrero, NA; Sharma, S1
Bonhaus, D; Khan, A; Koike, MA; Masliah, E; Price, DL; Rockenstein, E; Wrasidlo, W1
Baz, M; Boivin, G; Carbonneau, J; Cavanagh, MH; Rhéaume, C1
Li, Y; Zhang, T; Zhou, Y; Zhu, Z1
Ge, J; Lai, Z; Qiu, J; Tang, M; Wu, C; Wu, Y; Xu, Z; Yang, M; Yang, Y; Yu, K; Zhuang, J1
Beckmann, RP; Blosser, W; Cole, KA; Dowless, M; Erickson, SW; Gorlick, R; Hawkins, DS; Houghton, PJ; Iversen, PW; Kang, MH; Kolb, EA; Krytska, K; Kurmasheva, RT; Lin, AB; Lowery, CD; Maris, JM; Renschler, M; Reynolds, CP; Rubin, BP; Smith, MA; Stancato, LF; Stephens, JR; Teicher, BA; VanWye, AB1
Guo, M; Hao, MH; Ma, XY; Sun, WP; Tang, Y; Zhu, HY1
Govorkova, EA; Marathe, BM; Pascua, PNQ; Vogel, P; Webby, RJ1
Brasel, T; Comer, JE; Escaffre, O; Freiberg, AN; Juelich, TL; Kalveram, B; Massey, S; Neef, N; Perez, DD; Smith, J; Smith, JK; Zhang, L1
Chen, B; Hu, G; Lin, Y; Ma, Y; Wei, J; Xue, X1
Cheng, Y; Cheng, Z; Jin, H; Xia, H; Xu, Y1
Ge, J; Hu, D; Li, K; Luo, Z; Rong, H; Tang, M; Wu, Y; Xian, B; Zhuang, J1
Gu, S; Hua, X; Mou, Z; Ni, J; Shen, H; Zheng, T; Zhou, Y1
Gao, T; Jiang, JD; Li, T; Shi, T; Wiesenfeld-Hallin, Z; Xu, XJ1
Cao, J; Chen, H; Li, N; Liu, W; Liu, Y; Sun, Y; Wang, Y; Wu, L; Zhang, G; Zhang, Z1
Carroll, NK; Higgins, GA; Silenieks, LB; Taylor, C; Upton, N; Van Niekerk, A; Van Niekerk, E1
Hirano, M; Kaneko, N; Konagai, S; Koshio, H; Kuromitsu, S; Matsuya, T; Mori, M; Sakagami, H; Takeuchi, M; Tanaka, H; Yamamoto, H; Yamanaka, Y; Yuri, M1
Liu, W; Su, Z; Sun, Y; Wang, Y; Wu, L; Yu, P; Zha, L; Zhang, G; Zhang, Z; Zhu, Z1
Bailey, T; Boon, ACM; Bricker, TL; Diamond, MS; Gounder, AP; Jagger, BW; Janowski, AB; Kwon, JH; Shafiuddin, M; Wang, D; Williams, GD; Zhao, G1
Fernández, FM; Gaul, DA; Huang, D; Kim, J; Nan, H1
Dzinic, SH; Edwards, H; Ge, Y; Knight, T; Kushner, J; Lin, H; Ma, J; Polin, L; Qiao, X; Taub, JW; Wang, G; Wang, Y; White, K; Zhao, L; Zhao, S1
Davies, FE; Fryer, RA; Graham, TJ; Morgan, GJ; Robinson, SP; Smith, EM; Walker-Samuel, S1
Fu, D; Gong, X; Lu, H; Norgren, S; Tang, X; Wang, G; Wang, Q; Wang, Y1
Brandstetter, M; Engelhard, K; Förster, CY; Neuhaus, W; Schaible, EV; Scheffer, D; Thal, SC; Wunder, C1
Jampel, SB; Jasper, JR; Malik, FI; Miciak, JJ; Tankersley, C; Tibbs, ME; Wagner, KR; Warsing, LC1
Dixit, TS; Elased, KM; Lucot, JB; Sharma, AN1
Eba, S; Hoshikawa, Y; Ishida, K; Kondo, T; Mitsuishi, Y; Moriguchi, T; Okada, Y; Satoh, H; Shimizu, T; Shimokawa, H; Watanabe, T; Yamamoto, M1
Chettab, K; Dumontet, C; Herveau, S; Huber, AL; Jordheim, LP; Manié, S; Matera, EL; Tagoug, I1
Gao, H; Hu, J; Sun, R; Wang, F; Wang, L; Wang, Y; Wang, Z; Yan, S; Yu, X; Zhao, W1
Baughn, LB; Janz, S; Linden, MA; Mansoor, A; Stessman, HA; Van Ness, B; Zhan, F1
Lin, M; Luan, Y; Ma, Y; Wang, YB; Wang, YY; Zhang, X; Zhang, ZH; Zhu, XB1
Gesheva, VV; Nikolova-Ganeva, KA; Todorov, TA; Vassilev, TL; Voll, RE1
Geltink, RI; Grosveld, GC; Marshall, AD; Picchione, F1
Amaral, A; Bourret, A; Buonamici, S; Dai, M; Dorsch, M; Green, J; Guo, R; He, F; Kelleher, JF; Lagu, B; Maniara, W; McEwan, M; Miller-Moslin, K; Peukert, S; Ramamurthy, A; Sun, Y; Vattay, A; Wang, A; Wang, K; Williams, J; Yuan, J; Yusuff, N; Zhang, R1
Chen, YG; Huang, LL; Liu, B; Tao, XG; Wang, JQ; Wei, L; Zhang, L1
De Bruyne, E; De Bryune, E; De Raeve, H; Handisides, D; Hart, CP; Hu, J; Menu, E; Van Camp, B; Van Valckenborgh, E; Vanderkerken, K; Xu, D; Xu, S1
Fan, X; Huang, C; Li, Y; Wang, W; Zhan, X1
Chang, LT; Chen, YL; Cho, CL; Chua, S; Chung, SY; Kao, YH; Leu, S; Sheu, JJ; Sun, CK; Sung, HC; Tsai, TH; Yeh, KH; Yip, HK1
Cimburek, Z; Dovolilová, E; Saudek, F; Vargová, L; Vojtová, L; Zacharovová, K1
Antonio, EL; Arruda-Junior, DF; Barreto, AL; Campos, LC; dos Santos, L; Girardi, AC; Krieger, JE; Mansur, AJ; Pereira, AC; Salles, TA; Tucci, PJ1
Gál, P; Guzy, J; Pekárová, T; Tomečková, V; Tóth, Š; Varga, J; Veselá, J1
Bondada, L; Boykin, DW; Brun, R; Hu, L; Munde, M; Patel, A; Wang, MZ; Wenzler, T; Wilson, WD; Yang, S1
Brown, KJ; Cakir, E; Coley, W; Dillingham, BC; Hathout, Y; Kinder, TB; Nagaraju, K; Rayavarapu, S; Tappeta, K; Van der Meulen, JH1
Akhavan, D; Assuncao, A; Babic, I; Bonetti, B; Cavenee, WK; Chopra, R; Cloughesy, TF; Furnari, FB; Gini, B; Gu, Y; Guo, D; Heath, JR; Hege, K; Ikegami, S; James, CD; Kroemer, G; Lin, K; Masui, K; Matsutani, T; Mischel, PS; Mortensen, DS; Nathanson, D; Raymon, HK; Shackelford, D; Tanaka, K; Villa, GR; Xu, S; Yang, H; Zanca, C; Zhu, S1
Chang, G; Duan, Q; Lu, K; Qin, S; Wang, Y; Ye, L; Zhang, D; Zhang, P; Zheng, A1
Alinari, L; Baiocchi, RA; Blum, KA; Byrd, JC; Johnston, JS; Li, X; Lin, TS; Lustberg, ME; Porcu, P1
Babina, M; Mudnakudu Nagaraju, KK; Worm, M1
Engelhardt, M; Fiebig, HH; Klingner, K; May, AM; Schueler, J; Siegers, GM; Wäsch, R; Wider, D1
Ares-Carrasco, S; Caro-Vadillo, A; Egido, J; Iborra, C; Lorenzo, O; Picatoste, B; Ramírez, E; Tuñón, J1
Du, J; Duan, H; Guo, B; Lee, SM; Wang, Y; Xu, D; Zhang, Z1
Canta, A; Carozzi, V; Cavaletti, G; Chiorazzi, A; Meregalli, C; Monbaliu, J; Oggioni, N; Sala, B; VAN DE Velde, H1
Gao, Y; Huang, Y; Lau, CW; Liu, J; Liu, L; Ng, CF; Tian, XY; Wong, WT; Xu, A; Xu, G; Yao, X1
Boutley, H; Karcher, G; Lacolley, P; Lhuillier, M; Louis, H; Marie, PY; Maskali, F; Poussier, S; Thornton, SN1
Brasel, T; Freiberg, AN; Furuta, Y; Gowen, BB; Hill, TE; Juelich, TL; Pietzsch, C; Sefing, EJ; Smith, JK; Tigabu, B; Yun, T; Zhang, L1
Berno, T; Kamalakar, A; Pappas, L; Suva, LJ; Tricot, G; Xu, H; Yang, Y; Yoon, D; Zangari, M; Zeng, M1
Gallacher, DJ; Hemmeryckx, B; Roger Lijnen, H; Rong Lu, H; Swinnen, M1
Alé, A; Bruna, J; Monbaliu, J; Morell, M; Navarro, X; Udina, E; van de Velde, H1
Cunningham, C; Dey, M; Forest, T; Frederick, C; Holder, D; Prahalada, S; Smith, A; Yao, X1
Eastaugh, LS; Lenk, RP; Lever, MS; Nelson, M; Smither, SJ; Steward, JA1
Bailey, KW; Furuta, Y; Gowen, BB; Kumaki, Y; Scharton, D; Van Wettere, A; Vest, Z; Westover, JB1
Chen, N; Chen, W; Lu, Y; Yin, L; Zhu, J; Zhu, M1
Ahn, KS; Chng, WJ; Kannaiyan, R; Kumar, AP; Li, F; Mustafa, N; Sethi, G; Siveen, KS1
Akar, FG; Chaanine, AH; Hajjar, RJ; Jin, D; Kohlbrenner, E; Kovacic, JC; Nonnenmacher, M; Weber, T1
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Han, R; Li, J; Luo, Q; Shen, J; Tang, Q; Xiao, H1
Asano, T; Ito, K; Sato, A1
Buckley, CL; Horton, JS; Stokes, AJ1
Gao, XM; Leng, YF; Wang, SX; Xing, YH1
Bach, HH; Gamelli, RL; Laporte, HM; Majetschak, M; Wong, YM1
Chen, DM; Shi, CG; Sun, MZ; Wang, GF; Wang, HF; Wang, L; Wu, SX; Xu, ZQ1
Adams, J2
Antolín, M; Guarner, F; Malagelada, JR; Medina, C; Radomski, A; Radomski, MW; Salas, A; Videla, S; Vilaseca, J1
Li, Y; Shi, J; Sun, L; Wang, X1
Mundy, GR; Oyajobi, BO1
Boehncke, WH; Elliott, PJ; Zollner, TM1
Begleiter, A; Bird, RP; Curphey, TJ; Sivananthan, K1
Chen, JL; Chen, NW; Chen, WX; Wu, YL; Zhang, MJ; Zhou, T; Zhu, JS1
Ambo, A; Bryant, SD; Jinsmaa, Y; Lazarus, LH; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y1
Bardag-Gorce, F; French, BA; French, SW; Li, J; Lue, YH; Montgomery, RO; Nan, L; Riley, NE1
Cardoso, F; Durbecq, V; Picart, MJ; Ross, JS; Sotiriou, C1
Chang, H; Conlon, PR; Engber, TM; Haque, S; Kiesman, WF; Kumaravel, G; Petter, RC; Sha, L; Wang, J; Whalley, ET; Yao, G1
Li, HL; Wang, WJ; Wang, XH; Yang, L1
Beretta, GL; Brigliadori, G; Corna, E; De Cesare, M; Fabbri, F; Ricotti, L; Rosetti, M; Supino, R; Tesei, A; Ulivi, P; Zoli, W; Zunino, F1
Böll, B; Borchmann, P; Engert, A; Hansen, H; Heuck, F; Pogge von Strandmann, E; Reiners, K; Rothe, A1
Ahsan, MH; Purchio, AF; West, DB; Zhang, N1
Ayyub, E; Chang, HX; Dowling, JE; Engber, T; Haque, S; Jin, X; Kumaravel, G; Petter, RC; Phadke, D; van Vloten, K; Vessels, JT; Wang, J1
Blum, E; Buhl, T; Di Padova, FE; Feifel, R; Gram, H; Hiestand, P; Manning, U; Neumann, U; Revesz, L; Rucklin, G1
Kiselyov, A1
Barbera, S; Bigini, P; De Paola, M; Fumagalli, E; Mennini, T1
Dispenzieri, A; Geyer, SM; Goel, A; Greiner, S; Peng, KW; Russell, SJ1
Barrett, JE; Dunlop, J; Harrison, BL; Mazandarani, H; Rosenzweig-Lipson, S; Sabalski, J; Sabb, A; Stack, G; Welmaker, G; Zhang, J1
Díaz-Gonzalez, F; Farre, E; Medina, C; Paz, MC; Quintero, E; Radomski, MW; Salas, A; Santana, A1
Bouley, J; Fisher, M; Henninger, N; Sicard, KM; Stagliano, NE1
Chopp, M; Hozeska, A; Liu, X; Lu, M; Riordan, W; Stagliano, N; Zhang, L; Zhang, ZG1
Arnold, AC; Back, TC; Hixon, JA; Khan, T; Lincoln, E; Lockett, S; Powell, D; Salcedo, R; Sayers, TJ; Stauffer, JK; Wigginton, JM; Williams, R1
Feng, Y; Howard, AD; Li, C; Li, Z; Moller, DE; Mu, J; Roy, RS; Thornberry, NA; Woods, J; Zhang, BB; Zhou, YP; Zhu, L; Zycband, E1
Cheng, B; Dang, XQ; Fan, LH; Wang, CS; Wang, KZ1
Gao, Y; Guo, P; Li, YF; Liang, QD; Ma, BP; Ma, ZC; Tan, HL; Tan, W; Wang, SQ; Zhou, Z1
Burtrum, D; Ludwig, DL; Moore, MA; Wu, KD; Zhou, L1
Brown, J; Chapin, DS; Chiang, P; Guanowsky, V; Iredale, PA; Marala, R; McCarthy, SA; Patterson, T; Seymour, PA; Siuciak, JA; Swick, A1
Christoph, T; Erdmann, VA; Frank, R; Gillen, C; Grünweller, A; Kurreck, J; Mika, J; Schäfer, MK; Wade, EJ; Weihe, E1
Fujita, M; Harada, E; Ikegame, S; Inoshima, I; Nakanishi, Y; Ouchi, H; Ye, Q1
Davey, AK; Evans, AM; Li, Y; Wang, J; Xu, D; Zhang, S1
Chen, CH; Chen, TH; Chu, YL; Hou, CC; Hsu, YH; Juan, SH; Lin, H; Sue, YM1
Dang, SC; Qu, JG; Wang, XQ; Zhang, JX1
Amano, S; Ehama, R; Matsunaga, Y; Nishiyama, T; Ogura, Y; Tagami, H1
Chu, K; Jung, KH; Kim, BS; Kim, EH; Kim, JM; Kim, M; Lee, ST; Park, DK; Roh, JK; Sinn, DI; Song, EC; Yoon, SS1
Fu, H; Li, J; Li, QX; Shao, L; Xia, L1
Chiou, GC; Jiang, W; Zou, Y1
Dang, SC; Fan, X; Qu, JG; Wang, XQ; Zhang, JX1
Auradé, F; Chaligné, R; Gastinne, T; Giraudier, S; Gonin, P; Lacout, C; Pisani, DF; Tulliez, M; Vainchenker, W; Villeval, JL; Wagner-Ballon, O1
Furuta, Y; Julander, JG; Shafer, K; Sidwell, RW1
Adams, W; Adedoyin, A; Barry, A; Cummons, TA; Harrison, J; Jones, PG; Leventhal, L; Lu, P; Piesla, MJ; Ramdass, R; Schantz, J; Smith, VA; Spangler, TB; Strassle, BW; Sullivan, NR; Sun, SC; Uveges, AJ; Whiteside, GT1
Cai, YX; Fu, YB; Li, L; Meng, FY; Sun, QX1
De Man, JG; De Schepper, HU; De Winter, BY; Deiteren, A; Herman, AG; Martinet, W; Pelckmans, PA; Ruyssers, NE; Timmermans, JP; Van Nassauw, L1
Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL1
Burke, SL; Huang, Z; Karnachi, P; Lagu, B; Murray, WV; Rhodes, KJ; Scannevin, RH; Wang, B; Wilson, LJ; Yang, SM1
Dirksen, WP; Fernandez, SA; Lairmore, MD; Nadella, MV; Rosol, TJ; Shu, ST; Thudi, NK; Werbeck, JL1
Bai, M; Fang, ZY; Feng, G; Tao, XN; Xiong, L1
Kita, Y; Nakazato-Imasato, E; Tanimoto-Mori, S; Toide, K1
Eller, M; Foreman, MM; Hanania, T; Stables, JP; Stratton, SC; White, HS; Wilcox, KS1
Anderson, KC; Campbell, RM; Chauhan, D; Dios, AD; Hideshima, T; Ishitsuka, K; Kiziltepe, T; Munshi, N; Neri, P; Ocio, EM; Okawa, Y; Raje, N; Shen, Z; Shih, C; Shiraishi, N; Starling, JJ; Tamura, K; Tassone, P; Vallet, S1
Beers, DS; Brodbeck, RM; Chenard, BL; Guo, Q; Hammer, J; Hutchison, AJ; Kershaw, M; Krause, JE; Mao, J; Maynard, GD; Near, KE; Wustrow, DJ; Yuan, J; Zhao, H; Zhou, D1
Hulter, HN; Ilnicki, LP; Licht, JH; Sebastian, A1
Matsumoto, K; Ni, JW; Watanabe, H1
Matsui, S; Matsumori, A; Sasayama, S1
Helzlsouer, KJ; Kensler, TW1
Nakano, M; Nakashima, M; Nishiyama, H; Saniabadi, AR; Takiguchi, Y; Umemura, K; Wada, K1
Phillis, JW1
Kawamura, M; Moriya, N; Terashita, Z; Tsuji, N1
Kang, KW; Kim, ND; Kim, SG; Schini-Kerth, VB1
Beyer, KH; Follansbee, MH; Griffith, JW; Vesell, ES1
Chen, B; Davidson, NE; De Flora, S; Egner, PA; Enger, CL; Fang, X; Gordon, GB; Gorman, MB; Groopman, JD; He, X; Jacobson, LP; Kensler, TW; Kuang, SY; Li, YF; Muñoz, A; Prochaska, HJ; Qian, GS; Wang, JB; Wang, JS; Wu, Y; Yu, LY; Zarba, A; Zhang, BC; Zhang, QN; Zhu, YR1
Clapper, ML; Szarka, CE1
Chang, FC; Chen, KJ; Hong, CY; Huang, YT; Lin, HC; Lin, JG1
Chen, SJ; Liao, MH; Wu, CC; Yen, MH1
Cowan, DB; del Nido, PJ; McGowan, FX; Munakata, M; Poutias, DN; Takeuchi, K1
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Bohme, GA; Boireau, A; Bouquerel, J; Damour, D; Debono, MW; Genevois-Borella, A; Hardy, JC; Hubert, P; Jimonet, P; Manfré, F; Mignani, S; Nemecek, P; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Dolan, PM; Itoh, K; Kensler, TW; Kwak, MK; Ramos-Gomez, M; Talalay, P; Yamamoto, M1
Maehara, K; Maruyama, Y; Midorikawa, J; Ohtani, H; Ushiroda, S; Watanabe, T; Yaoita, H1
Adams, J; Chen, Z; Crowl Bancroft, C; Dong, G; Elliott, P; Sausville, E; Sunwoo, JB; Van Waes, C; Yeh, N1
Elliott, PJ; Ross, JS1
Birraux, G; Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Stutzmann, JM; Vuilhorgne, M; Wahl, F1
Chen, S; Dong, H; Lu, Z; Sang, H; Wang, Q; Xiong, L; Zhu, Z1
Curphey, T; Groopman, J; Helzlsouer, K; Kensler, T; Maxuitenko, Y; Roebuck, BD; Styczynski, P1
Gwilt, M; Henderson, CG; Orme, J; Rourke, JD1
Futaki, S; Goto, Y; Hata, K; Kawaguchi, O; Nishioka, T; Saeki, A; Suga, H; Takasago, T1
Alberti, KG; Aynsley-Green, A1
Freerksen, E; Rosenfeld, M1

Reviews

16 review(s) available for pyrazines and Disease Models, Animal

ArticleYear
The role and mechanism of tetramethylpyrazine for atherosclerosis in animal models: A systematic review and meta-analysis.
    PloS one, 2022, Volume: 17, Issue:5

    Topics: Animals; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Humans; Pyrazines

2022
Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials.
    CPT: pharmacometrics & systems pharmacology, 2020, Volume: 9, Issue:5

    Topics: Amides; Animals; Antiviral Agents; Clinical Trials as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Hemorrhagic Fever, Ebola; Humans; Models, Theoretical; Pyrazines

2020
Rodent models of chemotherapy-induced peripheral neuropathy.
    ILAR journal, 2014, Volume: 54, Issue:3

    Topics: Animals; Antineoplastic Agents; Axons; Boronic Acids; Bortezomib; Cisplatin; Disease Models, Animal; Mice; Nerve Degeneration; Paclitaxel; Peripheral Nervous System Diseases; Pyrazines; Rats; Vincristine

2014
Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10

    Topics: Amides; Amidines; Androstenes; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antiviral Agents; Benzofurans; Cytosine; Disease Models, Animal; Disease Outbreaks; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Immune Sera; Organophosphonates; Pyrazines; RNA, Small Interfering; Stilbenes; Virus Replication

2015
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
    Frontiers in bioscience : a journal and virtual library, 2008, May-01, Volume: 13

    Topics: Adamantane; Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Hypoglycemic Agents; Incretins; Nitriles; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Vildagliptin

2008
Proteasome inhibition for antibody-mediated rejection.
    Current opinion in organ transplantation, 2009, Volume: 14, Issue:6

    Topics: Animals; Antibodies; Boronic Acids; Bortezomib; Disease Models, Animal; Graft Rejection; Graft Survival; HLA Antigens; Humans; Immunity, Humoral; Kidney Transplantation; Plasma Cells; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines

2009
Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?
    Critical reviews in oncology/hematology, 2013, Volume: 85, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Neoplasms; Pyrazines; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand

2013
Proteasome inhibitors as new anticancer drugs.
    Current opinion in oncology, 2002, Volume: 14, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle Proteins; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Rats; Transcription Factors; Tumor Cells, Cultured

2002
Proteasome inhibition: a new anti-inflammatory strategy.
    Journal of molecular medicine (Berlin, Germany), 2003, Volume: 81, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Asthma; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Inflammation; Lysine; Models, Biological; Models, Chemical; Multienzyme Complexes; Multiple Sclerosis; Neoplasms; NF-kappa B; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Psoriasis; Pyrazines; Reperfusion Injury

2003
The proteasome: structure, function, and role in the cell.
    Cancer treatment reviews, 2003, Volume: 29 Suppl 1

    Topics: Animals; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Multienzyme Complexes; Neoplasms; Polyubiquitin; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines

2003
Targeting the ubiquitin-proteasome pathway in breast cancer.
    Clinical breast cancer, 2004, Volume: 5, Issue:2

    Topics: Animals; Boronic Acids; Bortezomib; Breast Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cysteine Endopeptidases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Mice; Molecular Biology; Multienzyme Complexes; Neoplasm Transplantation; NF-kappa B; Proteasome Endopeptidase Complex; Protein Transport; Pyrazines; Risk Factors; Sensitivity and Specificity; Survival Rate; Treatment Outcome; Ubiquitin

2004
Oltipraz: clinical opportunities for cancer chemoprevention. p.
    Journal of cellular biochemistry. Supplement, 1995, Volume: 22

    Topics: Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Disease Models, Animal; Evaluation Studies as Topic; Humans; Liver Neoplasms; Pyrazines; Risk Factors; Schistosomicides; Thiones; Thiophenes

1995
Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.
    Journal of cellular biochemistry. Supplement, 1997, Volume: 28-29

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Disease Models, Animal; Double-Blind Method; Humans; Liver Neoplasms; Placebos; Pyrazines; Rats; Thiones; Thiophenes; Treatment Outcome

1997
Glutathione S-transferases--biomarkers of cancer risk and chemopreventive response.
    Chemico-biological interactions, 1998, Apr-24, Volume: 111-112

    Topics: Animals; Anticarcinogenic Agents; Biomarkers; Brassica; Colitis, Ulcerative; Colorectal Neoplasms; Disease Models, Animal; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Inactivation, Metabolic; Mice; Neoplasms; Pyrazines; Risk Factors; Thiones; Thiophenes

1998
The proteasome: a new target for novel drug therapies.
    American journal of clinical pathology, 2001, Volume: 116, Issue:5

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Carcinoma, Lewis Lung; Clinical Trials, Phase I as Topic; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Humans; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Pyrazines

2001
Mechanisms of chemoprotection by oltipraz.
    Journal of cellular biochemistry. Supplement, 1992, Volume: 16I

    Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Humans; Pyrazines; Thiones; Thiophenes

1992

Trials

3 trial(s) available for pyrazines and Disease Models, Animal

ArticleYear
Phase 2 trial of rituximab and bortezomib in patients with relapsed or refractory mantle cell and follicular lymphoma.
    Cancer, 2011, Jun-01, Volume: 117, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Male; Mice; Middle Aged; Neoplasm Staging; Polymorphism, Single Nucleotide; Proteasome Inhibitors; Pyrazines; Receptors, IgG; Recurrence; Rituximab; Treatment Outcome

2011
Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Anorexia; Antineoplastic Agents; B-Lymphocytes; Benzamides; Cell Line, Tumor; Diarrhea; Disease Models, Animal; Disease-Free Survival; Dogs; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Humans; Lethargy; Lymphoma, Large B-Cell, Diffuse; Male; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Vomiting; Weight Loss

2016
Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.
    Journal of cellular biochemistry. Supplement, 1997, Volume: 28-29

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Disease Models, Animal; Double-Blind Method; Humans; Liver Neoplasms; Placebos; Pyrazines; Rats; Thiones; Thiophenes; Treatment Outcome

1997

Other Studies

397 other study(ies) available for pyrazines and Disease Models, Animal

ArticleYear
Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1-Deficient Polycystic Kidney Disease in Animal Model.
    Journal of the American Society of Nephrology : JASN, 2021, Volume: 32, Issue:9

    Topics: Aminopyridines; Animals; Benzamides; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Dogs; Epithelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Polycystic Kidney, Autosomal Dominant; Pyrazines; Signal Transduction; Sulfonamides

2021
The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model.
    EBioMedicine, 2021, Volume: 72

    Topics: Amides; Animals; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytidine; Disease Models, Animal; Drug Therapy, Combination; Female; Hydroxylamines; Lung; Mesocricetus; Pyrazines; RNA, Viral; Treatment Outcome; Viral Load

2021
Favipiravir Inhibits Mayaro Virus Infection in Mice.
    Viruses, 2021, 11-03, Volume: 13, Issue:11

    Topics: Alanine Transaminase; Alphavirus; Alphavirus Infections; Amides; Animals; Antiviral Agents; Aspartate Aminotransferases; Cell Line; Chlorocebus aethiops; Disease Models, Animal; Female; Liver; Mice; Mice, Inbred C57BL; Pyrazines; Vero Cells; Virus Replication

2021
Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Computational Biology; Disease Models, Animal; Immunoglobulin E; Lung; Male; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Rats; Rats, Sprague-Dawley; Respiratory Hypersensitivity; RNA, Messenger

2022
A novel approach for relapsed/refractory FLT3
    Molecular cancer, 2022, 03-04, Volume: 21, Issue:1

    Topics: Aniline Compounds; Animals; Disease Models, Animal; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; NF-kappa B p52 Subunit; NK Cell Lectin-Like Receptor Subfamily K; Protein Kinase Inhibitors; Pyrazines; T-Lymphocytes

2022
A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets.
    Biochimica et biophysica acta. Molecular cell research, 2022, Volume: 1869, Issue:8

    Topics: Animals; Blood Glucose; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Hypoglycemic Agents; Melatonin; Mice; Pyrazines; Sitagliptin Phosphate; Triazoles

2022
Tetramethylpyrazine nitrone TBN extends the lifespan of C. elegans by activating the Nrf2/SKN-1 signaling pathway.
    Biochemical and biophysical research communications, 2022, 07-23, Volume: 614

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; DNA-Binding Proteins; Longevity; NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Signal Transduction; Transcription Factors

2022
Susceptibility of Type I Interferon Receptor Knock-Out Mice to Heartland Bandavirus (HRTV) Infection and Efficacy of Favipiravir and Ribavirin in the Treatment of the Mice Infected with HRTV.
    Viruses, 2022, 07-28, Volume: 14, Issue:8

    Topics: Amides; Animals; Disease Models, Animal; Humans; Mice; Mice, Knockout; Phlebovirus; Pyrazines; Receptor, Interferon alpha-beta; Ribavirin; Solvents; Thrombocytopenia

2022
Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice.
    Alzheimer's research & therapy, 2022, 10-11, Volume: 14, Issue:1

    Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Luciferases; Mice; Mice, Transgenic; Mitophagy; Piperazine; PPAR gamma; Presenilin-1; Protein Kinases; Pyrazines; Rats; Sequestosome-1 Protein; Ubiquitin-Protein Ligases

2022
A STAT3-based gene signature stratifies glioma patients for targeted therapy.
    Nature communications, 2019, 08-09, Volume: 10, Issue:1

    Topics: Animals; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genetic Predisposition to Disease; Glioblastoma; Humans; Imidazoles; Insulin-Like Growth Factor Binding Protein 2; Mice; Pyrazines; Pyrazoles; Pyrimidines; Receptor, IGF Type 1; STAT3 Transcription Factor; Temozolomide; Xenograft Model Antitumor Assays

2019
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1
    Journal of medicinal chemistry, 2019, 09-12, Volume: 62, Issue:17

    Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Glutathione Transferase; Humans; Molecular Structure; Pyrazines; Rats; Structure-Activity Relationship

2019
Inhibition of TRPA1 and IL-6 signal alleviates neuropathic pain following chemotherapeutic bortezomib.
    Physiological research, 2019, 10-25, Volume: 68, Issue:5

    Topics: Acetanilides; Analgesics; Animals; Bortezomib; Disease Models, Animal; Ganglia, Spinal; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Proteasome Inhibitors; Purines; Pyrazines; Quinoxalines; Rats, Sprague-Dawley; Receptors, Interleukin-6; Sensory Receptor Cells; Signal Transduction; TRPA1 Cation Channel

2019
Hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites for ischemic stroke.
    Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19

    Topics: Animals; Apigenin; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Neurons; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats; Reperfusion Injury; Stroke

2019
Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes.
    Life sciences, 2019, Nov-01, Volume: 236

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Glucose Transporter Type 4; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Wistar; Signal Transduction; Vasodilator Agents

2019
Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice.
    Immunology, 2019, Volume: 158, Issue:4

    Topics: Animals; Antibodies, Antinuclear; Cell Differentiation; Cells, Cultured; Dendritic Cells; Dexamethasone; Disease Models, Animal; Humans; Immune Tolerance; Immunotherapy, Adoptive; Kidney; Lupus Erythematosus, Systemic; Lymphocyte Activation; Mice; Mice, Inbred MRL lpr; Pyrazines; Pyrroles; Rosiglitazone; T-Lymphocytes, Regulatory

2019
Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Benzamides; Cecum; Disease Models, Animal; Heart; Heart Diseases; Inflammasomes; Ligation; Male; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase Inhibitors; Punctures; Pyrazines; Pyrazoles; Pyrimidines; Sepsis

2019
Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood-stasis migraine model by blood-brain microdialysis method.
    Journal of pharmaceutical and biomedical analysis, 2020, Jan-05, Volume: 177

    Topics: Administration, Oral; Animals; Benzyl Alcohols; Blood-Brain Barrier; Cold Temperature; Coumaric Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Extracellular Fluid; Gastrodia; Glucosides; Humans; Ligusticum; Male; Microdialysis; Migraine Disorders; Permeability; Pyrazines; Rats; Specific Pathogen-Free Organisms; Vasoconstriction

2020
Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator
    International journal of molecular sciences, 2019, Oct-10, Volume: 20, Issue:20

    Topics: Animals; Copper Transporter 1; Diaphragm; Disease Models, Animal; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Myopathies, Nemaline; Pyrazines; Troponin

2019
Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling.
    Microvascular research, 2020, Volume: 128

    Topics: Angiotensin II; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelin-1; Hypertension, Renovascular; Ligation; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyrazines; Rats, Sprague-Dawley; Renal Artery; Signal Transduction; Temporal Arteries; Vascular Remodeling

2020
Ligustrazine suppresses renal NMDAR1 and caspase-3 expressions in a mouse model of sepsis-associated acute kidney injury.
    Molecular and cellular biochemistry, 2020, Volume: 464, Issue:1-2

    Topics: Acute Kidney Injury; Animals; Caspase 3; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Pyrazines; Receptors, N-Methyl-D-Aspartate; Sepsis

2020
Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus.
    Archives of pharmacal research, 2019, Volume: 42, Issue:12

    Topics: Administration, Oral; Animals; Diabetes, Gestational; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Female; Inflammation; Mice; Mice, Inbred C57BL; Oxidative Stress; Placenta; Pregnancy; Pyrazines

2019
Antitumor Potency of an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, Lisocabtagene Maraleucel in Combination With Ibrutinib or Acalabrutinib.
    Journal of immunotherapy (Hagerstown, Md. : 1997), 2020, Volume: 43, Issue:4

    Topics: Adenine; Animals; Antigens, CD19; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Biomarkers; Combined Modality Therapy; Cytokines; Cytotoxicity, Immunologic; Disease Models, Animal; Humans; Immunotherapy, Adoptive; Lymphocyte Activation; Mice; Neoplasms; Piperidines; Pyrazines; Receptors, Antigen, T-Cell; Receptors, Chimeric Antigen; T-Lymphocytes; Treatment Outcome; Xenograft Model Antitumor Assays

2020
Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.
    British journal of pharmacology, 2020, Volume: 177, Issue:12

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Pharmaceutical Preparations; Pulmonary Artery; Pyrazines; Rats; Rats, Sprague-Dawley

2020
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
    The Journal of clinical investigation, 2020, 05-01, Volume: 130, Issue:5

    Topics: Acinar Cells; Animals; Calcium; Calcium Signaling; Cell Death; Disease Models, Animal; Female; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Pancreas; Pancreatitis; Pressure; Pyrazines; Thiadiazoles; TRPV Cation Channels

2020
Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates.
    Antiviral research, 2020, Volume: 177

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Macaca fascicularis; Pyrazines; Ribavirin; Viral Load; Virus Replication

2020
NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
    BMC pulmonary medicine, 2020, Apr-06, Volume: 20, Issue:1

    Topics: Acetamides; Animals; Antihypertensive Agents; Disease Models, Animal; Heart Ventricles; Hemodynamics; Humans; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Pyrazines; Rats; Rats, Inbred WKY; Receptors, Thromboxane; Sildenafil Citrate; Vascular Remodeling

2020
Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020.
    Emerging infectious diseases, 2020, Volume: 26, Issue:7

    Topics: Amides; Animals; Belgium; Disease Models, Animal; Female; Humans; Junin virus; Pyrazines; Ribavirin

2020
6-Amino[1,2,5]oxadiazolo[3,4-
    Journal of medicinal chemistry, 2020, 06-11, Volume: 63, Issue:11

    Topics: Alanine Transaminase; Aniline Compounds; Animals; Cell Line; Diet, High-Fat; Disease Models, Animal; Half-Life; Liver; Mice; Mitochondria; Myoblasts; Non-alcoholic Fatty Liver Disease; Oxygen Consumption; Pyrazines; Rats; Structure-Activity Relationship; Triglycerides; Uncoupling Protein 1

2020
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
    Nature communications, 2020, 05-14, Volume: 11, Issue:1

    Topics: Adipose Tissue; Administration, Oral; Animals; Blood Glucose; Body Temperature; Body Weight; Diamines; Diet, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Clamp Technique; Humans; Insulin Resistance; Liver; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Obesity; Oxadiazoles; Oxidative Stress; Pyrazines

2020
Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Movement; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Male; Microglia; NF-kappa B; Pyrazines; Rats, Sprague-Dawley; Retinal Ganglion Cells; Signal Transduction; Toll-Like Receptor 4; Uveitis

2020
Efficacy of favipiravir (T-705) against Crimean-Congo hemorrhagic fever virus infection in cynomolgus macaques.
    Antiviral research, 2020, Volume: 181

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Drug Administration Schedule; Female; Hemorrhagic Fever Virus, Crimean-Congo; Hemorrhagic Fever, Crimean; Macaca fascicularis; Male; Pyrazines; Viral Load; Viremia; Virus Shedding

2020
Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson's disease models through activating the MEF2-PGC1α and BDNF/CREB pathways.
    Aging, 2020, 07-24, Volume: 12, Issue:14

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hydrazones; MEF2 Transcription Factors; Mice; Neurogenesis; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pyrazines; Rats; Signal Transduction; Treatment Outcome

2020
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
    Bioorganic & medicinal chemistry letters, 2020, 09-01, Volume: 30, Issue:17

    Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental; Binding Sites; Bridged Bicyclo Compounds; Crystallography, X-Ray; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Half-Life; Humans; Imidazoles; Molecular Dynamics Simulation; Protein Kinase Inhibitors; Pyrazines; Rats; Rats, Wistar; src-Family Kinases; Structure-Activity Relationship

2020
The Effect of Umbilical Cord Mesenchymal Stem Cells Combined with Tetramethylpyrazine Therapy on Ischemic Brain Injury: A Histological Study.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020, Volume: 29, Issue:12

    Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Combined Modality Therapy; Disease Models, Animal; Humans; Male; Mesenchymal Stem Cell Transplantation; Motor Activity; Nerve Regeneration; Neurogenesis; Neuroprotective Agents; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Umbilical Cord

2020
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 10-27, Volume: 117, Issue:43

    Topics: Amides; Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Coronavirus Infections; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Disease Transmission, Infectious; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Hydroxychloroquine; Lung; Pyrazines; SARS-CoV-2; Treatment Outcome; Vero Cells; Viral Load

2020
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats.
    PloS one, 2020, Volume: 15, Issue:10

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetamides; Animals; Cell Proliferation; Collagen Type I; Disease Models, Animal; Heart Ventricles; Hemodynamics; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Lung; Male; Pulmonary Arterial Hypertension; Pyrazines; Pyrroles; Rats, Sprague-Dawley; Receptors, Epoprostenol; Systole; Vascular Remodeling

2020
X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Benzamides; Disease Models, Animal; Inflammasomes; Macrophages; Male; Mice; Mice, Inbred CBA; Multiple Organ Failure; Phagocytosis; Piperidines; Protein Kinase Inhibitors; Pyrazines; Sepsis; X-Linked Combined Immunodeficiency Diseases

2020
The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease.
    Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Avoidance Learning; Cognition Disorders; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Hydrazones; MAP Kinase Signaling System; Memantine; Mice; Mice, Transgenic; Morris Water Maze Test; Neuroprotective Agents; Phosphorylation; Protein Processing, Post-Translational; Pyrazines; Random Allocation; Recognition, Psychology; Signal Transduction; tau Proteins; TOR Serine-Threonine Kinases

2021
2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation.
    Journal of molecular medicine (Berlin, Germany), 2021, Volume: 99, Issue:3

    Topics: Activating Transcription Factor 4; Animals; Cell Line, Tumor; Disease Models, Animal; Drug Evaluation, Preclinical; Electroretinography; Endoplasmic Reticulum Stress; Eye Proteins; Fasting; Female; Glucose; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Prion Proteins; Protein Aggregates; Protein Aggregation, Pathological; Pyrazines; Retina; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Single-Blind Method; Solubility; Specific Pathogen-Free Organisms; Transcription, Genetic

2021
Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway.
    The American journal of Chinese medicine, 2021, Volume: 49, Issue:2

    Topics: Animals; Becaplermin; Cell Cycle; Cell Proliferation; China; Disease Models, Animal; Inflammation; Male; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pyrazines; Rats; Rats, Sprague-Dawley

2021
Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model.
    Nature communications, 2021, 03-19, Volume: 12, Issue:1

    Topics: Amides; Animals; Antiviral Agents; Chlorocebus aethiops; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Female; Genome, Viral; Lung; Mesocricetus; Pyrazines; SARS-CoV-2; Vero Cells; Viral Load

2021
Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates.
    PLoS neglected tropical diseases, 2021, Volume: 15, Issue:3

    Topics: Amides; Animals; Antiviral Agents; Cytokine Release Syndrome; Cytokines; Disease Models, Animal; Ebolavirus; Hemorrhagic Fever, Ebola; Macaca fascicularis; Pyrazines; T-Lymphocytes; Viral Load; Viremia; Virus Replication

2021
Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats.
    Current medical science, 2021, Volume: 41, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Hippocampus; Humans; Hyperhomocysteinemia; Memory Disorders; Neurons; Neuroprotective Agents; Phosphorylation; Pyrazines; Rats; Rats, Sprague-Dawley

2021
Favipiravir treatment prolongs the survival in a lethal mouse model intracerebrally inoculated with Jamestown Canyon virus.
    PLoS neglected tropical diseases, 2021, Volume: 15, Issue:7

    Topics: Amides; Animals; Antiviral Agents; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalitis Virus, California; Encephalitis, California; Female; Humans; Mice; Mice, Inbred C57BL; Pyrazines; Vero Cells

2021
Tetramethylpyrazine inhibits neutrophil extracellular traps formation and alleviates hepatic ischemia/reperfusion injury in rat liver transplantation.
    Experimental cell research, 2021, 09-01, Volume: 406, Issue:1

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cell-Free Nucleic Acids; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Extracellular Traps; In Situ Nick-End Labeling; Liver; Liver Transplantation; Male; NADPH Oxidases; Neutrophils; Onium Compounds; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome

2021
Bioluminescent Optogenetics: A Novel Experimental Therapy to Promote Axon Regeneration after Peripheral Nerve Injury.
    International journal of molecular sciences, 2021, Jul-05, Volume: 22, Issue:13

    Topics: Animals; Axons; Disease Models, Animal; Evoked Potentials, Motor; Female; Humans; Imidazoles; Luminescent Agents; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Nerve Regeneration; Optogenetics; Peripheral Nerve Injuries; Pyrazines; Recombinant Fusion Proteins; Regenerative Medicine

2021
STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV).
    Viruses, 2021, 07-17, Volume: 13, Issue:7

    Topics: Amides; Animals; Antibodies, Viral; Antiviral Agents; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Male; Mice; Mice, Knockout; Pyrazines; STAT1 Transcription Factor; Viral Proteins

2021
Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice.
    Neurobiology of disease, 2021, Volume: 159

    Topics: Action Potentials; Animals; Asymptomatic Diseases; Disease Models, Animal; Mice; Mice, Knockout; Morpholinos; Muscle, Skeletal; Neuromuscular Junction; Oligonucleotides, Antisense; Pyrazines; Pyrimidines; Spinal Muscular Atrophies of Childhood; Survival of Motor Neuron 1 Protein

2021
Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia.
    Neuropharmacology, 2017, 05-15, Volume: 118

    Topics: Animals; Axons; Caspase 3; Cell Hypoxia; Cells, Cultured; Cerebrovascular Circulation; Disease Models, Animal; Embryo, Mammalian; Glucose; Hippocampus; Hypoxia-Ischemia, Brain; Male; Maze Learning; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Recognition, Psychology

2017
Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents.
    Chemical & pharmaceutical bulletin, 2017, Volume: 65, Issue:4

    Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Lactates; Male; Molecular Structure; Myocardial Ischemia; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship

2017
Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia.
    Investigational new drugs, 2017, Volume: 35, Issue:5

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Disease Models, Animal; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Nude; Mutation; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrazines; Receptor Protein-Tyrosine Kinases; Xenograft Model Antitumor Assays

2017
Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, Oct-01, Volume: 23, Issue:19

    Topics: Adenosine; Agammaglobulinaemia Tyrosine Kinase; Animals; Apoptosis; B-Lymphocytes; Benzamides; Cell Line, Tumor; Cell Proliferation; Class Ia Phosphatidylinositol 3-Kinase; Disease Models, Animal; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Quinolines; Tumor Microenvironment

2017
Inhibitory effects of tetramethylpyrazine on pain transmission of trigeminal neuralgia in CCI-ION rats.
    Brain research bulletin, 2017, Volume: 134

    Topics: Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; HEK293 Cells; Humans; Hyperalgesia; Male; MAP Kinase Signaling System; Membrane Potentials; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Pyrazines; Random Allocation; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; RNA, Messenger; Trigeminal Ganglion; Trigeminal Neuralgia

2017
Enhanced protection against experimental Junin virus infection through the use of a modified favipiravir loading dose strategy.
    Antiviral research, 2017, Volume: 145

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hemorrhagic Fever, American; Junin virus; Pyrazines; Survival Analysis; Viral Load

2017
Tetramethylpyrazine alleviates neural apoptosis in injured spinal cord via the downregulation of miR-214-3p.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 94

    Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Down-Regulation; Flow Cytometry; HEK293 Cells; Humans; In Situ Nick-End Labeling; Male; MicroRNAs; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Injuries; Up-Regulation

2017
Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation.
    Cephalalgia : an international journal of headache, 2018, Volume: 38, Issue:7

    Topics: Animals; Benzyl Alcohols; Disease Models, Animal; Dura Mater; Glucosides; Levetiracetam; Male; Medicine, Chinese Traditional; Migraine Disorders; Neurons, Afferent; Nociceptive Pain; Pain Management; Propranolol; Pyrazines; Rats, Sprague-Dawley; Trigeminal Nerve

2018
Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir.
    Virology, 2017, Volume: 511

    Topics: Amides; Animal Structures; Animals; Antiviral Agents; Bunyaviridae Infections; Chemoprevention; Cricetinae; Disease Models, Animal; Inflammation; Interferon Type I; Pyrazines; STAT2 Transcription Factor; Treatment Outcome

2017
Determining Ribavirin's mechanism of action against Lassa virus infection.
    Scientific reports, 2017, 09-15, Volume: 7, Issue:1

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Drug Therapy, Combination; Lassa Fever; Lassa virus; Mice, Inbred C57BL; Models, Theoretical; Pyrazines; Ribavirin; Treatment Outcome; Viral Load

2017
Effects of Ligustrazine on Airway Inflammation in A Mouse Model of Neutrophilic Asthma.
    Chinese journal of integrative medicine, 2018, Volume: 24, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Interleukin-10; Interleukin-17; Leukocyte Count; Lung; Mice, Inbred C57BL; Neutrophils; Pneumonia; Pyrazines; Respiratory Hypersensitivity

2018
Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice.
    Glia, 2018, Volume: 66, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Transporter 2; Forkhead Transcription Factors; Homeodomain Proteins; Male; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Nuclear Proteins; Pentylenetetrazole; Pyrazines; Receptors, N-Methyl-D-Aspartate; Seizures; Transcription Factors

2018
Intracellular conversion and in vivo dose response of favipiravir (T-705) in rodents infected with Ebola virus.
    Antiviral research, 2018, Volume: 151

    Topics: Amides; Animals; Antiviral Agents; Cell Line; Cell Survival; Cytoplasm; Disease Models, Animal; Dose-Response Relationship, Drug; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Marburgvirus; Mice, Inbred C57BL; Pyrazines; Survival Analysis; Virus Replication

2018
Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus.
    Antiviral research, 2018, Volume: 151

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Male; Marburg Virus Disease; Marburgvirus; Primates; Pyrazines; RNA, Viral; Survival Analysis; Viral Load

2018
Successful treatment of Marburg virus with orally administrated T-705 (Favipiravir) in a mouse model.
    Antiviral research, 2018, Volume: 151

    Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Chlorocebus aethiops; Disease Models, Animal; Female; Marburg Virus Disease; Marburgvirus; Mice, Inbred BALB C; Pyrazines; RNA, Viral; Survival Analysis; Vero Cells; Viral Load; Virus Replication

2018
Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke.
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: Animals; Brain Ischemia; Carnitine; Disease Models, Animal; Male; NADPH Oxidase 2; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Stroke

2017
Role of the serotonergic system in urethral continence reflexes during sneezing in rats.
    American journal of physiology. Renal physiology, 2018, 07-01, Volume: 315, Issue:1

    Topics: Animals; Disease Models, Animal; Female; Fenclonine; Piperazines; Pressure; Pyrazines; Rats, Sprague-Dawley; Receptors, Serotonin; Reflex; Serotonergic Neurons; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists; Sneezing; Urethra; Urinary Incontinence, Stress

2018
Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.
    JCI insight, 2018, 03-08, Volume: 3, Issue:5

    Topics: Animals; beta Catenin; Disease Models, Animal; Female; Heterocyclic Compounds, 3-Ring; Humans; Injections, Intraperitoneal; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Polycystic Kidney, Autosomal Dominant; Pyrazines; Pyridines; Random Allocation; Survival Analysis; Treatment Outcome; TRPP Cation Channels; Wnt Signaling Pathway

2018
Bioluminescence-driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model.
    Journal of neuroscience research, 2020, Volume: 98, Issue:3

    Topics: Animals; Disease Models, Animal; Female; Imidazoles; Luminescent Agents; Luminescent Measurements; Luminescent Proteins; Male; Mice, Transgenic; Motor Activity; Neural Stem Cells; Opsins; Optogenetics; Parkinson Disease; Pyrazines; Rotarod Performance Test

2020
The effect of combined drugs therapy on the course of clinical rabies infection in a murine model.
    Vaccine, 2019, 08-02, Volume: 37, Issue:33

    Topics: Amides; Animals; Antibodies, Viral; Antiviral Agents; Disease Models, Animal; Drug Therapy, Combination; Female; Immunity, Innate; Mice; Mice, Inbred C57BL; Pyrazines; Rabies; Rabies virus; Ribavirin; Serpins; Viral Proteins; Virus Replication

2019
Second-Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018, Volume: 33, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Animals; Bone and Bones; Cherubism; Disease Models, Animal; Indazoles; Inflammation; Mice; Protein Kinase Inhibitors; Pyrazines; Syk Kinase

2018
Effective Treatment of Experimental Lymphocytic Choriomeningitis Virus Infection: Consideration of Favipiravir for Use With Infected Organ Transplant Recipients.
    The Journal of infectious diseases, 2018, 07-13, Volume: 218, Issue:4

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Female; Immunocompromised Host; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Male; Mice, Inbred NZB; Pyrazines; Ribavirin; Survival Analysis; Transplant Recipients; Treatment Outcome; Viral Load

2018
Favipiravir (T-705) protects against Nipah virus infection in the hamster model.
    Scientific reports, 2018, 05-15, Volume: 8, Issue:1

    Topics: Administration, Oral; Amides; Animals; Cricetinae; Disease Models, Animal; Female; Hendra Virus; Henipavirus Infections; Humans; Injections, Subcutaneous; Nipah Virus; Pyrazines; Transcription, Genetic; Treatment Outcome; Virus Replication

2018
Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization.
    Investigative ophthalmology & visual science, 2018, 04-01, Volume: 59, Issue:5

    Topics: Animals; Blotting, Western; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; Nuclear Respiratory Factor 1; Pyrazines; Real-Time Polymerase Chain Reaction; Receptors, CXCR4; Sodium Hydroxide; Vasodilator Agents

2018
Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice.
    Antiviral research, 2018, Volume: 157

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Hemorrhagic Fever Virus, Crimean-Congo; Hemorrhagic Fever, Crimean; Mice; Pyrazines; Ribavirin; RNA, Viral; Survival Analysis; Treatment Outcome; Viral Load

2018
Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage.
    Neurochemical research, 2018, Volume: 43, Issue:8

    Topics: Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; eIF-2 Kinase; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Subarachnoid Hemorrhage; Vasodilator Agents

2018
Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers.
    The Journal of clinical investigation, 2018, 08-31, Volume: 128, Issue:9

    Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Cell Line, Tumor; Coumarins; Crizotinib; Disease Models, Animal; Drug Resistance, Neoplasm; Genes, p53; Humans; Indoles; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mutation, Missense; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-met; Pyrazines; Sulfonamides; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Triazoles

2018
Tetramethylpyrazine‑2'O‑sodium ferulate provides neuroprotection against neuroinflammation and brain injury in MCAO/R rats by suppressing TLR-4/NF-κB signaling pathway.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 176

    Topics: Animals; Brain Edema; Brain Injuries; Chemokine CCL2; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA

2019
New Optical Imaging Reporter-labeled Anaplastic Thyroid Cancer-Derived Extracellular Vesicles as a Platform for In Vivo Tumor Targeting in a Mouse Model.
    Scientific reports, 2018, 09-10, Volume: 8, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Extracellular Vesicles; Female; Genes, Reporter; Humans; Imidazoles; Luciferases, Renilla; Luminescent Agents; Mice; Mice, Nude; Optical Imaging; Pyrazines; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Xenograft Model Antitumor Assays

2018
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:12

    Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Antimalarials; Biotransformation; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Gene Expression; Humans; Malaria, Falciparum; Male; Mice; Mice, Inbred NOD; Mice, SCID; Parasitemia; Plasmodium falciparum; Prodrugs; Pyrazines; Sulfones; Sulfoxides; Treatment Outcome

2018
Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies.
    Nature communications, 2018, 10-01, Volume: 9, Issue:1

    Topics: Amides; Animals; Antiviral Agents; Cytokines; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Host-Pathogen Interactions; Interferon-alpha; Macaca; Models, Theoretical; Pyrazines; Survival Analysis; Time Factors; Viral Load

2018
SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.
    JCI insight, 2018, 10-04, Volume: 3, Issue:19

    Topics: Administration, Oral; Animals; B-Lymphocytes; Disease Models, Animal; Drug Evaluation, Preclinical; Eye; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Indazoles; Mice; Protein Kinase Inhibitors; Pyrazines; Skin; Survival Analysis; Syk Kinase; T-Lymphocytes; Treatment Outcome

2018
Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Administration, Oral; Amides; Animals; Antibodies, Neutralizing; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Phlebotomus Fever; Phlebovirus; Pyrazines; Vero Cells

2018
Favipiravir inhibits in vitro Usutu virus replication and delays disease progression in an infection model in mice.
    Antiviral research, 2018, Volume: 160

    Topics: Amides; Animal Structures; Animals; Antiviral Agents; Disease Models, Animal; Flavivirus; Flavivirus Infections; Mice; Microbial Sensitivity Tests; Pyrazines; Treatment Outcome; Viral Load; Virus Replication

2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.
    Scientific reports, 2018, 11-01, Volume: 8, Issue:1

    Topics: alpha-Synuclein; Animals; Cerebral Cortex; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; Lewy Body Disease; Mice; Mice, Transgenic; Multiple System Atrophy; Neurons; Parkinson Disease; Piperidines; Protein Aggregation, Pathological; Protein Folding; Pyrazines; Pyrimidines; Retina

2018
Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus.
    Viruses, 2018, 11-03, Volume: 10, Issue:11

    Topics: Amides; Animals; Antiviral Agents; Cytokines; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Female; Immunocompromised Host; Influenza A Virus, H1N1 Subtype; Mice; Orthomyxoviridae Infections; Oseltamivir; Pyrazines

2018
Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-κB and Nrf-2/HO-1 pathways.
    Archives of pharmacal research, 2019, Volume: 42, Issue:9

    Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Heme Oxygenase (Decyclizing); Inflammation; Injections, Subcutaneous; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Sirtuin 1; Structure-Activity Relationship

2019
Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: Alkalies; Animals; Burns, Chemical; Cell Line; Cell Movement; Cornea; Corneal Neovascularization; Disease Models, Animal; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrazines; Receptors, CXCR4; Signal Transduction; Up-Regulation

2019
Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 04-01, Volume: 25, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cells, Cultured; Checkpoint Kinase 1; Child; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Humans; Mice; Neoplasms; Protein Kinase Inhibitors; Pyrazines; Pyrazoles; Sarcoma, Ewing; Xenograft Model Antitumor Assays

2019
Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cytokines; Disease Models, Animal; Fibrosis; Heart Failure; Inflammation Mediators; Isoproterenol; Myocytes, Cardiac; Oxidative Stress; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Thiones; Thiophenes; Ventricular Function, Left; Ventricular Remodeling

2018
Optimizing T-705 (favipiravir) treatment of severe influenza B virus infection in the immunocompromised mouse model.
    The Journal of antimicrobial chemotherapy, 2019, 05-01, Volume: 74, Issue:5

    Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Disease Models, Animal; Dogs; Epithelial Cells; Female; Immunocompromised Host; Influenza B virus; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Orthomyxoviridae Infections; Pyrazines; Viral Load; Virus Replication

2019
Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir.
    Viruses, 2019, 02-03, Volume: 11, Issue:2

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Ebolavirus; Female; Filoviridae; Filoviridae Infections; Gene Knockout Techniques; Hemorrhagic Fever, Ebola; Liver; Male; Marburg Virus Disease; Marburgvirus; Mice; Mice, Knockout; Proof of Concept Study; Pyrazines; Receptors, Interferon; RNA, Viral; Spleen; Virulence

2019
Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet.
    Molecular medicine reports, 2019, Volume: 19, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Biopsy; Blood Glucose; Cytokines; Diet, High-Fat; Disease Models, Animal; Female; Hepatitis; Inflammation Mediators; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Pyrazines; Reactive Oxygen Species

2019
The Controlled Release and Anti-Inflammatory Activity of a Tetramethylpyrazine-Loaded Thermosensitive Poloxamer Hydrogel.
    Pharmaceutical research, 2019, Feb-19, Volume: 36, Issue:4

    Topics: Acetic Acid; Adhesiveness; Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Animals; Anti-Inflammatory Agents; Biological Availability; Blood-Brain Barrier; Capillary Permeability; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Liberation; Gastritis; Hydrogels; Poloxamer; Pyrazines; Rats, Sprague-Dawley; Temperature; Viscosity

2019
BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
    Stem cell research & therapy, 2019, 02-22, Volume: 10, Issue:1

    Topics: Amacrine Cells; Animals; Apoptosis; Caspase 3; Cell Differentiation; Diamines; Disease Models, Animal; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Ki-67 Antigen; Neurofilament Proteins; Neurons; Oxadiazoles; Photoreceptor Cells; Protective Agents; Pyrazines; Retina; Retinal Ganglion Cells; Specimen Handling; Transportation; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53

2019
Tetramethylpyrazine reduces the consequences of nitric oxide inhibition in pregnant rats.
    Journal of cellular physiology, 2019, Volume: 234, Issue:11

    Topics: Animals; Blood Pressure; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Female; Gene Expression Regulation; Heat-Shock Proteins; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Placenta; Pre-Eclampsia; Pregnancy; Pyrazines; Rats; Transcription Factor CHOP; Vascular Endothelial Growth Factor Receptor-1

2019
Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
    European journal of pharmacology, 2019, Jul-05, Volume: 854

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Gabapentin; Male; Mice; Mice, Inbred C57BL; Morphinans; Neuralgia; Peripheral Nerve Injuries; Pyrazines; Spinal Cord Injuries

2019
Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke.
    Neuroreport, 2019, 06-12, Volume: 30, Issue:9

    Topics: Animals; Disease Models, Animal; Doublecortin Protein; Hydrazones; Male; Nerve Regeneration; Neurogenesis; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function; Stroke

2019
Evaluation of Selective 5-HT
    ACS chemical neuroscience, 2019, 07-17, Volume: 10, Issue:7

    Topics: Animals; Benzazepines; Disease Models, Animal; Ethylamines; Fenfluramine; Indoles; Mice; Piperazines; Pyrazines; Rats; Receptor, Serotonin, 5-HT2C; Seizures; Serotonin 5-HT2 Receptor Agonists; Treatment Outcome

2019
Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression.
    Molecular cancer therapeutics, 2019, Volume: 18, Issue:8

    Topics: Animals; Axl Receptor Tyrosine Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mutation; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrazines; Pyrrolidines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Xenograft Model Antitumor Assays

2019
Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models.
    Neuromolecular medicine, 2019, Volume: 21, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Basilar Artery; Brain Damage, Chronic; Cerebral Cortex; Disease Models, Animal; Free Radicals; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Hippocampus; Hydrogen Peroxide; Isometric Contraction; Male; Nerve Tissue Proteins; NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial

2019
Therapeutic efficacy of favipiravir against Bourbon virus in mice.
    PLoS pathogens, 2019, Volume: 15, Issue:6

    Topics: Amides; Animals; Antiviral Agents; Chlorocebus aethiops; Disease Models, Animal; Humans; Mice; Mice, Knockout; Orthomyxoviridae Infections; Pyrazines; Receptor, Interferon alpha-beta; Thogotovirus; Vero Cells; Viral Tropism

2019
Deep Metabolomics of a High-Grade Serous Ovarian Cancer Triple-Knockout Mouse Model.
    Journal of proteome research, 2019, 08-02, Volume: 18, Issue:8

    Topics: Animals; Bilirubin; Biomarkers, Tumor; Chromatography, Liquid; Cystadenocarcinoma, Serous; Disease Models, Animal; Female; Humans; Metabolomics; Mice; Mice, Knockout; Neoplasm Staging; Oligopeptides; Ovarian Neoplasms; Phospholipids; Pyrazines; Sphingomyelins; Sterols; Tandem Mass Spectrometry; Uridine

2019
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 11-15, Volume: 25, Issue:22

    Topics: Aniline Compounds; Animals; Apoptosis; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; fms-Like Tyrosine Kinase 3; Gene Duplication; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Staurosporine; Sulfonamides; Xenograft Model Antitumor Assays

2019
Characterization of a novel mouse model of multiple myeloma and its use in preclinical therapeutic assessment.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Boronic Acids; Bortezomib; Disease Models, Animal; Gene Expression; Genes, Reporter; Graft Survival; Humans; Injections; Luciferases; Luminescent Measurements; Magnetic Resonance Imaging; Melphalan; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Neoplasm Transplantation; Paraproteins; Plasma Cells; Pyrazines; Syndecan-1; Tibia; Tumor Microenvironment

2013
Tetramethylpyrazine prevents contrast-induced nephropathy by inhibiting p38 MAPK and FoxO1 signaling pathways.
    American journal of nephrology, 2013, Volume: 37, Issue:3

    Topics: Acute Kidney Injury; Animals; Apoptosis; Contrast Media; Disease Models, Animal; Forkhead Transcription Factors; Immunohistochemistry; Kidney Cortex Necrosis; Male; Microscopy, Electron, Transmission; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction

2013
Inhibition of proteasomal glucocorticoid receptor degradation restores dexamethasone-mediated stabilization of the blood-brain barrier after traumatic brain injury.
    Critical care medicine, 2013, Volume: 41, Issue:5

    Topics: Animals; Blood Gas Analysis; Blood-Brain Barrier; Blotting, Western; Boronic Acids; Bortezomib; Brain Edema; Brain Injuries; Dexamethasone; Disease Models, Animal; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Multivariate Analysis; Proteasome Endopeptidase Complex; Pyrazines; Random Allocation; Real-Time Polymerase Chain Reaction; Receptors, Glucocorticoid; Reference Values; RNA, Messenger; Sensitivity and Specificity; Statistics, Nonparametric

2013
Fast skeletal muscle troponin activator in the dy2J muscular dystrophy model.
    Muscle & nerve, 2013, Volume: 48, Issue:2

    Topics: Analysis of Variance; Animals; Creatine Kinase; Disease Models, Animal; Female; Imidazoles; Laminin; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Fibers, Skeletal; Muscle Strength; Muscular Dystrophies; Mutation; Physical Endurance; Pyrazines; Respiratory Physiological Phenomena; Troponin

2013
Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis.
    Physiology & behavior, 2013, Apr-10, Volume: 114-115

    Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dopamine Agonists; Glucagon-Like Peptide 1; Liraglutide; Male; Mice; Psychotic Disorders; Pyrazines; Sitagliptin Phosphate; Statistics, Nonparametric; Triazoles

2013
The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.
    American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Cytoskeletal Proteins; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Knockout; NF-E2-Related Factor 2; Pulmonary Disease, Chronic Obstructive; Pyrazines; Tenascin; Thiones; Thiophenes

2013
Therapeutic enhancement of ER stress by insulin-like growth factor I sensitizes myeloma cells to proteasomal inhibitors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jul-01, Volume: 19, Issue:13

    Topics: Animals; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Female; Humans; Insulin-Like Growth Factor I; Multiple Myeloma; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Pyrazines; Signal Transduction; Unfolded Protein Response; Xenograft Model Antitumor Assays

2013
Effect of combined therapy of human Wharton's jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats.
    Endocrine, 2014, Volume: 45, Issue:2

    Topics: Animals; C-Peptide; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Streptozocin; Treatment Outcome; Triazoles; Umbilical Cord

2014
Reduced CXCR4 expression is associated with extramedullary disease in a mouse model of myeloma and predicts poor survival in multiple myeloma patients treated with bortezomib.
    Leukemia, 2013, Volume: 27, Issue:10

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Mice; Multiple Myeloma; Prognosis; Pyrazines; Receptors, CXCR4; Sarcoma, Myeloid; Survival Rate

2013
Proteasome inhibitor PS-341 attenuates flow-induced pulmonary arterial hypertension.
    Clinical and experimental medicine, 2014, Volume: 14, Issue:3

    Topics: Animals; Blotting, Western; Boronic Acids; Bortezomib; Disease Models, Animal; Gene Expression Profiling; Hypertension, Pulmonary; Immunohistochemistry; Lung; Male; NF-kappa B; Proliferating Cell Nuclear Antigen; Proteasome Inhibitors; Pyrazines; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Smad Proteins; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Remodeling

2014
Targeted silencing of DNA-specific B cells combined with partial plasma cell depletion displays additive effects on delaying disease onset in lupus-prone mice.
    Clinical and experimental immunology, 2013, Volume: 174, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Autoantigens; B-Lymphocytes; Boronic Acids; Bortezomib; Cyclophosphamide; Disease Models, Animal; Disease Susceptibility; DNA; Female; Humans; Lupus Erythematosus, Systemic; Lymphocyte Depletion; Mice; Mice, Inbred MRL lpr; Peptide Fragments; Pyrazines; Receptors, IgG; Recombinant Fusion Proteins

2013
PAX3-FOXO1 induces up-regulation of Noxa sensitizing alveolar rhabdomyosarcoma cells to apoptosis.
    Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:7

    Topics: Animals; Apoptosis; Biphenyl Compounds; Boronic Acids; Bortezomib; Cell Line, Tumor; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Mice; Myoblasts; Nitrophenols; Oligopeptides; Oncogene Proteins, Fusion; Paired Box Transcription Factors; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rhabdomyosarcoma, Alveolar; Sulfonamides; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2013
Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened.
    ChemMedChem, 2013, Volume: 8, Issue:8

    Topics: Animals; Cell Line; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Half-Life; Humans; Mice; Pyrazines; Pyridazines; Rats; Receptors, G-Protein-Coupled; Smoothened Receptor; Solubility; Structure-Activity Relationship

2013
Tetramethylpyrazine upregulates the aquaporin 8 expression of hepatocellular mitochondria in septic rats.
    The Journal of surgical research, 2013, Volume: 185, Issue:1

    Topics: Animals; Aquaporins; Calcium Channel Blockers; Disease Models, Animal; Hepatocytes; Liver Diseases; Male; Mitochondria, Liver; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis; Tumor Necrosis Factor-alpha; Up-Regulation

2013
Synergistic induction of apoptosis in multiple myeloma cells by bortezomib and hypoxia-activated prodrug TH-302, in vivo and in vitro.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Myeloma; Nitroimidazoles; Phosphoramide Mustards; Pyrazines; Signal Transduction

2013
[Effects of combination of Salvia and Ligustrazine on TNF-α and TGF-β1 in serum and BALF of rats with pulmonary fibrosis].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2013, Volume: 29, Issue:7

    Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drugs, Chinese Herbal; Idiopathic Pulmonary Fibrosis; Lung; Male; Pyrazines; Rats; Salvia; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2013
Sitagliptin therapy enhances the number of circulating angiogenic cells and angiogenesis-evaluations in vitro and in the rat critical limb ischemia model.
    Cytotherapy, 2013, Volume: 15, Issue:9

    Topics: Adipose Tissue; Animals; Arteries; Biomarkers; Cell Movement; Disease Models, Animal; Endothelial Cells; Hindlimb; Ischemia; Male; Neovascularization, Physiologic; Pyrazines; Rats; Rats, Inbred F344; Regional Blood Flow; Sitagliptin Phosphate; Stem Cells; Triazoles

2013
The effects of DPP-IV inhibition in NOD mice with overt diabetes.
    Folia biologica, 2013, Volume: 59, Issue:3

    Topics: Animals; Diabetes Mellitus, Type 1; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Islets of Langerhans; Lymph Nodes; Mice; Mice, Inbred NOD; Pyrazines; Sitagliptin Phosphate; Spleen; T-Lymphocyte Subsets; Time Factors; Triazoles

2013
Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure.
    Circulation. Heart failure, 2013, Sep-01, Volume: 6, Issue:5

    Topics: Adult; Aged; Animals; Apoptosis; Biomarkers; Case-Control Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Glucagon-Like Peptide 1; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Myocardium; Natriuretic Peptide, Brain; Pulmonary Edema; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling

2013
Intravenous administration of tetramethylpyrazine reduces intestinal ischemia-reperfusion injury in rats.
    The American journal of Chinese medicine, 2013, Volume: 41, Issue:4

    Topics: Administration, Intravenous; Animals; Apoptosis; Disease Models, Animal; Goblet Cells; Intestinal Mucosa; Jejunum; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Paneth Cells; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents

2013
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
    Bioorganic & medicinal chemistry, 2013, Nov-01, Volume: 21, Issue:21

    Topics: Animals; Antiprotozoal Agents; Aza Compounds; Cations; Cell Line; Cell Survival; Disease Models, Animal; Mice; Myoblasts; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Poly dA-dT; Prodrugs; Pyrazines; Rats; Structure-Activity Relationship; Transition Temperature; Trypanosoma brucei rhodesiense; Trypanosomiasis, African

2013
Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:12

    Topics: Animals; Boronic Acids; Bortezomib; Disease Models, Animal; Endoplasmic Reticulum Stress; Mice; Muscle Weakness; Muscle, Skeletal; Myositis; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Signal Transduction; Ubiquitin; Ubiquitination

2013
The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Oct-15, Volume: 19, Issue:20

    Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Humans; Imidazoles; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Protein Biosynthesis; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Pyrazines; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays

2013
Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: Animals; Apoptosis; Body Weight; Cardiotonic Agents; Creatine Kinase, MB Form; Disease Models, Animal; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glutathione Peroxidase; Heart; Heart Ventricles; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocytes, Cardiac; Organ Size; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles

2013
Opposing effects on immune function and skin barrier regulation by the proteasome inhibitor bortezomib in an allergen-induced eczema model.
    Experimental dermatology, 2013, Volume: 22, Issue:11

    Topics: Animals; Boronic Acids; Bortezomib; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dermatitis, Atopic; Disease Models, Animal; Eczema; Female; Immune System; Immunoglobulin E; Immunohistochemistry; Inflammation; Mice; Mice, Inbred BALB C; Organ Culture Techniques; Proteasome Inhibitors; Pyrazines; Skin

2013
Intratibial injection of human multiple myeloma cells in NOD/SCID IL-2Rγ(null) mice mimics human myeloma and serves as a valuable tool for the development of anticancer strategies.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Dexamethasone; Disease Models, Animal; Flow Cytometry; Humans; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Pyrazines; Receptors, Interleukin-2

2013
Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Fibronectins; Fibrosis; Glucagon-Like Peptide 1; Glucose Intolerance; Hypoglycemic Agents; Insulin; Male; Metformin; Myocardium; Myocytes, Cardiac; PPAR delta; Protein Isoforms; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles

2013
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Ligusticum; Male; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxidopamine; Parkinson Disease; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Substantia Nigra; Zebrafish

2014
Antibody against tumor necrosis factor-α reduces bortezomib-induced allodynia in a rat model.
    Anticancer research, 2013, Volume: 33, Issue:12

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Female; Hyperalgesia; Pyrazines; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2013
Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
    Antioxidants & redox signaling, 2014, Oct-10, Volume: 21, Issue:11

    Topics: Animals; Cyclooxygenase 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Exenatide; Gene Expression Regulation; Humans; Hypertension; Ion Channels; Male; Mice; Mitochondria; Mitochondrial Proteins; Models, Biological; Oxidative Stress; Peptides; Pyrazines; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Renal Artery; Sitagliptin Phosphate; Triazoles; Uncoupling Protein 2; Vasoconstriction; Venoms

2014
Assessment of the early stage of cardiac remodeling of spontaneously hypertensive heart failure rats using the quantitative 3-dimensional analysis provided by acipimox-enhanced FDG-PET.
    The international journal of cardiovascular imaging, 2014, Volume: 30, Issue:2

    Topics: Animals; Arterial Pressure; Cardiac Catheterization; Disease Models, Animal; Fibrosis; Fluorodeoxyglucose F18; Heart Failure; Heart Ventricles; Hypertension; Imaging, Three-Dimensional; Lipid Metabolism; Male; Positron-Emission Tomography; Predictive Value of Tests; Pyrazines; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke Volume; Time Factors; Ventricular Function, Left; Ventricular Remodeling

2014
Favipiravir (T-705) inhibits Junín virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:12

    Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Disease Models, Animal; Guinea Pigs; Hemorrhagic Fever, American; Injections, Intraperitoneal; Junin virus; Male; Plasma; Pyrazines; Survival Analysis; Viremia

2013
Parathyroid hormone receptor mediates the anti-myeloma effect of proteasome inhibitors.
    Bone, 2014, Volume: 61

    Topics: Animals; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Humans; Male; Mice; Multiple Myeloma; Oligopeptides; Proteasome Inhibitors; Pyrazines; Receptor, Parathyroid Hormone, Type 1

2014
Effect of sitagliptin treatment on metabolism and cardiac function in genetic diabetic mice.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Heart; Heart Function Tests; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium; Pyrazines; Sitagliptin Phosphate; Triazoles

2014
Treatment with anti-TNF alpha protects against the neuropathy induced by the proteasome inhibitor bortezomib in a mouse model.
    Experimental neurology, 2014, Volume: 253

    Topics: Action Potentials; Animals; Antibodies; Boronic Acids; Bortezomib; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Mice; Motor Activity; Neural Conduction; Neurotoxicity Syndromes; Pain Measurement; Pain Threshold; Proteasome Inhibitors; Pyrazines; Sciatic Nerve; Sensory Receptor Cells; Time Factors; Tumor Necrosis Factor-alpha

2014
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin.
    Endocrinology, 2014, Volume: 155, Issue:3

    Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Keratins; Ki-67 Antigen; Male; Metformin; Pancreas, Exocrine; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Triazoles

2014
Post-exposure efficacy of oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model.
    Antiviral research, 2014, Volume: 104

    Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Disease Models, Animal; Ebolavirus; Hemorrhagic Fever, Ebola; Mice; Mice, Knockout; Pyrazines

2014
Favipiravir (T-705) protects against peracute Rift Valley fever virus infection and reduces delayed-onset neurologic disease observed with ribavirin treatment.
    Antiviral research, 2014, Volume: 104

    Topics: Amides; Animals; Antiviral Agents; Cell Line; Central Nervous System Viral Diseases; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Microbial Sensitivity Tests; Pyrazines; Rift Valley Fever; Rift Valley fever virus; Viral Load

2014
Tetramethylpyrazine improves oxazolone-induced colitis by inhibiting the NF-κB pathway.
    Clinical and investigative medicine. Medecine clinique et experimentale, 2014, Feb-01, Volume: 37, Issue:1

    Topics: Animals; Caco-2 Cells; Colitis; Cytokines; Disease Models, Animal; Humans; Inflammation Mediators; Intestinal Mucosa; Male; Mice; NF-kappa B; Oxazolone; Oxidative Stress; Phytotherapy; Pyrazines; Signal Transduction

2014
Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model.
    Oncotarget, 2014, Feb-15, Volume: 5, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoquinones; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Multiple Myeloma; NF-kappa B; Pyrazines; Random Allocation; Signal Transduction; Xenograft Model Antitumor Assays

2014
Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure.
    Gene therapy, 2014, Volume: 21, Issue:4

    Topics: Animals; Boronic Acids; Bortezomib; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Heart Failure; Humans; Myocardium; Myocytes, Cardiac; Pyrazines; Rats; Sarcoplasmic Reticulum Calcium-Transporting ATPases

2014
Design, synthesis, and preliminary cardioprotective effect evaluation of danshensu derivatives.
    Chemical biology & drug design, 2014, Volume: 84, Issue:3

    Topics: Animals; Cardiotonic Agents; Cell Line, Tumor; Creatine Kinase; Disease Models, Animal; Drug Design; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heme Oxygenase-1; Ischemia; L-Lactate Dehydrogenase; Lactates; Malondialdehyde; NF-E2-Related Factor 2; Phenylpropionates; Phosphatidylinositol 3-Kinases; Protein Binding; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Signal Transduction; Stereoisomerism

2014
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model.
    Antiviral research, 2014, Volume: 105

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Ebolavirus; Hemorrhagic Fever, Ebola; Mice, Inbred C57BL; Mice, Knockout; Pyrazines; Survival Analysis; Viral Load; Virus Replication

2014
Bortezomib partially improves laminin α2 chain-deficient muscular dystrophy.
    The American journal of pathology, 2014, Volume: 184, Issue:5

    Topics: Animals; Apoptosis; Body Weight; Boronic Acids; Bortezomib; Cells, Cultured; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Laminin; Locomotion; Mice, Inbred C57BL; MicroRNAs; Muscle Cells; Muscles; Muscular Dystrophy, Animal; Organ Specificity; Proteasome Endopeptidase Complex; Pyrazines; Survival Analysis

2014
In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma.
    Bioorganic & medicinal chemistry letters, 2014, Apr-15, Volume: 24, Issue:8

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glaucoma; Guinea Pigs; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Pyrazines; Pyridines; rho-Associated Kinases

2014
Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson's disease induced by MPTP.
    International journal of biological sciences, 2014, Volume: 10, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cytochromes c; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Down-Regulation; Glutamate-Cysteine Ligase; Male; MPTP Poisoning; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats, Wistar; Up-Regulation

2014
Transcriptome analysis of the hippocampus in novel rat model of febrile seizures.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Animals; Cell Line, Tumor; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Hippocampus; Pyrazines; Rats; Rats, Sprague-Dawley; Seizures, Febrile; Sitagliptin Phosphate; Triazoles

2014
Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes.
    European journal of haematology, 2014, Volume: 93, Issue:4

    Topics: Amides; Animals; Antineoplastic Agents; Blood Platelets; Bone Marrow; Boronic Acids; Bortezomib; Colony-Forming Units Assay; Disease Models, Animal; Male; Megakaryocyte Progenitor Cells; Megakaryocytes; Mice; Multiple Myeloma; Platelet Count; Pyrazines; Pyridines; rho-Associated Kinases; Thrombocytopenia; Thrombopoiesis; Thrombopoietin

2014
Bortezomib protects from varicose-like venous remodeling.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014, Volume: 28, Issue:8

    Topics: Animals; Animals, Outbred Strains; Boronic Acids; Bortezomib; Cell Division; Cell Movement; Cells, Cultured; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteolysis; Pyrazines; Spheroids, Cellular; Trans-Activators; Varicose Veins

2014
Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes.
    Bulletin of experimental biology and medicine, 2014, Volume: 156, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Proline; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles

2014
Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes.
    British journal of pharmacology, 2014, Volume: 171, Issue:7

    Topics: Animals; Azetidines; Biomarkers; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Administration Schedule; Enzyme Activation; Enzyme Activators; Glucokinase; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Knockout; Pyrazines; Rats; Rats, Zucker; Sulfones; Thiadiazoles; Translational Research, Biomedical; Triglycerides

2014
Ligustrazine corrects Th1/Th2 and Treg/Th17 imbalance in a mouse asthma model.
    International immunopharmacology, 2014, Volume: 21, Issue:1

    Topics: Animals; Asthma; Cells, Cultured; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Eosinophils; Female; Gene Expression Regulation; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyrazines; T-Lymphocytes, Regulatory; Th1-Th2 Balance; Th17 Cells; Transcription Factors

2014
Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever.
    PLoS neglected tropical diseases, 2014, Volume: 8, Issue:5

    Topics: Amides; Animals; Antiviral Agents; Chlorocebus aethiops; Disease Models, Animal; Female; Hemorrhagic Fever Virus, Crimean-Congo; Hemorrhagic Fever, Crimean; Indoles; Liver; Male; Mice; Mice, Transgenic; Pyrazines; Receptor, Interferon alpha-beta; Ribavirin; Vero Cells

2014
Antiproliferative effects of TRPV1 ligands on nonspecific and enteroantigen-specific T cells from wild-type and Trpv1 KO mice.
    Inflammatory bowel diseases, 2014, Volume: 20, Issue:6

    Topics: Animals; Antigens; Antipruritics; beta 2-Microglobulin; Capsaicin; CD4-Positive T-Lymphocytes; Cell Proliferation; Colitis; Cytokines; Disease Models, Animal; Ligands; Lymphoid Tissue; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Pyrazines; Pyridines; Signal Transduction; TRPV Cation Channels

2014
Critical neuroprotective roles of heme oxygenase-1 induction against axonal injury-induced retinal ganglion cell death.
    Journal of neuroscience research, 2014, Volume: 92, Issue:9

    Topics: Animals; Axons; Disease Models, Animal; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Heme Oxygenase-1; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Optic Nerve Injuries; Protoporphyrins; Pyrazines; Pyrroles; Retinal Ganglion Cells; Statistics, Nonparametric; Stilbamidines; Time Factors

2014
Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Female; Humans; Imidazoles; Mice; Mice, Transgenic; Motor Neurons; Muscle Strength; Muscle, Skeletal; Pyrazines; Troponin

2014
Bortezomib treatment produces nocifensive behavior and changes in the expression of TRPV1, CGRP, and substance P in the rat DRG, spinal cord, and sciatic nerve.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Behavior, Animal; Boronic Acids; Bortezomib; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Ganglia, Spinal; Gene Expression Regulation; Nerve Tissue Proteins; Nociception; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; Substance P; TRPV Cation Channels

2014
Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy.
    Brain research, 2014, Jul-29, Volume: 1574

    Topics: Action Potentials; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Lumbar Vertebrae; Male; Motor Activity; Neurons; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Pyrazines; Rats, Sprague-Dawley; Spinal Cord; Temperature; Touch

2014
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:10

    Topics: Amides; Animals; Antiviral Agents; Cell Line; Chikungunya Fever; Chikungunya virus; Cytopathogenic Effect, Viral; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Viral; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; Pyrazines; Reproducibility of Results; Viral Nonstructural Proteins; Virus Replication

2014
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: Allosteric Site; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Male; Mice; Molecular Structure; Picolinic Acids; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship

2014
Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson's disease.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014, Volume: 35, Issue:12

    Topics: Analysis of Variance; Animals; Benzofurans; Corpus Striatum; Cytokines; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Mice; Neurons; Parkinsonian Disorders; Patch-Clamp Techniques; Postural Balance; Psychomotor Performance; Pyrazines; Quinolines; Vasodilator Agents

2014
Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats.
    Journal of pharmacological sciences, 2014, Volume: 125, Issue:4

    Topics: Animals; Atherosclerosis; Blood Glucose; Carotid Arteries; Chemokine CCL2; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression; Glucose Tolerance Test; In Vitro Techniques; Insulin; Linagliptin; Malondialdehyde; NADPH Oxidases; Purines; Pyrazines; Quinazolines; Rats, Zucker; Sitagliptin Phosphate; Triazoles; Vasodilation

2014
Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014, Volume: 20, Issue:12

    Topics: Acute Disease; Animals; Antibodies, Neutralizing; Antineoplastic Agents; Boronic Acids; Bortezomib; CD8-Positive T-Lymphocytes; Disease Models, Animal; Female; Graft vs Host Disease; Interleukin-6; Liver Diseases; Mice; Organ Specificity; Pyrazines; Skin Diseases

2014
Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.
    Leukemia, 2015, Volume: 29, Issue:3

    Topics: Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents; Benzodiazepinones; beta 2-Microglobulin; Biomarkers, Tumor; Boronic Acids; Bortezomib; Depsipeptides; Disease Models, Animal; Drug Therapy, Combination; Gene Expression Regulation, Leukemic; Humans; Interleukin-2 Receptor alpha Subunit; Leukemia-Lymphoma, Adult T-Cell; Mice; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Pyrazines; Receptor, Notch1; Signal Transduction; Tumor Burden

2015
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.
    Neuropharmacology, 2014, Volume: 86

    Topics: Analgesics; Animals; Boronic Acids; Bortezomib; Ceftriaxone; Cell Line, Tumor; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hyperalgesia; Injections, Spinal; Male; Neural Conduction; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5

2014
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
    Bioorganic & medicinal chemistry, 2014, Oct-01, Volume: 22, Issue:19

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship

2014
A Refined Guinea Pig Model of Foot-and-Mouth Disease Virus Infection for Assessing the Efficacy of Antiviral Compounds.
    Transboundary and emerging diseases, 2016, Volume: 63, Issue:2

    Topics: Animals; Antibodies, Viral; Antiviral Agents; Disease Models, Animal; Europe; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus; Guinea Pigs; Pyrazines; RNA, Viral; Vaccination; Viral Vaccines

2016
Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells.
    BMC urology, 2014, Aug-30, Volume: 14

    Topics: Acetylation; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Endoplasmic Reticulum Stress; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Indoles; Kidney Neoplasms; Mice, Inbred BALB C; Panobinostat; Pyrazines; Ubiquitinated Proteins

2014
Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myeloma.
    Leukemia, 2015, Volume: 29, Issue:3

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Cycle; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Multiple Myeloma; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Transplantation; Phosphorylation; Primary Cell Culture; Pyrazines; RNA, Small Interfering; S-Phase Kinase-Associated Proteins; Signal Transduction; Survival Analysis

2015
Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glycated Hemoglobin; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Retina; Rhodanine; Spiro Compounds; Thiazolidines; Time Factors

2014
Synthesis of new perhydropyrrolo[1,2-a]pyrazine derivatives and their evaluation in animal models of epilepsy.
    Molecules (Basel, Switzerland), 2014, Oct-07, Volume: 19, Issue:10

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Male; Mice; Molecular Structure; Pyrazines

2014
Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:1

    Topics: Animals; Blood Pressure; Blood Pressure Determination; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Hypertension; Male; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2015
Radiofrequency ablation-induced upregulation of hypoxia-inducible factor-1α can be suppressed with adjuvant bortezomib or liposomal chemotherapy.
    Journal of vascular and interventional radiology : JVIR, 2014, Volume: 25, Issue:12

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Breast Neoplasms; Catheter Ablation; Chemotherapy, Adjuvant; Disease Models, Animal; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Liposomes; Liver; Pyrazines; Rats; Rats, Inbred F344; Up-Regulation

2014
The combination of astragalus membranaceus and ligustrazine ameliorates micro-haemorrhage by maintaining blood-brain barrier integrity in cerebrally ischaemic rats.
    Journal of ethnopharmacology, 2014, Dec-02, Volume: 158 Pt A

    Topics: Animals; Astragalus Plant; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Intracranial Hemorrhages; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction

2014
Short-term inhibition of DPP-4 enhances endothelial regeneration after acute arterial injury via enhanced recruitment of circulating progenitor cells.
    International journal of cardiology, 2014, Nov-15, Volume: 177, Issue:1

    Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Carotid Arteries; Cell Movement; Cell Proliferation; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Pyrazines; Regeneration; Signal Transduction; Sitagliptin Phosphate; Stem Cells; Triazoles; Tunica Intima

2014
The effect of bortezomib on expression of inflammatory cytokines and survival in a murine sepsis model induced by cecal ligation and puncture.
    Yonsei medical journal, 2015, Volume: 56, Issue:1

    Topics: Animals; Boronic Acids; Bortezomib; Cecum; Cell Adhesion Molecules; Cell Line; Cell Proliferation; Cell Survival; Chymotrypsin; Cytokines; Disease Models, Animal; Inflammation Mediators; Ligation; Lipopolysaccharides; Lung; Male; Mice, Inbred C57BL; Nitric Oxide; Proteasome Inhibitors; Punctures; Pyrazines; Sepsis

2015
Novel role for endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:3

    Topics: Adult; Aged; Aneurysm, Ruptured; Animals; Cells, Cultured; Disease Models, Animal; E-Selectin; Endothelium, Vascular; Female; Hepatocyte Growth Factor; Humans; Intracranial Aneurysm; Male; Mice; Mice, Inbred C57BL; Middle Aged; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-met; Pyrazines; Signal Transduction; Triazoles; Vascular Cell Adhesion Molecule-1

2015
The proteasome inhibitor Bortezomib (Velcade) as potential inhibitor of estrogen receptor-positive breast cancer.
    International journal of cancer, 2015, Aug-01, Volume: 137, Issue:3

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Death; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Prognosis; Proteasome Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2015
Preparation and evaluation of a novel biodegradable long-acting intravitreal implant containing ligustrazine for the treatment of proliferative vitreoretinopathy.
    The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:2

    Topics: Absorbable Implants; Animals; Biocompatible Materials; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Female; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Pyrazines; Rabbits; Retina; Vitreoretinopathy, Proliferative; Vitreous Body

2015
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling.
    World journal of gastroenterology, 2014, Dec-28, Volume: 20, Issue:48

    Topics: Animals; Boronic Acids; Bortezomib; Chronic Disease; Colitis; Colon; Disease Models, Animal; Fibrosis; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats, Sprague-Dawley; Signal Transduction; Tight Junction Proteins; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid

2014
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.
    Basic research in cardiology, 2015, Volume: 110, Issue:2

    Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endotoxemia; Glucagon-Like Peptide 1; Inflammation; Linagliptin; Lipopolysaccharides; Liraglutide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Purines; Pyrazines; Quinazolines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles

2015
Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway.
    The international journal of neuropsychopharmacology, 2015, Jan-24, Volume: 18, Issue:8

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurogenesis; Neuropsychological Tests; Pyrazines; Signal Transduction; Tryptophan Hydroxylase

2015
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Jun-15, Volume: 21, Issue:12

    Topics: Animals; Antineoplastic Agents; Carcinoma, Papillary; Carcinoma, Renal Cell; Cell Line, Tumor; Crizotinib; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Indoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Pyrazoles; Pyridines; Pyrroles; Sunitinib; Triazines; Tumor Burden; Xenograft Model Antitumor Assays

2015
Opposite roles for neuropeptide S in the nucleus accumbens and bed nucleus of the stria terminalis in learned helplessness rats.
    Behavioural brain research, 2015, Sep-15, Volume: 291

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Depressive Disorder; Disease Models, Animal; Helplessness, Learned; Male; Memory; Motor Activity; Neuropeptides; Nucleus Accumbens; Oxazolidinones; Pyrazines; Rats, Sprague-Dawley; Receptors, Neuropeptide; Septal Nuclei

2015
[The effect of ligustrazin in intestinal ischemia reperfusion injury generated on rats].
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2015, Volume: 21, Issue:3

    Topics: Animals; Disease Models, Animal; Ileum; Jejunum; Male; Mesenteric Ischemia; Pyrazines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents

2015
Ligustrazine effect on lipopolysaccharide-induced pulmonary damage in rats.
    Burns : journal of the International Society for Burn Injuries, 2015, Volume: 41, Issue:6

    Topics: Animals; Blood Gas Analysis; Cell-Derived Microparticles; Disease Models, Animal; Endothelial Cells; Injections, Intraperitoneal; Lipopolysaccharides; Lung; Lung Injury; Male; Oxygen; Partial Pressure; Platelet Endothelial Cell Adhesion Molecule-1; Pyrazines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Sepsis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vasodilator Agents

2015
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy.
    Blood, 2015, Aug-06, Volume: 126, Issue:6

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Gene Expression; Genetic Loci; Heavy Chain Disease; Humans; Immunoglobulin Heavy Chains; Kidney Diseases; Kidney Glomerulus; Mice; Mice, Transgenic; Molecular Sequence Data; Plasma Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Aggregation, Pathological; Protein Structure, Tertiary; Pyrazines; Sequence Deletion; Unfolded Protein Response

2015
LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:9

    Topics: Animals; Antineoplastic Agents; cdc25 Phosphatases; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2; Disease Models, Animal; DNA Damage; DNA Replication; Female; Humans; Mice; Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Pyrazines; Pyrazoles; S Phase; Xenograft Model Antitumor Assays

2015
Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever.
    Antiviral research, 2015, Volume: 121

    Topics: Amides; Animal Structures; Animals; Antiviral Agents; Disease Models, Animal; Female; Hemorrhagic Fevers, Viral; Mesocricetus; Plasma; Pyrazines

2015
Adaptation of a Gaussia princeps Luciferase reporter system in Candida albicans for in vivo detection in the Galleria mellonella infection model.
    Virulence, 2015, Volume: 6, Issue:7

    Topics: Adaptation, Physiological; Animals; Candida albicans; Candidiasis; Copepoda; Disease Models, Animal; Fluconazole; Imidazoles; Larva; Lepidoptera; Luciferases; Luminescent Measurements; Moths; Pyrazines; Virulence

2015
Ebola virus dynamics in mice treated with favipiravir.
    Antiviral research, 2015, Volume: 123

    Topics: Amides; Animals; Antiviral Agents; Disease Models, Animal; Ebolavirus; Female; Hemorrhagic Fever, Ebola; Mice, Inbred C57BL; Models, Theoretical; Pyrazines; Survival Analysis; Viral Load

2015
A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats.
    International journal of molecular sciences, 2015, 09-09, Volume: 16, Issue:9

    Topics: Animals; Behavior, Animal; Brain Ischemia; Ca(2+) Mg(2+)-ATPase; Cell Differentiation; Cell Survival; Cyclooxygenase 2; Disease Models, Animal; Immunohistochemistry; Neuroprotective Agents; NF-kappa B; PC12 Cells; Pyrazines; Rats; Stroke; Superoxide Dismutase; Toxicity Tests, Acute; Vascular Endothelial Growth Factor A

2015
Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy.
    Biomedical and environmental sciences : BES, 2015, Volume: 28, Issue:9

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Learning; Male; Memory; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; Vasodilator Agents

2015
Efficacy of Favipiravir (T-705) in Rabies Postexposure Prophylaxis.
    The Journal of infectious diseases, 2016, Apr-15, Volume: 213, Issue:8

    Topics: Amides; Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Mice; Post-Exposure Prophylaxis; Pyrazines; Rabies; Treatment Outcome; Viral Load

2016
Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses.
    Antiviral research, 2016, Volume: 126

    Topics: Amides; Animals; Antiviral Agents; Arenavirus; Chlorocebus aethiops; Cricetinae; Dengue Virus; Disease Models, Animal; Drug Synergism; Female; Guinea Pigs; Hemorrhagic Fever Virus, Crimean-Congo; Hemorrhagic Fever, American; Hemorrhagic Fever, Ebola; Hemorrhagic Fevers, Viral; Junin virus; Male; Mesocricetus; Mice; Orthohantavirus; Pyrazines; Ribavirin; RNA Viruses; Vero Cells

2016
Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants.
    Antimicrobial agents and chemotherapy, 2015, Dec-28, Volume: 60, Issue:3

    Topics: Amides; Animals; Caliciviridae Infections; Cytidine; Disease Models, Animal; Feces; Gastroenteritis; Mice; Mice, Knockout; Norovirus; Pyrazines; Receptors, Interferon; Transplant Recipients; Virus Shedding

2015
Chemiluminescence Imaging of Superoxide Anion Detects Beta-Cell Function and Mass.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Cell Respiration; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose; HeLa Cells; Humans; Hyperglycemia; Imaging, Three-Dimensional; Imidazoles; Insulin-Secreting Cells; Luminescent Measurements; Mice, Inbred NOD; Organ Size; Pyrazines; Pyridines; Ranolazine; Superoxides

2016
Reactive Oxygen Species Imaging in a Mouse Model of Inflammatory Bowel Disease.
    Molecular imaging and biology, 2016, Volume: 18, Issue:4

    Topics: Animals; Disease Models, Animal; Imaging, Three-Dimensional; Imidazoles; Inflammatory Bowel Diseases; Luminescent Measurements; Male; Mice; Mice, Inbred BALB C; Pyrazines; RAW 264.7 Cells; Reactive Oxygen Species

2016
Micro-CT as a Tool to Investigate the Efficacy of Tetramethylpyrazine in a Rat Spinal Cord Injury Model.
    Spine, 2016, Aug-15, Volume: 41, Issue:16

    Topics: Animals; Disease Models, Animal; Hindlimb; Male; Motor Activity; Neuroprotective Agents; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; X-Ray Microtomography

2016
Antinociceptive activity of intraperitoneally administered novel and potent anticonvulsive compound, CY-PROLL-SS, in animal neuropathic pain models.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:3

    Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Male; Neuralgia; Pain Measurement; Pyrazines; Pyrroles; Rats; Streptozocin

2016
Inhibition of Lipolysis Ameliorates Diabetic Phenotype in a Mouse Model of Obstructive Sleep Apnea.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:2

    Topics: Adipocytes; Adiposity; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Fatty Acids; Gene Expression Regulation; Glucose; Hypoxia; Insulin; Lipolysis; Male; Mice, Inbred C57BL; Phenotype; Pyrazines; Signal Transduction; Sleep Apnea, Obstructive

2016
Rat exposure in mice with neuropathic pain induces fear and antinociception that is not reversed by 5-HT2C receptor activation in the dorsal periaqueductal gray.
    Behavioural brain research, 2016, 07-01, Volume: 307

    Topics: Analysis of Variance; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Exploratory Behavior; Fear; Male; Mice; Microinjections; Pain Measurement; Periaqueductal Gray; Pyrazines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2C; Sciatica; Serotonin Receptor Agonists

2016
Ligustrazine improves blood circulation by suppressing Platelet activation in a rat model of allergic asthma.
    Environmental toxicology and pharmacology, 2016, Volume: 45

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Asthma; Blood Circulation; Blood Platelets; Cell Adhesion; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Male; Platelet Activation; Pneumonia; Pyrazines; Rats, Sprague-Dawley

2016
Tetramethylpyrazine enhances functional recovery after contusion spinal cord injury by modulation of MicroRNA-21, FasL, PDCD4 and PTEN expression.
    Brain research, 2016, 10-01, Volume: 1648, Issue:Pt A

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Contusions; Disease Models, Animal; Fas Ligand Protein; Male; MicroRNAs; Neuroprotective Agents; PTEN Phosphohydrolase; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries

2016
Synthesis, structure-activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Allosteric Regulation; Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Half-Life; Humans; Mice; Microsomes, Liver; Protein Binding; Pyrazines; Pyrazoles; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship

2016
Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model.
    Environmental toxicology and pharmacology, 2016, Volume: 46

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Chemokines; Disease Models, Animal; Female; Interleukins; Lung; MAP Kinase Signaling System; Mice, Inbred BALB C; Ovalbumin; Pyrazines; Receptors, CCR7; STAT3 Transcription Factor

2016
Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 82

    Topics: Acinar Cells; Acute Disease; Amylases; Animals; Apoptosis; Cell Line; Cytokines; Disease Models, Animal; Down-Regulation; Inflammation Mediators; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pancreatitis; Peroxidase; Phosphorylation; Pyrazines; Rats, Sprague-Dawley

2016
Assessment of the Anti-anginal Effect of Tetramethylpyrazine Using Vasopressin-Induced Angina Model Rats.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:8

    Topics: Animals; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Heart Rate; Male; Myocardial Ischemia; Pyrazines; Rats; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins

2016
Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions.
    Molecular neurobiology, 2017, Volume: 54, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain; Cyclooxygenase 2; Disease Models, Animal; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Pyrazines; Rats, Sprague-Dawley; Rotenone; Vasodilator Agents

2017
Human heme oxygenase 1 is a potential host cell factor against dengue virus replication.
    Scientific reports, 2016, 08-24, Volume: 6

    Topics: Animals; Biliverdine; Carbon Monoxide; Dengue; Dengue Virus; Disease Models, Animal; Diterpenes; Enzyme Inhibitors; Heme Oxygenase-1; Host-Pathogen Interactions; Humans; Interferon-alpha; Iron; Metalloporphyrins; Mice, Inbred ICR; Protoporphyrins; Pyrazines; Pyrroles; Serine Endopeptidases; Virus Replication

2016
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
    Journal of medicinal chemistry, 2016, 11-10, Volume: 59, Issue:21

    Topics: Animals; Antimalarials; Disease Models, Animal; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Hep G2 Cells; Humans; Life Cycle Stages; Malaria; Mice; Mice, SCID; Microsomes, Liver; Molecular Structure; Parasitic Diseases, Animal; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrazines; Solubility; Structure-Activity Relationship; Water

2016
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy.
    Scientific reports, 2016, 11-14, Volume: 6

    Topics: Animals; Biomarkers; Blood-Brain Barrier; Brain Infarction; Disease Models, Animal; Macaca fascicularis; Male; Nerve Tissue Proteins; Neuroprotective Agents; Pyrazines; Schiff Bases; Stroke

2016
Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir.
    Journal of virology, 2017, Feb-01, Volume: 91, Issue:3

    Topics: Amides; Animals; Animals, Genetically Modified; Antiviral Agents; Bunyaviridae Infections; Cricetinae; Disease Models, Animal; Disease Susceptibility; Genotype; Humans; Models, Biological; Phenotype; Phlebovirus; Pyrazines; STAT2 Transcription Factor

2017
Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT
    Molecular brain, 2016, 12-08, Volume: 9, Issue:1

    Topics: Alternative Splicing; Animals; Anorexia; Appetite; Arcuate Nucleus of Hypothalamus; Base Sequence; Disease Models, Animal; Feeding Behavior; Mice; Mutant Proteins; Neurons; Prader-Willi Syndrome; Pro-Opiomelanocortin; Proto-Oncogene Proteins c-fos; Pyrazines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists

2016
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
    British journal of pharmacology, 2017, Volume: 174, Issue:5

    Topics: Animals; Benzoquinones; Carbon Tetrachloride; Disease Models, Animal; Hedgehog Proteins; Hepatic Stellate Cells; HSP90 Heat-Shock Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Lactams, Macrocyclic; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Mustard Compounds; Neovascularization, Pathologic; Phenylpropionates; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Smoothened Receptor

2017
Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process.
    BioMed research international, 2017, Volume: 2017

    Topics: Animals; beta Catenin; Bronchoalveolar Lavage Fluid; Cell Adhesion; Cell-Derived Microparticles; Cytoskeleton; Disease Models, Animal; Endothelium, Vascular; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Microscopy, Fluorescence; Neutrophils; p21-Activated Kinases; Pyrazines; Respiration, Artificial; Respiratory Function Tests; Tidal Volume; Toll-Like Receptor 4; Ventilator-Induced Lung Injury

2017
Tetramethylpyrazine Facilitates Functional Recovery after Spinal Cord Injury by Inhibiting MMP2, MMP9, and Vascular Endothelial Cell Apoptosis.
    Current neurovascular research, 2017, Volume: 14, Issue:2

    Topics: Animals; Apoptosis; Disease Models, Animal; Endothelial Cells; Follow-Up Studies; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neurologic Examination; Platelet Aggregation Inhibitors; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Time Factors

2017
Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents.
    Antiviral research, 2008, Volume: 80, Issue:3

    Topics: Administration, Oral; Amides; Animals; Brain; Cricetinae; Disease Models, Animal; Drug Administration Schedule; Female; Humans; Mesocricetus; Mice; Mice, Inbred C57BL; Pyrazines; West Nile Fever; West Nile virus

2008
Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats.
    Neuroscience letters, 2009, Jan-02, Volume: 449, Issue:1

    Topics: Analysis of Variance; Animals; Brain Infarction; Disease Models, Animal; Ischemic Attack, Transient; Male; Neurologic Examination; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Thioredoxins; Time Factors; Vasodilator Agents

2009
Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Culture Techniques; Cells, Cultured; Disease Models, Animal; Gentamicins; Heme Oxygenase-1; Kidney Cortex Necrosis; Kidney Tubules; Male; Mice; Pyrazines; Rats; Vasodilator Agents

2009
The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo.
    American journal of hematology, 2009, Volume: 84, Issue:1

    Topics: Animals; Bone Density; Bone Density Conservation Agents; Bone Development; Boronic Acids; Bortezomib; Disease Models, Animal; Humans; Mice; Multiple Myeloma; Osteoblasts; Osteoclasts; Osteolysis; Protease Inhibitors; Pyrazines; Rabbits

2009
Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin.
    PloS one, 2008, Volume: 3, Issue:11

    Topics: Absorption; Administration, Oral; Alanine Transaminase; Amides; Animals; Arenaviridae Infections; Aspartate Aminotransferases; Cricetinae; Disease Models, Animal; Disease Progression; Female; Hemorrhagic Fevers, Viral; Interferon Type I; Liver Diseases; Mesocricetus; Pichinde virus; Pyrazines; Ribavirin; Survival Analysis; Treatment Outcome; Viral Load

2008
Effects of bortezomib on bone disease in multiple myeloma.
    American journal of hematology, 2009, Volume: 84, Issue:1

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Humans; Mice; Multiple Myeloma; Osteoclasts; Osteolysis; Pyrazines

2009
[The efficacy of tetramethylpyrazine-eluting stents on inhibiting neointima formation in porcine coronary arteries].
    Zhonghua xin xue guan bing za zhi, 2008, Volume: 36, Issue:9

    Topics: Animals; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Double-Blind Method; Drug-Eluting Stents; Pyrazines; Swine; Tunica Intima

2008
[The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2008, Volume: 20, Issue:12

    Topics: Animals; Anthracenes; Disease Models, Animal; Hemodynamics; JNK Mitogen-Activated Protein Kinases; Male; Myocardial Reperfusion Injury; Protein Kinase Inhibitors; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley

2008
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.
    Pediatric blood & cancer, 2009, Volume: 53, Issue:2

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Disease Models, Animal; Gene Knock-In Techniques; Hedgehog Proteins; Humans; Immunoblotting; Immunoprecipitation; Loss of Heterozygosity; Medulloblastoma; Mice; Mice, Knockout; Patched Receptors; Patched-1 Receptor; PAX7 Transcription Factor; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyrazines; Receptors, Cell Surface

2009
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Curcumin; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Nude; Multiple Myeloma; NF-kappa B; Proto-Oncogene Proteins c-akt; Pyrazines; Signal Transduction; Thalidomide; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2009
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Administration, Oral; Animals; Cell Line; Constriction, Pathologic; Disease Models, Animal; Drug Discovery; Enzyme Inhibitors; Fluoroquinolones; Formaldehyde; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Nitric Oxide Synthase Type II; Pain; Protein Multimerization; Protein Structure, Quaternary; Pyrazines; Quinolones; Structure-Activity Relationship; Substrate Specificity

2009
Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin.
    Diabetes, 2009, Volume: 58, Issue:7

    Topics: Amyloid; Animals; Animals, Genetically Modified; Arginine; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose Clamp Technique; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Islet Amyloid Polypeptide; Islets of Langerhans; Metformin; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles

2009
Effect of T-705 treatment on western equine encephalitis in a mouse model.
    Antiviral research, 2009, Volume: 82, Issue:3

    Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Body Weight; Chlorocebus aethiops; Disease Models, Animal; Encephalomyelitis, Western Equine; Mice; Mice, Inbred C57BL; Pyrazines; Serum; Survival Analysis; Vero Cells

2009
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
    Toxicology letters, 2009, Jul-10, Volume: 188, Issue:1

    Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors

2009
The proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Boronic Acids; Bortezomib; CD4 Lymphocyte Count; Creatinine; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Necrosis; Nephritis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Reperfusion Injury; Time Factors

2009
Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.
    Cancer research, 2009, Jul-01, Volume: 69, Issue:13

    Topics: Animals; Antineoplastic Agents; Bone Diseases; Boronic Acids; Bortezomib; Disease Models, Animal; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Multiple Myeloma; Neovascularization, Pathologic; Osteolysis; Pyrazines

2009
The protective mechanism of ligustrazine against renal ischemia/reperfusion injury.
    The Journal of surgical research, 2011, Volume: 166, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Disease Models, Animal; Gene Expression; Intercellular Adhesion Molecule-1; Kidney; Kidney Diseases; Kidney Transplantation; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxidative Stress; Peroxidase; Pyrazines; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2011
The anti-histaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylase inhibitor.
    British journal of haematology, 2009, Volume: 146, Issue:6

    Topics: Actins; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cyclin D1; Cyproheptadine; Disease Models, Animal; Histamine H1 Antagonists; Histone Deacetylase Inhibitors; Lymphoma, Mantle-Cell; Mice; Protease Inhibitors; Pyrazines

2009
Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Oct-01, Volume: 33, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mice; Microinjections; Motor Activity; Periaqueductal Gray; Pyrazines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reproducibility of Results; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Serotonin Agents

2009
Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour.
    Schizophrenia research, 2009, Volume: 115, Issue:1

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Body Composition; Body Weight; Clozapine; Dibenzothiazepines; Dietary Fats; Disease Models, Animal; Eating; Exenatide; Food Preferences; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Peptides; Pyrazines; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles; Venoms

2009
Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.
    Burns : journal of the International Society for Burn Injuries, 2010, Volume: 36, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Disease Models, Animal; Drug Evaluation, Preclinical; Ganglia, Spinal; Hyperalgesia; Male; Pain Threshold; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Skin

2010
Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models.
    Antiviral research, 2010, Volume: 86, Issue:2

    Topics: Amides; Animals; Antiviral Agents; Bunyaviridae Infections; Chlorocebus aethiops; Cricetinae; Disease Models, Animal; Female; Liver; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Nucleosides; Pyrazines; Serum; Survival Analysis; Treatment Outcome; Vero Cells; Viral Load

2010
Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation.
    Journal of hepatology, 2010, Volume: 52, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Niacinamide; Okadaic Acid; Phenylurea Compounds; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Pyrazines; Pyridines; Sorafenib; Treatment Outcome; Xenograft Model Antitumor Assays

2010
[Effect of bortezomib on acute graft-versus-host disease in mice model and its mechanism].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2009, Volume: 30, Issue:6

    Topics: Animals; Apoptosis; Boronic Acids; Bortezomib; Cell Survival; Cells, Cultured; Disease Models, Animal; Female; Graft vs Host Disease; Interferon-gamma; Interleukin-2; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrazines; Tumor Necrosis Factor-alpha

2009
In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma.
    Haematologica, 2010, Volume: 95, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cell Line, Tumor; Cells, Cultured; Dexamethasone; Disease Models, Animal; Humans; Hydroxamic Acids; Indoles; Lenalidomide; Mice; Mice, SCID; Multiple Myeloma; Panobinostat; Pyrazines; Random Allocation; Thalidomide; Xenograft Model Antitumor Assays

2010
Novel thioamide derivatives as neutral CB1 receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2010, Jan-15, Volume: 20, Issue:2

    Topics: Animals; Anti-Obesity Agents; Disease Models, Animal; Mice; Mice, Obese; Obesity; Pyrazines; Receptor, Cannabinoid, CB1; Structure-Activity Relationship; Thioamides

2010
Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates.
    Transplantation, 2009, Dec-27, Volume: 88, Issue:12

    Topics: Animals; Boronic Acids; Bortezomib; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Resistance; Graft Rejection; Immunologic Memory; Immunosuppressive Agents; Lymphocyte Activation; Macaca mulatta; Male; Pancreas Transplantation; Protease Inhibitors; Pyrazines; Sirolimus; Swine; Swine, Miniature; T-Lymphocytes; T-Lymphocytes, Regulatory

2009
Functional evaluation of therapeutic response for a mouse model of medulloblastoma.
    Transgenic research, 2010, Volume: 19, Issue:5

    Topics: Animals; Antineoplastic Agents; Ataxia; Boronic Acids; Bortezomib; Cerebellar Neoplasms; Disease Models, Animal; Disease Progression; Drug Screening Assays, Antitumor; Gait Disorders, Neurologic; Lameness, Animal; Magnetic Resonance Imaging; Medulloblastoma; Mice; Mice, Knockout; Patched Receptors; Patched-1 Receptor; Protease Inhibitors; Psychomotor Performance; Pyrazines; Receptors, Cell Surface

2010
Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway.
    Journal of neuroinflammation, 2010, Feb-26, Volume: 7

    Topics: Animals; Brain; Butadienes; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Male; MAP Kinase Kinase Kinases; Neurologic Examination; Nitric Oxide Synthase Type II; Nitriles; Pyrazines; Rats; Rats, Wistar; Signal Transduction; Sulfonamides; Time Factors

2010
[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:21

    Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Gene Expression; Humans; Male; Pyrazines; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A

2009
[Studies on protection and mechanism of tetramethylpyrazine on myocardial injury of rats with DHF].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:21

    Topics: Animals; Calcium; Calcium-Transporting ATPases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Heart Failure, Diastolic; Humans; Male; Myocardium; Pyrazines; Random Allocation; Rats; Rats, Wistar; Ventricular Pressure

2009
Therapeutic potential of proteasome inhibition in Duchenne and Becker muscular dystrophies.
    The American journal of pathology, 2010, Volume: 176, Issue:4

    Topics: Animals; Boronic Acids; Bortezomib; Disease Models, Animal; Dystroglycans; Evans Blue; Gene Expression Regulation; Glycoproteins; Mice; Mice, Inbred C57BL; Muscular Dystrophy, Duchenne; Mutation; Proteasome Inhibitors; Pyrazines; Sarcoglycans; Ubiquitin

2010
Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia.
    Neurological research, 2010, Volume: 32, Issue:5

    Topics: Adult Stem Cells; Aging; Animals; Body Water; Brain; Brain Infarction; Brain Ischemia; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurogenesis; Neurons; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Stem Cell Niche

2010
Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Jul-15, Volume: 16, Issue:14

    Topics: Aminopterin; Animals; Apoptosis; Boronic Acids; Bortezomib; Caspase 8; Caspase 9; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Lymphoma, T-Cell; Mice; Mice, SCID; Neoplasm Transplantation; Pyrazines; Xenograft Model Antitumor Assays

2010
Effect of noncompetitive proteasome inhibition on bortezomib resistance.
    Journal of the National Cancer Institute, 2010, Jul-21, Volume: 102, Issue:14

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyquinolines; Immunoblotting; Inhibitory Concentration 50; Male; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; NF-kappa B; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Transplantation, Heterologous

2010
Stimulation of medial prefrontal cortex serotonin 2C (5-HT(2C)) receptors attenuates cocaine-seeking behavior.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:10

    Topics: Aminopyridines; Animals; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Indoles; Male; Prefrontal Cortex; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists

2010
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
    European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:2-3

    Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea

2010
Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis.
    Gut, 2010, Volume: 59, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Boronic Acids; Bortezomib; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Immunity, Mucosal; Inflammation Mediators; Interleukin-17; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Neutrophil Infiltration; NF-kappa B; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Signal Transduction; T-Lymphocyte Subsets; Th1 Cells

2010
The treatment of traumatic brain injury with velcade.
    Journal of neurotrauma, 2010, Volume: 27, Issue:9

    Topics: Animals; Boronic Acids; Bortezomib; Brain Injuries; Disease Models, Animal; Male; Pyrazines; Rats; Rats, Wistar; Spatial Behavior; Treatment Outcome

2010
Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat).
    Mediators of inflammation, 2010, Volume: 2010

    Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glycated Hemoglobin; Insulin; Insulin Resistance; Interleukin-1beta; Lipids; Male; Oxidative Stress; Pancreas; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles

2010
Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: a strategy for broad clinical application.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2010, Volume: 18, Issue:11

    Topics: Animals; Blood Coagulation; Boronic Acids; Bortezomib; Cell Nucleus; Combined Modality Therapy; Dependovirus; Disease Models, Animal; Dogs; Factor IX; Factor VIII; Female; Genetic Therapy; Genetic Vectors; Genome, Viral; Hemophilia B; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protease Inhibitors; Pyrazines; Transgenes

2010
Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy.
    Glia, 2010, Volume: 58, Issue:16

    Topics: Adaptation, Physiological; Animals; Axons; Boronic Acids; Bortezomib; Disease Models, Animal; Endoplasmic Reticulum; Female; Macrophages; Mice; Mice, Inbred C57BL; Myelin Proteins; Myelin Sheath; Oligonucleotide Array Sequence Analysis; Peripheral Nerves; Peripheral Nervous System Diseases; Protease Inhibitors; Protein Unfolding; Pyrazines; Schwann Cells; Stress, Physiological

2010
Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies.
    Experimental neurology, 2010, Volume: 226, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents; Body Weight; Boronic Acids; Bortezomib; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nerve Fibers, Myelinated; Neural Conduction; Paclitaxel; Peripheral Nervous System Diseases; Pyrazines; Sciatic Nerve

2010
Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats.
    Spinal cord, 2011, Volume: 49, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Deferoxamine; Disease Models, Animal; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Siderophores; Spinal Cord Ischemia

2011
Effects of tetramethylpyrazine on nitric oxide/cGMP signaling after cerebral vasospasm in rabbits.
    Brain research, 2010, Nov-18, Volume: 1361

    Topics: Animals; Basilar Artery; Blotting, Western; Calcium Signaling; Cerebral Angiography; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Endothelial Cells; Male; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrazines; Rabbits; Signal Transduction; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Ultrasonography, Doppler, Transcranial; Vasodilator Agents; Vasospasm, Intracranial

2010
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
    Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22

    Topics: Administration, Oral; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Ganglia, Spinal; Humans; Microsomes; NAV1.8 Voltage-Gated Sodium Channel; Neuralgia; Neurons; Pyrazines; Rats; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship

2010
Synthesis of novel ligustrazine derivatives as NA+/H+ exchange inhibitors.
    Chemistry & biodiversity, 2010, Volume: 7, Issue:11

    Topics: Animals; Benzamides; Cardiotonic Agents; Creatine Kinase; Disease Models, Animal; Myocardial Infarction; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Structure-Activity Relationship

2010
[Effect of ligustrazine on the expression and activity of heme oxygenase-1 in the pulmonary ischemia/reperfusion injury in rabbits].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2005, Volume: 21, Issue:4

    Topics: Animals; Disease Models, Animal; Heme Oxygenase-1; Lung; Pyrazines; Rabbits; Reperfusion Injury

2005
Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis.
    Methods and findings in experimental and clinical pharmacology, 2010, Volume: 32, Issue:9

    Topics: Acute Disease; Animals; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Ginsenosides; Isoflavones; Kidney; Liver; Male; Panax; Pancreas; Pancreatitis; Pyrazines; Rats; Rats, Sprague-Dawley; Saponins; Severity of Illness Index

2010
Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum.
    Journal of gastroenterology and hepatology, 2011, Volume: 26, Issue:6

    Topics: Animals; Asteraceae; Bilirubin; Biomarkers; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Early Growth Response Protein 1; Female; Gene Expression Regulation; Hepatic Veno-Occlusive Disease; Liver; Mice; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Serum Albumin; Thromboplastin; Time Factors; Transaminases; Transcription Factor RelA

2011
Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats.
    Experimental biology and medicine (Maywood, N.J.), 2011, Volume: 236, Issue:3

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles

2011
Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis.
    Arthritis and rheumatism, 2011, Volume: 63, Issue:3

    Topics: Animals; Arthritis; Bone and Bones; Bone Resorption; Boronic Acids; Bortezomib; Cartilage, Articular; Chronic Disease; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Osteoclasts; Osteoprotegerin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; RANK Ligand; Synovial Membrane; Tumor Necrosis Factor-alpha

2011
Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.
    Journal of vascular surgery, 2011, Volume: 54, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Male; Neurologic Examination; Neuroprotective Agents; Neutrophil Infiltration; NF-kappa B; Peroxidase; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Time Factors; Tumor Necrosis Factor-alpha

2011
Proteasome inhibition improves diaphragm function in an animal model for COPD.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:1

    Topics: Animals; Biomechanical Phenomena; Boronic Acids; Bortezomib; Contractile Proteins; Cricetinae; Diaphragm; Disease Models, Animal; Male; Organ Specificity; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pyrazines

2011
S35972, a direct-acting thrombin inhibitor with high oral bioavailability and antithrombotic efficacy.
    Journal of thrombosis and haemostasis : JTH, 2011, Volume: 9, Issue:7

    Topics: Administration, Oral; Animals; Anticoagulants; Benzimidazoles; Biological Availability; Blood Coagulation Tests; Dabigatran; Disease Models, Animal; Dogs; Drug Evaluation; Humans; In Vitro Techniques; Inhibitory Concentration 50; Pyrazines; Pyridines; Pyrroles; Rats; Thrombin; Thrombosis

2011
A diabetes drug, sitagliptin, also has a potential to prevent diabetes.
    Experimental biology and medicine (Maywood, N.J.), 2011, Volume: 236, Issue:3

    Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles

2011
Proteasome inhibitor treatment in alcoholic liver disease.
    World journal of gastroenterology, 2011, May-28, Volume: 17, Issue:20

    Topics: Animals; Boronic Acids; Bortezomib; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Humans; Liver Diseases, Alcoholic; Oxidative Stress; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Rats; Reactive Oxygen Species

2011
Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats.
    Experimental eye research, 2011, Volume: 93, Issue:1

    Topics: Administration, Topical; Animals; Calcium; Calcium Channel Blockers; Catalase; Cataract; Disease Models, Animal; Drugs, Chinese Herbal; Glutathione Peroxidase; Lens, Crystalline; Ligusticum; Malondialdehyde; Photometry; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium Selenite; Superoxide Dismutase

2011
Levels of p27 sensitize to dual PI3K/mTOR inhibition.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:8

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Drug Synergism; Gene Expression Regulation, Neoplastic; Mice; Multiple Endocrine Neoplasia; Phosphoinositide-3 Kinase Inhibitors; Pituitary Neoplasms; Proteasome Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Signal Transduction; TOR Serine-Threonine Kinases

2011
Improved outcome of islet transplantation in partially pancreatectomized diabetic mice by inhibition of dipeptidyl peptidase-4 with sitagliptin.
    Pancreas, 2011, Volume: 40, Issue:6

    Topics: Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred C57BL; Pancreatectomy; Pyrazines; Sitagliptin Phosphate; Triazoles

2011
Anti-inflammatory and immunomodulatory effects of bortezomib in various in vivo models.
    Pharmacology, 2011, Volume: 88, Issue:1-2

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Anti-Inflammatory Agents; Boronic Acids; Bortezomib; Dinitrofluorobenzene; Disease Models, Animal; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Female; Hypersensitivity, Delayed; Imiquimod; Immunologic Factors; Irritants; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Peritonitis; Psoriasis; Pyrazines; Random Allocation; Temperature; Thioglycolates

2011
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.
    Thorax, 2012, Volume: 67, Issue:2

    Topics: Animals; Autocrine Communication; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; PPAR gamma; Proteasome Inhibitors; Pulmonary Fibrosis; Pyrazines; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta1

2012
Radioresistance of prostate cancer cells with low proteasome activity.
    The Prostate, 2012, Jun-01, Volume: 72, Issue:8

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Male; Mice; Mice, Nude; Phenotype; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pyrazines; Radiation Tolerance; Radiotherapy; Treatment Failure

2012
Evaluation of pre-existing neuropathy and bortezomib retreatment as risk factors to develop severe neuropathy in a mouse model.
    Journal of the peripheral nervous system : JPNS, 2011, Volume: 16, Issue:3

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Disease Models, Animal; Female; Immunohistochemistry; Mice; Neurotoxicity Syndromes; Peripheral Nervous System Diseases; Pyrazines; Risk Factors

2011
Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever.
    PLoS neglected tropical diseases, 2011, Volume: 5, Issue:10

    Topics: Amides; Animals; Antiviral Agents; Arenavirus; Disease Models, Animal; Guinea Pigs; Hemorrhagic Fever, American; Humans; Lethal Dose 50; Male; Molecular Sequence Data; Pyrazines; RNA, Viral; Sequence Analysis, DNA; Survival Analysis; Treatment Outcome

2011
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.
    Bioorganic & medicinal chemistry, 2011, Dec-01, Volume: 19, Issue:23

    Topics: Animals; Antitubercular Agents; Bacterial Proteins; Cytoskeletal Proteins; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Pyrazines; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazines

2011
Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors.
    Bioorganic & medicinal chemistry, 2011, Dec-01, Volume: 19, Issue:23

    Topics: Administration, Oral; Animals; Azepines; Bleomycin; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Oxazines; Pulmonary Fibrosis; Pyrazines; Pyridones; Structure-Activity Relationship

2011
Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure.
    European journal of heart failure, 2012, Volume: 14, Issue:1

    Topics: Animals; Calmodulin; Cardiac Pacing, Artificial; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Glomerular Filtration Rate; Heart Failure; Heart Rate; Hemodynamics; Interleukin-6; Natriuretic Peptide, Brain; Pyrazines; Sitagliptin Phosphate; Sodium-Calcium Exchanger; Swine; Triazoles

2012
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
    Nature medicine, 2011, Nov-06, Volume: 17, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Boronic Acids; Bortezomib; Breast Neoplasms; Carboxypeptidases; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Humans; Mice; Mice, Inbred BALB C; Mice, SCID; Microarray Analysis; Multiple Myeloma; Piperidones; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Tumor Suppressor Protein p53; Ubiquitin; Ubiquitin Thiolesterase; Ubiquitination

2011
Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channels.
    Journal of neurophysiology, 2012, Volume: 107, Issue:4

    Topics: Acetanilides; Action Potentials; Analysis of Variance; Animals; Cornea; Disease Models, Animal; Dose-Response Relationship, Drug; Dry Eye Syndromes; Eye; Male; Mannitol; Neurons, Afferent; Osmolar Concentration; Purines; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Stimulation, Chemical; Tears; Temperature; Transient Receptor Potential Channels; Vision, Ocular

2012
Acipimox-enhanced ¹⁸F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model.
    The international journal of cardiovascular imaging, 2012, Volume: 28, Issue:6

    Topics: Animals; Diastole; Disease Models, Animal; Fluorodeoxyglucose F18; Hypolipidemic Agents; Male; Myocardial Infarction; Myocardium; Positron-Emission Tomography; Predictive Value of Tests; Pyrazines; Radiopharmaceuticals; Rats; Rats, Wistar; Time Factors; Ventricular Function, Left; Ventricular Remodeling

2012
Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Animals; Area Under Curve; Cardiomyopathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression Regulation; Glomerular Filtration Rate; Glucagon-Like Peptide 1; Heart; Humans; Kidney Failure, Chronic; Linagliptin; Myocardium; Natriuretic Peptide, Brain; Nephrectomy; Piperidines; Purines; Pyrazines; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles; Uracil; Uremia

2011
Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2011, Volume: 10, Issue:6

    Topics: Animals; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Immunity; Intestine, Small; Isoflavones; Ligusticum; Lymphoid Tissue; Pancreatitis, Acute Necrotizing; Pyrazines; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Vasodilator Agents

2011
Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat).
    Experimental diabetes research, 2011, Volume: 2011

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Insulin; Kidney Glomerulus; Lipid Peroxidation; Lipids; Male; Obesity; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2011
Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.
    Journal of ethnopharmacology, 2012, Mar-06, Volume: 140, Issue:1

    Topics: Animals; Astragalus Plant; Cardiovascular Agents; Caspase 3; Disease Models, Animal; Drug Synergism; Glucose; Hippocampus; Ischemic Attack, Transient; Male; Malondialdehyde; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Positron-Emission Tomography; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Saponins; Superoxide Dismutase; Triterpenes

2012
Long-term bortezomib treatment reduces allergen-specific IgE but fails to ameliorate chronic asthma in mice.
    International archives of allergy and immunology, 2012, Volume: 158, Issue:1

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Boronic Acids; Bortezomib; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Immunoglobulin G; Lung; Mice; Mice, Inbred BALB C; Plasma Cells; Pyrazines; Treatment Failure

2012
Ginsenoside-Rb1 and tetramethylpyrazine phosphate act synergistically to prevent dilated cardiomyopathy in cTnTR141W transgenic mice.
    Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:5

    Topics: Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cardiomyopathy, Dilated; Disease Models, Animal; Disease Progression; Drug Synergism; Drug Therapy, Combination; Echocardiography; Gene Expression Regulation; Ginsenosides; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction

2012
Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:6

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; CA1 Region, Hippocampal; Carbocyanines; Cell Line, Transformed; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; In Vitro Techniques; Intravitreal Injections; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurofilament Proteins; Neurons; Neuropeptides; Oxazolidinones; Protein Transport; Pyrazines; Receptors, AMPA; Receptors, Neuropeptide; Rhodamines; RNA, Messenger; Synapsins; Transfection

2012
The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture.
    Nephron. Experimental nephrology, 2012, Volume: 120, Issue:2

    Topics: Animals; Boronic Acids; Bortezomib; Collagen Type IV; Disease Models, Animal; Female; Humans; Immunohistochemistry; Injections, Intravenous; Kidney Glomerulus; Kidney Tubules; Lupus Nephritis; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Microscopy, Electron; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Survival Rate; Time Factors; Treatment Outcome

2012
Ischemia-reperfusion injury in rat steatotic liver is dependent on NFκB P65 activation.
    Transplant immunology, 2012, Volume: 26, Issue:4

    Topics: Animals; Boronic Acids; Bortezomib; Chemokine CXCL2; Disease Models, Animal; Fatty Liver; Humans; Inflammation Mediators; Interleukin-1beta; Liver; Proteasome Inhibitors; Pyrazines; Rats; Rats, Zucker; Reperfusion Injury; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2012
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.
    Laboratory investigation; a journal of technical methods and pathology, 2012, Volume: 92, Issue:5

    Topics: Animals; Carbolines; Dextran Sulfate; Disease Models, Animal; Electromyography; Hyperalgesia; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nociception; Pyrazines; Pyridines; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Time Factors; TRPV Cation Channels; Tryptophan Hydroxylase; Visceral Afferents

2012
Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Animals; Body Weight; Boronic Acids; Bortezomib; Disease Models, Animal; Humans; Immunoblotting; Immunohistochemistry; Kidney Diseases, Cystic; Kidney Neoplasms; Metformin; Mice; Pyrazines; Treatment Outcome; Tuberous Sclerosis

2012
TMP prevents retinal neovascularization and imparts neuroprotection in an oxygen-induced retinopathy model.
    Investigative ophthalmology & visual science, 2012, Apr-24, Volume: 53, Issue:4

    Topics: Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Ligusticum; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nerve Tissue Proteins; Neuroprotective Agents; Oxygen; Pyrazines; Reperfusion Injury; Retinal Neovascularization; Retinal Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vasodilator Agents

2012
Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies.
    AAPS PharmSciTech, 2012, Volume: 13, Issue:2

    Topics: Acrylic Resins; Administration, Cutaneous; Alzheimer Disease; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Escape Reaction; Ethanol; Glutathione Peroxidase; Lipid Peroxidation; Male; Malondialdehyde; Memory; Mice; Mice, Inbred ICR; Mice, Nude; Microscopy, Confocal; Permeability; Phosphatidylcholines; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine; Skin; Skin Absorption; Superoxide Dismutase; Technology, Pharmaceutical; Time Factors

2012
Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice.
    Antiviral research, 2012, Volume: 94, Issue:1

    Topics: Acids, Carbocyclic; Amides; Animals; Antiviral Agents; California; Cyclopentanes; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Mice; Mice, Inbred BALB C; Pandemics; Pyrazines

2012
Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models.
    Journal of neuroscience research, 2012, Volume: 90, Issue:8

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function

2012
Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy.
    Blood, 2012, Jul-12, Volume: 120, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Genes, myc; Humans; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Transgenic; Multiple Myeloma; Myeloma Proteins; Neoplasm Transplantation; Predictive Value of Tests; Pyrazines

2012
AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo.
    Human gene therapy, 2012, Volume: 23, Issue:6

    Topics: Animals; Antineoplastic Agents; Benzaldehydes; Boronic Acids; Bortezomib; Dependovirus; Disease Models, Animal; DNA End-Joining Repair; Gene Targeting; Genetic Vectors; Immunohistochemistry; Mice; Mice, Knockout; Plasmids; Polymerase Chain Reaction; Proteasome Endopeptidase Complex; Pyrazines; Recombinant Proteins

2012
Attenuation of early atherogenesis in low-density lipoprotein receptor-deficient mice by proteasome inhibition.
    Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Aortic Diseases; Atherosclerosis; Boronic Acids; Bortezomib; Chemokine CCL2; Cholesterol; Computational Biology; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-6; Lipid Peroxidation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Receptors, LDL; Superoxides; Time Factors; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents

2012
Anti-inflammatory effect of the proteasome inhibitor bortezomib on endotoxin-induced uveitis in rats.
    Investigative ophthalmology & visual science, 2012, Jun-26, Volume: 53, Issue:7

    Topics: Animals; Anterior Chamber; Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Down-Regulation; Electrophoretic Mobility Shift Assay; Immunohistochemistry; Male; NF-kappa B; Polymerase Chain Reaction; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Inbred Lew; Uveitis, Anterior

2012
Mesenchymal stem cells are conditionally therapeutic in preclinical models of rheumatoid arthritis.
    Annals of the rheumatic diseases, 2012, Volume: 71, Issue:10

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Boronic Acids; Bortezomib; Disease Models, Animal; Flow Cytometry; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrazines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; T-Lymphocytes

2012
Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2.
    Bioorganic & medicinal chemistry letters, 2012, Jul-01, Volume: 22, Issue:13

    Topics: Animals; Binding Sites; Casein Kinase II; Computer Simulation; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Indazoles; Injections, Intraperitoneal; Nephritis; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrazines; Rats; Structure-Activity Relationship

2012
[Effect of Ligustrazine on expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal muscle atrophy rats].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2012, Volume: 26, Issue:5

    Topics: Animals; Disease Models, Animal; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Injections, Intraperitoneal; Muscle Denervation; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Time Factors; Tripartite Motif Proteins; Ubiquitin-Protein Ligases

2012
Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:9

    Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Inflammation; Lung; Male; Mice; Nitric Oxide Synthase Type II; Ovalbumin; Pyrazines; RNA, Messenger; Sitagliptin Phosphate; Triazoles

2012
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.
    Bioorganic & medicinal chemistry letters, 2012, Aug-15, Volume: 22, Issue:16

    Topics: Administration, Oral; Animals; Apoptosis; Cell Line, Tumor; Cytochromes; Disease Models, Animal; Half-Life; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Microsomes, Liver; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyrazines; TOR Serine-Threonine Kinases; Transplantation, Heterologous

2012
Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:3

    Topics: Aged; Aged, 80 and over; Animals; Blood Pressure; Cells, Cultured; Cyclic AMP; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypertension; In Vitro Techniques; Kidney; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide; Peptides; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Glucagon; Regional Blood Flow; Renal Artery; Signal Transduction; Sitagliptin Phosphate; Triazoles; Venoms

2012
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
    Cell cycle (Georgetown, Tex.), 2012, Sep-15, Volume: 11, Issue:18

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Animal; Liver; Liver Neoplasms; Mice; Phenobarbital; Pyrazines; Thiostrepton

2012
Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:3

    Topics: Acetamides; Acetates; Alprostadil; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Hypertension, Pulmonary; In Vitro Techniques; Male; Pulmonary Artery; Pyrazines; Rats; Rats, Wistar; Receptors, Epoprostenol; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2012
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.
    Experimental neurology, 2012, Volume: 238, Issue:2

    Topics: Acetylcarnitine; Activating Transcription Factor 3; Adenosine Triphosphate; Analysis of Variance; Animals; Antineoplastic Agents; Axons; Boronic Acids; Bortezomib; Citrate (si)-Synthase; Disease Models, Animal; Electron Transport Complex II; Ganglia, Spinal; Hyperalgesia; Male; Mitochondria; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Time Factors; Ubiquitin Thiolesterase

2012
Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress-induced detrusor overactivity pathways in conscious rats.
    Neurourology and urodynamics, 2013, Volume: 32, Issue:5

    Topics: Administration, Intravenous; Animals; Cold Temperature; Consciousness; Disease Models, Animal; Female; Methanol; Pressure; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; TRPM Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urodynamics

2013
Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.
    Brain research, 2012, Dec-07, Volume: 1488

    Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome

2012
Vorinostat and bortezomib synergistically cause ubiquitinated protein accumulation in prostate cancer cells.
    The Journal of urology, 2012, Volume: 188, Issue:6

    Topics: Animals; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Hydroxamic Acids; Male; Mice; Mice, Nude; Molecular Targeted Therapy; Prostatic Neoplasms; Pyrazines; Random Allocation; RNA, Small Interfering; Sensitivity and Specificity; Ubiquitinated Proteins; Vorinostat; Xenograft Model Antitumor Assays

2012
Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.
    Channels (Austin, Tex.), 2013, Jan-01, Volume: 7, Issue:1

    Topics: Animals; Apoptosis; Cardiomegaly; Disease Models, Animal; Heart Failure; Humans; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Natriuretic Peptide, Brain; Pyrazines; Pyridines; TRPV Cation Channels

2013
Effects of tetramethylpyrazine on neuronal apoptosis in the superficial dorsal horn in a rat model of neuropathic pain.
    The American journal of Chinese medicine, 2012, Volume: 40, Issue:6

    Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Male; Neuralgia; Neurons; Posterior Horn Cells; Pyrazines; Rats

2012
Proteasome inhibition prolongs survival during lethal hemorrhagic shock in rats.
    The journal of trauma and acute care surgery, 2013, Volume: 74, Issue:2

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Boronic Acids; Bortezomib; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Rats, Inbred Lew; Shock, Hemorrhagic

2013
Tetramethylpyrazine attenuates atherosclerosis development and protects endothelial cells from ox-LDL.
    Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:3

    Topics: Animals; Aorta, Abdominal; Atherosclerosis; Cell Adhesion; Cell Culture Techniques; Cell Movement; Cells, Cultured; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Endothelial Cells; Immunohistochemistry; Ligusticum; Lipoproteins, LDL; Male; Plaque, Atherosclerotic; Pyrazines; Rabbits; Rats; Rats, Sprague-Dawley; Triglycerides

2013
Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 284, Issue:1

    Topics: Animals; Anticoagulants; Colitis, Ulcerative; Colon; Dextran Sulfate; Diarrhea; Disease Models, Animal; Gastrointestinal Hemorrhage; Hydroxamic Acids; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides

2003
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
    Microsurgery, 2002, Volume: 22, Issue:8

    Topics: Animals; Disease Models, Animal; Endothelin-1; Free Radical Scavengers; Kidney; Kidney Diseases; Malondialdehyde; Pyrazines; Random Allocation; Rats; Rats, Wistar; Renal Artery; Reperfusion Injury; Superoxide Dismutase

2002
Receptor activator of NF-kappaB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma.
    Cancer, 2003, Feb-01, Volume: 97, Issue:3 Suppl

    Topics: Animals; Antibodies, Monoclonal; Boronic Acids; Bortezomib; Carrier Proteins; Chemokine CCL3; Chemokine CCL4; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Glycoproteins; Macrophage Inflammatory Proteins; Membrane Glycoproteins; Mice; Multienzyme Complexes; Multiple Myeloma; Osteolysis; Osteoprotegerin; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteins; Pyrazines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor

2003
Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003, Volume: 12, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Dimethyl Fumarate; Disease Models, Animal; Enzyme Induction; Fumarates; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Intestinal Mucosa; Liver; Male; NAD(P)H Dehydrogenase (Quinone); NADP; Pyrazines; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes

2003
Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.
    World journal of gastroenterology, 2003, Volume: 9, Issue:7

    Topics: Animals; Disease Models, Animal; Free Radical Scavengers; Kidney; Liver; Male; P-Selectin; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury

2003
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Guinea Pigs; Male; Mice; Molecular Mimicry; Morphine; Pain; Pyrazines; Receptors, Opioid, mu; Tyrosine

2004
The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation.
    Experimental and molecular pathology, 2004, Volume: 76, Issue:1

    Topics: Actins; Animals; Boronic Acids; Bortezomib; Cell Membrane; Cells, Cultured; Chlormethiazole; Dicarbethoxydihydrocollidine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Fluorescent Antibody Technique, Indirect; Hepatocytes; Inclusion Bodies; Keratins; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Microscopy, Confocal; Phosphoproteins; Protease Inhibitors; Pyrazines; Zonula Occludens-1 Protein

2004
Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2005, Feb-01, Volume: 15, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Administration, Oral; Alkynes; Animals; Catalepsy; Cerebral Cortex; Disease Models, Animal; Mice; Oxidopamine; Parkinson Disease; Pyrazines; Rats; Structure-Activity Relationship; Triazoles

2005
[Effect of ligustrazine on airway remodeling in asthmatic rats].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2004, Volume: 27, Issue:12

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Collagen Type III; Disease Models, Animal; Drugs, Chinese Herbal; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Ovalbumin; Pyrazines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta

2004
Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Camptothecin; Disease Models, Animal; DNA Topoisomerases, Type I; Down-Regulation; Female; Humans; Mice; Mice, Nude; Protease Inhibitors; Pyrazines; RNA, Messenger; S Phase; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2005
The fully human anti-CD30 antibody 5F11 activates NF-{kappa}B and sensitizes lymphoma cells to bortezomib-induced apoptosis.
    Blood, 2005, Sep-01, Volume: 106, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cytotoxicity, Immunologic; Disease Models, Animal; Drug Synergism; Hodgkin Disease; Humans; Intracellular Signaling Peptides and Proteins; Ki-1 Antigen; Mice; NF-kappa B; Pyrazines; Signal Transduction; Xenograft Model Antitumor Assays

2005
Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Jun-15, Volume: 174, Issue:12

    Topics: Acute Disease; Animals; Arthritis, Experimental; Boronic Acids; Bortezomib; Dermatitis, Contact; Disease Models, Animal; Enzyme Induction; Female; Genetic Vectors; Lipopolysaccharides; Luciferases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Organ Specificity; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Sepsis; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha

2005
Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists.
    Bioorganic & medicinal chemistry letters, 2005, Nov-01, Volume: 15, Issue:21

    Topics: Adenosine A2 Receptor Antagonists; Animals; Brain; Cell Membrane; Disease Models, Animal; Parkinson Disease; Pyrazines; Radioligand Assay; Rats; Structure-Activity Relationship

2005
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.
    Bioorganic & medicinal chemistry letters, 2006, Jan-15, Volume: 16, Issue:2

    Topics: Administration, Oral; Animals; Arthritis, Experimental; Disease Models, Animal; Enzyme Inhibitors; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinase 14; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2006
Drug Discovery Technology and Development 2005 - IBC's Tenth World Congress. Cancer mouse models and other techniques for improved prediction of efficacy.
    IDrugs : the investigational drugs journal, 2005, Volume: 8, Issue:10

    Topics: Angiogenesis Inhibitors; Animals; Boronic Acids; Bortezomib; Camptothecin; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Forecasting; Gemcitabine; Green Fluorescent Proteins; Humans; Image Enhancement; Irinotecan; Luminescent Proteins; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Pyrazines; Red Fluorescent Protein; Technology, Pharmaceutical; Treatment Outcome

2005
Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease.
    Experimental neurology, 2006, Volume: 198, Issue:1

    Topics: Animals; Body Weight; Brain-Derived Neurotrophic Factor; CD11b Antigen; Cell Death; Choline O-Acetyltransferase; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Imidazoles; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Motor Activity; Motor Neurons; Neurodegenerative Diseases; Psychomotor Performance; Pyrazines; Radioimmunoassay; Riluzole

2006
Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma.
    Blood, 2006, May-15, Volume: 107, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Combined Modality Therapy; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Multiple Myeloma; Organometallic Compounds; Organophosphorus Compounds; Protease Inhibitors; Pyrazines; Radiopharmaceuticals

2006
Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503.
    Brain research, 2006, Feb-16, Volume: 1073-1074

    Topics: Animals; Anti-Obesity Agents; Arachidonic Acid; Behavior, Animal; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Eating; Humans; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphoric Monoester Hydrolases; Pyrazines; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium

2006
Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:5

    Topics: Animals; Colitis; Colon; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hydroxamic Acids; Inflammation Mediators; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neutrophils; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides; Trinitrobenzenesulfonic Acid; Up-Regulation

2006
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia.
    Neuroscience letters, 2006, May-08, Volume: 398, Issue:3

    Topics: Animals; Boronic Acids; Bortezomib; Brain Infarction; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Intracranial Embolism; Male; Neuroprotective Agents; Proteasome Inhibitors; Pyrazines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley

2006
Treatment of embolic stroke in rats with bortezomib and recombinant human tissue plasminogen activator.
    Thrombosis and haemostasis, 2006, Volume: 95, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Boronic Acids; Bortezomib; Brain; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Fibrinolytic Agents; Humans; Infarction, Middle Cerebral Artery; Intracranial Embolism; Male; NF-kappa B; Nitric Oxide Synthase Type III; Platelet Aggregation; Protease Inhibitors; Pyrazines; Rats; Rats, Wistar; Recombinant Proteins; Stroke; Time Factors; Tissue Plasminogen Activator; Vascular Patency

2006
Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors.
    Journal of immunology (Baltimore, Md. : 1950), 2006, May-15, Volume: 176, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Models, Animal; Growth Inhibitors; Interleukin-12; Interleukin-2; Liver Neoplasms; Male; Mice; Mice, Inbred A; Neuroblastoma; Proteasome Inhibitors; Pyrazines

2006
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.
    Diabetes, 2006, Volume: 55, Issue:6

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Disease Models, Animal; Dyslipidemias; Glipizide; Hypoglycemic Agents; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred ICR; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Triazoles

2006
Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.
    BMC neuroscience, 2006, Jun-14, Volume: 7

    Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Male; Malondialdehyde; Microscopy, Electron, Transmission; Motor Neurons; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rabbits; Spinal Cord; Spinal Cord Ischemia; Superoxide Dismutase; Treatment Outcome; Up-Regulation

2006
Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:7

    Topics: Animals; Benzoates; Body Weight; Bone Marrow Cells; Bridged-Ring Compounds; Colony-Forming Units Assay; Coumaric Acids; Disease Models, Animal; Dose-Response Relationship, Radiation; Drugs, Chinese Herbal; Female; Fructose; Gamma Rays; Glucosides; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Monoterpenes; Pyrazines; Radiation-Protective Agents; Stem Cells; Thymus Gland

2006
Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis.
    Cancer immunology, immunotherapy : CII, 2007, Volume: 56, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Humans; Injections, Intravenous; Injections, Subcutaneous; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Neovascularization, Pathologic; Pyrazines; Receptor, IGF Type 1; Structure-Activity Relationship; Survival Rate; Xenograft Model Antitumor Assays

2007
CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Amphetamines; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Helplessness, Learned; Humans; Hyperkinesis; Inhibition, Psychological; Male; Mice; Motor Activity; NIH 3T3 Cells; Piperazines; Protein Binding; Psychotic Disorders; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists

2007
Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo.
    Biochemical and biophysical research communications, 2006, Nov-10, Volume: 350, Issue:1

    Topics: Animals; Base Sequence; Capsaicin; Chlorocebus aethiops; Colitis; COS Cells; Disease Models, Animal; Humans; Male; Mice; Molecular Sequence Data; Nervous System Diseases; Pain; Pyrazines; Pyridines; Rats; RNA Interference; Sequence Alignment; Sequence Homology, Amino Acid; TRPV Cation Channels

2006
Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function.
    Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Doxycycline; Drug Resistance, Bacterial; Hydroxamic Acids; Immunologic Factors; Inflammation; Lipopolysaccharides; Lung; Lung Diseases; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Neutrophils; Pulmonary Alveoli; Pyrazines; Streptococcus pneumoniae; Sulfonamides

2007
The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.
    Life sciences, 2007, Jan-02, Volume: 80, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Heart Rate; Hydroxy Acids; Injections, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pyrazines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Fibrillation

2007
Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Cytochromes c; Disease Models, Animal; DNA; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression; Gentamicins; In Situ Nick-End Labeling; Kidney Tubules, Proximal; Ligusticum; Male; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Tumor Necrosis Factor-alpha; Vasodilator Agents

2007
Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis.
    World journal of gastroenterology, 2006, Dec-21, Volume: 12, Issue:47

    Topics: Acute Disease; Animals; Disease Models, Animal; Kidney Diseases; Pancreatitis, Acute Necrotizing; Pyrazines; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilator Agents

2006
Establishment of a mouse skin model of the lichenification in human chronic eczematous dermatitis.
    The British journal of dermatology, 2007, Volume: 156, Issue:5

    Topics: Animals; Disease Models, Animal; Eczema; Epidermis; Glycine; Glycine Agents; Humans; Hydroxamic Acids; Male; Metalloendopeptidases; Mice; Mice, Hairless; Pyrazines; Skin Aging; Sulfonamides

2007
Proteasomal inhibition in intracerebral hemorrhage: neuroprotective and anti-inflammatory effects of bortezomib.
    Neuroscience research, 2007, Volume: 58, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Boronic Acids; Bortezomib; Brain Edema; Cerebral Cortex; Cerebral Hemorrhage; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Gliosis; Inflammation Mediators; Male; Microglia; Neuroprotective Agents; Neutrophils; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Treatment Outcome

2007
Protective effect of ligustrazine on accelerated anti-glomerular basement membrane antibody nephritis in rats is based on its antioxidant properties.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Animals; Anti-Glomerular Basement Membrane Disease; Antibodies; Antioxidants; Autoantibodies; Blood Urea Nitrogen; Catalase; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Kidney; Male; Malondialdehyde; Proteinuria; Pyrazines; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase

2007
Effect of tetramethylpyrazine on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitro.
    Current eye research, 2007, Volume: 32, Issue:1

    Topics: Animals; Capillary Permeability; Cell Proliferation; Cells, Cultured; Choroidal Neovascularization; Dextrans; Disease Models, Animal; Endothelium, Vascular; Fluorescein Angiography; Fluorescein-5-isothiocyanate; Injections, Intraperitoneal; Laser Coagulation; Male; Platelet Aggregation Inhibitors; Pyrazines; Rats; Rats, Inbred BN; Umbilical Veins

2007
Ligustrazine alleviates gastric mucosal injury in a rat model of acute necrotizing pancreatitis.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2007, Volume: 6, Issue:2

    Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Female; Gastric Mucosa; Inflammation Mediators; Interleukin-1beta; Ligusticum; Male; Microcirculation; Pancreas; Pancreatitis, Acute Necrotizing; Peroxidase; Phytotherapy; Pyrazines; Rats; Rats, Sprague-Dawley; Regional Blood Flow

2007
Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.
    Blood, 2007, Jul-01, Volume: 110, Issue:1

    Topics: Animals; Boronic Acids; Bortezomib; Disease Models, Animal; Mice; NF-kappa B; Osteosclerosis; Primary Myelofibrosis; Protease Inhibitors; Pyrazines; Survival Rate; Thrombopoietin

2007
Activity of T-1106 in a hamster model of yellow Fever virus infection.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6

    Topics: Amides; Animals; Antiviral Agents; Chlorocebus aethiops; Cricetinae; Disease Models, Animal; Female; Humans; Mesocricetus; Pyrazines; Treatment Outcome; Vero Cells; Yellow Fever; Yellow fever virus

2007
Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:3

    Topics: Animals; Biological Availability; Bridged-Ring Compounds; Chronic Disease; Disease Models, Animal; Inflammation; Inhibitory Concentration 50; Muscarinic Agonists; Pain; Pyrazines; Rats; Receptors, Muscarinic

2007
[Effect of bortezomib used alone or in combination with arsenic trioxide on HL-60 cell xenograft in nude mice].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:10

    Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Proliferation; Disease Models, Animal; HL-60 Cells; Humans; Leukemia; Male; Mice; Mice, Nude; Oxides; Pyrazines; Random Allocation; Xenograft Model Antitumor Assays

2007
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Intestinal Mucosa; Intestines; Male; Muscle Relaxation; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels

2008
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 102, Issue:1

    Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenobarbital; Protective Agents; Pyrazines; Pyridines; RNA, Messenger; Symporters; Thiones; Thiophenes; Time Factors; Up-Regulation

2008
beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents.
    Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3

    Topics: Amino Acids; Animals; Brain Edema; Disease Models, Animal; Drug Design; Gelatinases; Humans; Hydroxamic Acids; Matrix Metalloproteinase Inhibitors; Microsomes, Liver; Middle Cerebral Artery; Molecular Structure; Pyrazines; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfonamides

2008
A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphoma.
    Cancer research, 2007, Dec-15, Volume: 67, Issue:24

    Topics: Animals; Apoptosis; Boronic Acids; Bortezomib; Cell Survival; Disease Models, Animal; Genes, Reporter; HTLV-I Infections; Humans; Jurkat Cells; Luciferases; Male; Mice; Mice, Inbred NOD; Mice, SCID; Protease Inhibitors; Pyrazines

2007
Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model.
    The American journal of Chinese medicine, 2007, Volume: 35, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Lung; Male; Ovalbumin; Pyrazines; Rats; T-Box Domain Proteins; Th1 Cells; Th2 Cells

2007
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
    Behavioural pharmacology, 2008, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Temperature; Constriction, Pathologic; Disease Models, Animal; Diterpenes; gamma-Aminobutyric Acid; Male; Mexiletine; Morphine; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregabalin; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sodium Channel Blockers; TRPV Cation Channels

2008
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:4

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Behavior, Animal; Calcium Channel Blockers; Central Nervous System; Disease Models, Animal; Epilepsy; Humans; Kindling, Neurologic; Lamotrigine; Male; Mice; Molecular Structure; Motor Activity; Pyrazines; Rats; Rats, Sprague-Dawley; Seizures; Sodium Channel Blockers; Triazines

2008
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
    British journal of haematology, 2008, Volume: 141, Issue:5

    Topics: Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Heat-Shock Proteins; Hematopoietic Stem Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mice; Mice, SCID; Multiple Myeloma; Neoplasm Transplantation; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrazines; Pyridines; Tumor Cells, Cultured

2008
Aminopyrazine CB1 receptor inverse agonists.
    Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11

    Topics: Animals; Blood Glucose; Combinatorial Chemistry Techniques; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Feeding Behavior; Humans; Microsomes, Liver; Molecular Structure; Obesity; Piperidines; Pyrazines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship

2008
On the mechanism of diminished urinary carbon dioxide tension caused by amiloride.
    Kidney international, 1982, Volume: 21, Issue:1

    Topics: Acidosis, Renal Tubular; Amiloride; Animals; Carbon Dioxide; Carbonic Anhydrases; Disease Models, Animal; Dogs; Partial Pressure; Pyrazines

1982
Tetramethylpyrazine improves spatial cognitive impairment induced by permanent occlusion of bilateral common carotid arteries or scopolamine in rats.
    Japanese journal of pharmacology, 1995, Volume: 67, Issue:2

    Topics: Animals; Brain Ischemia; Carotid Arteries; Cognition; Disease Models, Animal; Male; Maze Learning; Pyrazines; Rats; Rats, Wistar; Scopolamine; Spatial Behavior; Vasodilator Agents

1995
Vesnarinone prolongs survival and reduces lethality in a murine model of lethal endotoxemia.
    Life sciences, 1994, Volume: 55, Issue:22

    Topics: Animals; Disease Models, Animal; Female; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Pyrazines; Quinolines; Toxemia; Tumor Necrosis Factor-alpha

1994
A chemiluminescent detection of superoxide radical produced by adherent leucocytes to the subendothelium following thrombolysis: studies with a photochemically induced thrombosis model in the guinea pig femoral artery.
    Atherosclerosis, 1996, Volume: 122, Issue:2

    Topics: Animals; Cell Adhesion; Disease Models, Animal; Endothelium, Vascular; Femoral Artery; Guinea Pigs; Imidazoles; Light; Luminescent Measurements; Male; Neutrophils; Plasminogen Activators; Pyrazines; Recombinant Proteins; Rose Bengal; Superoxides; Thrombolytic Therapy; Thrombosis

1996
The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil.
    Brain research, 1995, Dec-24, Volume: 705, Issue:1-2

    Topics: Animals; Behavior, Animal; Caffeine; Carotid Arteries; Cerebral Cortex; Cerebrovascular Disorders; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Locomotion; Male; Purinergic P1 Receptor Antagonists; Pyrazines; Reperfusion Injury; Xanthines

1995
Effects of TAK-029, a novel GPIIb/IIIa antagonist, on arterial thrombosis in guinea pigs, dogs and monkeys.
    Thrombosis research, 1997, May-15, Volume: 86, Issue:4

    Topics: Animals; Basilar Artery; Bleeding Time; Carotid Artery Thrombosis; Coronary Thrombosis; Disease Models, Animal; Dogs; Female; Guanidines; Guinea Pigs; Injections, Intravenous; Macaca fascicularis; Male; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrazines; Thrombosis

1997
Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia.
    Biochemical and biophysical research communications, 1997, Oct-09, Volume: 239, Issue:1

    Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors; Lipopolysaccharides; Male; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Organ Culture Techniques; Phenylephrine; Pyrazines; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

1997
Studies on pyrazinoylguanidine. 5. Temporal effects over 24 weeks demonstrating attenuation of diabetic nephropathy in STZ-diabetic rats.
    Pharmacology, 1997, Volume: 54, Issue:5

    Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Guanidines; Hydrochlorothiazide; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Kidney; Kidney Function Tests; Male; Molecular Weight; Pyrazines; Rats; Rats, Sprague-Dawley; Serum Albumin; Streptozocin

1997
Beneficial effects of combined terlipressin and tetramethylpyrazine administration on portal hypertensive rats.
    Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:8

    Topics: Animals; Antihypertensive Agents; Cholestasis; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Portal; Lypressin; Male; Portal Vein; Pyrazines; Rats; Rats, Sprague-Dawley; Terlipressin; Vasodilator Agents

1999
Tetramethylpyradizine prevents inducible NO synthase expression and improves survival in rodent models of endotoxic shock.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:4

    Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Heart Rate; In Vitro Techniques; Lipopolysaccharides; Lung; Male; Mice; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Norepinephrine; Pyrazines; Rats; Rats, Inbred WKY; Shock, Septic; Tumor Necrosis Factor-alpha; Vasodilator Agents

1999
Vesnarinone restores contractility and calcium handling in early endotoxemia.
    Circulation, 2000, Nov-07, Volume: 102, Issue:19 Suppl 3

    Topics: Animals; Calcium; Cardiac Pacing, Artificial; Cardiotonic Agents; Disease Models, Animal; Endotoxemia; Fluorescent Dyes; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Infusions, Intravenous; Intracellular Fluid; Lipopolysaccharides; Myocardial Contraction; Oxygen Consumption; Pyrazines; Quinolines; Rabbits; Ventricular Function, Left

2000
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
    Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Cell Membrane; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Agonists; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Inhibitory Concentration 50; Male; Mice; Mice, Inbred DBA; Oocytes; Protein Binding; Pyrazines; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Time Factors; Xenopus

2000
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
    Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Disease Models, Animal; Excitatory Amino Acid Antagonists; Imidazoles; Inhibitory Concentration 50; Male; Mice; Oocytes; Pyrazinamide; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship

2001
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Nucleus; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Epoxide Hydrolases; Female; FMN Reductase; Gene Expression; Genotype; Glucuronosyltransferase; Glutathione Transferase; Mice; Mice, Inbred ICR; Mice, Knockout; NADH, NADPH Oxidoreductases; NF-E2-Related Factor 2; Pyrazines; Stomach Neoplasms; Thiones; Thiophenes; Trans-Activators

2001
Continuous observation of superoxide generation in an in-situ ischemia-reperfusion rat lung model.
    Japanese circulation journal, 2001, Volume: 65, Issue:3

    Topics: Animals; Arterial Occlusive Diseases; Disease Models, Animal; Free Radical Scavengers; Imidazoles; Kinetics; Luminescent Measurements; Lung; Male; Pulmonary Artery; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Superoxides

2001
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:5

    Topics: Animals; Antineoplastic Agents; Blood Vessels; Boronic Acids; Bortezomib; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cysteine Endopeptidases; Cytokines; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Inbred BALB C; Mice, SCID; Multienzyme Complexes; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; NF-kappa B; Proteasome Endopeptidase Complex; Pyrazines; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2001
9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): selective anticonvulsive and neuroprotective AMPA antagonist.
    Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:5

    Topics: Animals; Anticonvulsants; Brain Injuries; Brain Ischemia; Disease Models, Animal; Gerbillinae; Imidazoles; Male; Neuroprotective Agents; Oocytes; Protein Binding; Pyrazines; Radioligand Assay; Rats; Receptors, AMPA; Reperfusion Injury; Seizures; Spinal Cord Compression; Synapses; Xenopus

2002
Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic cross-clamping in rabbits.
    BMC neurology, 2002, Apr-17, Volume: 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Cell Count; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motor Activity; Neurologic Examination; Neurons; Paraplegia; Pyrazines; Rabbits; Spinal Cord; Spinal Cord Ischemia; Thoracic Surgical Procedures; Treatment Outcome

2002
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
    European journal of pharmacology, 1992, Sep-22, Volume: 220, Issue:2-3

    Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation

1992
Left ventricular contractility and energetic cost in disease models--an approach from the pressure-volume diagram.
    Japanese circulation journal, 1992, Volume: 56, Issue:7

    Topics: Animals; Calcium; Disease Models, Animal; Dogs; Epinephrine; Heart Diseases; Myocardial Contraction; Oxygen Consumption; Propranolol; Pyrazines; Quinolines; Rabbits

1992
Diuretics and carbohydrate metabolism: the effects of furosemide and amiloride on blood glucose, plasma insulin and cations in the rat.
    Diabetologia, 1973, Volume: 9, Issue:1

    Topics: Adrenalectomy; Amiloride; Animals; Blood Glucose; Chemical Phenomena; Chemistry; Diabetes Mellitus; Disease Models, Animal; Diuretics; Erythrocytes; Furosemide; Glucose Tolerance Test; Hyperkalemia; Insulin; Male; Potassium; Pyrazines; Rats; Sodium; Streptozocin

1973
A new analogous model for the detection and evaluation of chemotherapeutic products effective in leprosy.
    Arzneimittel-Forschung, 1972, Volume: 22, Issue:8

    Topics: Aniline Compounds; Animals; Dapsone; Disease Models, Animal; Drug Combinations; Ethionamide; Humans; Isoniazid; Leprosy; Mice; Models, Biological; Mycobacterium Infections; Phenazines; Pyrazines; Rabbits; Rifampin; Sulfonamides; Trimethoprim

1972