pyrazines has been researched along with Chronic Illness in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (25.45) | 18.7374 |
| 1990's | 7 (12.73) | 18.2507 |
| 2000's | 7 (12.73) | 29.6817 |
| 2010's | 24 (43.64) | 24.3611 |
| 2020's | 3 (5.45) | 2.80 |
| Authors | Studies |
|---|---|
| Abe, K; Ako, J; Ikeda, Y; Joho, S; Kinoshita, H; Maki, H; Matoba, S; Motoki, H; Ogo, T; Saeki, T; Sakao, S; Shimokawahara, H; Shiota, N; Sugano, T; Takama, N; Tanabe, N; Tanaka, S; Tatsumi, K; Tsujino, I; Yamamoto, C; Yoshioka, K | 1 |
| Bossory Goike, L; Dean, S | 1 |
| Guo, Z; He, S; Hu, Z; Jiang, K; Lin, C; Su, H; Yuan, G; Zeng, Y; Zhong, F | 1 |
| Bates, RE; Frantz, RP; Thurber, KM; Williams, BM | 1 |
| Atkinson, C; Breuer, J; Brown, LK; Burns, SO; Goldstein, R; Jacobs, M; Lowe, DM; Roy, S; Ruis, C; Williams, R; Yara-Romero, E | 1 |
| Berlier, C; Lichtblau, M; Saxer, S; Schwarz, EI; Ulrich, S | 1 |
| McNeil, C | 1 |
| Ahn, C; Han, M; Jeon, HJ; Jeong, JC; Kim, MG; Kim, YJ; Koo, TY; Kwon, HY; Park, HC; Yang, J | 1 |
| Abedi, M; Ames, E; Blazar, BR; Chen, M; Grossenbacher, SK; Jagdeo, J; Mirsoian, A; Murphy, WJ; Pai, CC; Sun, K; Tellez, J | 1 |
| Alyea, EP; Antin, JH; Armand, P; Bindra, B; Blazar, BR; Cutler, CS; Herrera, AF; Ho, VT; Jones, KT; Kim, HT; Koreth, J; Nikiforow, S; Ritz, J; Soiffer, RJ | 1 |
| Fu, R; Guan, J; Li, L; Liu, H; Mei, S; Qu, W; Ruan, E; Shao, Z; Song, J; Wang, G; Wang, H; Wang, X; Wu, Y; Xing, L | 1 |
| Aziz, M; Bertrand, J; Coëffier, M; Déchelotte, P; Guérin, C; Herranen, A; Loeuillard, E; Marion-Letellier, R; Melchior, C; Savoye, G | 1 |
| Abu Jawdeh, BG; Alloway, RR; Cardi, MA; Ejaz, NS; Sadaka, B; Shields, AR; Wadih, G; Witte, D; Woodle, ES | 1 |
| Feng, EZ; Huang, NX; Tian, ZX; Yang, SY; Yin, H; Zhang, Y | 1 |
| Chen, J; Raj, JU; Ramchandran, R; Sun, M; Yang, Q | 1 |
| Jagannath, S; Mazumder, A; Vesole, DH | 1 |
| Daniel, C; Gückel, E; Hugo, C; Meister, S; Starke, C; Stief, A; Vogelbacher, R; Voll, R; Wittmann, S | 1 |
| Bøtker, HE; Eiskjær, H; Gøtzsche, L; Halbirk, M; Møller, N; Nielsen, R; Nielsen, SS; Nielsen, TT; Nielsen-Kudsk, JE; Nørrelund, H; Schmitz, O; Wiggers, H | 1 |
| Baum, W; Distler, JH; Frey, B; Gückel, E; Meister, S; Neubert, K; Polzer, K; Schett, G; Voll, RE; Zwerina, J | 1 |
| Spellman, CW | 1 |
| Alvarez Fernández, GM; de Alarcón Jiménez, RM; García Hernández, MA; Jimeno Griñó, C; Molina Núñez, M; Navarro Parreño, MJ; Roca Meroño, S; Zarco Pedrinaci, E | 1 |
| Everly, MJ | 1 |
| Böhmig, GA; Haidbauer, B; Regele, H; Schmidt, A; Schwaiger, E; Wahrmann, M; Werzowa, J | 1 |
| Chan, L; Cooper, JE; Wiseman, AC | 1 |
| Fehrenbach, H; Lunding, L; Manz, RA; Orinska, Z; Wegmann, M; Wong, DM | 1 |
| Fehr, T; Gaspert, A | 1 |
| Al-Otaibi, T; Al-Waheeb, S; Gheith, O; Halim, M; Ibraheim, M; Muzeirei, I; Nair, P; Nampoory, N; Saied, T | 1 |
| Bax, JJ; Boersma, E; Kam, BL; Krenning, EP; Poldermans, D; Rambaldi, R; Reijs, AE; Rietveld, T; Roelandt, JR; Valkema, R | 1 |
| Atanackovic, D; Ayuk, F; Kröger, N; Renges, H; Schieder, H; Zabelina, T; Zander, A | 1 |
| Dodd, PG; Gayton, S; Greener, BS; Harbottle, GW; Mantell, SJ; Maw, GN; Osborne, SA; Owen, DR; Rees, H; Ringer, TJ; Rodriguez-Lens, M; Smith, GF | 1 |
| Burton, AW; Cata, JP; Dougherty, PM; Giralt, S; Villareal, H; Weng, HR | 1 |
| Castagna, L; Mazza, R; Nozza, A; Rahal, D; Santoro, A; Sarina, B; Todisco, E | 1 |
| Adams, W; Adedoyin, A; Barry, A; Cummons, TA; Harrison, J; Jones, PG; Leventhal, L; Lu, P; Piesla, MJ; Ramdass, R; Schantz, J; Smith, VA; Spangler, TB; Strassle, BW; Sullivan, NR; Sun, SC; Uveges, AJ; Whiteside, GT | 1 |
| Kita, Y; Nakazato-Imasato, E; Tanimoto-Mori, S; Toide, K | 1 |
| Khorunzhaia, LV; Merzon, KA; Tsoĭ, AN | 1 |
| Glynn, RD; Hulter, HN; Ilnicki, LP; Licht, JH; Sebastian, A | 1 |
| Sato, N; Uehara, M | 1 |
| Arnal, F; Hill, NS; Klinger, JR; Petit, RD; Warburton, RR; Wrenn, DS | 1 |
| Asanoi, H; Inoue, H | 1 |
| Cheng, J; Kamiya, K; Kodama, I; Lee, JK; Suzuki, R; Toyama, J | 1 |
| DiSesa, VJ; Fyfe, BS; Goldstein, C; Mohiuddin, M; Momeni, R; Shen, Z; Whitman, GJ; Yokoyama, H | 1 |
| Bourge, R; Carson, P; Feldman, AM; Holubkov, R; Jaski, B; Loftus, S; Soran, O; White, BG; Young, JD | 1 |
| Evsikov, EM; Kharchenko, VI; Sidorenko, BA | 1 |
| Barer, GR; Cai, YN | 1 |
| Duan, SF; Peng, W | 1 |
| Barer, GR; Cai, YN; Emery, CJ; Russell, PC | 1 |
| Beeley, JM; Darke, CS; Weber, JC | 1 |
| Brown, JJ; Davies, DL; Fraser, R; Kremer, D; Lever, AF; Robertson, JI | 1 |
| Kaiser, I | 1 |
| Hillenbrand, P; Sherlock, S | 1 |
| Tello, F | 1 |
| Bogarelli, D; Ferliga, G; Paroli, M | 1 |
| Kalachnikoff, P; Laugié, H; Leclerc, P; Lengrand, J | 1 |
| Boccitto, G; Sbampato, M; Sternini, N | 1 |
5 review(s) available for pyrazines and Chronic Illness
| Article | Year |
|---|---|
Pharmacology of GLP-1 agonists: describing the therapeutic potential to patients.
Topics: Algorithms; Chronic Disease; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Male; Middle Aged; Peptides; Pyrazines; Sitagliptin Phosphate; Triazoles; Venoms | 2011 |
[Partial recovery of kidney function for an autologous transplant in a patient with chronic kidney disease and multiple myeloma].
Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Chronic Disease; Combined Modality Therapy; Dexamethasone; Down-Regulation; Doxorubicin; Hematopoietic Stem Cell Transplantation; Humans; Immunoglobulin lambda-Chains; Kidney Diseases; Male; Melphalan; Middle Aged; Multiple Myeloma; Myeloma Proteins; Pyrazines; Remission Induction; Renal Dialysis; Transplantation, Autologous | 2011 |
Antibody-mediated kidney allograft rejection: therapeutic options and their experimental rationale.
Topics: Acute Disease; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Boronic Acids; Bortezomib; Chronic Disease; Graft Rejection; Graft Survival; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosorbent Techniques; Isoantibodies; Kidney Transplantation; Plasma Exchange; Pyrazines; Rituximab; Splenectomy | 2012 |
Effective therapy for acute antibody-mediated rejection with mild chronic changes: case report and review of the literature.
Topics: Adult; Antibodies; Biopsy; Boronic Acids; Bortezomib; Chronic Disease; Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunity, Humoral; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Pyrazines; Time Factors; Treatment Outcome; Young Adult | 2012 |
Ion channel blockers in the treatment of chronic heart failure.
Topics: Amiodarone; Animals; Calcium Channel Blockers; Chronic Disease; Heart Failure; Humans; Potassium Channel Blockers; Pyrazines; Quinolines | 1996 |
11 trial(s) available for pyrazines and Chronic Illness
| Article | Year |
|---|---|
Selexipag for the treatment of chronic thromboembolic pulmonary hypertension.
Topics: Acetamides; Antihypertensive Agents; Chronic Disease; Dyspnea; Humans; Hypertension, Pulmonary; Pulmonary Embolism; Pyrazines; Treatment Outcome | 2022 |
Treatment of chronic graft-versus-host disease with bortezomib.
Topics: Animals; Boronic Acids; Bortezomib; Chronic Disease; Female; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrazines; Scleroderma, Systemic; Skin; Transplantation, Homologous; Treatment Outcome; Tumor Cells, Cultured | 2014 |
A phase II study of bortezomib plus prednisone for initial therapy of chronic graft-versus-host disease.
Topics: Adult; Aged; Antineoplastic Agents; Boronic Acids; Bortezomib; Chronic Disease; Cohort Studies; Female; Graft vs Host Disease; Humans; Male; Middle Aged; Prednisone; Prospective Studies; Pyrazines | 2014 |
Plasma endothelin-1 and nitric oxide correlate with ligustrazine alleviation of pulmonary artery hypertension in patients of chronic cor pulmonale from high altitude plateau during acute exacerbation.
Topics: Altitude; Blood Gas Analysis; Chronic Disease; Endothelin-1; Humans; Hypertension, Pulmonary; Nitric Oxide; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pyrazines; Respiration | 2014 |
Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Chronic Disease; Cross-Over Studies; Double-Blind Method; Exercise Tolerance; Fatty Acids, Nonesterified; Female; Heart; Heart Failure; Humans; Hypolipidemic Agents; Male; Metabolism; Middle Aged; Pyrazines; Stroke Volume; Vascular Resistance | 2010 |
Feasibility and image quality of dual-isotope SPECT using 18F-FDG and (99m)Tc-tetrofosmin after acipimox administration.
Topics: Administration, Oral; Chronic Disease; Coronary Artery Disease; Echocardiography; Feasibility Studies; Female; Fluorodeoxyglucose F18; Heart; Humans; Male; Middle Aged; Organophosphorus Compounds; Organotechnetium Compounds; Pyrazines; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon; Ventricular Dysfunction, Left | 2003 |
Bortezomib after dose-reduced allogeneic stem cell transplantation for multiple myeloma to enhance or maintain remission status.
Topics: Adult; Antineoplastic Agents; Boronic Acids; Bortezomib; CD3 Complex; Chronic Disease; Cyclosporine; Disease-Free Survival; Female; Graft vs Host Disease; Herpes Zoster; Humans; Leukopenia; Male; Middle Aged; Multiple Myeloma; Prospective Studies; Pyrazines; Remission Induction; Stem Cell Transplantation; Thrombocytopenia; Transplantation, Homologous | 2006 |
Effect of inotrope withdrawal on morbidity and mortality in patients with chronic heart failure: results of the vesnarinone trial withdrawal substudy. Vest Withdrawal Substudy Group.
Topics: Cardiotonic Agents; Cause of Death; Chronic Disease; Disease Progression; Follow-Up Studies; Heart Failure; Humans; Middle Aged; Myocardial Contraction; Pyrazines; Quinolines; Retrospective Studies; Substance Withdrawal Syndrome; Survival Rate | 1999 |
[Therapeutic use of amiloride and its combinations with hydrochlorothiazide and furosemide in chronic circulatory insufficiency].
Topics: Adult; Aged; Amiloride; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Diuresis; Drug Combinations; Drug Evaluation; Drug Synergism; Female; Furosemide; Humans; Hydrochlorothiazide; Male; Middle Aged; Natriuresis; Potassium; Pyrazines; Time Factors | 1978 |
A placebo-controlled, randomized, double-blind study of OPC-8212 in patients with mild chronic heart failure. OPC-8212 Multicenter Research Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Cardiotonic Agents; Chronic Disease; Double-Blind Method; Echocardiography; Female; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Pyrazines; Quality of Life; Quinolines; Severity of Illness Index | 1990 |
Sulfametopyrazine in the prophylaxis of exacerbations of chronic bronchitis.
Topics: Acute Disease; Ampicillin; Attitude of Health Personnel; Attitude to Health; Bronchitis; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Male; Placebos; Pyrazines; Sputum; Sulfonamides | 1972 |
39 other study(ies) available for pyrazines and Chronic Illness
| Article | Year |
|---|---|
Images in Vascular Medicine. Rumpel-Leede phenomenon in a patient with chronic lymphocytic leukemia treated with acalabrutinib.
Topics: Agammaglobulinaemia Tyrosine Kinase; Aged, 80 and over; Antineoplastic Agents; Benzamides; Capillary Fragility; Chronic Disease; Ecchymosis; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyrazines; Risk Factors; Stockings, Compression; Treatment Outcome; Venous Insufficiency | 2020 |
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Chromones; Chronic Disease; Fibrinolytic Agents; Hepatic Stellate Cells; Inflammation; Liver Cirrhosis; Male; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Transition of Intravenous Treprostinil to Oral Therapy in a Patient with Functional Class IV Chronic Thromboembolic Pulmonary Hypertension.
Topics: Acetamides; Administration, Oral; Adult; Antihypertensive Agents; Chronic Disease; Epoprostenol; Humans; Hypertension, Pulmonary; Infusions, Intravenous; Male; Paraplegia; Pyrazines; Severity of Illness Index; Ventricular Dysfunction, Right | 2017 |
Mutagenesis in Norovirus in Response to Favipiravir Treatment.
Topics: Amides; Antiviral Agents; Caliciviridae Infections; Chronic Disease; Common Variable Immunodeficiency; Diarrhea; Fatal Outcome; Humans; Male; Middle Aged; Mutagenesis; Norovirus; Pyrazines | 2018 |
Real-Life Experience with Selexipag as an Add-On Therapy to Oral Combination Therapy in Patients with Pulmonary Arterial or Distal Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis.
Topics: Acetamides; Aged; Antihypertensive Agents; Chronic Disease; Cohort Studies; Drug Therapy, Combination; Echocardiography; Endothelin Receptor Antagonists; Enzyme Activators; Exercise Test; Female; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Oxygen Consumption; Peptide Fragments; Phosphodiesterase 5 Inhibitors; Pulmonary Arterial Hypertension; Pulmonary Embolism; Pyrazines; Quality of Life; Retrospective Studies; Soluble Guanylyl Cyclase; Tricuspid Valve; Walk Test | 2019 |
Preventing graft-versus-host disease: transplanters glimpse hope beyond immunosuppressants.
Topics: Acute Disease; Bone Marrow Transplantation; Boronic Acids; Bortezomib; Chronic Disease; Clinical Trials as Topic; Cyclohexanes; Cyclophosphamide; Cyclosporine; Evidence-Based Medicine; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Hydroxamic Acids; Immunosuppressive Agents; Maraviroc; Methotrexate; Pentostatin; Peripheral Blood Stem Cell Transplantation; Pyrazines; Quality of Life; Tacrolimus; Triazoles; Vorinostat | 2013 |
Outcomes of combination therapy for chronic antibody-mediated rejection in renal transplantation.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Boronic Acids; Bortezomib; Chronic Disease; Female; Glomerular Filtration Rate; Graft Rejection; HLA Antigens; Humans; Immunoglobulins, Intravenous; Isoantibodies; Kidney; Kidney Transplantation; Male; Middle Aged; Plasmapheresis; Pyrazines; Retrospective Studies; Rituximab | 2013 |
Hepcidin and GDF15 in anemia of multiple myeloma.
Topics: Adult; Aged; Anemia; Antineoplastic Agents; Boronic Acids; Bortezomib; Chronic Disease; Dexamethasone; Female; Ferritins; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; Hemoglobins; Hepcidins; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Multiple Myeloma; Pyrazines; Remission Induction; RNA, Messenger | 2014 |
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling.
Topics: Animals; Boronic Acids; Bortezomib; Chronic Disease; Colitis; Colon; Disease Models, Animal; Fibrosis; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats, Sprague-Dawley; Signal Transduction; Tight Junction Proteins; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2014 |
A Banff Component Scoring-based Histologic Assessment of Bortezomib-based Antibody-mediated Rejection Therapy.
Topics: Acute Disease; Adult; Atrophy; Biomarkers; Biopsy; Boronic Acids; Bortezomib; Chi-Square Distribution; Chronic Disease; Complement C4b; Drug Monitoring; Female; Fibrosis; Graft Rejection; Humans; Immunity, Humoral; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Middle Aged; Peptide Fragments; Predictive Value of Tests; Pyrazines; Time Factors; Treatment Outcome | 2015 |
Smooth Muscle Insulin-Like Growth Factor-1 Mediates Hypoxia-Induced Pulmonary Hypertension in Neonatal Mice.
Topics: Animals; Animals, Newborn; Blood Pressure; Cell Proliferation; Chronic Disease; Gene Deletion; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Imidazoles; Insulin-Like Growth Factor I; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Myocytes, Smooth Muscle; Organ Specificity; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyrazines; Receptor, IGF Type 1; RNA, Messenger; Systole; Up-Regulation; Vascular Remodeling | 2016 |
Vorinostat plus bortezomib for the treatment of relapsed/refractory multiple myeloma: a case series illustrating utility in clinical practice.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Chronic Disease; Clinical Trials as Topic; Disease Progression; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; Multiple Myeloma; Pyrazines; Recurrence; Vorinostat | 2010 |
Bortezomib and sirolimus inhibit the chronic active antibody-mediated rejection in experimental renal transplantation in the rat.
Topics: Animals; Boronic Acids; Bortezomib; Chronic Disease; Graft Rejection; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Lymphocyte Depletion; Male; Plasma Cells; Pyrazines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Sirolimus; Spleen; T-Lymphocytes; Transplantation, Homologous | 2010 |
Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis.
Topics: Animals; Arthritis; Bone and Bones; Bone Resorption; Boronic Acids; Bortezomib; Cartilage, Articular; Chronic Disease; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Osteoclasts; Osteoprotegerin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; RANK Ligand; Synovial Membrane; Tumor Necrosis Factor-alpha | 2011 |
An update on antibody reduction and rejection reversal following bortezomib use: a report of 52 cases across 10 centers.
Topics: Acute Disease; Boronic Acids; Bortezomib; Chronic Disease; Down-Regulation; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Isoantibodies; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Time Factors; Transplants; Treatment Outcome | 2010 |
Bortezomib for the treatment of chronic antibody-mediated kidney allograft rejection: a case report.
Topics: Biopsy; Boronic Acids; Bortezomib; Chronic Disease; Complement C4b; Drug Therapy, Combination; Graft Rejection; Graft Survival; HLA Antigens; Humans; Immunity, Humoral; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Male; Middle Aged; Peptide Fragments; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Time Factors; Treatment Outcome | 2010 |
Bortezomib use in chronic antibody-mediated allograft dysfunction: updates and additional cases.
Topics: Adult; Boronic Acids; Bortezomib; Chronic Disease; Female; Graft Rejection; Graft Survival; HLA Antigens; Humans; Immunity, Humoral; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Male; Middle Aged; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Time Factors; Treatment Outcome; Young Adult | 2010 |
Long-term bortezomib treatment reduces allergen-specific IgE but fails to ameliorate chronic asthma in mice.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Boronic Acids; Bortezomib; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Immunoglobulin G; Lung; Mice; Mice, Inbred BALB C; Plasma Cells; Pyrazines; Treatment Failure | 2012 |
Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; CHO Cells; Chronic Disease; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutamic Acid; Pain; Pyrazines; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2007 |
Quantitative sensory findings in patients with bortezomib-induced pain.
Topics: Aged; Antineoplastic Agents; Boronic Acids; Bortezomib; Chronic Disease; Cold Temperature; Female; Hot Temperature; Humans; Lymphoma, B-Cell; Male; Middle Aged; Multiple Myeloma; Pain; Pain Measurement; Pain Threshold; Psychomotor Performance; Pyrazines; Sensation; Sensation Disorders; Thermosensing; Touch | 2007 |
Inhibition of chronic graft-vs-host disease with retention of anti-myeloma effects by the proteasome inhibitor bortezomib.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Boronic Acids; Bortezomib; Chronic Disease; gamma-Glutamyltransferase; Graft vs Host Disease; Humans; Male; Middle Aged; Multiple Myeloma; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Recurrence; Remission Induction | 2007 |
Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.
Topics: Animals; Biological Availability; Bridged-Ring Compounds; Chronic Disease; Disease Models, Animal; Inflammation; Inhibitory Concentration 50; Muscarinic Agonists; Pain; Pyrazines; Rats; Receptors, Muscarinic | 2007 |
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Temperature; Constriction, Pathologic; Disease Models, Animal; Diterpenes; gamma-Aminobutyric Acid; Male; Mexiletine; Morphine; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregabalin; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sodium Channel Blockers; TRPV Cation Channels | 2008 |
[Use of antipotassiuretic diuretic amiloride in patients with chronic cardiac failure].
Topics: Amiloride; Chronic Disease; Diuresis; Heart Failure; Humans; Potassium; Potassium Deficiency; Pyrazines | 1983 |
Pathophysiology of chronic renal tubular acidosis induced by administration of amiloride.
Topics: Acidosis, Renal Tubular; Adrenalectomy; Amiloride; Animals; Cell Membrane Permeability; Chronic Disease; Diet, Sodium-Restricted; Dogs; Female; Membrane Potentials; Potassium; Pyrazines; Sodium | 1980 |
Impaired ability of neutrophils to produce oxygen-derived free radicals in patients with chronic liver disease and hepatocellular carcinoma.
Topics: Alanine Transaminase; Bilirubin; Carcinoma, Hepatocellular; Chronic Disease; Female; Free Radicals; Hepatitis, Chronic; Humans; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Luminescent Measurements; Luminol; Male; Middle Aged; Neutrophils; Oxygen; Prothrombin Time; Pyrazines; Serum Albumin | 1994 |
Neutral endopeptidase inhibition attenuates development of hypoxic pulmonary hypertension in rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Chronic Disease; Cyclic GMP; Dioxolanes; Dipeptides; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Imidazoles; Male; Muscle, Smooth, Vascular; Myocardium; Neprilysin; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Positive inotropic agents: a double-edged sword for chronic heart failure.
Topics: Cardiotonic Agents; Chronic Disease; Clinical Trials as Topic; Dose-Response Relationship, Drug; Heart Failure; Humans; Pyrazines; Pyridazines; Quinolines | 1996 |
Effects of vesnarinone, a novel orally active inotropic agent with an immunosuppressive action, on experimental cardiac transplantation in rats.
Topics: Acute Disease; Animals; Cardiotonic Agents; Chronic Disease; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Male; Pyrazines; Quinolines; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew | 1996 |
Effect of ligustrazine on pulmonary vascular changes induced by chronic hypoxia in rats.
Topics: Animals; Blood Pressure; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Pulmonary Artery; Pyrazines; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
[Evaluation of the immediate effect of ligustrazine in chronic cor pulmonale].
Topics: Adult; Aged; Chronic Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Plethysmography, Impedance; Pulmonary Heart Disease; Pyrazines; Vasodilator Agents | 1989 |
Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Almitrine; Angiotensin I; Animals; Bradykinin; Chronic Disease; Hypoxia; Male; Platelet Activating Factor; Pulmonary Circulation; Pyrazines; Rats; Rats, Inbred Strains; Reference Values; Respiration; Vasoconstriction; Vasodilator Agents; Vasomotor System | 1989 |
Amiloride in primary hyperaldosteronism with chronic peptic ulceration.
Topics: Aged; Amiloride; Bicarbonates; Blood Pressure; Body Water; Chlorides; Chronic Disease; Diuretics; Female; Humans; Hyperaldosteronism; Hypertension; Peptic Ulcer; Potassium; Pyrazines; Sodium; Spironolactone; Urea | 1973 |
[Treatment of chronic low serum potassium levels in potassium losing kidney by amiloride (author's transl)].
Topics: Administration, Oral; Adult; Amiloride; Chronic Disease; Diuretics; Drug Evaluation; Humans; Hypokalemia; Kidney; Kidney Diseases; Male; Potassium; Potassium Chloride; Pyrazines | 1974 |
Use of metolazone in the treatment of ascites due to liver disease.
Topics: Adult; Ascites; Chlorides; Chronic Disease; Diuretics; Female; Hepatic Encephalopathy; Humans; Hypokalemia; Hyponatremia; Ketones; Liver Diseases; Male; Middle Aged; Nitrogen; Pyrazines; Quinazolines; Spironolactone; Sulfonamides; Uremia | 1971 |
Results of combined use of cycloserine in pulmonary tuberculosis.
Topics: Chronic Disease; Cycloserine; Ethionamide; Humans; Pyrazines; Tuberculosis, Pulmonary | 1970 |
[Prevention of the reacutization of chronic bronchitis with sulfamethopyrazine].
Topics: Aged; Asthma; Bronchiectasis; Bronchitis; Chronic Disease; Humans; Male; Middle Aged; Pulmonary Emphysema; Pulmonary Fibrosis; Pyrazines | 1969 |
[Apropos of persistent tuberculous cystitis and its treatment in a sanitorium].
Topics: Anti-Bacterial Agents; Chronic Disease; Cycloserine; Cystitis; Diet Therapy; Female; Humans; Kanamycin; Muscles; Nephrectomy; Psychotherapy; Pyrazines; Tuberculosis, Urogenital | 1968 |
[Behavior of certain biologic parameters of hepatic and renal function during therapy with rifomycin B diethylamide (rifamide) administered by venous infusion].
Topics: Adult; Aged; Aminosalicylic Acids; Antitubercular Agents; Chronic Disease; Cycloserine; Empyema, Tuberculous; Ethambutol; Humans; Isonicotinic Acids; Kidney Function Tests; Liver Function Tests; Lung Diseases; Middle Aged; Morpholines; Pyrazines; Rifampin; Tuberculosis, Miliary; Tuberculosis, Pulmonary | 1968 |