pyrazines has been researched along with Cerebral Ischemia in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.79) | 18.7374 |
| 1990's | 7 (12.50) | 18.2507 |
| 2000's | 19 (33.93) | 29.6817 |
| 2010's | 22 (39.29) | 24.3611 |
| 2020's | 7 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, BY; Gao, G; Hu, J; Liu, F; Meng, XB; Sun, GB; Sun, XB; Wang, H; Wu, Y; Zhang, SX; Zhu, T | 1 |
| Gong, L; Guo, C; He, L; Li, Y; Ma, C; Peng, C; Wan, Y; Wang, C; Zhang, Y; Zhou, H | 1 |
| Fu, B; Gao, G; Meng, S | 1 |
| Chen, J; Dong, L; Dong, Y; Fu, X; Guo, T; Liu, M; Mao, Y; Qiao, C; Yang, Y; Zhang, J; Zhang, X; Zhao, Y | 1 |
| Liu, JX; Ren, JG; Wang, M; Yao, MJ | 1 |
| Huang, ZJ; Wu, JB; Yin, W; Zhang, YH; Zhang, YQ | 1 |
| Cao, H; Cheng, Y; Ge, L; Xu, M; Zhang, J | 1 |
| Dong, Z; Li, P; Liu, J; Yuan, C; Zhang, Q | 1 |
| Chu, L; Fang, Y; Gu, J; Li, L; Qu, T; Yang, Y; Yin, Y; Zhang, J | 1 |
| Alexander, JC; Candelario-Jalil, E; DeMars, KM; Febo, M; Yang, C | 1 |
| Gu, J; Li, C; Li, N; Liu, W; Shan, L; Sun, Y; Tang, Y; Wang, Y; Wu, L; Yang, GY; Yang, X; Yu, P; Zhang, G; Zhang, T; Zhang, Z; Zhao, C | 1 |
| Gong, X; He, X; Sun, M; Sun, Y; Wang, BO; Wang, M; Wang, X; Wang, Z; Wei, X; Yi, F; Zhang, Y; Zhou, Z | 1 |
| Gao, F; Li, P; Luo, L; Shen, M; Teng, F; Tu, J; Yeh, CK; Zhang, C; Zhang, D | 1 |
| Chang, CY; Chen, CJ; Chen, WY; Kao, TK; Kuan, YH; Li, GZ; Liao, SL; Ou, YC; Pan, HC | 1 |
| Chen, L; Li, S; Liu, H; Liu, X; Wei, X; Zhang, X | 1 |
| Chen, L; Hou, Y; Li, S; Liu, H; Liu, X; Sun, B; Wei, X | 1 |
| Bie, XD; Ge, LJ; Han, J; Wan, HT; Yang, JH; Zhang, YY | 1 |
| Teng, F; Tu, J; Zhang, C; Zhang, D | 1 |
| Chen, L; Cheng, L; Kong, L; Liu, H; Liu, X; Wei, X; Yan, S; Zhang, X | 1 |
| Cai, J; Chen, X; Hou, Z; Huang, RY; Huang, S; Huang, Y; Jia, X; Li, Y; Pan, R; Sun, J; Yang, GY | 1 |
| Ain-Shoka, AA; Attia, AS; El-Sahar, AE; Safar, MM; Zaki, HF | 1 |
| Chang, CY; Chen, CJ; Chen, WY; Kao, TK; Li, JR; Liao, SL; Ou, YC; Raung, SL | 1 |
| Chen, C; Hao, Y; Hong, Y; Lei, H; Li, G; Tian, Y; Wang, P; Zhang, Y | 1 |
| Jiang, J; Liu, W; Sun, Y; Wang, L; Wang, Y; Xu, C; Yu, P; Zhang, Z | 1 |
| Guo, QC; Hu, YS; Jia, J; Li, NN; Wang, QZ; Wu, CQ; Wu, Y; Yu, HX; Zhang, X | 1 |
| Catarzi, D; Ciampi, O; Colotta, V; Filacchioni, G; Lenzi, O; Martini, C; Morizzo, E; Moro, S; Pedata, F; Pugliese, AM; Traini, C; Trincavelli, L; Varano, F | 1 |
| Buller, B; Chopp, M; Jiang, J; Jiang, Y; Liu, X; Morris, D; Zhang, L; Zhang, ZG; Zhao, D | 1 |
| Chen, X; Liu, Y; Qi, C; Qiu, F; Xiao, X; Yang, P; Zhang, J | 1 |
| Duan, GX; Men, XL; Peng, J | 1 |
| Li, JH; Wan, HT; Zhu, ZH | 1 |
| Cheng, Y; Sun, J; Wang, H; Yang, C; Zhang, S | 1 |
| Liu, HW; Yan, YL; Zhou, LL | 1 |
| Han, R; Li, J; Luo, Q; Shen, J; Tang, Q; Xiao, H | 1 |
| Chen, CJ; Chen, SY; Chen, WY; Kao, TK; Liao, SL; Lin, YS; Lu, HC; Raung, SL; Wu, CW | 1 |
| Bai, M; Jiang, AH; Ma, KL; Wang, QM; Wang, YJ | 1 |
| Chen, CJ; Chen, WY; Kao, TK; Kuo, JS; Liao, SL; Ling, NN; Ou, YC; Peng, WH; Wu, CW; Zhang, YH | 1 |
| Bouley, J; Fisher, M; Henninger, N; Sicard, KM; Stagliano, NE | 1 |
| Chen, YC; Chou, DS; Hsiao, G; Lin, CH; Lin, JH; Lin, KH; Sheu, JR | 1 |
| Kamada, N; Kikuchi, S; Kobayashi, S; Komatsu, Y; Kusama, H; Mukaiyama, H; Nishimura, T; Oonota, H; Ozawa, T | 1 |
| Chen, XL; Kang, QY; Liu, Y; Qi, CF; Qiu, F; Tian, YF; Zhang, PB; Zhao, JJ | 1 |
| Chang, Y; Chen, SH; Chen, YC; Chou, DS; Hsiao, G; Lin, JH; Lin, KH; Sheu, JR | 1 |
| Chen, XL; Liu, Y; Qi, CF; Tian, YM; Xiao, XL; Zhang, JF; Zhang, JS; Zhang, PB | 1 |
| Edvinsson, L; Henriksson, M; Jamali, R; Maddahi, A; Stenman, E | 1 |
| Chen, XL; Liu, Y; Qi, CF; Qiu, F; Tian, YM; Xiao, XL; Zhang, JS; Zhang, PB | 1 |
| Liu, Y; Qian, YH; Qiu, F | 1 |
| Gao, S; Kong, LH; Mao, JJ; Su, FR; Sun, GJ | 1 |
| Matsumoto, K; Ni, JW; Watanabe, H | 1 |
| Ge, JY; Zhang, ZL | 1 |
| Ma, XL | 1 |
| Auguet, M; Chabrier, PE; Demerlé-Pallardy, C | 1 |
| Wang, D; Wei, M; Zhang, H; Zhao, S | 1 |
| Dawson, VL | 1 |
| Auguet, M; Chabrier, PE; Cornet, S; Demerlé-Pallardy, C; Marin, JG; Spinnewyn, B | 1 |
| Birraux, G; Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Stutzmann, JM; Vuilhorgne, M; Wahl, F | 1 |
| Shao, GF | 1 |
| Ho, WK; Lee, CM; Wen, HL | 1 |
5 review(s) available for pyrazines and Cerebral Ischemia
| Article | Year |
|---|---|
[Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia].
Topics: Benzofurans; Brain Ischemia; Cerebral Infarction; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Neuroprotective Agents; Panax notoginseng; Pyrazines; Saponins | 2020 |
[Progress in pharmacology and clinical application of Ligusticum wallichii].
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Free Radical Scavengers; Humans; Platelet Aggregation Inhibitors; Pyrazines | 1994 |
[Protection of Chinese medicinal herb extracts against cerebral ischemia-reperfusion injury].
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Drugs, Chinese Herbal; Ginsenosides; Pyrazines; Reperfusion Injury; Saponins | 1993 |
Nitric oxide synthases: targets for therapeutic strategies in neurological diseases.
Topics: Alzheimer Disease; Amidines; Amyotrophic Lateral Sclerosis; Animals; Benzylamines; Brain Injuries; Brain Ischemia; Enzyme Induction; Humans; Huntington Disease; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Nervous System Diseases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Organ Specificity; Polymethacrylic Acids; Pyrazines; Thiophenes | 1999 |
Potent neuroprotectants linked to bifunctional inhibition.
Topics: Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Free Radical Scavengers; Mice; Models, Biological; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Pyrazines; Rats; Thiophenes | 1999 |
51 other study(ies) available for pyrazines and Cerebral Ischemia
| Article | Year |
|---|---|
Folium
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ginkgo biloba; Infarction, Middle Cerebral Artery; Inflammasomes; Ischemic Stroke; Male; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
Research progress on the pharmacy of tetramethylpyrazine and its pharmacological activity in cardiovascular and cerebrovascular diseases.
Topics: Brain Ischemia; Endothelial Cells; Humans; Pharmacy; Pyrazines | 2022 |
A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study.
Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Humans; Pyrazines; Retrospective Studies; S100 Calcium Binding Protein beta Subunit; Stroke | 2022 |
Hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites for ischemic stroke.
Topics: Animals; Apigenin; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Neurons; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats; Reperfusion Injury; Stroke | 2019 |
Design, synthesis, and biological evaluation of ligustrazine/resveratrol hybrids as potential anti-ischemic stroke agents.
Topics: Animals; Antioxidants; Brain Ischemia; Molecular Structure; Neuroprotective Agents; PC12 Cells; Platelet Aggregation; Pyrazines; Rabbits; Rats; Resveratrol | 2020 |
The Effect of Umbilical Cord Mesenchymal Stem Cells Combined with Tetramethylpyrazine Therapy on Ischemic Brain Injury: A Histological Study.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Combined Modality Therapy; Disease Models, Animal; Humans; Male; Mesenchymal Stem Cell Transplantation; Motor Activity; Nerve Regeneration; Neurogenesis; Neuroprotective Agents; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Umbilical Cord | 2020 |
Effects of Floium ginkgo extract and tertram ethypyrazine sodium chloride injection on expression of inflammatory cytokines and cerebral infarction.
Topics: Aged; Brain Ischemia; Cerebral Infarction; Cytokines; Female; Ginkgo biloba; Humans; Inflammation; Male; Plant Extracts; Proteins; Pyrazines; Sodium Chloride | 2020 |
Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats.
Topics: Animals; Bone Marrow Cells; Brain Ischemia; Cell Movement; Chemokine CXCL12; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microvessels; Neovascularization, Physiologic; Pyrazines; Rats, Sprague-Dawley; Receptors, CXCR4; Recovery of Function; RNA, Messenger | 2017 |
Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog.
Topics: Acetates; Age Factors; Animals; Brain Ischemia; Epoprostenol; Infarction, Middle Cerebral Artery; Male; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Stroke | 2017 |
Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Nitrogen Oxides; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function; Regeneration | 2018 |
Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke.
Topics: Animals; Brain Ischemia; Carnitine; Disease Models, Animal; Male; NADPH Oxidase 2; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Stroke | 2017 |
Ultrasound-Enhanced Protective Effect of Tetramethylpyrazine via the ROS/HIF-1A Signaling Pathway in an in Vitro Cerebral Ischemia/Reperfusion Injury Model.
Topics: Animals; Brain Ischemia; Cell Survival; Cells, Cultured; Flow Cytometry; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Polymerase Chain Reaction; Pyrazines; Rats; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Ultrasonic Waves; Vasodilator Agents | 2018 |
Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats.
Topics: Animals; Antigens, Ly; Brain Edema; Brain Ischemia; CD11b Antigen; Cerebral Infarction; Encephalitis; Fibrinolytic Agents; Functional Laterality; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Leukocyte Common Antigens; Male; Nerve Tissue Proteins; Neuroglia; Neurons; NF-E2-Related Factor 2; Pyrazines; Rats; Rats, Sprague-Dawley | 2013 |
Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion injury in the rat by an antioxidant action via inhibition of NADPH oxidase and iNOS expression.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Brain; Brain Ischemia; Glutathione Peroxidase; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Piperazines; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2013 |
Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Neuroprotective Agents; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinase; Piperazines; Pyrazines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2014 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Microdialysis; Molecular Structure; Neurotransmitter Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine; Time Factors | 2014 |
Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury.
Topics: Animals; bcl-2-Associated X Protein; Brain Ischemia; Glutamic Acid; High-Energy Shock Waves; Interleukin-8; Ligusticum; Medicine, Chinese Traditional; Microscopy, Electron, Scanning; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2014 |
Tetramethylpyrazine analogue CXC195 ameliorates cerebral ischemia-reperfusion injury by regulating endothelial nitric oxide synthase phosphorylation via PI3K/Akt signaling.
Topics: Animals; Brain Ischemia; Humans; Male; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Piperazines; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2015 |
The combination of astragalus membranaceus and ligustrazine ameliorates micro-haemorrhage by maintaining blood-brain barrier integrity in cerebrally ischaemic rats.
Topics: Animals; Astragalus Plant; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Intracranial Hemorrhages; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2014 |
Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: implication of the oxidative-inflammatory-apoptotic pathway.
Topics: Animals; Brain Ischemia; Caspase 3; Cytochromes c; Diabetes Complications; Diabetes Mellitus, Experimental; Hippocampus; Hypoglycemic Agents; Interleukin-10; Male; Neuroprotective Agents; Neutrophil Infiltration; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Sitagliptin Phosphate; Triazoles | 2015 |
Tetramethylpyrazine inhibits neutrophil activation following permanent cerebral ischemia in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cells, Cultured; Male; Neuroprotective Agents; Neutrophil Activation; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2015 |
A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats.
Topics: Animals; Behavior, Animal; Brain Ischemia; Ca(2+) Mg(2+)-ATPase; Cell Differentiation; Cell Survival; Cyclooxygenase 2; Disease Models, Animal; Immunohistochemistry; Neuroprotective Agents; NF-kappa B; PC12 Cells; Pyrazines; Rats; Stroke; Superoxide Dismutase; Toxicity Tests, Acute; Vascular Endothelial Growth Factor A | 2015 |
Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
Topics: Animals; Antioxidants; Brain Ischemia; Fibrinolytic Agents; Nitrogen Oxides; Pyrazines; Rats; Stroke; Thrombolytic Therapy | 2008 |
Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism.
Topics: Animals; Apoptosis; Brain Ischemia; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thioredoxin Reductase 1; Thioredoxins | 2009 |
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Cattle; Cell Line; Cerebral Cortex; Corpus Striatum; Cricetinae; Cricetulus; Cyclic AMP; Heterocyclic Compounds, 3-Ring; Hippocampus; Humans; Hydrogen Bonding; In Vitro Techniques; Ligands; Male; Models, Molecular; Pyrazines; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Synaptic Transmission; Triazoles | 2009 |
Combination treatment with VELCADE and low-dose tissue plasminogen activator provides potent neuroprotection in aged rats after embolic focal ischemia.
Topics: Aging; Animals; Boronic Acids; Bortezomib; Brain Ischemia; Drug Administration Schedule; Drug Therapy, Combination; Intracranial Embolism; Male; Neuroprotective Agents; Protease Inhibitors; Pyrazines; Rats; Rats, Wistar; Tissue Plasminogen Activator | 2010 |
Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia.
Topics: Adult Stem Cells; Aging; Animals; Body Water; Brain; Brain Infarction; Brain Ischemia; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurogenesis; Neurons; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Stem Cell Niche | 2010 |
[The effects of tetramethylpyrazine on lung injury induced by brain ischemia/reperfusion].
Topics: Animals; Blood Gas Analysis; Brain Ischemia; Lung Injury; Male; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury | 2006 |
Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Interleukin-1beta; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger; Saponins; Triterpenes | 2011 |
Neuroprotective effects of NKN on focal cerebral ischemia in rats.
Topics: Abietanes; Acetophenones; Animals; Benzoates; Brain Ischemia; Bridged-Ring Compounds; Drug Combinations; Endothelin-1; Glucosides; Immunohistochemistry; In Situ Hybridization; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neurologic Examination; Neurons; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stroke; Superoxide Dismutase | 2012 |
[Comparison of the brain pharmacokinetics of nasal tetramethylpyrazine phosphate pH-sensitive in situ gel in normal rats and model rats].
Topics: Administration, Intranasal; Animals; Area Under Curve; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Gels; Hydrogen-Ion Concentration; Infarction, Middle Cerebral Artery; Male; Microdialysis; Phosphates; Pyrazines; Rats; Rats, Sprague-Dawley | 2012 |
Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2012 |
Tetramethylpyrazine reduces ischemic brain injury in rats.
Topics: Animals; Brain Ischemia; Cells, Cultured; Male; Pyrazines; Rats; Rats, Sprague-Dawley | 2004 |
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
Topics: Animals; Brain Ischemia; Endothelin-1; Female; Infarction, Middle Cerebral Artery; Insulin; Insulin Resistance; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2003 |
Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats.
Topics: Animals; Apoptosis; Behavior, Animal; Blotting, Western; Brain Ischemia; Immunohistochemistry; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley | 2006 |
The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia.
Topics: Animals; Boronic Acids; Bortezomib; Brain Infarction; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Intracranial Embolism; Male; Neuroprotective Agents; Proteasome Inhibitors; Pyrazines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley | 2006 |
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Ligusticum; Male; Neuroprotective Agents; Neutrophils; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Wistar; Respiratory Burst; Telencephalon; Tyrosine | 2006 |
Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke.
Topics: Acute Disease; Animals; Brain Ischemia; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Neuroprotective Agents; Pyrazines; Rats; Spectrophotometry, Infrared; src-Family Kinases; Stroke; Structure-Activity Relationship | 2007 |
[The effect of ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult rats].
Topics: Animals; Apiaceae; Brain Ischemia; Cell Count; Cell Proliferation; Cerebral Cortex; Corpus Striatum; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Male; Plants, Medicinal; Pyrazines; Rats; Rats, Sprague-Dawley | 2006 |
Tetramethylpyrazine suppresses HIF-1alpha, TNF-alpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Arterial Occlusive Diseases; Brain Ischemia; Caspase 3; Enzyme Activation; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Cerebral Artery; Pyrazines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2007 |
[Effect of ligustrazine on nNOS expression and neuranagenesis in adult rats after cerebral ischemia-reperfusion injury].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain; Brain Ischemia; Cell Proliferation; Cerebral Ventricles; Dentate Gyrus; Immunohistochemistry; Male; Nerve Regeneration; Nitric Oxide Synthase Type I; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2007 |
Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Brain Ischemia; Drug Synergism; Endothelin A Receptor Antagonists; Infarction, Middle Cerebral Artery; Male; Pyrazines; Rats; Rats, Wistar; Sulfonamides; Tetrazoles | 2007 |
[Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury].
Topics: Animals; Blotting, Western; Brain Ischemia; Cell Proliferation; Cerebral Ventricles; Infarction, Middle Cerebral Artery; Male; Nitric Oxide Synthase Type I; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors | 2007 |
[Effect of ligustrazine on migration of neuronal precursors after focal cerebral ischemia in adult rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Movement; Doublecortin Domain Proteins; Doublecortin Protein; Immunohistochemistry; Male; Microtubule-Associated Proteins; Neurons; Neuropeptides; Pyrazines; Rats; Rats, Sprague-Dawley | 2007 |
[Effects of acupoint-embedding of medicinal thread and electroacupuncture on contents of TNF-alpha and IL-6 of hippocampus tissue in rats with focal cerebral ischemia-reperfusion injury].
Topics: Acupuncture Points; Animals; Brain Ischemia; Collagen; Electroacupuncture; Female; Hippocampus; Interleukin-6; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2007 |
Tetramethylpyrazine improves spatial cognitive impairment induced by permanent occlusion of bilateral common carotid arteries or scopolamine in rats.
Topics: Animals; Brain Ischemia; Carotid Arteries; Cognition; Disease Models, Animal; Male; Maze Learning; Pyrazines; Rats; Rats, Wistar; Scopolamine; Spatial Behavior; Vasodilator Agents | 1995 |
[Prophylactic effects of magnesium sulfate and ligustrazin on the hypoxic-ischemic brain damage in neonatal rats].
Topics: Animals; Animals, Newborn; Brain Ischemia; Calcium Channel Blockers; Cerebral Cortex; Female; Hypoxia; Magnesium Sulfate; Male; Malondialdehyde; Neurons; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase | 1997 |
BN 80933 inhibits F2-isoprostane elevation in focal cerebral ischaemia and hypoxic neuronal cultures.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Dinoprost; Enzyme Inhibitors; F2-Isoprostanes; Hypoxia, Brain; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Neuroprotective Agents; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Thiophenes | 2000 |
9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): selective anticonvulsive and neuroprotective AMPA antagonist.
Topics: Animals; Anticonvulsants; Brain Injuries; Brain Ischemia; Disease Models, Animal; Gerbillinae; Imidazoles; Male; Neuroprotective Agents; Oocytes; Protein Binding; Pyrazines; Radioligand Assay; Rats; Receptors, AMPA; Reperfusion Injury; Seizures; Spinal Cord Compression; Synapses; Xenopus | 2002 |
[Changes in gerbil brain tissue following cerebral ischemia and postischemic reperfusion and studies of the effects of the Chinese drugs].
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cerebrovascular Circulation; Drugs, Chinese Herbal; Female; Gerbillinae; Glucose; Lactates; Male; Plant Extracts; Pyrazines; Reperfusion Injury; Salvia miltiorrhiza | 1992 |
Tetramethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils.
Topics: Animals; Binding, Competitive; Brain; Brain Ischemia; Cerebrovascular Disorders; Gerbillinae; Male; Pyrazines | 1989 |