pyrazines has been researched along with Asthma, Bronchial in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Z; Tong, J; Wang, Y; Zhu, H | 2 |
| Andersson, U; Andreasson, T; Bergström, EL; Björkstrand, E; Bonn, B; Chang, HF; Chapman, D; Davis, AM; Ek, M; Glader, P; Gordon, E; Jiang, F; Johannesson, P; Käck, H; Lundqvist, AJ; Malmberg, A; Munck Af Rosenschöld, M; Nikitidis, A; Nikitidis, G; Pettersen, A; Ripa, L; Rohman, M; Rönn, R; Swedin, L; Tyrchan, C; Ullah, V; Wågberg, F; Zhou, XH | 1 |
| Aggarwal, A; Arfvidsson, C; Chen, Y; Forsman, H; Prothon, S; Tehler, U; Wählby Hamrén, U; Yoon, E | 1 |
| Bian, ZR; Che, XW; Liu, XM; Wang, YB; Wu, Q | 1 |
| Cheng, H; Huang, M; Ji, NF; Wang, H; Xie, YC; Yin, KS; Zhang, MS; Zhao, X | 1 |
| Dong, J; Du, X; Li, M; Liu, F; Liu, J; Luo, Q; Sun, J; Wei, K; Wei, Y; Xu, F; Zhang, H | 1 |
| Che, XW; Wang, H; Wang, W; Zhang, Y | 1 |
| Luo, YC; Wang, Q; Xiang, QW | 1 |
| Baraldi, PG; Kalla, RV; Tabrizi, MA; Zablocki, J | 1 |
| Fehrenbach, H; Lunding, L; Manz, RA; Orinska, Z; Wegmann, M; Wong, DM | 1 |
| El-Agamy, DS; El-Awady, MS; Nader, MA; Shalaby, AA | 1 |
| Boehncke, WH; Elliott, PJ; Zollner, TM | 1 |
| Dong, JC; Gong, ZH; Ni, J | 1 |
| Li, HL; Wang, WJ; Wang, XH; Yang, L | 1 |
| Aizu-Yokota, E; Hatake, K; Kasahara, T; Kuniyoshi, R; Mishima, Y; Rokudai, A; Sonoda, Y; Terui, Y | 1 |
| Bai, M; Fang, ZY; Feng, G; Tao, XN; Xiong, L | 1 |
| Zhang, KJ; Zhang, YX | 1 |
| Branscheid, D; Dent, G; Egerland, J; Magnussen, H; Marx, D; Poppe, H; Rabe, KF; Szelenyi, I | 1 |
| Kobayashi, H; Kobayashi, S; Kurosawa, M; Nakano, M | 1 |
| Kato, M; Kimura, H; Kuroume, T; Morikawa, A; Nakano, M; Shigeta, M | 1 |
| Paterson, JW; Richards, AJ; Walker, SR | 1 |
| Bogarelli, D; Ferliga, G; Paroli, M | 1 |
4 review(s) available for pyrazines and Asthma, Bronchial
| Article | Year |
|---|---|
Recent developments in A2B adenosine receptor ligands.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Aminopyridines; Animals; Asthma; Drug Discovery; Humans; Pyrazines; Pyrimidines; Receptor, Adenosine A2B; Xanthines | 2009 |
Proteasome inhibition: a new anti-inflammatory strategy.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Asthma; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Inflammation; Lysine; Models, Biological; Models, Chemical; Multienzyme Complexes; Multiple Sclerosis; Neoplasms; NF-kappa B; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Psoriasis; Pyrazines; Reperfusion Injury | 2003 |
[Recent advances in experimental and clinical study on ligustrazine in treating respiratory disease].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Lung Diseases; Pyrazines | 1995 |
A new anti-asthmatic drug (ICI 58 301): blood levels and spirometry.
Topics: Acetamides; Adult; Asthma; Cyclic AMP; Female; Humans; Male; Middle Aged; Nausea; Phosphoric Monoester Hydrolases; Pyrazines; Spirometry; Time Factors; Triazoles | 1971 |
2 trial(s) available for pyrazines and Asthma, Bronchial
| Article | Year |
|---|---|
Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers.
Topics: Administration, Inhalation; Adult; Asthma; Benzamides; Dose-Response Relationship, Drug; Dry Powder Inhalers; Healthy Volunteers; Humans; Japan; Male; Middle Aged; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazines; Receptors, Glucocorticoid | 2019 |
Effect of ligustrazine injection on levels of interleukin-4 and interferon-gamma in patients with bronchial asthma.
Topics: Adrenergic beta-Agonists; Aged; Aged, 80 and over; Asthma; Case-Control Studies; Female; Humans; Injections; Interferon-gamma; Interleukin-4; Male; Middle Aged; Pyrazines; Respiratory Function Tests; Terbutaline | 2008 |
17 other study(ies) available for pyrazines and Asthma, Bronchial
| Article | Year |
|---|---|
Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Computational Biology; Disease Models, Animal; Immunoglobulin E; Lung; Male; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Rats; Rats, Sprague-Dawley; Respiratory Hypersensitivity; RNA, Messenger | 2022 |
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1
Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Glutathione Transferase; Humans; Molecular Structure; Pyrazines; Rats; Structure-Activity Relationship | 2019 |
Effects of Ligustrazine on Airway Inflammation in A Mouse Model of Neutrophilic Asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Interleukin-10; Interleukin-17; Leukocyte Count; Lung; Mice, Inbred C57BL; Neutrophils; Pneumonia; Pyrazines; Respiratory Hypersensitivity | 2018 |
Ligustrazine corrects Th1/Th2 and Treg/Th17 imbalance in a mouse asthma model.
Topics: Animals; Asthma; Cells, Cultured; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Eosinophils; Female; Gene Expression Regulation; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyrazines; T-Lymphocytes, Regulatory; Th1-Th2 Balance; Th17 Cells; Transcription Factors | 2014 |
Ligustrazine improves blood circulation by suppressing Platelet activation in a rat model of allergic asthma.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Asthma; Blood Circulation; Blood Platelets; Cell Adhesion; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Male; Platelet Activation; Pneumonia; Pyrazines; Rats, Sprague-Dawley | 2016 |
Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Chemokines; Disease Models, Animal; Female; Interleukins; Lung; MAP Kinase Signaling System; Mice, Inbred BALB C; Ovalbumin; Pyrazines; Receptors, CCR7; STAT3 Transcription Factor | 2016 |
[Effect of ligustrazine on expression of RhoA mRNA, ROCK-II protein in the lung and airway inflammation of allergic asthma model mice].
Topics: Animals; Asthma; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Pyrazines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger | 2008 |
Long-term bortezomib treatment reduces allergen-specific IgE but fails to ameliorate chronic asthma in mice.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Boronic Acids; Bortezomib; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Immunoglobulin G; Lung; Mice; Mice, Inbred BALB C; Plasma Cells; Pyrazines; Treatment Failure | 2012 |
Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Inflammation; Lung; Male; Mice; Nitric Oxide Synthase Type II; Ovalbumin; Pyrazines; RNA, Messenger; Sitagliptin Phosphate; Triazoles | 2012 |
[Experimental study on prevention and treatment of bronchial asthma by compound Chinese herbal monomer recipe].
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Drugs, Chinese Herbal; Female; Flavonoids; Ginkgo biloba; Guinea Pigs; Male; Pyrazines; Random Allocation | 2004 |
[Effect of ligustrazine on airway remodeling in asthmatic rats].
Topics: Animals; Anti-Asthmatic Agents; Asthma; Collagen Type III; Disease Models, Animal; Drugs, Chinese Herbal; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Ovalbumin; Pyrazines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2004 |
Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast.
Topics: Asthma; Boronic Acids; Bortezomib; Cell Line; Chemokine CCL11; Chemokine CCL26; Chemokines, CC; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Humans; Hypersensitivity; Immunoblotting; Interleukin-4; Leupeptins; Lung; Mitogen-Activated Protein Kinases; NF-kappa B; Pyrazines; Recombinant Proteins; STAT6 Transcription Factor; Tumor Necrosis Factor-alpha | 2006 |
Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Lung; Male; Ovalbumin; Pyrazines; Rats; T-Box Domain Proteins; Th1 Cells; Th2 Cells | 2007 |
Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Asthma; Bronchi; Cyclic Nucleotide Phosphodiesterases, Type 4; Eosinophilia; Eosinophils; Guinea Pigs; Humans; Hypersensitivity; Imidazoles; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pulmonary Artery; Pyrazines | 1998 |
Failure of inhibitory effects by platelets on super-oxide anion generation from stimulated neutrophils in a severe bronchial asthmatic.
Topics: Adult; Asthma; Blood Platelets; Cell Communication; Chromatography, Gel; Female; Humans; Imidazoles; Luminescent Measurements; Neutrophils; Platelet Count; Pyrazines; Superoxide Dismutase; Superoxides | 1991 |
Ability of polymorphonuclear leukocytes to generate active oxygen species in children with bronchial asthma. Use of chemiluminescence probes with a Cypridina luciferin analog and luminol.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Imidazoles; Luminol; Lymphocyte Activation; Male; Neutrophils; Pyrazines; Superoxides | 1991 |
[Prevention of the reacutization of chronic bronchitis with sulfamethopyrazine].
Topics: Aged; Asthma; Bronchiectasis; Bronchitis; Chronic Disease; Humans; Male; Middle Aged; Pulmonary Emphysema; Pulmonary Fibrosis; Pyrazines | 1969 |