pyrazines has been researched along with Cardiovascular Stroke in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 7 (22.58) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deng, H; Hu, H; Luo, J; Shan, L; Wang, Y; Yu, P; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Deng, H; Luo, J; Shan, L; Wang, Y; Xu, B; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Assmann, G; Brenner, C; Brunner, S; David, R; Franz, WM; Gross, L; Mueller-Hoecker, J; Nathan, P; Steinbeck, G; Theiss, HD; Vallaster, M; Vogeser, M | 1 |
| Andersson, C; Mogensen, UM; Scheller, NM; Torp-Pedersen, C; Vaag, A | 1 |
| Begum, SS; Hausenloy, DJ; Mocanu, MM; Riksen, N; Theodorou, L; Whittington, HJ; Wynne, AM; Yellon, DM | 1 |
| Bethel, MA; Califf, RM; Green, JB; Holman, RR; Kaufman, KD; Paul, SK; Ring, A; Shapiro, DR | 1 |
| Chang, NC; Chen, WT; Lee, TM; Lin, SZ; Yang, CC | 1 |
| Bi, S; Han, D; Li, Y; Wang, C; Yang, X; Zhang, D; Zhang, Y | 1 |
| Amatruda, JF; Bao, X; Bassel-Duby, R; Feng, JQ; Liu, Y; Lum, L; Moon, J; Morlock, LK; Olson, EN; Palecek, SP; Tan, W; Williams, NS; Zhang, LS; Zhang, S; Zhou, H | 1 |
| Brenner, C; Engelmann, MG; Franz, WM; Henschel, V; Huber, B; Mansmann, U; Reiser, M; Steinbeck, G; Theiss, HD; Wintersperger, B; Zaruba, MM | 1 |
| Ban, K; Drucker, DJ; Henkelman, RM; Husain, M; Momen, MA; Sauvé, M; Zhou, YQ | 1 |
| Birnbaum, Y; Keyes, KT; Lin, Y; Perez-Polo, JR; Ye, Y; Zhang, C | 1 |
| Kotani, T; Nakao, S; Okumura, H; Sawazaki, A; Takamatsu, H; Yamashita, T | 1 |
| Dong, J; Gong, G; Ren, M; Wen, N; Xu, Y | 1 |
| Cheng, Y; Gong, JB; Jiang, SS; Lv, L; Xu, J | 1 |
| Bousquenaud, M; Boutley, H; Devaux, Y; Karcher, G; Marie, PY; Maskali, F; Poussier, S; Wagner, DR | 1 |
| Advani, A; Advani, SL; Connelly, KA; Gilbert, RE; Thai, K; Yuen, DA; Zhang, Y | 1 |
| Chen, Q; Li, BL; Song, ZJ | 1 |
| Dunn, ST; Garrett, MW; Huang, S; Kaufman, KM; Kem, DC; Metcalf, JP; Patterson, E; Yu, X; Zhu, M | 1 |
| Chen, SY; Cheng, PY; Hsiao, G; Hwang, HR; Lee, YM | 1 |
| Davey, AK; Evans, AM; Li, Y; Wang, J; Xu, D; Zhang, S | 1 |
| Dneprovskaia, E; Doukas, J; Fine, RM; Hood, J; Kang, X; Lohse, D; Martin, M; Noronha, G; Palanki, MS; Soll, RM; Wrasidlo, W; Yee, S; Zhu, H | 1 |
| De Aos, I; Garrett, MW; Huang, S; Kem, DC; Patterson, E; Yu, X | 1 |
| Chen, ZQ; Hong, L; Wang, H | 1 |
| Chen, JM; Fan, GH; Xiao, CQ | 1 |
| Bergman, J; Haaparanta, M; Härkönen, R; Hartiala, J; Knuuti, MJ; Mäki, M; Nuutila, P; Ruotsalainen, U; Teräs, M; Voipio-Pulkki, LM; Wegelius, U; Yki-Järvinen, H | 1 |
| Marsh, JD; Vander Heide, RS | 1 |
| Funaya, H; Hori, M; Kitakaze, M; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Bax, JJ; Cornel, JH; Fioretti, PM; Krenning, EP; Poldermans, D; Rambaldi, R; Valkema, R; van Lingen, A; Visser, FC | 1 |
| Chapelle, M; Chiche, P | 1 |
| Savoie, L; Selye, H; Somogyi, A | 1 |
1 review(s) available for pyrazines and Cardiovascular Stroke
| Article | Year |
|---|---|
FDG SPECT in the assessment of myocardial viability. Comparison with dobutamine echo.
Topics: Cardiotonic Agents; Deoxyglucose; Dobutamine; Echocardiography; Exercise Test; Fluorodeoxyglucose F18; Glucose; Humans; Hypolipidemic Agents; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Predictive Value of Tests; Pyrazines; Radiopharmaceuticals; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon | 1997 |
4 trial(s) available for pyrazines and Cardiovascular Stroke
| Article | Year |
|---|---|
Rationale, design, and organization of a randomized, controlled Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) in patients with type 2 diabetes and established cardiovascular disease.
Topics: Aged; Aged, 80 and over; Angina, Unstable; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Myocardial Infarction; Pioglitazone; Pyrazines; Research Design; Sitagliptin Phosphate; Stroke; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome; Triazoles | 2013 |
Safety and efficacy of SITAgliptin plus GRanulocyte-colony-stimulating factor in patients suffering from Acute Myocardial Infarction (SITAGRAMI-Trial)--rationale, design and first interim analysis.
Topics: Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Male; Middle Aged; Myocardial Infarction; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2010 |
[Effect of tetramethylpyrazine on platelet activation and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention].
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Drugs, Chinese Herbal; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Pyrazines | 2007 |
[Effect of ligustrazine on plasma lipid peroxidation, superoxide dismutase of the coronary heart disease].
Topics: Aged; Female; Humans; Lipid Peroxides; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyrazines; Sulfhydryl Compounds; Superoxide Dismutase | 1994 |
26 other study(ies) available for pyrazines and Cardiovascular Stroke
| Article | Year |
|---|---|
A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway.
Topics: Animals; Cell Line; Cell Survival; Free Radicals; Heme Oxygenase-1; Iodoacetic Acid; Lactates; Ligusticum; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; NF-E2-Related Factor 2; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Salvia miltiorrhiza; tert-Butylhydroperoxide; Up-Regulation | 2017 |
A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs.
Topics: Animals; Arterial Pressure; Calcium; Cardiotonic Agents; Coronary Circulation; Cyclic GMP; Dogs; Extracellular Matrix; Intracellular Space; Lactates; Male; Myocardial Infarction; Nitric Oxide; Potassium Channels; Pyrazines; Rats; Receptors, Adrenergic, beta; Vasodilation; Vasodilator Agents | 2018 |
Antidiabetic gliptins in combination with G-CSF enhances myocardial function and survival after acute myocardial infarction.
Topics: Adamantane; Animals; Cell Survival; Drug Therapy, Combination; Granulocyte Colony-Stimulating Factor; Heart; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Nitriles; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Vildagliptin | 2013 |
All-cause mortality and cardiovascular effects associated with the DPP-IV inhibitor sitagliptin compared with metformin, a retrospective cohort study on the Danish population.
Topics: Denmark; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dipeptidyl-Peptidase IV Inhibitors; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Pyrazines; Retrospective Studies; Sitagliptin Phosphate; Stroke; Treatment Outcome; Triazoles | 2014 |
Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner.
Topics: Adamantane; Animals; Cyclic AMP-Dependent Protein Kinases; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Heart; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitriles; Pyrazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glucagon; Severity of Illness Index; Signal Transduction; Sitagliptin Phosphate; Triazoles; Vildagliptin | 2013 |
Sitagliptin attenuates sympathetic innervation via modulating reactive oxygen species and interstitial adenosine in infarcted rat hearts.
Topics: Adenosine; Animals; Heart; Male; Myocardial Infarction; Pyrazines; Rats; Rats, Wistar; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles | 2015 |
Tetramethylpyrazine and Astragaloside IV Synergistically Ameliorate Left Ventricular Remodeling and Preserve Cardiac Function in a Rat Myocardial Infarction Model.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; Myocardial Infarction; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Vasodilator Agents; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.
Topics: Acyltransferases; Animals; Atrial Remodeling; Cells, Cultured; Collagen Type VI; Enzyme Inhibitors; Gene Expression; HEK293 Cells; Humans; Membrane Proteins; Mice, Inbred C57BL; Molecular Structure; Myocardial Infarction; Pyrazines; Pyridines; Regeneration; Wnt Signaling Pathway | 2017 |
Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice.
Topics: Animals; Cardiovascular System; Coronary Vessels; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Gene Deletion; Heart; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Ischemia; Pyrazines; Reference Values; Reperfusion; Sitagliptin Phosphate; Survivors; Triazoles | 2010 |
The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Culture Media; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptidyl-Peptidase IV Inhibitors; Eicosanoids; Glucagon-Like Peptide 1; Hypertrophy, Left Ventricular; Hypoglycemic Agents; In Vitro Techniques; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Organ Size; Phospholipases A2; Pioglitazone; Prostaglandin-Endoperoxide Synthases; Protective Agents; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles | 2010 |
Ischemic heart disease associated with bortezomib treatment combined with dexamethasone in a patient with multiple myeloma.
Topics: Aged; Antineoplastic Agents; Boronic Acids; Bortezomib; Coronary Vessels; Dexamethasone; Female; Humans; Multiple Myeloma; Myocardial Infarction; Pyrazines | 2010 |
Synthesis of novel ligustrazine derivatives as NA+/H+ exchange inhibitors.
Topics: Animals; Benzamides; Cardiotonic Agents; Creatine Kinase; Disease Models, Animal; Myocardial Infarction; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Structure-Activity Relationship | 2010 |
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.
Topics: Animals; Apoptosis; Cardiotonic Agents; Caspase 3; Enzyme Inhibitors; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction | 2012 |
Acipimox-enhanced ¹⁸F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model.
Topics: Animals; Diastole; Disease Models, Animal; Fluorodeoxyglucose F18; Hypolipidemic Agents; Male; Myocardial Infarction; Myocardium; Positron-Emission Tomography; Predictive Value of Tests; Pyrazines; Radiopharmaceuticals; Rats; Rats, Wistar; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2012 |
DPP-4 inhibition attenuates cardiac dysfunction and adverse remodeling following myocardial infarction in rats with experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Heart; Myocardial Infarction; Pyrazines; Rats; Rats, Inbred F344; Sitagliptin Phosphate; Streptozocin; Triazoles; Ventricular Remodeling | 2013 |
[Protective effect of tetramethylpyrazine and L-arginine on rats with acute myocardial infarction].
Topics: Animals; Arginine; Creatine Kinase; Drug Synergism; Female; Male; Myocardial Infarction; P-Selectin; Pyrazines; Rats; Rats, Sprague-Dawley; Troponin T | 2004 |
Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction.
Topics: Animals; Boronic Acids; Bortezomib; Death, Sudden, Cardiac; Dogs; Electrocardiography; G-Protein-Coupled Receptor Kinase 5; Immunoblotting; Ligation; Male; Microscopy, Confocal; Microscopy, Fluorescence; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pericardium; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Tachycardia, Ventricular | 2005 |
Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats.
Topics: Animals; Arrhythmias, Cardiac; Chemotaxis; Fibrinolytic Agents; Gene Expression; Heme Oxygenase-1; Humans; Ligusticum; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Respiratory Burst; Superoxides | 2006 |
The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.
Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Heart Rate; Hydroxy Acids; Injections, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pyrazines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Fibrillation | 2007 |
Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.
Topics: Animals; Antigens, CD; Cadherins; Capillary Permeability; Cell Proliferation; Cells, Cultured; Endothelial Cells; Humans; Isoenzymes; Male; Models, Molecular; Myocardial Infarction; Myocardial Reperfusion Injury; Phenols; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pteridines; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Umbilical Veins; Vascular Endothelial Growth Factor A | 2007 |
Proteasome inhibition 1 h following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a model of myocardial infarction.
Topics: Animals; Blotting, Western; Boronic Acids; Bortezomib; Catecholamines; Chymotrypsin; Coronary Vessels; Death, Sudden, Cardiac; Dogs; Electrocardiography; Electrophysiology; G-Protein-Coupled Receptor Kinase 3; Heart Ventricles; HSP72 Heat-Shock Proteins; Ligation; Male; Myocardial Infarction; Myocardial Ischemia; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Tachycardia; Trypsin | 2008 |
Enhancement of myocardial [fluorine-18]fluorodeoxyglucose uptake by a nicotinic acid derivative.
Topics: Adult; Aged; Coronary Angiography; Deoxyglucose; Diabetes Mellitus, Type 2; Echocardiography; Female; Fluorodeoxyglucose F18; Glucose; Glucose Clamp Technique; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Nicotinic Acids; Pyrazines; Radionuclide Ventriculography; Tomography, Emission-Computed | 1994 |
Through the looking glass: a positive inotropic drug and ischemic preconditioning.
Topics: 5'-Nucleotidase; Adenosine; Animals; Cardiotonic Agents; Dogs; Drug Approval; Enzyme Activation; Heart Failure; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardium; Neutropenia; Protein Kinase C; Pyrazines; Quinolines; Second Messenger Systems | 1997 |
Vesnarinone limits infarct size via adenosine-dependent mechanisms in the canine heart.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Cardiotonic Agents; Dipyridamole; Dogs; Enzyme Activation; Enzyme Inhibitors; Infusions, Intra-Arterial; Ion Channel Gating; Myocardial Infarction; Myocardial Reperfusion Injury; Potassium Channels; Pyrazines; Quinolines; Receptors, Purinergic P1; Theophylline | 1997 |
[Potassium depletion in cardiology. Action of amiloride, a potassium sparing diuretic].
Topics: Adult; Aged; Amiloride; Arrhythmias, Cardiac; Coronary Disease; Digitalis Glycosides; Diuretics; Female; Heart Diseases; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Potassium Deficiency; Pyrazines | 1973 |
Prevention of stress-induced cardiac necrosis by amiloride.
Topics: Animals; Diuretics; Ethacrynic Acid; Female; Heart Diseases; Hydrochlorothiazide; Immobilization; Myocardial Infarction; Necrosis; Potassium; Pyrazines; Rats; Stress, Physiological | 1969 |