pyrazines has been researched along with Diabetic Neuropathies in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Fujita, T; Inoue, K; Ishii, D; Itou, M; Kakuyama, H; Takagaki, T; Uchida, N | 1 |
| Deng, Z; Fan, Y; Liu, M; Wang, M | 1 |
| Baba, M; Hamatani, T; Imai, T; Kohara, N; Komori, T; Naito, Y; Satoh, J; Sekiguchi, K; Yamaguchi, Y | 1 |
| Resham, K; Sharma, SS | 1 |
| Cappuccio, F; Ceriello, A; Genovese, S; Schnell, O; Standl, E; Valensi, P | 1 |
| Giannoukakis, N | 1 |
| Arezzo, J; Bradshaw, KL; Bril, V; Gordon, RJ; Junor, RW; Nash, M; Polydefkis, M; Shaibani, A | 1 |
| Carcolé, M; Castany, S; Leánez, S; Pol, O | 1 |
| Kohara, N; Satoh, J; Sekiguchi, K; Yamaguchi, Y | 1 |
| Bril, V; Kuromiya, A; Matsumoto, T; Ono, Y; Toyosawa, K; Ueda, Y | 1 |
| Bril, V; Kuromiya, A; Kurono, M; Matsumoto, T; Nakamura, K; Ono, Y | 1 |
| Bril, V; Buchanan, R; Hirose, T; Tomioka, S | 1 |
| Chen, W; Chen, Y; Huang, X; Li, L; Li, Z; Zhang, L | 1 |
| Collet, P; Marotte, H; Nizeica, V | 1 |
| Bril, V; Buchanan, RA | 2 |
| Cañadell Vidal, J | 1 |
2 review(s) available for pyrazines and Diabetic Neuropathies
| Article | Year |
|---|---|
Type 1 diabetes and cardiovascular disease.
Topics: Antihypertensive Agents; Autonomic Nervous System Diseases; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Neuropathies; Drug Therapy, Combination; Exenatide; Exercise Therapy; Glucagon-Like Peptide 1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Insulin; Oxidative Stress; Peptides; Pyrazines; Sitagliptin Phosphate; Triazoles; Venoms | 2013 |
Evaluation of ranirestat for the treatment of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Biomarkers; Clinical Trials as Topic; Diabetic Neuropathies; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Mice; Pyrazines; Rats; Reproducibility of Results; Spiro Compounds | 2014 |
7 trial(s) available for pyrazines and Diabetic Neuropathies
| Article | Year |
|---|---|
Pharmacokinetics and Safety of Ranirestat in Patients With Hepatic Impairment.
Topics: Adult; Aged; Area Under Curve; Diabetic Neuropathies; Enzyme Inhibitors; Female; Healthy Volunteers; Humans; Liver Diseases; Male; Middle Aged; Protein Binding; Pyrazines; Spiro Compounds | 2020 |
Aldose reductase inhibitor ranirestat significantly improves nerve conduction velocity in diabetic polyneuropathy: A randomized double-blind placebo-controlled study in Japan.
Topics: Adult; Aged; Aldehyde Reductase; Diabetic Neuropathies; Double-Blind Method; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Neural Conduction; Prognosis; Pyrazines; Quality of Life; Spiro Compounds; Young Adult | 2019 |
Safety and efficacy of ranirestat in patients with mild-to-moderate diabetic sensorimotor polyneuropathy.
Topics: Aged; Diabetic Neuropathies; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Neural Conduction; Polyneuropathies; Pyrazines; Quality of Life; Spiro Compounds; Treatment Outcome | 2015 |
Effect of Ranirestat on Sensory and Motor Nerve Function in Japanese Patients with Diabetic Polyneuropathy: A Randomized Double-Blind Placebo-Controlled Study.
Topics: Administration, Oral; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Japan; Kidney Function Tests; Liver Function Tests; Male; Middle Aged; Motor Neurons; Neural Conduction; Pyrazines; Sensory Receptor Cells; Severity of Illness Index; Spiro Compounds; Temperature | 2016 |
Ranirestat for the management of diabetic sensorimotor polyneuropathy.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Median Nerve; Middle Aged; Motor Neurons; Neural Conduction; Placebos; Pyrazines; Sensory Thresholds; Spiro Compounds; Sural Nerve; Young Adult | 2009 |
Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electromyography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neural Conduction; Polyneuropathies; Probability; Pyrazines; Reference Values; Risk Assessment; Severity of Illness Index; Spiro Compounds; Sural Nerve; Treatment Outcome | 2004 |
Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Enzyme Inhibitors; Glycated Hemoglobin; Humans; Motor Neurons; Neural Conduction; Patient Selection; Peripheral Nerves; Peroneal Nerve; Placebos; Pyrazines; Spiro Compounds; Sural Nerve | 2006 |
8 other study(ies) available for pyrazines and Diabetic Neuropathies
| Article | Year |
|---|---|
Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with mecobalamin for treating diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis.
Topics: Diabetic Neuropathies; Drugs, Chinese Herbal; Humans; Injections; Meta-Analysis as Topic; Neural Conduction; Phytotherapy; Pyrazines; Salvia miltiorrhiza; Systematic Review as Topic; Vitamin B 12 | 2021 |
Pharmacologic Inhibition of Porcupine, Disheveled, and β-Catenin in Wnt Signaling Pathway Ameliorates Diabetic Peripheral Neuropathy in Rats.
Topics: Animals; beta Catenin; Depsipeptides; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dishevelled Proteins; Enzyme Inhibitors; Male; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2019 |
The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1.
Topics: Analgesics, Opioid; Animals; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enzyme Induction; Heme Oxygenase-1; Hyperalgesia; Injections, Subcutaneous; Male; Mice, Inbred C57BL; Organometallic Compounds; Physical Stimulation; Pyrazines; Pyrroles; Receptors, Opioid, delta; Ruthenium | 2016 |
Long-term treatment with ranirestat (AS-3201), a potent aldose reductase inhibitor, suppresses diabetic neuropathy and cataract formation in rats.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Neuropathies; Enzyme Inhibitors; Pyrazines; Rats; Spiro Compounds | 2008 |
Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Diabetic Neuropathies; Enzyme Inhibitors; Male; Neural Conduction; Pyrazines; Rats; Rats, Wistar; Sorbitol; Spiro Compounds; Streptozocin | 2008 |
[Effects of naokang erhao decoction on cognitive ability and hippocampal apoptosis-related proteins in diabetic rats].
Topics: Abietanes; Acetophenones; Animals; Apoptosis; bcl-2-Associated X Protein; Benzoates; Bridged-Ring Compounds; CA1 Region, Hippocampal; Caspase 3; Cognition Disorders; Diabetic Neuropathies; Drug Combinations; Drugs, Chinese Herbal; Glucosides; Male; Maze Learning; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats | 2011 |
Bortezomib induced a phrenic palsy in a multiple myeloma patient.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Boronic Acids; Bortezomib; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diagnosis, Differential; Diphosphonates; gamma-Aminobutyric Acid; Humans; Imidazoles; Male; Melphalan; Multiple Myeloma; Nerve Compression Syndromes; Neuralgia; Phrenic Nerve; Prednisone; Pregabalin; Protease Inhibitors; Pyrazines; Respiratory Paralysis; Zoledronic Acid | 2013 |
[Clinical trial of glypizide].
Topics: Administration, Oral; Cyclohexanes; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Diabetic Retinopathy; Drug Evaluation; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Pyrazines; Sulfonylurea Compounds | 1974 |