Compounds > pyrazines
Page last updated: 2024-08-21

pyrazines and Cancer of Colon

pyrazines has been researched along with Cancer of Colon in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (13.33)18.2507
2000's23 (51.11)29.6817
2010's13 (28.89)24.3611
2020's3 (6.67)2.80

Authors

AuthorsStudies
Chen, Y; Dong, Y; Gu, Y; He, J; Li, Y; Liang, H; Liu, C; Ou, J; Shen, K; Tan, J; Wang, H; Wang, L; Wang, Y; Wei, L; Wu, S; Xie, G; Zhang, C; Zhang, Y; Zhao, X; Zhao, Y; Zheng, W; Zhou, Q1
Kanda, Y; Miyazaki, T; Mori, Y; Ochiai, A; Ohata, H; Okamoto, K; Owa, T; Sakai, H; Shiokawa, D; Yokoi, A1
Ahn, KS; Blough, BE; Eng, H; Jung, YY; Kumar, AP; Mohan, CD; Namjoshi, OA; Narula, AS; Rangappa, KS; Sethi, G1
Dow, LE; Elemento, O; Han, T; Murphy, C; Schatoff, EM; Wilkinson, JE; Zafra, MP1
Choi, J; Chung, SH; Ham, YJ; Jang, SY; Kang, SJ; Kim, YH; Lee, JW; Min, KH; Suh, KH1
Caderni, G; Femia, AP; Lodovici, M; Maglieri, G; Mannucci, E; Raimondi, L1
Ding, Y; Ju, S; Mao, L; Shi, F; Wang, Y; Wu, X; Zhu, W1
Bartlett, DL; Kim, SY; Kwon, YT; Lee, YJ; Song, X; Tang, D; Zhang, L1
Barda, D; Barnard, D; Beckmann, R; Burke, T; Diaz, HB; Donoho, G; Jones, B; King, C; Marshall, M1
Bertoglio, J; Bréard, J; Mérino, D; Micheau, O; Ndozangue-Touriguine, O; Sebbagh, M1
Brattain, MG; Hauser, J; Hu, YP; Humphrey, LE; Li, W; Panasiewicz, M; Patil, SB1
Eckhardt, SG; Kaufman, SA; Morrow, M; Pitts, TM; Tentler, JJ1
Begleiter, A; Bird, RP; Lefas, GM; Maksymiuk, AW; Sivananthan, K1
Carew, JS; Esquivel, JA; Giles, FJ; Huang, P; Kelly, K; Mahalingam, D; Medina, EC; Mita, AC; Mita, MM; Nawrocki, ST; Swords, R; Zhang, H1
Chen, X; Ding, WX; Gao, W; Kang, JH; Liu, J; Ni, HM; Stolz, DB; Yin, XM1
Blank, JL; Burkhardt, AL; Chen, S; Chen, W; Driscoll, DL; Garcia, K; Gray, J; Hales, P; Leroy, PJ; Lightcap, ES; Lingaraj, T; Liu, XJ; Menon, S; Morgenstern, JP; Peters, T; Pickard, MD; Rabino, C; Rappoli, DM; Ringeling, J; Sappal, DS; Spelman, JJ; Yu, J1
Ahn, BC; Bae, SA; Ha, JH; Jeon, YH; Lee, J; Lee, SW; Lee, YJ; Lee, YL; Yoon, GS1
Sargent, DJ1
Heo, DS; Hong, SW; Hong, YS; Jin, DH; Kim, KP; Kim, SM; Kim, TW; Lee, JL; Lee, JS; Shin, JS; Yoon, DH1
Downward, J; Hancock, DC; Howell, M; Kelly, G; Kuznetsov, H; Marani, M; Molina-Arcas, M; Saunders, B; Steckel, M; Warne, PH; Weigelt, B1
Hansen, LS; Hare, KJ; Hartmann, B; Holst, JJ; Kissow, H; Poulsen, SS; Rosenkilde, MM; Viby, NE1
Begleiter, A; Bird, RP; Curphey, TJ; Sivananthan, K1
Adachi, M; Hinoda, Y; Imai, K; Kawamura, R; Minami, T; Zhang, Y; Zhao, X1
Blackey, R; Cassidy, J; Choi, L; Devlin, M; Eatock, M; Johnson, J; Morrison, R; Owen, S; Twelves, C1
Adams, J; Coultas, L; Johnson, T; Kraft, AS; Nikrad, M; Puthalalath, H1
Chiao, PJ; Davis, JJ; Dong, F; Fang, B; Guo, W; Teraishi, F; Wu, S; Zhang, L; Zhu, H1
Ebert, B; Lampen, A; Seidel, A1
Matono, K; Mizobe, T; Nagase, H; Nakajima, M; Ogata, Y; Sasatomi, T; Shirouzu, K1
Adachi, M; Imai, K; Kawamura, R; Minami, T; Shinomura, Y; Zhang, Y1
Davis, JJ; Dong, F; Fang, B; Guo, W; Teraishi, F; Wu, S; Zhang, L; Zhu, H1
Braun, T; Carvalho, G; Castedo, M; Coquelle, A; Kroemer, G; Métivier, D; Mouhamad, S; Pequignot, MO; Vivet, S1
Barti-Juhász, H; Conte, P; Dominici, M; Douglas, L; Houghton, JA; Izeradjene, K; Kopper, L; Luca Cervo, G; Mihalik, R; Nagy, K; Peták, I; Spano, C; Székely-Szüts, K; Tillman, M1
Avendaño, C; de la Cuesta, E; González, JF1
Chao, TH; Cusack, JC; Liu, R; Neuteboom, ST; Niu, W; Palladino, MA; Palombella, VJ; Pien, C; Xia, L1
Birle, DC; Hedley, DW1
Chen, X; Ding, WX; Ni, HM; Yin, XM; Yu, J; Zhang, L1
Holt, PR; Liu, T; Mokuolu, AO; Rao, CV; Reddy, BS1
Braguer, D; Briand, C; Carles, G; Garcia, P1
Katiwalla, M; Kelloff, GJ; Rao, CV; Reddy, BS; Rivenson, A1
Reddy, BS1
Clayton, M; Halbherr, T; Myers, CB; O'Dwyer, PJ; Yao, Ks1
Chiba, T; Ko, K; Konda, Y; Nakajima, M; Takahashi, R; Yazumi, S; Yoshikawa, K1
Ahn, B; Choi, KS; Kang, JS; Kim, DJ; Kim, KS; Kim, ND; Park, KH; Surh, YJ1
Bardiau, C; Guillouzo, A; Lagadic-Gossmann, D; Le Ferrec, E; Le Vee, M; Maheo, K; Massiere, F; Morel, F; Rauch, C1
Nayini, J; Rao, CV; Reddy, BS1

Reviews

1 review(s) available for pyrazines and Cancer of Colon

ArticleYear
Chemoprevention of colon cancer by dietary administration of naturally-occurring and related synthetic agents.
    Advances in experimental medicine and biology, 1997, Volume: 400B

    Topics: Allyl Compounds; Anethole Trithione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Arachidonic Acids; Aspirin; Colon; Colonic Neoplasms; Dinoprostone; Disulfides; Eflornithine; Food, Fortified; Ibuprofen; Intestinal Mucosa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Piroxicam; Pyrazines; Thiones; Thiophenes

1997

Trials

1 trial(s) available for pyrazines and Cancer of Colon

ArticleYear
A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MMI270 (previously termed CGS27023A) with 5-FU and folinic acid.
    Cancer chemotherapy and pharmacology, 2005, Volume: 55, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Hydroxamic Acids; Leucovorin; Male; Metalloendopeptidases; Middle Aged; Protease Inhibitors; Pyrazines; Rectal Neoplasms; Sulfonamides

2005

Other Studies

43 other study(ies) available for pyrazines and Cancer of Colon

ArticleYear
ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation.
    Nature communications, 2021, 11-18, Volume: 12, Issue:1

    Topics: 1-Acylglycerol-3-Phosphate O-Acyltransferase; Animals; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Male; Methylation; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Neoplastic Stem Cells; Proto-Oncogene Proteins c-met; Pyrazines; Triazines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins

2021
NF-κB suppression synergizes with E7386, an inhibitor of CBP/β-catenin interaction, to block proliferation of patient-derived colon cancer spheroids.
    Biochemical and biophysical research communications, 2022, 01-01, Volume: 586

    Topics: Adenocarcinoma; beta Catenin; Cell Cycle Checkpoints; Cell Proliferation; Colonic Neoplasms; CREB-Binding Protein; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; NF-kappa B; Phenylenediamines; Primary Cell Culture; Pyrazines; Spheroids, Cellular; Triazines; Wnt Signaling Pathway

2022
2,3,5,6-Tetramethylpyrazine Targets Epithelial-Mesenchymal Transition by Abrogating Manganese Superoxide Dismutase Expression and TGFβ-Driven Signaling Cascades in Colon Cancer Cells.
    Biomolecules, 2022, 06-25, Volume: 12, Issue:7

    Topics: Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3; Humans; Phosphatidylinositol 3-Kinases; Pyrazines; Superoxide Dismutase; Transforming Growth Factor beta

2022
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
    Nature communications, 2017, 07-11, Volume: 8

    Topics: Acyltransferases; Animals; Chromosome Aberrations; Chromosomes; Colonic Neoplasms; Female; Gene Rearrangement; Humans; Intestines; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Pyrazines; Pyridines; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Thrombospondins; Wnt Proteins

2017
Synthesis and anti-tumor activity of imidazopyrazines as TAK1 inhibitors.
    European journal of medicinal chemistry, 2019, Feb-01, Volume: 163

    Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Heterografts; Humans; Inflammation; MAP Kinase Kinase Kinases; Mice; Neoplasms; Protein Kinase Inhibitors; Pyrazines

2019
Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats.
    International journal of cancer, 2013, Nov-15, Volume: 133, Issue:10

    Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogenesis; Colonic Neoplasms; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Intestinal Mucosa; Intestines; Male; Mucins; Pyrazines; Random Allocation; Rats; Rats, Inbred F344; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles

2013
Role of CIP2A in the antitumor effect of bortezomib in colon cancer.
    Molecular medicine reports, 2014, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autoantigens; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Down-Regulation; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Nude; Pyrazines; RNA Interference; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic; Transplantation, Heterologous

2014
Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer.
    Cell death & disease, 2014, Oct-30, Volume: 5

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Enzyme Activation; Humans; Kinetics; Melphalan; Membrane Proteins; Mice; Mitochondria; Phosphorylation; Phosphoserine; Pyrazines; Sirolimus

2014
LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models.
    Investigational new drugs, 2016, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Checkpoint Kinase 1; Colonic Neoplasms; Deoxycytidine; DNA Damage; Female; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phenylurea Compounds; Protein Kinase Inhibitors; Protein Kinases; Pyrazines; Xenograft Model Antitumor Assays

2016
A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma.
    Oncogene, 2008, Oct-09, Volume: 27, Issue:46

    Topics: Antineoplastic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Boronic Acids; Bortezomib; Carcinoma; Cell Membrane Permeability; Colonic Neoplasms; Disease Progression; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Mitochondria; Pyrazines; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein

2008
Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor.
    Cancer research, 2008, Oct-01, Volume: 68, Issue:19

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Quinazolines; Receptor Cross-Talk; Receptor, IGF Type 1; Signal Transduction; Tumor Cells, Cultured

2008
Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Hydroxamic Acids; Pyrazines; Signal Transduction; Vorinostat

2009
Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
    Oncology reports, 2009, Volume: 21, Issue:6

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Intestinal Mucosa; Male; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Time Factors

2009
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation.
    Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Boronic Acids; Bortezomib; Carcinoma; Cell Line, Tumor; Cell Survival; Chloroquine; Colonic Neoplasms; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; HT29 Cells; Humans; Hydroxamic Acids; Lysosomes; Mice; Mice, Inbred BALB C; Mice, Nude; Proteasome Endopeptidase Complex; Pyrazines; Superoxides; Ubiquitinated Proteins; Vorinostat; Xenograft Model Antitumor Assays

2010
Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:7

    Topics: Animals; Antimalarials; Apoptosis; Autophagy; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chloroquine; Colonic Neoplasms; Drug Therapy, Combination; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Xenograft Model Antitumor Assays

2009
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib.
    Cancer research, 2010, Jun-01, Volume: 70, Issue:11

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Death; Colonic Neoplasms; DNA Damage; Gene Knockdown Techniques; HCT116 Cells; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Melanoma; Protease Inhibitors; Proteasome Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Pyrazines; Ribosomes; RNA, Small Interfering; TOR Serine-Threonine Kinases; Transfection

2010
Evaluation of the reversal of multidrug resistance by MDR1 ribonucleic acid interference in a human colon cancer model using a Renilla luciferase reporter gene and coelenterazine.
    Molecular imaging, 2010, Volume: 9, Issue:6

    Topics: Adenoviridae; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Genes, Reporter; Humans; Imidazoles; Immunohistochemistry; Luciferases, Renilla; Luminescent Measurements; Mice; Models, Biological; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering

2010
Chemotherapy: Failure of bevacizumab in early-stage colon cancer.
    Nature reviews. Clinical oncology, 2011, Volume: 8, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Clinical Trials, Phase III as Topic; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Pyrazines; Treatment Failure

2011
Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1.
    International journal of oncology, 2012, Volume: 41, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Boronic Acids; Bortezomib; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Checkpoint Kinase 1; Colonic Neoplasms; Cyclin B; Cyclin-Dependent Kinases; DNA-Binding Proteins; G2 Phase Cell Cycle Checkpoints; Humans; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyrazines; Reactive Oxygen Species; Tumor Suppressor Proteins

2012
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.
    Cell research, 2012, Volume: 22, Issue:8

    Topics: Alleles; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Deoxycytidine; DNA Topoisomerases, Type I; GATA2 Transcription Factor; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mutation; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrazines; ras Proteins; RNA Interference; RNA, Small Interfering; Topoisomerase I Inhibitors; Topotecan; Transcriptional Activation

2012
Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice.
    Regulatory peptides, 2012, Nov-10, Volume: 179, Issue:1-3

    Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenoma; Anatomy, Cross-Sectional; Animals; Chlorocebus aethiops; Colon; Colonic Neoplasms; COS Cells; Cyclic AMP; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptide-2 Receptor; Hypoglycemic Agents; Intestinal Mucosa; Intestine, Small; Liraglutide; Mice; Mice, Inbred C57BL; Organ Size; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Transfection; Triazoles; Venoms

2012
Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003, Volume: 12, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Dimethyl Fumarate; Disease Models, Animal; Enzyme Induction; Fumarates; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Intestinal Mucosa; Liver; Male; NAD(P)H Dehydrogenase (Quinone); NADP; Pyrazines; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes

2003
Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-01, Volume: 10, Issue:11

    Topics: Adenocarcinoma; Annexin A5; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Caspase 3; Caspases; Cell Line, Tumor; Cinnamates; Colonic Neoplasms; Depsipeptides; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Free Radicals; Gastrointestinal Neoplasms; Histones; Humans; Microscopy, Confocal; Oligopeptides; Oxygen; Phosphorylation; Proteasome Inhibitors; Pyrazines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors

2004
The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Blotting, Western; Boronic Acids; Bortezomib; Carrier Proteins; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Colonic Neoplasms; Dose-Response Relationship, Drug; Down-Regulation; Fibroblasts; Green Fluorescent Proteins; Humans; Immunoprecipitation; Male; Membrane Glycoproteins; Membrane Proteins; Mice; Mitochondrial Proteins; Peptide Fragments; Plasmids; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Interference; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha

2005
Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors.
    Oncogene, 2005, Jul-21, Volume: 24, Issue:31

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Female; Humans; Kidney; Membrane Proteins; Mitochondrial Proteins; NF-kappa B; Ovarian Neoplasms; Protease Inhibitors; Proteasome Inhibitors; Pyrazines

2005
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
    Carcinogenesis, 2005, Volume: 26, Issue:10

    Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Biological Transport; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Neoplasm Proteins; Polychlorinated Dibenzodioxins; Pyrazines; Receptors, Aryl Hydrocarbon; Reserpine; RNA, Messenger; Thiones; Thiophenes

2005
Efficacy of the MMP inhibitor MMI270 against lung metastasis following removal of orthotopically transplanted human colon cancer in rat.
    International journal of cancer, 2006, Jan-01, Volume: 118, Issue:1

    Topics: Administration, Oral; Animals; Apoptosis; Chemoprevention; Colonic Neoplasms; Humans; Hydroxamic Acids; Lung Neoplasms; Neoplastic Cells, Circulating; Neovascularization, Pathologic; Pyrazines; Rats; Rats, Nude; Sulfonamides; Survival Analysis; Transplantation, Heterologous

2006
Sulindac enhances the proteasome inhibitor bortezomib-mediated oxidative stress and anticancer activity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jul-15, Volume: 11, Issue:14

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Death; Colonic Neoplasms; Disease Progression; DNA Damage; Drug Interactions; Humans; Mice; Mice, Nude; Oxidative Stress; Pyrazines; Reactive Oxygen Species; Sulindac; Transplantation, Heterologous

2005
Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation.
    Cancer biology & therapy, 2005, Volume: 4, Issue:7

    Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Boronic Acids; Bortezomib; Caspases; Cell Proliferation; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Cytochromes c; Drug Resistance, Neoplasm; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Mitochondrial Proteins; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2005
Cell cycle-dependent cytotoxic and cytostatic effects of bortezomib on colon carcinoma cells.
    Cell death and differentiation, 2006, Volume: 13, Issue:5

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Carcinoma; Cell Cycle; Colonic Neoplasms; Cyclin B; Humans; Pyrazines; Transcription Factor RelA

2006
Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria.
    Pathology oncology research : POR, 2006, Volume: 12, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Boronic Acids; Bortezomib; Caspase 3; Caspase 8; Colonic Neoplasms; Drug Synergism; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Mitochondria; Mitochondrial Proteins; Oligopeptides; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; TNF-Related Apoptosis-Inducing Ligand

2006
Synthesis and cytotoxic activity of pyrazino[1,2-b]-isoquinolines, 1-(3-isoquinolyl)isoquinolines, and 6,15-iminoisoquino[3,2-b]-3-benzazocines.
    Bioorganic & medicinal chemistry, 2007, Jan-01, Volume: 15, Issue:1

    Topics: Azocines; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Lung Neoplasms; Molecular Conformation; Pyrazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2007
NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Nov-15, Volume: 12, Issue:22

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Cycle; Colonic Neoplasms; Drug Administration Routes; Drug Synergism; Female; Humans; Lactones; Mice; Mice, Nude; NF-kappa B; Proteasome Endopeptidase Complex; Pyrazines; Pyrroles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2006
Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
    Cancer research, 2007, Feb-15, Volume: 67, Issue:4

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Boronic Acids; Bortezomib; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Colonic Neoplasms; E1A-Associated p300 Protein; Enzyme Activation; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Leupeptins; Male; Prostatic Neoplasms; Protease Inhibitors; Protein Binding; Pyrazines; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2007
A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:3

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Boronic Acids; Bortezomib; Caspase Inhibitors; Caspases; Cell Nucleus; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Cytochromes c; Humans; Leupeptins; Mice; Mitochondria; Proteasome Inhibitors; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Reactive Oxygen Species; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2007
Regional chemoprevention of carcinogen-induced tumors in rat colon.
    Gastroenterology, 1995, Volume: 109, Issue:4

    Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Eflornithine; Ellagic Acid; Male; Piroxicam; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes

1995
[Effect of the association of antimitotic agents on cell lines of human adenocarcinoma].
    Bulletin du cancer, 1994, Volume: 81, Issue:10

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Colonic Neoplasms; Docetaxel; Humans; Paclitaxel; Pyrazines; Pyridines; Skin Neoplasms; Taxoids; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Vinblastine; Vinorelbine

1994
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
    Cancer research, 1993, Jun-01, Volume: 53, Issue:11

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes

1993
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:5

    Topics: Adenocarcinoma; Anticarcinogenic Agents; Cell Cycle; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Inactivation, Metabolic; Kinetics; NAD(P)H Dehydrogenase (Quinone); Pyrazines; RNA, Messenger; Thiones; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured

1997
Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact Co-cultures.
    International journal of cancer, 2000, Jul-15, Volume: 87, Issue:2

    Topics: Basement Membrane; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Membrane; Chelating Agents; Coculture Techniques; Colonic Neoplasms; Edetic Acid; Enzyme Activation; Fibroblasts; Gelatin; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Protease Inhibitors; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured

2000
Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM).
    Cancer letters, 2001, May-26, Volume: 166, Issue:2

    Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Enzyme Inhibitors; Intestinal Mucosa; Male; Organ Size; Pyrazines; Rats; Rats, Inbred F344

2001
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
    The Journal of biological chemistry, 2002, Jul-05, Volume: 277, Issue:27

    Topics: Animals; Anticarcinogenic Agents; Base Sequence; Caco-2 Cells; Colonic Neoplasms; Cytochrome P-450 CYP1A1; DNA Primers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Male; Molecular Sequence Data; Promoter Regions, Genetic; Pyrazines; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon; RNA, Messenger; Thiones; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured

2002
Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1991, Volume: 197, Issue:1

    Topics: Animals; Antineoplastic Agents; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Cytosol; DNA; Glutathione Transferase; Intestinal Mucosa; Liver; Male; Methylation; Ornithine Decarboxylase; Protein-Tyrosine Kinases; Pyrazines; Rats; Rats, Inbred F344; Reference Values; Thiones; Thiophenes

1991