Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and Cancer of Stomach

pyrazines has been researched along with Cancer of Stomach in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.70)18.7374
1990's2 (7.41)18.2507
2000's7 (25.93)29.6817
2010's14 (51.85)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
Liang, L; Ma, G; Wang, D; Xu, L; Xu, X1
Aigner, A; Büch, T; Holzhäuser-Rein, M; Jenke, R; Lordick, F; Mueller-Wilke, S1
Markham, A1
Bai, R; Chen, N; Fan, Y; Hao, LJ; Hao, Y; Li, GS; Liu, YJ; Mao, Y; Shi, C; Wang, YJ; Xia, GX; Yu, JX; Zhang, CC; Zhang, J; Zhang, LD; Zhao, F1
Bartfeld, S; Chan, AKW; Chan, AS; Chan, ASY; Chan, D; Cheng, PSW; Clevers, H; Fan, X; Ho, SL; Kwong, DLW; Lam, KO; Law, S; Lee, BCH; Leung, SY; Ma, S; Mak, TW; Man, AHY; Shi, J; Siu, HC; Tsui, WY; Wong, JWH; Yan, HHN; Yue, SSK; Yuen, ST; Zhang, J1
Fang, D; Hu, P; Ni, L; Xu, J; Xu, Z1
Hu, X; Li, C; Li, E; Liu, Y; Ma, Y; Qu, X; Song, N; Xu, L; Zhu, Z1
Besanceney-Webler, C; Chen, EX; Cheng, J; Christos, P; Dilts, KT; Holloway, S; Keresztes, R; Lane, ME; Lin, J; Matulich, D; Ocean, AJ; Papetti, M; Schnoll-Sussman, F; Shah, MA; Sparano, JA; Ward, M; Wright, JJ; Xiang, J; Yantiss, RK1
Huang, XE; Ji, AJ; Ju, WZ; Liu, SL1
Fan, S; Fu, H; Gavine, PR; Han, L; Jiao, L; Liu, YJ; Lv, J; Qing, W; Ren, Y; Su, W; Su, X; Wang, H; Wang, L; Wang, QM; Xie, L; Xu, S; Xu, W; Yin, X; Yu, Y; Zhang, T; Zhang, W; Zhou, F1
Gu, Y; Zhang, B1
Li, H; Li, X; Liu, Y; Luo, Y; Qu, X; Xu, L; Zhao, L; Zhu, Z1
Chae, CH; Cho, SY; Choi, SU; Ha, JD; Jang, IY; Jung, H; Kim, HR; Lee, CO; Lee, HK; Park, CH1
Ambinder, RF; Chen, J; Chong, JM; Foss, CA; Fox, JJ; Fu, DX; Fukayama, M; Hobbs, RF; Kowalski, J; Pomper, MG; Sgouros, G; Tanhehco, Y1
Chen, Z; Ding, WB; Lou, YJ; Ye, ZQ; Yu, YP; Zhang, YD1
Hou, KZ; Liu, J; Liu, YP; Qu, JL; Qu, XJ; Xu, L; Zang, Y1
Capanu, M; Holen, KD; Ilson, DH; Kelsen, DP; Kemeny, MM; Kindler, HL; Power, DG; Shah, MA; Tang, L; Wright, JJ1
Hayakawa, Y; Hirata, Y; Kinoshita, H; Koike, K; Maeda, S; Nakagawa, H; Nakata, W; Sakamoto, K; Takahashi, R1
Banti, A; Gastari, V; Kaloutsi, V; Kartsios, C; Katodritou, E; Lazaraki, G; Lazaridou, A; Mihou, D; Verrou, E; Zervas, K1
Doihara, H; Fujita, T; Ino, H; Murakami, M; Naito, M; Shimizu, N; Washio, K1
Nawasreh, M1
Bae, SH; Hyun, MS; Kim, MK; Lee, KH; Ryoo, HM; Sin, JI1
Alberts, SR; Dakhil, SR; Flynn, PJ; Foster, NR; Hauge, MD; Jaslowski, AJ; Jatoi, A; Ma, C; Moore, DF; Rowland, KM; Stella, PJ; Thomas, SP1
Furukawa, F; Ikezaki, S; Kasahara, K; Lee, IS; Nishikawa, A; Takahashi, M; Tanakamura, Z1
Hayashi, K; Ito, R; Ono, S; Tahara, E; Yokozaki, H1
Dolan, PM; Itoh, K; Kensler, TW; Kwak, MK; Ramos-Gomez, M; Talalay, P; Yamamoto, M1
Bueding, E; Wattenberg, LW1

Reviews

1 review(s) available for pyrazines and Cancer of Stomach

ArticleYear
Savolitinib: First Approval.
    Drugs, 2021, Volume: 81, Issue:14

    Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; China; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Drug Approval; Humans; Kidney Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Pyrazines; Stomach Neoplasms; Triazines

2021

Trials

3 trial(s) available for pyrazines and Cancer of Stomach

ArticleYear
Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach.
    Investigational new drugs, 2014, Volume: 32, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Camptothecin; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Proteasome Inhibitors; Pyrazines; Stomach Neoplasms

2014
A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma.
    Investigational new drugs, 2011, Volume: 29, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Boronic Acids; Bortezomib; Esophagogastric Junction; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; NF-kappa B; Protease Inhibitors; Pyrazines; Stomach Neoplasms; Treatment Outcome

2011
Bortezomib, paclitaxel, and carboplatin as a first-line regimen for patients with metastatic esophageal, gastric, and gastroesophageal cancer: phase II results from the North Central Cancer Treatment Group (N044B).
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2008, Volume: 3, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carboplatin; Cardia; Disease Progression; Esophageal Neoplasms; Esophagogastric Junction; Female; Humans; Male; Middle Aged; Paclitaxel; Pyrazines; Stomach Neoplasms; Survival Rate; Treatment Outcome

2008

Other Studies

23 other study(ies) available for pyrazines and Cancer of Stomach

ArticleYear
Case report: apatinib plus selexipag as a novel therapy for pulmonary tumor thrombotic microangiopathy accompanied by pulmonary hypertension associated with gastric carcinoma.
    Medicine, 2022, Jul-15, Volume: 101, Issue:28

    Topics: Acetamides; Drug Therapy, Combination; Female; Humans; Hypertension, Pulmonary; Lung Neoplasms; Middle Aged; Pulmonary Artery; Pyrazines; Pyridines; Receptors, Epoprostenol; Receptors, Vascular Endothelial Growth Factor; Stomach Neoplasms; Thrombotic Microangiopathies

2022
SATB1-Mediated Upregulation of the Oncogenic Receptor Tyrosine Kinase HER3 Antagonizes MET Inhibition in Gastric Cancer Cells.
    International journal of molecular sciences, 2020, Dec-23, Volume: 22, Issue:1

    Topics: Cell Line, Tumor; Cell Proliferation; Humans; MAP Kinase Signaling System; Matrix Attachment Region Binding Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Receptor, ErbB-3; Stomach Neoplasms; Triazoles; Up-Regulation

2020
Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization.
    European journal of medicinal chemistry, 2017, Jul-07, Volume: 134

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Gastric Mucosa; Haplorhini; Humans; Lung; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Quinolines; Rats; Rats, Sprague-Dawley; Stomach; Stomach Neoplasms

2017
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
    Cell stem cell, 2018, 12-06, Volume: 23, Issue:6

    Topics: Aminopyridines; Antineoplastic Agents; Benzimidazoles; Benzofurans; Biological Specimen Banks; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles; Male; Naphthoquinones; Organoids; Precision Medicine; Pyrazines; Stomach Neoplasms

2018
Electrostatic explanation of D1228V/H/N-induced c-Met resistance and sensitivity to type I and type II kinase inhibitors in targeted gastric cancer therapy.
    Journal of molecular modeling, 2019, Jan-03, Volume: 25, Issue:1

    Topics: Anilides; Binding Sites; Drug Resistance, Neoplasm; Humans; Molecular Dynamics Simulation; Molecular Structure; Molecular Targeted Therapy; Mutation; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Pyridines; Static Electricity; Stomach Neoplasms; Triazines

2019
Lipid raft-regulated IGF-1R activation antagonizes TRAIL-induced apoptosis in gastric cancer cells.
    FEBS letters, 2013, Nov-29, Volume: 587, Issue:23

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Cell Line, Tumor; Humans; Imidazoles; Membrane Microdomains; Protein Transport; Proto-Oncogene Proteins c-cbl; Pyrazines; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; TNF-Related Apoptosis-Inducing Ligand

2013
Anti-proliferation effects and molecular mechanisms of action of tetramethypyrazine on human SGC-7901 gastric carcinoma cells.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:8

    Topics: Apoptosis; Blotting, Western; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Down-Regulation; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; NF-kappa B; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Up-Regulation

2014
Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models.
    Molecular oncology, 2015, Volume: 9, Issue:1

    Topics: Animals; Asian People; Cell Line, Tumor; Cohort Studies; Female; Gene Amplification; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Proto-Oncogene Proteins c-met; Pyrazines; Signal Transduction; Stomach Neoplasms; Triazines; Xenograft Model Antitumor Assays

2015
Bortezomib inhibits gastric carcinoma HGC-27 cells through the phospho-Jun N-terminal kinase (p-JNK) pathway in vitro.
    Gene, 2015, Apr-01, Volume: 559, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Shape; Cell Survival; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Pyrazines; Stomach Neoplasms; Up-Regulation

2015
Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells.
    Molecular medicine reports, 2015, Volume: 11, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cetuximab; Drug Resistance, Neoplasm; Humans; Imidazoles; Phosphorylation; Proto-Oncogene Proteins B-raf; Pyrazines; ras Proteins; Receptor, IGF Type 1; RNA Interference; RNA, Small Interfering; src-Family Kinases; Stomach Neoplasms

2015
Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells.
    BMC cancer, 2016, Jan-22, Volume: 16

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrazines; Signal Transduction; Stomach Neoplasms; Triazoles; Xenograft Model Antitumor Assays

2016
Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors.
    Nature medicine, 2008, Volume: 14, Issue:10

    Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Boronic Acids; Bortezomib; Burkitt Lymphoma; Cell Line, Tumor; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Iodine Radioisotopes; Male; Mice; Mice, SCID; Pyrazines; Radiopharmaceuticals; Sarcoma, Kaposi; Stomach Neoplasms; Thymidine Kinase

2008
[4, 8-disubstituted-8, 9-dihydro-pyrazine[2,3-g]quinazoline-7(6H)-ketones: a novel class of antitumor agents].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2010, Volume: 39, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; K562 Cells; Lung Neoplasms; Molecular Structure; Pyrazines; Quinazolines; Stomach Neoplasms; Structure-Activity Relationship

2010
Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells.
    Digestive diseases and sciences, 2010, Volume: 55, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Survival; Drug Synergism; Humans; Pyrazines; Stomach Neoplasms; TNF-Related Apoptosis-Inducing Ligand

2010
Anti-tumor activity of the proteasome inhibitor bortezomib in gastric cancer.
    International journal of oncology, 2011, Volume: 39, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Proliferation; Humans; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms; Xenograft Model Antitumor Assays

2011
Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case.
    Leukemia research, 2008, Volume: 32, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Humans; Male; Middle Aged; Plasmacytoma; Pyrazines; Stomach Neoplasms

2008
Antitumor effects and drug interactions of the proteasome inhibitor bortezomib (PS341) in gastric cancer cells.
    Anti-cancer drugs, 2007, Volume: 18, Issue:6

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Stomach Neoplasms

2007
Chemo-, regio-, and stereoselectivity of F-ring opening reactions in the cephalostatin series.
    Bioorganic & medicinal chemistry, 2008, Jan-01, Volume: 16, Issue:1

    Topics: Antineoplastic Agents; Boranes; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Phenazines; Pyrazines; Spiro Compounds; Steroids; Stomach Neoplasms; Structure-Activity Relationship

2008
Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapeutic agents in gastric cancer cell lines.
    Oncology reports, 2008, Volume: 19, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Docetaxel; Humans; Proteasome Inhibitors; Pyrazines; Stomach Neoplasms; Taxoids; Tumor Suppressor Protein p53

2008
Chemopreventive activity of oltipraz against induction of glandular stomach carcinogenesis in rats by N-methyl-N'-nitro-N-nitrosoguanidine.
    Carcinogenesis, 1998, Volume: 19, Issue:2

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Hyperplasia; Male; Methylnitronitrosoguanidine; Pylorus; Pyrazines; Rats; Rats, Wistar; Stomach Neoplasms; Thiones; Thiophenes

1998
Effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (vesnarinone) on the growth of gastric cancer cell lines.
    Cancer letters, 1999, Jun-01, Volume: 140, Issue:1-2

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Northern; Carcinoma; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Nucleus; Humans; Pyrazines; Quinolines; RNA, Messenger; Stomach Neoplasms; Time Factors; Tumor Cells, Cultured

1999
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Nucleus; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Epoxide Hydrolases; Female; FMN Reductase; Gene Expression; Genotype; Glucuronosyltransferase; Glutathione Transferase; Mice; Mice, Inbred ICR; Mice, Knockout; NADH, NADPH Oxidoreductases; NF-E2-Related Factor 2; Pyrazines; Stomach Neoplasms; Thiones; Thiophenes; Trans-Activators

2001
Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard.
    Carcinogenesis, 1986, Volume: 7, Issue:8

    Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Lung Neoplasms; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Pyrazines; Stomach Neoplasms; Thiones; Thiophenes; Uracil Mustard

1986