Compounds > pyrazines
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pyrazines and Cognition Disorders

pyrazines has been researched along with Cognition Disorders in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's0 (0.00)29.6817
2010's7 (70.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Iwashita, H; Nakashima, M; Shiraishi, E; Suzuki, N1
Chen, H; Cheng, J; Guo, B; Huang, C; Su, Z; Sun, Y; Wang, Y; Wu, J; Wu, L; Yang, X; Zhang, G; Zhang, Z; Zhu, Z1
Ashizawa, T; Hoffman, ID; Imada, H; Iwashita, H; Kamiguchi, N; Kawasaki, M; Kokubo, H; Mikami, S; Nakamura, S; Nakashima, K; Nomura, I; Oki, H; Sasaki, S; Suzuki, N; Taniguchi, T; Uchiyama, N; Zou, H1
Ashizawa, T; Hiura, Y; Hoffman, ID; Ikeda, S; Itou, Y; Iwashita, H; Kawasaki, M; Kokubo, H; Mikami, S; Miyamoto, M; Nakamura, S; Nakashima, M; Negoro, N; Nomura, I; Oki, H; Taniguchi, T; Uchiyama, N; Zou, H1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Pintana, H1
Bruce, SS; Connolly, ES; Heyer, EJ; Mergeche, JL1
Beaulieu, JM; Del'Guidice, T; Doré, FY; Escoffier, G; Etievant, A; Lemasson, M; Lemay, F; Levasseur-Moreau, J; Manta, S; Roman, FS1
Chen, W; Chen, Y; Huang, X; Li, L; Li, Z; Zhang, L1
Conrad, CA; Gelke, CK; Grove, W; Kudelka, AP; Meyers, CA; Pazdur, R1
Abou-Gharbia, M; Boast, CA; Husbands, GM; Moyer, JA; Sabb, AL; Stein, RP; Tasse, RP; Tokolics, J1

Trials

1 trial(s) available for pyrazines and Cognition Disorders

ArticleYear
Neurotoxicity of CI-980, a novel mitotic inhibitor.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Carbamates; Cognition; Cognition Disorders; Colorectal Neoplasms; Female; Humans; Male; Memory; Memory Disorders; Middle Aged; Neuropsychological Tests; Neurotoxins; Ovarian Neoplasms; Pyrazines; Pyridines

1997

Other Studies

9 other study(ies) available for pyrazines and Cognition Disorders

ArticleYear
TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.
    Behavioural brain research, 2019, 12-30, Volume: 376

    Topics: Aging; Animals; Brain; Cognition; Cognition Disorders; Cognitive Dysfunction; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Male; Memory Disorders; Memory, Episodic; Phosphodiesterase Inhibitors; Pyrazines; Pyridines; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Sprague-Dawley

2019
The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease.
    Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Avoidance Learning; Cognition Disorders; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Hydrazones; MAP Kinase Signaling System; Memantine; Mice; Mice, Transgenic; Morris Water Maze Test; Neuroprotective Agents; Phosphorylation; Protein Processing, Post-Translational; Pyrazines; Random Allocation; Recognition, Psychology; Signal Transduction; tau Proteins; TOR Serine-Threonine Kinases

2021
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor
    Journal of medicinal chemistry, 2017, 09-28, Volume: 60, Issue:18

    Topics: Animals; Brain; Cognition; Cognition Disorders; Crystallography, X-Ray; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Drug Design; Halogenation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Phosphodiesterase Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley

2017
Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (
    Chemical & pharmaceutical bulletin, 2017, Volume: 65, Issue:11

    Topics: 3T3 Cells; Administration, Oral; Animals; Cell Survival; Chlorocebus aethiops; Cognition Disorders; COS Cells; Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Drug Discovery; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Molecular Structure; Phosphodiesterase Inhibitors; Powder Diffraction; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Long-Evans; Solubility; Structure-Activity Relationship; Thermodynamics

2017
DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats.
    The Journal of endocrinology, 2013, Volume: 218, Issue:1

    Topics: Adamantane; Animals; Behavior, Animal; Brain; Cognition Disorders; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Hippocampus; Insulin Resistance; Male; Maze Learning; Memory; Memory Disorders; Mitochondria; Nitriles; Obesity; Oxidative Stress; Pyrazines; Pyrrolidines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles; Vildagliptin

2013
Inflammation and cognitive dysfunction in type 2 diabetic carotid endarterectomy patients.
    Diabetes care, 2013, Volume: 36, Issue:10

    Topics: Aged; Cognition Disorders; Diabetes Mellitus, Type 2; Endarterectomy, Carotid; Glyburide; Humans; Hypoglycemic Agents; Inflammation; Logistic Models; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Triazoles

2013
Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:5

    Topics: 5-Hydroxytryptophan; Animals; Avoidance Learning; Cognition; Cognition Disorders; Dopamine Uptake Inhibitors; Humans; Maze Learning; Methylphenidate; Mice; Mice, Transgenic; Motor Activity; Mutation; Olfactory Perception; Piperazines; Pyrazines; Receptor, Serotonin, 5-HT2C; Reversal Learning; Reward; Serotonin 5-HT2 Receptor Agonists; Serotonin Agents; Tryptophan Hydroxylase

2014
[Effects of naokang erhao decoction on cognitive ability and hippocampal apoptosis-related proteins in diabetic rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011, Volume: 36, Issue:11

    Topics: Abietanes; Acetophenones; Animals; Apoptosis; bcl-2-Associated X Protein; Benzoates; Bridged-Ring Compounds; CA1 Region, Hippocampal; Caspase 3; Cognition Disorders; Diabetic Neuropathies; Drug Combinations; Drugs, Chinese Herbal; Glucosides; Male; Maze Learning; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats

2011
Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and receptor modelling.
    Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

    Topics: Administration, Oral; Animals; Bridged-Ring Compounds; Carbachol; Cerebral Cortex; CHO Cells; Cognition Disorders; Computer Simulation; Cricetinae; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Humans; Macaca mulatta; Maze Learning; Models, Molecular; Muscarinic Agonists; Phosphatidylinositols; Protein Conformation; Pyrazines; Pyridines; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Salivation; Structure-Activity Relationship; Thiadiazoles

1999