Page last updated: 2024-08-21

pyrazines and Body Weight

pyrazines has been researched along with Body Weight in 133 studies

Research

Studies (133)

TimeframeStudies, this research(%)All Research%
pre-199026 (19.55)18.7374
1990's9 (6.77)18.2507
2000's22 (16.54)29.6817
2010's74 (55.64)24.3611
2020's2 (1.50)2.80

Authors

AuthorsStudies
Bugaj, JE; Dorshow, RB2
Alexopoulos, SJ; Beretta, M; Brandon, AE; Byrne, FL; Carrive, P; Chen, SY; Cooney, GJ; Garcia, CJ; Hargett, SR; Hoehn, KL; Lackner, C; Lawrence, RT; Lee, B; Olzomer, EM; Philp, A; Philp, AM; Salamoun, JM; Santos, WL; Shah, DP; Sligar, J; Tucker, SP; Turner, N1
Lin, L; Liu, N; Wang, JP; Wang, JQ; Zhang, FK1
Bartola, LD; Giampietro, C; Giampietro, O; Masoni, MC; Matteucci, E1
Badole, SL; Bagul, PP; Coutinho, EC; Ghule, AE; Jangam, GB; Joshi, AC; Khedkar, VM; Khose, RD; Mahamuni, SP; Raut, CG1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Pintana, H1
Bhargava, A; Del Prato, S; Dharmalingam, M; Garber, AJ; Philis-Tsimikas, A; Rasmussen, S; Satman, I; Skjøth, TV1
Caderni, G; Femia, AP; Lodovici, M; Maglieri, G; Mannucci, E; Raimondi, L1
Charbonnel, B; Dejager, S; Schweizer, A1
Scheen, AJ1
Han, J; Malloy, J; Meloni, A1
Du, Q; Liang, YY; Wang, YJ; Wu, B; Yang, S; Zhao, YY1
Badole, SL; Bagul, PP; Chaudhari, SM; Joshi, AC; Khose, RD; Mahamuni, SP; Raut, CG; Zanwar, AA1
Canovatchel, W; Davidson, J; Januszewicz, A; Lavalle-González, FJ; Meininger, G; Qiu, R; Tong, C1
Chang, G; Duan, Q; Lu, K; Qin, S; Wang, Y; Ye, L; Zhang, D; Zhang, P; Zheng, A1
Alba, M; Canovatchel, W; Cefalu, WT; Edwards, R; Jodar, E; Kim, KA; Meininger, G; Stenlöf, K; Tong, C1
Hardy, E; Jabbour, SA; Parikh, S; Sugg, J1
Bi, KS; Chen, XH; Lan, Z1
Gallacher, DJ; Hemmeryckx, B; Roger Lijnen, H; Rong Lu, H; Swinnen, M1
Cunningham, C; Dey, M; Forest, T; Frederick, C; Holder, D; Prahalada, S; Smith, A; Yao, X1
Friedman, TC; Ivey, R; Lee, D; Shin, CS; Sinha-Hikim, AP; Sinha-Hikim, I1
Schnell, O1
Coric, J; Dizdarevic-Bostandzic, A; Djelilovic-Vranic, J; Izetbegovic, S; Karamehic, J; Macic-Dzankovic, A; Panjeta, M; Velija-Asimi, Z1
Carmignac, V; Durbeej, M; Fontes-Oliveira, CC; Holmberg, J; Körner, Z1
Funahashi, T; Hayashi, M; Hibuse, T; Hirata, A; Kashine, S; Kimura, T; Kishida, K; Maeda, N; Minami, T; Nakagawa, Y; Nishizawa, H; Oka, A; Shimomura, I; Takeshita, E1
Ahrén, B; Cirkel, DT; Feinglos, MN; Johnson, SL; Perry, C; Stewart, M; Yang, F1
Guthrie, R; Slee, A; Traina, S1
Katakami, N; Matsuoka, TA; Shimomura, I; Shiraiwa, T; Takahara, M1
Bae, JY; Baek, LJ; Cheong, HJ; Heo, J; Hwang, MW; Jang, SI; Kim, D; Kim, H; Kim, JI; Lee, I; Lee, S; Park, MS; Park, S; Song, JW; Song, KJ1
Baerts, L; Behets, GJ; D'Haese, PC; De Meester, I; Glorie, L; Verhulst, A1
Gou, Z; Ma, M; Wang, F; Wang, T; Zhai, SD1
Kakehashi, A; Kinoshita, N; Matsumoto, T; Ota, A; Shimmura, M; Takano, H; Tanaka, Y; Toyoda, F; Tsuji, J1
Marchesini, G; Melchiorri, D; Montilla, S; Pani, L; Sammarco, A; Siviero, PD; Tomino, C; Trotta, MP1
Bailey, RA; Blonde, L; Meininger, GE; Rupnow, MF; Vijapurkar, U1
Al-Barazanji, K; Benson, W; Binz, J; Chen, L; Generaux, C; McNulty, J; Young, A1
Dai, X; Foretz, M; Liu, J; Liu, Z; Lu, Q; Ouyang, C; Song, P; Viollet, B; Wu, J; Wu, Y; Xie, Z; Yuan, Z; Zhang, W; Zhao, Z; Zhuo, X; Zou, MH1
Arndt, K; Budzinski, R; Heckel, A; Kley, JT; Lehmann, T; Lenter, M; Lotz, RR; Maier, GM; Markert, M; Müller, S; Oost, T; Roth, GJ; Rudolf, K; Stenkamp, D; Thomas, L1
Cho, DJ; Kim, DW; Kim, SH; Lee, JI; Noh, H; Oh, SJ; Park, HL; Park, MS; Zang, DY1
Drucker, DJ; Duez, H; Giacca, A; Lewis, GF; Smith, AC; Szeto, L; Xiao, C1
Davidson, JA; Gross, JL; Parente, EB1
Al-Husseini, I; Al-Salam, S; Ali, BH; Nemmar, A1
Mikhail, N2
Liu, Y; Lu, M; Wang, F; Zhang, Y; Zhou, J1
Furuta, Y; Julander, JG; Morrey, JD; Smee, DF1
Cognard, E; Shepherd, PR; Smith, GC; Vickers, MH1
Avezza, F; Canta, A; Carozzi, VA; Cavaletti, G; Ceresa, C; Chiorazzi, A; Crippa, L; Gilardini, A; Marmiroli, P; Meregalli, C; Oggioni, N1
Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Franzetti, IG; Gadaleta, G; Maffioli, P; Piccinni, MN; Querci, F; Ragonesi, PD; Salvadeo, SA1
Alexander, CM; Siler, SQ; Topp, BG; Waters, SB1
Birnbaum, Y; Keyes, KT; Lin, Y; Perez-Polo, JR; Ye, Y; Zhang, C1
Bilo, HJ; Goudswaard, AN; Houweling, ST; Kleefstra, N; Kooy, A; van Hateren, KJ; Verhoeven, S1
Bilan, VP; Jackson, EK; Tofovic, DS1
Davies, MJ; Engel, SS; Mavros, P; Radican, L; Rajagopalan, S; Yin, D; Zhang, Q1
Clar, C; Cummins, E; Marien, M; Philip, S; Richter, B; Royle, P; Waugh, N1
Fernandes, R; Ferreira, L; Garrido, P; Mega, C; Melo, A; Nunes, S; Parada, B; Pinto, F; Pinto, R; Reis, F; Santos, P; Sereno, J; Teixeira, F; Teixeira-de-Lemos, E; Vala, H; Velada, I1
Borelli, MI; Del Zotto, H; Flores, LE; Francini, F; Gagliardino, JJ; Madrid, VG; Maiztegui, B; Massa, ML; Raschia, MA; Rebolledo, OR1
Bossi, M; Canta, A; Carozzi, VA; Cavaletti, G; Chiorazzi, A; Marmiroli, P; Meregalli, C; Oggioni, N; Sala, B1
Coben, J; Dobrian, AD; Galkina, EV; Leone, KA; Lindsay, JW; Ma, K; Ma, Q; Nadler, JL1
Anjana, RM; Kishore, U; Mohan, V; Sudhakaran, C; Unnikrishnan, R1
Best, JH; Garrison, LP; Li, Y; Malloy, J; Peyrot, M; Rubin, RR; Yan, P1
Chen, B; Ernsberger, P; Escobedo, LV; Hou, D; Koletsky, MS; Koletsky, RJ; Moore, A1
Liang, Y; Si, LY; Xiao, L; Xu, Q; Yang, QH; Zhang, Y1
Cander, S; Ersoy, C; Ertürk, E; Gül, CB; Imamoğlu, S; Kırhan, E; Kıyıcı, S; Öz, Ö; Sarandol, E; Sığırlı, D; Tuncel, E; Ünal, OK; Yorulmaz, H1
Böhm, M; Kazakov, A; Laufs, U; Lenski, M; Marx, N1
Cho, JH; Ham, DS; Kim, ES; Kim, JW; Park, HS; Sun, C; Yeom, JA; Yoon, KH1
de Lemos, ET; Fernandes, R; Mascarenhas-Melo, F; Mega, C; Oliveira, J; Reis, F; Teixeira, F; Vala, H1
Holst, JJ; Liu, MK; Salen, G; Saumoy, M; Shang, Q; Xu, G1
Auricchio, N; Kwiatkowski, DJ; Malinowska, I; Manning, BD; Shaw, R1
Rabasseda, X1
Choi, SH; Hong, ES; Jang, HC; Kang, SM; Khang, AR; Lim, S; Park, KS; Shin, H; Walford, GA; Yoon, JW1
Ahrén, B; Deacon, CF; Mannucci, E1
Cheetham, S; Francis, J; Kirby, M; Poucher, SM; Vickers, SP; Zinker, B1
Guo, L; Sun, Y; Wang, A; Xu, C1
Burgmaier, M; Esser, M; Liberman, A; Ludwig, A; Marx, N; Ostertag, R; Vasic, D; Vittone, F; Walcher, D1
Aschner, P; Chan, J; Dain, MP; Echtay, A; Fonseca, V; Owens, DR; Picard, S; Pilorget, V; Wang, E1
Gupta, R; Keshwani, P; Saxena, GN; Srivastava, S1
Bailey, T; Davies, M; Filetti, S; Furber, S; Garber, AJ; Montanya, E; Nauck, MA; Pratley, RE; Thomsen, AB1
Isogawa, A; Iwamoto, M; Koike, K; Ohki, T; Ohsugi, M; Omata, M; Tagawa, K; Toda, N; Yoshida, H1
Aono, M; Fujita, Y; Harashima, SI; Inagaki, N; Koizumi, T; Murata, Y; Ogura, M; Seike, M; Tanaka, D; Wang, Y; Yamane, S1
Crajoinas, RO; Fonseca-Alaniz, MH; Giannocco, G; Girardi, AC; Maciel, RM; Oliveira, KC; Salles, TA; Venturini, G1
Badole, SL; Bagul, PP; Bodhankar, SL; Coutinho, EC; Ghule, AE; Joshi, AC; Khedkar, VM; Khose, RD; Mahamuni, SP; Raut, CG; Wagh, NK1
Arjona Ferreira, JC; Barzilai, N; Goldstein, BJ; Golm, GT; Guo, H; Kaufman, KD; Marre, M; Sisk, CM1
Kanamori, A; Kubota, A; Maeda, H; Matsuba, I; Tanaka, Y; Terauchi, Y1
Lee, LM; Liu, CF; Yang, PP1
Cho, MK; Kim, DH; Kim, SG; Kwon, JW; Lee, MG; Yim, YG1
Barbera, S; Bigini, P; De Paola, M; Fumagalli, E; Mennini, T1
Gao, Y; Guo, P; Li, YF; Liang, QD; Ma, BP; Ma, ZC; Tan, HL; Tan, W; Wang, SQ; Zhou, Z1
Bergman, A; Blum, R; Chen, L; Dilzer, S; Herman, GA; Hilliard, D; Lasseter, K; Liu, F; Meehan, AG; Snyder, K; Stevens, C; Tanaka, W; Tanen, M; Wagner, JA; Wang, AQ; Zeng, W1
Ahrén, B3
Alba, M; Amatruda, JM; Chen, Y; Hussain, S; Kaufman, KD; Langdon, RB; Raz, I; Stein, PP; Wu, M1
Davies, MJ; Engel, SS; Loeys, T; Scott, R1
Stastná, J; Tousek, J; Viklický, J; Zítková, L1
Eastell, R; Edmonds, CJ1
Cameron, IL; Pool, TB; Smith, NK; Sparks, RL1
Drayer, JI; Hoefnagels, WH; Kloppenborg, PW; Smals, AG1
Baron, JH; Gribble, RJ; Holdstock, DJ; Lewis, SI; Murgatroyd, RE; Reed, PI; Vincent-Brown, A1
Olesen, OV; Thomsen, K1
Grimshaw, JJ; Jaffé, G; Vallé-Jones, JC; Warnock, JM1
Antelman, SM; Kocan, D; Rowland, N1
Alcazar, JM; Diaz, VP; Jarillo, MD; Millet, VG; Rodicio, JL; Ruilope, L1
Clapper, ML; Lang, D; Leahy, K; Miknyoczki, S; Ruggeri, BA; Wood, M1
Hermann, M; Hromadová, M; Klimes, I; Minchenko, A; Mitková, A; Seböková, E1
Jemiolo, B; Novotny, M1
Kensler, TW; MacMillan, DL; Maxuitenko, YY; Roebuck, BD1
Ahmed, SA; Gad, MZ1
Kelloff, G; Rao, CV; Reddy, BS; Rivenson, A; Steele, V; Zang, E1
Crowell, JA; Goldenthal, EI; Hall, LB; Heath, JE; Kelloff, GJ; Page, JG; Rodman, LE1
Barnea, A; Gvaryahu, G; Katz, A; Robinzon, B; Snapir, N1
Furukawa, F; Hirose, M; Ikeda, T; Kasahara, KI; Miyauchi, M; Nakamura, H; Nishikawa, A; Son, HY1
Arif, JM; Gupta, RC; Smith, WA1
Ahn, B; Choi, KS; Kang, JS; Kim, DJ; Kim, KS; Kim, ND; Park, KH; Surh, YJ1
Bonaduce, D; D'Ascia, C; Ferrara, N; Petretta, M; Rengo, F; Saccá, L; Trimarco, B1
Mikkelsen, E; Pedersen, OL1
Antcliff, AC; Beevers, DG; Hamilton, M; Pearce, VR1
Dufour, JJ; Posternak, JM; Rogg, C; Vodoz, CA1
Nayini, J; Rao, CV; Reddy, BS1
Itoh, R; Ohta, A; Yamada, K1
Groopman, JD; Kensler, TW; Liu, YL; Roebuck, BD; Yager, JD1
Larochelle, P; Logan, AG1
Alon, U; Chan, JC1
Bühring, KU; Leopold, G; Pabst, J; Simane, Z; Ungethüm, W1
Breckenridge, AM; Dollery, CT; George, CF1
Nash, DT1
Fagerberg, SE; Johannessen, A1
Hohenegger, M1
Goulding, A; Irvine, RO; Jukes, C1
Irvine, RO; McKean, WI1
Jelinek, J; Krajny, M; Selye, H1
McNay, JL; Oran, E1

Reviews

13 review(s) available for pyrazines and Body Weight

ArticleYear
Combination therapy with DPP-4 inhibitors and insulin in patients with type 2 diabetes mellitus: what is the evidence?
    Hospital practice (1995), 2013, Volume: 41, Issue:2

    Topics: Adamantane; Body Weight; Diabetes Complications; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Drug Therapy, Combination; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Linagliptin; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Renal Insufficiency, Chronic; Sitagliptin Phosphate; Triazoles; Uracil; Vildagliptin

2013
Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomes.
    Postgraduate medicine, 2013, Volume: 125, Issue:3

    Topics: Adamantane; Blood Glucose; Blood Pressure; Body Weight; Cardiovascular System; Coronary Artery Disease; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglycemic Agents; Lipids; Nitriles; Pyrazines; Pyrrolidines; Risk Factors; Sitagliptin Phosphate; Triazoles; Vildagliptin

2013
Comparative effects of sitagliptin and metformin in patients with type 2 diabetes mellitus: a meta-analysis.
    Current medical research and opinion, 2013, Volume: 29, Issue:11

    Topics: Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Insulin-Secreting Cells; Metformin; Pyrazines; Sitagliptin Phosphate; Triazoles

2013
[Oral add-on therapy to metformin in type 2 diabetes mellitus: a direct comparison between canagliflozin and sitagliptin].
    Deutsche medizinische Wochenschrift (1946), 2014, Volume: 139 Suppl 2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endpoint Determination; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; Thiophenes; Triazoles; Young Adult

2014
Comparison of GLP-1 analogues versus sitagliptin in the management of type 2 diabetes: systematic review and meta-analysis of head-to-head studies.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Fasting; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Lipids; Pyrazines; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2014
Incretin mimetics and dipeptidyl peptidase-4 inhibitors: innovative treatment therapies for type 2 diabetes.
    Arquivos brasileiros de endocrinologia e metabologia, 2008, Volume: 52, Issue:6

    Topics: Adamantane; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Fasting; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Nitriles; Peptides; Postprandial Period; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin

2008
Combination therapy with DPP-4 inhibitors and pioglitazone in type 2 diabetes: theoretical consideration and therapeutic potential.
    Vascular health and risk management, 2008, Volume: 4, Issue:6

    Topics: Adamantane; Blood Glucose; Body Weight; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Edema; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipids; Nitriles; Pioglitazone; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Thiazolidinediones; Treatment Outcome; Triazoles; Vildagliptin

2008
[New blood glucose-lowering drugs in type 2 diabetes: a review of the literature].
    Nederlands tijdschrift voor geneeskunde, 2010, Volume: 154

    Topics: Adamantane; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Liraglutide; Nitriles; Peptides; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Venoms; Vildagliptin

2010
Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation.
    Health technology assessment (Winchester, England), 2010, Volume: 14, Issue:36

    Topics: Adamantane; Body Weight; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Nitriles; Peptides; Pyrazines; Pyrrolidines; Quality of Life; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; State Medicine; Thiazolidinediones; Triazoles; United Kingdom; Venoms; Vildagliptin

2010
Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis.
    Diabetes, obesity & metabolism, 2012, Volume: 14, Issue:8

    Topics: Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Fasting; Female; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Liraglutide; Male; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Venoms

2012
DPP-4 inhibitors.
    Best practice & research. Clinical endocrinology & metabolism, 2007, Volume: 21, Issue:4

    Topics: Adamantane; Animals; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Metabolism; Metformin; Nitriles; Pioglitazone; Protease Inhibitors; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Substrate Specificity; Thiazolidinediones; Triazoles; Vildagliptin

2007
GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors.
    Current diabetes reports, 2007, Volume: 7, Issue:5

    Topics: Adamantane; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Enzyme Inhibitors; Exenatide; Gastric Emptying; Glucagon-Like Peptide 1; Hypoglycemic Agents; Incretins; Islets of Langerhans; Liraglutide; Nitriles; Peptides; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin

2007
Incretin mimetics and dipeptidyl peptidase 4 inhibitors in clinical trials for the treatment of type 2 diabetes.
    Expert opinion on investigational drugs, 2008, Volume: 17, Issue:6

    Topics: Adamantane; Body Weight; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Incretins; Insulin; Insulin Secretion; Nausea; Nitriles; Peptides; Pyrazines; Pyrrolidines; Randomized Controlled Trials as Topic; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin; Vomiting

2008

Trials

31 trial(s) available for pyrazines and Body Weight

ArticleYear
Sitagliptin as add-on therapy in insulin deficiency: biomarkers of therapeutic efficacy respond differently in type 1 and type 2 diabetes.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Body Weight; Cholesterol, LDL; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Time Factors; Treatment Outcome; Triazoles

2013
Effect of insulin degludec versus sitagliptin in patients with type 2 diabetes uncontrolled on oral antidiabetic agents.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:8

    Topics: Administration, Oral; Argentina; Blood Glucose; Body Weight; Canada; Diabetes Mellitus, Type 2; Drug Administration Schedule; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; India; Insulin, Long-Acting; Male; Mexico; Middle Aged; Pyrazines; Sitagliptin Phosphate; South Africa; Treatment Outcome; Triazoles; Turkey; United States

2013
Efficacy and tolerability of exenatide once weekly versus sitagliptin in patients with type 2 diabetes mellitus: a retrospective analysis of pooled clinical trial data.
    Postgraduate medicine, 2013, Volume: 125, Issue:3

    Topics: Blood Glucose; Body Weight; Cardiovascular Diseases; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Double-Blind Method; Exenatide; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Peptides; Pyrazines; Retrospective Studies; Risk Factors; Sitagliptin Phosphate; Triazoles; Venoms

2013
Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial.
    Diabetologia, 2013, Volume: 56, Issue:12

    Topics: Adolescent; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Thiophenes; Treatment Outcome; Triazoles

2013
Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study.
    Current medical research and opinion, 2014, Volume: 30, Issue:2

    Topics: Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Exercise; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Middle Aged; Placebos; Pyrazines; Sitagliptin Phosphate; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Treatment Outcome; Triazoles; Triglycerides; Weight Loss

2014
Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study.
    Diabetes care, 2014, Volume: 37, Issue:3

    Topics: Benzhydryl Compounds; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Urinary Tract Infections; Weight Loss

2014
The effects of dipeptidyl peptidase-4 inhibitors in treatment of obese patients with type 2 diabetes.
    Medical archives (Sarajevo, Bosnia and Herzegovina), 2013, Volume: 67, Issue:5

    Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Mass Index; Body Weight; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Obesity; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Triglycerides

2013
A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus--a randomized controlled trial START-J study.
    Cardiovascular diabetology, 2014, May-24, Volume: 13

    Topics: Adiponectin; Aged; Asian People; Biomarkers; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Humans; Male; Middle Aged; Pilot Projects; Prospective Studies; Pyrazines; Sitagliptin Phosphate; Time Factors; Treatment Outcome; Triazoles

2014
HARMONY 3: 104-week randomized, double-blind, placebo- and active-controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin.
    Diabetes care, 2014, Volume: 37, Issue:8

    Topics: Aged; Body Weight; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Treatment Outcome; Triazoles

2014
The impact of weight loss on weight-related quality of life and health satisfaction: results from a trial comparing canagliflozin with sitagliptin in triple therapy among people with type 2 diabetes.
    Postgraduate medicine, 2014, Volume: 126, Issue:3

    Topics: Adult; Age Factors; Aged; Body Weight; Canagliflozin; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glucosides; Glycated Hemoglobin; Health Behavior; Humans; Hypoglycemic Agents; Male; Middle Aged; Personal Satisfaction; Pyrazines; Quality of Life; Self Efficacy; Sex Factors; Sexual Behavior; Sitagliptin Phosphate; Thiophenes; Triazoles; Weight Loss

2014
Efficacy of adding once-daily insulin glulisine in Japanese type 2 diabetes patients treated with insulin glargine and sitagliptin.
    Diabetes technology & therapeutics, 2014, Volume: 16, Issue:10

    Topics: Adult; Asian People; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Japan; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Time Factors; Treatment Outcome; Triazoles

2014
Diabetes-related quality measure attainment: canagliflozin versus sitagliptin based on a pooled analysis of 2 clinical trials.
    The American journal of managed care, 2014, Volume: 20, Issue:13 Suppl

    Topics: Blood Pressure; Body Mass Index; Body Weight; Canagliflozin; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipoproteins, LDL; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Thiophenes; Treatment Outcome; Triazoles

2014
Optimization of radotinib doses for the treatment of Asian patients with chronic myelogenous leukemia based on dose-response relationship analyses.
    Leukemia & lymphoma, 2016, Volume: 57, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents; Asian People; Benzamides; Body Surface Area; Body Weight; Dose-Response Relationship, Drug; Drug Dosage Calculations; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Philadelphia Chromosome; Protein Kinase Inhibitors; Pyrazines; Treatment Outcome; Young Adult

2016
Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:6

    Topics: Adiponectin; Blood Glucose; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Humans; Hypoglycemic Agents; Inflammation; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Pioglitazone; Pyrazines; Resistin; Sitagliptin Phosphate; Thiazolidinediones; Triazoles; Tumor Necrosis Factor-alpha

2010
Weight-related quality of life, health utility, psychological well-being, and satisfaction with exenatide once weekly compared with sitagliptin or pioglitazone after 26 weeks of treatment.
    Diabetes care, 2011, Volume: 34, Issue:2

    Topics: Adult; Body Weight; Diabetes Mellitus, Type 2; Exenatide; Female; Health Status; Humans; Hypoglycemic Agents; Male; Mental Health; Middle Aged; Patient Satisfaction; Peptides; Pioglitazone; Pyrazines; Quality of Life; Sitagliptin Phosphate; Thiazolidinediones; Treatment Outcome; Triazoles; Venoms

2011
Effect of sitagliptin monotherapy on serum total ghrelin levels in people with type 2 diabetes.
    Diabetes research and clinical practice, 2011, Volume: 94, Issue:2

    Topics: Aged; Analysis of Variance; Biomarkers; Blood Glucose; Body Mass Index; Body Weight; Chi-Square Distribution; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Down-Regulation; Female; Ghrelin; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Time Factors; Treatment Outcome; Triazoles; Turkey

2011
Comparison between sitagliptin as add-on therapy to insulin and insulin dose-increase therapy in uncontrolled Korean type 2 diabetes: CSI study.
    Diabetes, obesity & metabolism, 2012, Volume: 14, Issue:9

    Topics: Adult; Aged; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fasting; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Triazoles; Waist Circumference

2012
Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial.
    Lancet (London, England), 2012, Jun-16, Volume: 379, Issue:9833

    Topics: Adult; Aged; Body Weight; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Glargine; Insulin, Long-Acting; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2012
Comparing the efficacy and safety profile of sitagliptin versus glimepiride in patients of type 2 diabetes mellitus inadequately controlled with metformin alone.
    The Journal of the Association of Physicians of India, 2012, Volume: 60

    Topics: Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Metformin; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Time Factors; Treatment Outcome; Triazoles

2012
Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: a randomized, open-label trial.
    Diabetes care, 2012, Volume: 35, Issue:10

    Topics: Adult; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Liraglutide; Metformin; Nausea; Patient Satisfaction; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2012
Efficacy and safety of switching from basal insulin to sitagliptin in Japanese type 2 diabetes patients.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2013, Volume: 45, Issue:3

    Topics: Aged; Asian People; Body Mass Index; Body Weight; C-Peptide; Demography; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Japan; Male; Pyrazines; ROC Curve; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2013
Efficacy and safety of sitagliptin versus glipizide in patients with type 2 diabetes and moderate-to-severe chronic renal insufficiency.
    Diabetes care, 2013, Volume: 36, Issue:5

    Topics: Body Weight; Diabetes Mellitus, Type 2; Female; Glipizide; Humans; Hypoglycemic Agents; Male; Pyrazines; Renal Insufficiency, Chronic; Sitagliptin Phosphate; Triazoles

2013
Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:8

    Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Administration, Oral; Blood Glucose; Body Weight; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycoproteins; Humans; Hypoglycemic Agents; Male; Middle Aged; Obesity; Pyrazines; Sitagliptin Phosphate; Triazoles

2006
Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes.
    Current medical research and opinion, 2008, Volume: 24, Issue:2

    Topics: Adult; Aged; Area Under Curve; Body Weight; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2008
Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes.
    Diabetes, obesity & metabolism, 2008, Volume: 10, Issue:10

    Topics: Analysis of Variance; Biomarkers; Blood Glucose; Body Weight; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Lipids; Male; Metformin; Middle Aged; Pyrazines; Rosiglitazone; Sitagliptin Phosphate; Thiazolidinediones; Treatment Outcome; Triazoles; Triglycerides

2008
The influence of amiloride on the therapeutic and metabolic effects of carbenoxolone in patients with gastric ulcer. A double-blind controlled trial.
    Scandinavian journal of gastroenterology. Supplement, 1980, Volume: 65

    Topics: Adult; Amiloride; Blood Pressure; Body Weight; Carbenoxolone; Clinical Trials as Topic; Double-Blind Method; Female; Glycyrrhetinic Acid; Humans; Male; Middle Aged; Pyrazines; Random Allocation; Stomach Ulcer

1980
Individual factors influencing the response to a beta-adrenergic blocking agent given alone and in combination with a diuretic on arterial hypertension.
    European journal of clinical pharmacology, 1979, Volume: 16, Issue:5

    Topics: Adult; Aging; Amiloride; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Propanolamines; Pyrazines; Time Factors; Timolol

1979
Hydrochlorothiazide-amiloride versus hydrochlorothiazide alone for essential hypertension: effects on blood pressure and serum potassium level.
    Canadian Medical Association journal, 1985, Apr-01, Volume: 132, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aged; Amiloride; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pulse; Pyrazines; Random Allocation

1985
[Esmaloride--a new potassium neutral diuretic combination. Clinical pharmacologic properties].
    Fortschritte der Medizin, 1985, Feb-14, Volume: 103, Issue:6

    Topics: Aldosterone; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Creatinine; Drug Combinations; Female; Heart Rate; Humans; Hypertension; Male; Potassium; Pyrazines; Trichlormethiazide; Triglycerides; Uric Acid; Water-Electrolyte Balance

1985
Comparison of the potassium- retaining effects of amiloride and spironolactone in hypertensive patients with thiazide-induced hypokalaemia.
    Lancet (London, England), 1973, Dec-08, Volume: 2, Issue:7841

    Topics: Adult; Aged; Amiloride; Blood Pressure; Body Weight; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; Male; Middle Aged; Pyrazines; Sodium; Spironolactone; Time Factors; Urea

1973
Glipizide, a new oral antidiabetic agent (report of a controlled clinical study in Sweden).
    Diabetologia, 1973

    Topics: Administration, Oral; Adult; Aged; Blood Glucose; Body Weight; Cholesterol; Clinical Trials as Topic; Cyclohexanes; Diabetes Mellitus; Diet, Diabetic; Drug Evaluation; Female; Glycosuria; Humans; Hypoglycemic Agents; Male; Middle Aged; Placebos; Potassium; Pyrazines; Sodium; Sulfonylurea Compounds; Sweden; Time Factors

1973

Other Studies

89 other study(ies) available for pyrazines and Body Weight

ArticleYear
Absence of developmental or reproductive toxicity in rats for MB-102, a fluorescent tracer agent for point-of-care measurement of glomerular filtration rate.
    Regulatory toxicology and pharmacology : RTP, 2022, Volume: 131

    Topics: Animals; Body Weight; Cesarean Section; Coloring Agents; Dogs; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Point-of-Care Systems; Pregnancy; Pyrazines; Rabbits; Rats; Reproduction

2022
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
    Nature communications, 2020, 05-14, Volume: 11, Issue:1

    Topics: Adipose Tissue; Administration, Oral; Animals; Blood Glucose; Body Temperature; Body Weight; Diamines; Diet, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Clamp Technique; Humans; Insulin Resistance; Liver; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Obesity; Oxadiazoles; Oxidative Stress; Pyrazines

2020
Tetramethylpyrazine supplementation reduced Salmonella Typhimurium load and inflammatory response in broilers.
    Poultry science, 2019, Aug-01, Volume: 98, Issue:8

    Topics: Animal Feed; Animals; Body Weight; Chickens; Diet; Gastrointestinal Contents; Inflammation; Male; Permeability; Poultry Diseases; Pyrazines; Salmonella Infections, Animal; Salmonella typhimurium

2019
Oral L-glutamine increases active GLP-1 (7-36) amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats.
    Chemico-biological interactions, 2013, Apr-25, Volume: 203, Issue:2

    Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Experimental; Drinking; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Glutamine; Glycated Hemoglobin; Insulin; Lipid Metabolism; Male; Molecular Docking Simulation; Niacinamide; Oxidative Stress; Pancreas; Peptide Fragments; Protein Conformation; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles

2013
Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats.
    British journal of pharmacology, 2013, Volume: 169, Issue:5

    Topics: Adamantane; Animals; Blood Glucose; Blood Pressure; Body Weight; Cardiotonic Agents; Cholesterol; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Heart; Heart Rate; Insulin; Insulin Resistance; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Heart; Nitriles; Obesity; Oxidative Stress; Pyrazines; Pyrrolidines; Rats, Wistar; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles; Vildagliptin

2013
Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats.
    International journal of cancer, 2013, Nov-15, Volume: 133, Issue:10

    Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogenesis; Colonic Neoplasms; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Intestinal Mucosa; Intestines; Male; Mucins; Pyrazines; Random Allocation; Rats; Rats, Inbred F344; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles

2013
Effect of concomitant administration of L-glutamine and cycloart-23-ene-3β, 25-diol (B2) with sitagliptin in GLP-1 (7-36) amide secretion, biochemical and oxidative stress in streptozotocin - nicotinamide induced diabetic Sprague Dawley rats.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Experimental; Drinking Behavior; Feeding Behavior; Glucagon-Like Peptide 1; Glutamine; Glycated Hemoglobin; Insulin; Lipid Metabolism; Male; Niacinamide; Oxidative Stress; Pancreas; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Staining and Labeling; Streptozocin; Triazoles; Triterpenes

2013
Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: Animals; Apoptosis; Body Weight; Cardiotonic Agents; Creatine Kinase, MB Form; Disease Models, Animal; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glutathione Peroxidase; Heart; Heart Ventricles; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocytes, Cardiac; Organ Size; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles

2013
Ligustrazine attenuates elevated levels of indoxyl sulfate, kidney injury molecule-1 and clusterin in rats exposed to cadmium.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 63

    Topics: Animals; Body Weight; Cadmium; Cell Adhesion Molecules; Clusterin; Indican; Kidney; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2014
Effect of sitagliptin treatment on metabolism and cardiac function in genetic diabetic mice.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Heart; Heart Function Tests; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium; Pyrazines; Sitagliptin Phosphate; Triazoles

2014
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin.
    Endocrinology, 2014, Volume: 155, Issue:3

    Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Keratins; Ki-67 Antigen; Male; Metformin; Pancreas, Exocrine; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Triazoles

2014
Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice.
    Endocrinology, 2014, Volume: 155, Issue:3

    Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Body Weight; Diet, High-Fat; Fatty Acids, Nonesterified; Lipolysis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Muscle Fibers, Skeletal; Muscle, Skeletal; Nicotine; Obesity; Oxidative Stress; Pyrazines; Risk Factors; Smoking; Triglycerides

2014
Bortezomib partially improves laminin α2 chain-deficient muscular dystrophy.
    The American journal of pathology, 2014, Volume: 184, Issue:5

    Topics: Animals; Apoptosis; Body Weight; Boronic Acids; Bortezomib; Cells, Cultured; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Laminin; Locomotion; Mice, Inbred C57BL; MicroRNAs; Muscle Cells; Muscles; Muscular Dystrophy, Animal; Organ Specificity; Proteasome Endopeptidase Complex; Pyrazines; Survival Analysis

2014
Combination effects of peramivir and favipiravir against oseltamivir-resistant 2009 pandemic influenza A(H1N1) infection in mice.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Acids, Carbocyclic; Amides; Animals; Antiviral Agents; Body Weight; Cyclopentanes; Dogs; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Female; Guanidines; Influenza A Virus, H1N1 Subtype; Lung; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred DBA; Orthomyxoviridae Infections; Oseltamivir; Pyrazines; Survival Rate

2014
DPP IV inhibitor treatment attenuates bone loss and improves mechanical bone strength in male diabetic rats.
    American journal of physiology. Endocrinology and metabolism, 2014, Sep-01, Volume: 307, Issue:5

    Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Compressive Strength; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Male; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Streptozocin; Stress, Mechanical; Triazoles

2014
Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glycated Hemoglobin; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Retina; Rhodanine; Spiro Compounds; Thiazolidines; Time Factors

2014
Drug utilization, safety, and effectiveness of exenatide, sitagliptin, and vildagliptin for type 2 diabetes in the real world: data from the Italian AIFA Anti-diabetics Monitoring Registry.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014, Volume: 24, Issue:12

    Topics: Adamantane; Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; Exenatide; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Italy; Male; Metformin; Middle Aged; Monitoring, Physiologic; Nitriles; Peptides; Pyrazines; Pyrrolidines; Registries; Sex Factors; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin

2014
Pre-clinical toxicity evaluation of MB-102, a novel fluorescent tracer agent for real-time measurement of glomerular filtration rate.
    Regulatory toxicology and pharmacology : RTP, 2015, Volume: 72, Issue:1

    Topics: Animals; Body Weight; Coloring Agents; Dogs; Female; Fluorescent Dyes; Glomerular Filtration Rate; Humans; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Toxicity Tests

2015
Synergistic Effects of a GPR119 Agonist with Metformin on Weight Loss in Diet-Induced Obese Mice.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 353, Issue:3

    Topics: Animals; Body Weight; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Synergism; Eating; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oxadiazoles; Proto-Oncogene Proteins c-fos; Pyrazines; Receptors, G-Protein-Coupled; Weight Loss

2015
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
    Nature medicine, 2015, Volume: 21, Issue:4

    Topics: Adipocytes; Adiposity; AMP-Activated Protein Kinases; Animals; Body Composition; Body Weight; Dual Specificity Phosphatase 1; Enzyme Activation; HEK293 Cells; Homeostasis; Humans; Hypolipidemic Agents; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Phosphorylation; Pyrazines; Rats; Serine; Smoking

2015
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.
    Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16

    Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Body Weight; Cyclobutanes; Drug Discovery; Ether-A-Go-Go Potassium Channels; Hepatocytes; High-Throughput Screening Assays; Humans; In Vitro Techniques; Lipidoses; Microsomes, Liver; Phospholipids; Potassium Channel Blockers; Pyrazines; Pyridazines; Pyridines; Rats; Receptors, Somatostatin; Structure-Activity Relationship

2015
Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.
    Endocrinology, 2009, Volume: 150, Issue:1

    Topics: Animals; Blood Glucose; Body Weight; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucose Clamp Technique; Glucose Tolerance Test; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Mice; Mice, Inbred C57BL; Peptides; Pyrazines; Sitagliptin Phosphate; Triazoles; Venoms

2009
Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:4

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Body Weight; Creatinine; Gentamicins; Kidney Cortex; Male; Protective Agents; Protein Synthesis Inhibitors; Pyrazines; Rats; Rats, Wistar; Urea; Urodynamics

2009
[Effect of tetramethylpyrazine on expression of Smad7 and SnoN in rats with UUO].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:1

    Topics: Animals; Body Weight; Collagen; Gene Expression Regulation; Kidney; Male; Nerve Tissue Proteins; Peptide Fragments; Procollagen; Pyrazines; Rats; Smad7 Protein; Transcription Factors; Transforming Growth Factor beta; Ureteral Obstruction

2009
Effect of T-705 treatment on western equine encephalitis in a mouse model.
    Antiviral research, 2009, Volume: 82, Issue:3

    Topics: Administration, Oral; Amides; Animals; Antiviral Agents; Body Weight; Chlorocebus aethiops; Disease Models, Animal; Encephalomyelitis, Western Equine; Mice; Mice, Inbred C57BL; Pyrazines; Serum; Survival Analysis; Vero Cells

2009
Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour.
    Schizophrenia research, 2009, Volume: 115, Issue:1

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Body Composition; Body Weight; Clozapine; Dibenzothiazepines; Dietary Fats; Disease Models, Animal; Eating; Exenatide; Food Preferences; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Peptides; Pyrazines; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles; Venoms

2009
Bortezomib-induced painful neuropathy in rats: a behavioral, neurophysiological and pathological study in rats.
    European journal of pain (London, England), 2010, Volume: 14, Issue:4

    Topics: Animals; Antineoplastic Agents; Behavior, Animal; Blood Cell Count; Blood Chemical Analysis; Body Weight; Boronic Acids; Bortezomib; Dose-Response Relationship, Drug; Female; Hot Temperature; Neural Conduction; Neurotoxicity Syndromes; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve

2010
Treatment with sitagliptin or metformin does not increase body weight despite predicted reductions in urinary glucose excretion.
    Journal of diabetes science and technology, 2009, Volume: 3, Issue:1

    Topics: Body Weight; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoglycemic Agents; Metformin; Models, Theoretical; Pyrazines; Sitagliptin Phosphate; Triazoles

2009
The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:5

    Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Culture Media; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptidyl-Peptidase IV Inhibitors; Eicosanoids; Glucagon-Like Peptide 1; Hypertrophy, Left Ventricular; Hypoglycemic Agents; In Vitro Techniques; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Organ Size; Phospholipases A2; Pioglitazone; Prostaglandin-Endoperoxide Synthases; Protective Agents; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles

2010
Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with metabolic syndrome.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:7

    Topics: Angiotensin II; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Hypertension; Kidney; Male; Metabolic Syndrome; Proteinuria; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Sitagliptin Phosphate; Triazoles; Vasoconstriction; Vasoconstrictor Agents

2010
Differences in baseline characteristics between patients prescribed sitagliptin versus exenatide based on a US electronic medical record database.
    Advances in therapy, 2010, Volume: 27, Issue:4

    Topics: Adult; Age Factors; Aged; Body Mass Index; Body Weight; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Exenatide; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insurance Claim Review; Lipids; Male; Middle Aged; Peptides; Pyrazines; Retrospective Studies; Sex Factors; Sitagliptin Phosphate; Socioeconomic Factors; Triazoles; Venoms

2010
Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat).
    Mediators of inflammation, 2010, Volume: 2010

    Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glycated Hemoglobin; Insulin; Insulin Resistance; Interleukin-1beta; Lipids; Male; Oxidative Stress; Pancreas; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles

2010
Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats.
    Clinical science (London, England : 1979), 2011, Volume: 120, Issue:2

    Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Diet; Dipeptidyl-Peptidase IV Inhibitors; Drinking; Drug Evaluation, Preclinical; Eating; Exenatide; Fatty Liver; Fructose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Metabolic Syndrome; Peptides; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles; Venoms

2011
Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies.
    Experimental neurology, 2010, Volume: 226, Issue:2

    Topics: Analysis of Variance; Animals; Antineoplastic Agents; Body Weight; Boronic Acids; Bortezomib; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nerve Fibers, Myelinated; Neural Conduction; Paclitaxel; Peripheral Nervous System Diseases; Pyrazines; Sciatic Nerve

2010
[New data from the US-American Diabetes Congress. GLP-1 effect: more than reducing blood glucose].
    MMW Fortschritte der Medizin, 2010, Oct-07, Volume: 152, Issue:40

    Topics: Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Liraglutide; Pyrazines; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; Triazoles

2010
Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice.
    American journal of physiology. Endocrinology and metabolism, 2011, Volume: 300, Issue:2

    Topics: Adipocytes; Adipose Tissue; Adiposity; Animals; Anti-Inflammatory Agents; Body Weight; Cytokines; Dipeptidyl-Peptidase IV Inhibitors; Flow Cytometry; Glucose; Glucose Intolerance; Glucose Tolerance Test; Immunohistochemistry; Inflammation; Insulin; Islets of Langerhans; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Neutrophil Infiltration; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles

2011
Effectiveness of sitagliptin in asian Indian patients with type 2 diabetes-an Indian tertiary diabetes care center experience.
    Diabetes technology & therapeutics, 2011, Volume: 13, Issue:1

    Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Glycated Hemoglobin; Humans; Hypoglycemia; India; Insulin; Insulin Glargine; Insulin, Long-Acting; Male; Middle Aged; Pyrazines; Retrospective Studies; Sitagliptin Phosphate; Statistics, Nonparametric; Triazoles; Triglycerides

2011
Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats.
    Experimental biology and medicine (Maywood, N.J.), 2011, Volume: 236, Issue:3

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles

2011
Protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong on nephropathy in rats with streptozotocin-induced diabetes.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Oct-15, Volume: 18, Issue:13

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Ligusticum; Male; Phytotherapy; Plant Extracts; Protective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Endothelial Growth Factor A

2011
Effects of DPP-4 inhibition on cardiac metabolism and function in mice.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:6

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Body Weight; CD36 Antigens; Cell Membrane; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Fibrosis; Glucose Tolerance Test; Glucose Transporter Type 4; Glycation End Products, Advanced; Guanine; Heart; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phosphorylation; Protein Transport; Pyrazines; Sitagliptin Phosphate; Triazoles; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2011
Both sitagliptin analogue & pioglitazone preserve the beta-cell proportion in the islets with different mechanism in non-obese and obese diabetic mice.
    BMB reports, 2011, Volume: 44, Issue:11

    Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Fasting; Glucose Tolerance Test; Homeostasis; Insulin-Secreting Cells; Ki-67 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Organ Size; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles

2011
Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat).
    Experimental diabetes research, 2011, Volume: 2011

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Insulin; Kidney Glomerulus; Lipid Peroxidation; Lipids; Male; Obesity; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Treatment Outcome; Triazoles

2011
The combination of colesevelam with sitagliptin enhances glycemic control in diabetic ZDF rat model.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Apr-15, Volume: 302, Issue:8

    Topics: Allylamine; Animals; Anticholesteremic Agents; Apoptosis; Bile Acids and Salts; Blood Glucose; Body Weight; Cell Proliferation; Cell Size; Colesevelam Hydrochloride; Diabetes Mellitus, Type 2; Diet; Drug Synergism; Fluorescent Antibody Technique; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hypoglycemic Agents; In Situ Nick-End Labeling; Insulin; Insulin-Secreting Cells; Ki-67 Antigen; Male; Postprandial Period; Pyrazines; Rats; Rats, Zucker; Receptors, G-Protein-Coupled; RNA, Messenger; Sitagliptin Phosphate; Triazoles

2012
Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Animals; Body Weight; Boronic Acids; Bortezomib; Disease Models, Animal; Humans; Immunoblotting; Immunohistochemistry; Kidney Diseases, Cystic; Kidney Neoplasms; Metformin; Mice; Pyrazines; Treatment Outcome; Tuberous Sclerosis

2012
[Sitagliptin in the treatment of type 2 diabetes: new data presented during the American Diabetes Association annual meeting (San Diego, California, June 2011)].
    Drugs of today (Barcelona, Spain : 1998), 2011, Volume: 47 Suppl D

    Topics: Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Pyrazines; Sitagliptin Phosphate; Triazoles

2011
Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes.
    Diabetes, obesity & metabolism, 2012, Volume: 14, Issue:10

    Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptides; Drinking; Eating; Glucose Tolerance Test; Glycated Hemoglobin; Hypoglycemic Agents; Immunohistochemistry; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Pyrazines; Sitagliptin Phosphate; Triazoles

2012
Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.
    Molecules (Basel, Switzerland), 2012, May-08, Volume: 17, Issue:5

    Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Cardiotonic Agents; Catalase; Glutathione Peroxidase; Heart; Heart Failure; Interleukin-6; Isoproterenol; Malondialdehyde; Organ Size; Organophosphates; Oxidative Stress; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Tablets; Tumor Necrosis Factor-alpha; Ventricular Function, Left

2012
Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (-/-) mice.
    Diabetologia, 2012, Volume: 55, Issue:8

    Topics: Animals; Apolipoproteins E; Arteriosclerosis; Body Weight; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Immunohistochemistry; Lipid Metabolism; Macrophages; Male; Mice; Mice, Inbred C57BL; Pyrazines; Sitagliptin Phosphate; Triazoles

2012
The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Adult; Alanine Transaminase; Blood Glucose; Body Weight; Comorbidity; Diabetes Mellitus, Type 2; Drug Evaluation; Drug Therapy, Combination; Fatty Liver; Female; Follow-Up Studies; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Inflammation; Liraglutide; Liver Cirrhosis; Logistic Models; Male; Middle Aged; Multivariate Analysis; Non-alcoholic Fatty Liver Disease; Odds Ratio; Pioglitazone; Platelet Count; Pyrazines; Retrospective Studies; Sitagliptin Phosphate; Thiazolidinediones; Treatment Outcome; Triazoles

2012
Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats.
    European journal of pharmacology, 2013, Jan-05, Volume: 698, Issue:1-3

    Topics: Animals; Blood Pressure; Body Weight; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 4; Heart; Homeostasis; Intracellular Space; Male; Muscle, Skeletal; Myocytes, Cardiac; Phosphorylation; Protein Transport; Pyrazines; Rats; Rats, Inbred SHR; RNA, Messenger; Signal Transduction; Sitagliptin Phosphate; Triazoles; Up-Regulation

2013
Cycloart-23-ene-3β, 25-diol stimulates GLP-1 (7-36) amide secretion in streptozotocin-nicotinamide induced diabetic Sprague Dawley rats: a mechanistic approach.
    European journal of pharmacology, 2013, Jan-05, Volume: 698, Issue:1-3

    Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drinking; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Male; Molecular Docking Simulation; Niacinamide; Oxidative Stress; Pancreas; Peptide Fragments; Protein Conformation; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Time Factors; Triazoles; Triterpenes

2013
Long-term efficacy and safety of sitagliptin in the treatment of Japanese Type 2 diabetes (ASSET-K1) to a target of HbA1c <7%.
    Journal of endocrinological investigation, 2013, Volume: 36, Issue:8

    Topics: Aged; Asian People; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Fasting; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Postprandial Period; Pyrazines; Sitagliptin Phosphate; Triazoles

2013
Effect of tetramethylpyrazine on lipid peroxidation in streptozotocin-induced diabetic mice.
    The American journal of Chinese medicine, 2002, Volume: 30, Issue:4

    Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabetes Mellitus, Experimental; Free Radical Scavengers; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Pyrazines; Thiobarbituric Acid Reactive Substances

2002
Effects of cysteine on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats with protein-calorie malnutrition.
    International journal of pharmaceutics, 2003, Apr-14, Volume: 255, Issue:1-2

    Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Cysteine; Eating; Injections, Intravenous; Male; Organ Size; Protective Agents; Protein-Energy Malnutrition; Pyrazines; Rats; Rats, Sprague-Dawley; Tissue Distribution

2003
Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease.
    Experimental neurology, 2006, Volume: 198, Issue:1

    Topics: Animals; Body Weight; Brain-Derived Neurotrophic Factor; CD11b Antigen; Cell Death; Choline O-Acetyltransferase; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Imidazoles; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Motor Activity; Motor Neurons; Neurodegenerative Diseases; Psychomotor Performance; Pyrazines; Radioimmunoassay; Riluzole

2006
Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:7

    Topics: Animals; Benzoates; Body Weight; Bone Marrow Cells; Bridged-Ring Compounds; Colony-Forming Units Assay; Coumaric Acids; Disease Models, Animal; Dose-Response Relationship, Radiation; Drugs, Chinese Herbal; Female; Fructose; Gamma Rays; Glucosides; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Monoterpenes; Pyrazines; Radiation-Protective Agents; Stem Cells; Thymus Gland

2006
Toxicity of morphazinamide compared with pyrazinamide.
    Czechoslovak medicine, 1983, Volume: 6, Issue:3

    Topics: Animals; Blood Chemical Analysis; Body Weight; Eating; Liver; Male; Pyrazinamide; Pyrazines; Rats; Rats, Inbred Strains

1983
Hyponatraemia associated with trimethoprim and a diuretic.
    British medical journal (Clinical research ed.), 1984, Dec-15, Volume: 289, Issue:6459

    Topics: Aged; Amiloride; Body Weight; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hyponatremia; Pyrazines; Trimethoprim; Urinary Tract Infections; Urodynamics

1984
Effects of amiloride on tumor growth and intracellular element content of tumor cells in vivo.
    Cancer research, 1983, Volume: 43, Issue:1

    Topics: Adenocarcinoma; Amiloride; Animals; Body Weight; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Liver Neoplasms, Experimental; Male; Mice; Pyrazines; Sodium

1983
Spironolactone and amiloride in hypertensive patients with and without aldosterone excess.
    Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:3

    Topics: Adult; Amiloride; Blood Pressure; Body Weight; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Renin; Spironolactone; Urea

1980
A comparison between the natriuretic response to potassium in lithium- and amiloride-treated rats.
    Acta pharmacologica et toxicologica, 1981, Volume: 48, Issue:5

    Topics: Amiloride; Animals; Body Weight; Dose-Response Relationship, Drug; Drinking; Lithium; Male; Natriuresis; Potassium; Pyrazines; Rats; Rats, Inbred Strains; Renin; Sodium; Time Factors

1981
A comparative study of Moducren and Moduretic and their effect on plasma potassium in essential hypertension.
    The Practitioner, 1982, Volume: 226, Issue:1364

    Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Body Weight; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Propanolamines; Pyrazines; Random Allocation; Timolol

1982
Differences among 'serotonergic' anorectics in a cross-tolerance paradigm: do they all act on serotonin systems?
    European journal of pharmacology, 1982, Jun-16, Volume: 81, Issue:1

    Topics: Animals; Appetite Depressants; Body Weight; Drug Tolerance; Fenfluramine; Male; Pyrazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin

1982
A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension.
    Clinical therapeutics, 1980, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Aged; Amiloride; Blood Chemical Analysis; Blood Pressure; Body Weight; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Hydrochlorothiazide; Hyperglycemia; Hypertension; Male; Middle Aged; Pyrazines; Uric Acid

1980
Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters.
    Carcinogenesis, 1995, Volume: 16, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Ductal, Breast; Cricetinae; Female; Glutathione Transferase; Immunohistochemistry; Liver; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Pyrazines; Thiones; Thiophenes; Tumor Suppressor Protein p53

1995
Modulation of the hypolipidemic effect of fish oil by inhibition of adipose tissue lipolysis with acipimox, a nicotinic acid analog.
    Annals of the New York Academy of Sciences, 1993, Jun-14, Volume: 683

    Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Blood Glucose; Body Weight; Cholesterol; Dietary Fats, Unsaturated; Eating; Fatty Acids, Nonesterified; Fish Oils; Insulin; Lipids; Lipolysis; Liver; Male; Pyrazines; Rats; Rats, Wistar; Receptors, LDL; Sucrose; Triglycerides

1993
Inhibition of sexual maturation in juvenile female and male mice by a chemosignal of female origin.
    Physiology & behavior, 1994, Volume: 55, Issue:3

    Topics: Animals; Body Weight; Female; Male; Mice; Mice, Inbred ICR; Organ Size; Pregnancy; Pyrazines; Seminal Vesicles; Sex Attractants; Sexual Maturation; Smell; Social Environment; Testis

1994
Evaluation of the post-initiation effects of oltipraz on aflatoxin B1-induced preneoplastic foci in a rat model of hepatic tumorigenesis.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Body Weight; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes; Time Factors

1993
Effect of schistosomal infection and its treatment on some key enzymes of glucose metabolism in mice livers.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:12

    Topics: Animals; Body Weight; Citric Acid Cycle; Female; Glucose; Glycolysis; Liver; Liver Glycogen; Male; Mice; Organ Size; Oxamniquine; Pentose Phosphate Pathway; Praziquantel; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes

1995
Inhibition of 2-Amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz.
    Cancer research, 1996, Aug-01, Volume: 56, Issue:15

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Imidazoles; Intestinal Neoplasms; Lymphoma; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes

1996
Chronic toxicity studies of 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione, a potential chemopreventive agent.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1997, Volume: 35, Issue:1

    Topics: Administration, Oral; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Blood Chemical Analysis; Body Weight; Cholesterol; Dogs; Female; Hematologic Tests; Kidney; Liver; Male; No-Observed-Adverse-Effect Level; Organ Size; Prostate; Pyrazines; Rats; Rats, Inbred F344; Survival Rate; Thiones; Thiophenes

1997
The effect of pyrazine odor on body weight and the weight of various organs in chicks (Gallus gallus domesticus).
    Poultry science, 1999, Volume: 78, Issue:12

    Topics: Adipose Tissue; Adrenal Glands; Animals; Body Weight; Bursa of Fabricius; Chick Embryo; Chickens; Comb and Wattles; Female; Liver; Male; Odorants; Organ Size; Ovary; Pyrazines; Sex Characteristics; Spleen; Thyroid Gland; Time Factors

1999
Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters.
    Cancer letters, 2000, May-29, Volume: 153, Issue:1-2

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; Female; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Organ Size; Pyrazines; Thiones; Thiophenes

2000
1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenz.
    International journal of cancer, 2001, Jan-01, Volume: 91, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzopyrenes; Body Weight; Chromatography; DNA Adducts; Female; Liver; Lung; Mammary Glands, Animal; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes

2001
Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM).
    Cancer letters, 2001, May-26, Volume: 166, Issue:2

    Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Enzyme Inhibitors; Intestinal Mucosa; Male; Organ Size; Pyrazines; Rats; Rats, Inbred F344

2001
Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed mice.
    Acta physiologica Scandinavica, 2001, Volume: 171, Issue:2

    Topics: Animals; Blood Glucose; Body Weight; Dietary Fats; Fatty Acids, Nonesterified; Female; Glucose Intolerance; Glucose Tolerance Test; Hypolipidemic Agents; Injections, Intraperitoneal; Insulin; Mice; Mice, Inbred C57BL; Pyrazines

2001
Potassium sparing effect of amiloride in patients receiving diuretics: a quantitative study.
    Acta cardiologica, 1979, Volume: 34, Issue:4

    Topics: Adult; Amiloride; Body Weight; Diuretics; Female; Humans; Hydrochlorothiazide; Male; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors

1979
Total exchangeable potassium in response to amiloride.
    Postgraduate medical journal, 1978, Volume: 54, Issue:634

    Topics: Amiloride; Body Weight; Carbon Dioxide; Humans; Hypertension; Hypokalemia; Potassium; Pyrazines; Time Factors

1978
Toxicological tests on flavouring matters. II. Pyrazines and other compounds.
    Food and cosmetics toxicology, 1975, Volume: 13, Issue:4

    Topics: Animals; Body Weight; Diet; Female; Kidney; Liver; Male; Organ Size; Pyrazines; Rats; Rats, Inbred Strains

1975
Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1991, Volume: 197, Issue:1

    Topics: Animals; Antineoplastic Agents; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Cytosol; DNA; Glutathione Transferase; Intestinal Mucosa; Liver; Male; Methylation; Ornithine Decarboxylase; Protein-Tyrosine Kinases; Pyrazines; Rats; Rats, Inbred F344; Reference Values; Thiones; Thiophenes

1991
Influence of pyrazine derivatives on the day of vaginal opening in juvenile female rats.
    Japanese journal of pharmacology, 1989, Volume: 49, Issue:4

    Topics: Animals; Body Weight; Female; Organ Size; Ovary; Pyrazines; Rats; Rats, Inbred Strains; Uterus; Vagina

1989
Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat.
    Toxicology and applied pharmacology, 1988, Volume: 93, Issue:3

    Topics: Aflatoxin B1; Aflatoxins; Animals; Body Weight; Butylated Hydroxytoluene; DNA; Enzyme Induction; Glutathione Transferase; Liver; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes

1988
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus.
    American journal of nephrology, 1985, Volume: 5, Issue:1

    Topics: Adult; Alkalosis; Amiloride; Body Weight; Child; Diabetes Insipidus; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypokalemia; Kidney Tubules; Male; Pyrazines; Tolmetin

1985
A clinical study of Co-hydroDiuril a combination of an antikaliuretic (amiloride) and hydrochlorothiazide.
    Current therapeutic research, clinical and experimental, 1972, Volume: 14, Issue:9

    Topics: Adult; Aged; Amiloride; Blood Pressure; Blood Urea Nitrogen; Body Weight; Diuretics; Drug Combinations; Drug Eruptions; Female; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Pyrazines; Urinary Incontinence; Vertigo

1972
Potassium-escape phenomenon in rats during continuous application of amiloride. IV. Etiology of the escape phenomenon.
    Pharmacology, 1973, Volume: 9, Issue:1

    Topics: Amiloride; Animals; Body Weight; Diet; Diuretics; Feces; Male; Potassium; Pyrazines; Rats

1973
Effects of hydrochlorothiazide and amiloride on potassium distribution in skeletal muscle of the rat.
    Pharmacology, 1973, Volume: 9, Issue:5

    Topics: Amiloride; Animals; Body Weight; Chlorides; Diuretics; Extracellular Space; Hydrochlorothiazide; Male; Muscles; Potassium; Pyrazines; Rats; Sodium; Water

1973
Evaluation of amiloride combined with hydrochlorothiazide in the treatment of congestive heart failure.
    The New Zealand medical journal, 1970, Volume: 72, Issue:459

    Topics: Aged; Amidines; Body Weight; Diuretics; Drug Synergism; Female; Heart Failure; Humans; Hydrochlorothiazide; Male; Middle Aged; Potassium; Pyrazines; Sodium; Time Factors; Urea

1970
Prevention of digitoxin poisoning by various steroids.
    Journal of pharmaceutical sciences, 1969, Volume: 58, Issue:9

    Topics: Anabolic Agents; Androstanes; Animals; Body Weight; Desoxycorticosterone; Digitoxin; Diuretics; Estradiol; Ethisterone; Ethylestrenol; Female; Fluoxymesterone; Hydrocortisone; Ketones; Methyltestosterone; Nandrolone; Norethandrolone; Norethynodrel; Organ Size; Oxandrolone; Oxymetholone; Poisoning; Pregnanes; Pregnenolone; Progesterone; Pyrazines; Rats; Spironolactone; Testosterone; Triamterene

1969
Possible predisposition of diabetic patients to hyperkalemia following administration of potassium-retaining diuretic, amiloride (MK 870).
    Metabolism: clinical and experimental, 1970, Volume: 19, Issue:1

    Topics: Adult; Aged; Bicarbonates; Blood Pressure; Body Weight; Chemical Phenomena; Chemistry; Chlorides; Creatinine; Diabetes Mellitus; Diuretics; Electrocardiography; Female; Humans; Hyperkalemia; Male; Middle Aged; Potassium; Pyrazines; Sodium; Spironolactone; Triamterene; Water-Electrolyte Balance

1970