pyrazines has been researched along with Airflow Obstruction, Chronic in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aggarwal, A; Arfvidsson, C; Chen, Y; Forsman, H; Prothon, S; Tehler, U; Wählby Hamrén, U; Yoon, E | 1 |
| Evans, R; Raubo, P; Willis, P | 1 |
| Asimus, S; Brown, MN; Clarke, GW; Cunoosamy, DM; Ersdal, E; Fagerås, M; Greenaway, S; Hegelund-Myrbäck, T; Jansson, P; Korsback, K; Kristensson, C; Kurian, N; Lundin, S; Make, BJ; Palmér, R; Pardali, K; Patel, NR; Rennard, SI; Siew, L; Taib, Z; Wise, RA | 1 |
| Huang, LJ; Miu, CL; Wang, WT; Wu, CY; Zhang, CC; Zhao, MP; Zheng, MX | 1 |
| Eba, S; Hoshikawa, Y; Ishida, K; Kondo, T; Mitsuishi, Y; Moriguchi, T; Okada, Y; Satoh, H; Shimizu, T; Shimokawa, H; Watanabe, T; Yamamoto, M | 1 |
| Feng, EZ; Huang, NX; Tian, ZX; Yang, SY; Yin, H; Zhang, Y | 1 |
| Jauhiainen, A; Taib, Z | 1 |
| Dekhuijzen, R; Ennen, L; Heunks, L; Linkels, M; Ottenheijm, C; van Hees, H | 1 |
| Lin, CL; Xu, YJ; Zhang, ZX | 2 |
4 trial(s) available for pyrazines and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers.
Topics: Administration, Inhalation; Adult; Asthma; Benzamides; Dose-Response Relationship, Drug; Dry Powder Inhalers; Healthy Volunteers; Humans; Japan; Male; Middle Aged; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazines; Receptors, Glucocorticoid | 2019 |
The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Benzamides; Cross-Over Studies; Disease Progression; Double-Blind Method; Female; Humans; Lung; Macrophages, Alveolar; Male; Middle Aged; Mitogen-Activated Protein Kinase 14; Proof of Concept Study; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazines; Time Factors; Treatment Outcome; Young Adult | 2018 |
[The effects and mechanisms of ligustrazine injection on pulmonary arterial hypertension in COPD patients].
Topics: Humans; Hypercapnia; Hypertension, Pulmonary; Pulmonary Disease, Chronic Obstructive; Pyrazines | 2016 |
Plasma endothelin-1 and nitric oxide correlate with ligustrazine alleviation of pulmonary artery hypertension in patients of chronic cor pulmonale from high altitude plateau during acute exacerbation.
Topics: Altitude; Blood Gas Analysis; Chronic Disease; Endothelin-1; Humans; Hypertension, Pulmonary; Nitric Oxide; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pyrazines; Respiration | 2014 |
6 other study(ies) available for pyrazines and Airflow Obstruction, Chronic
| Article | Year |
|---|---|
The discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors.
Topics: Administration, Inhalation; Alkanes; Amines; Animals; Anti-Inflammatory Agents; Benzamides; Dogs; Drug Evaluation, Preclinical; Humans; Inflammation; Mitogen-Activated Protein Kinase 14; Models, Molecular; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazines; Quinazolines; Rats; Structure-Activity Relationship | 2020 |
The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Cytoskeletal Proteins; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Knockout; NF-E2-Related Factor 2; Pulmonary Disease, Chronic Obstructive; Pyrazines; Tenascin; Thiones; Thiophenes | 2013 |
COPD biomarkers as tools for decision making in early clinical drug development.
Topics: Acetates; Biomarkers; Clinical Trials as Topic; Cluster Analysis; Endpoint Determination; Humans; Interleukin-6; Lung; Prognosis; Pulmonary Disease, Chronic Obstructive; Pyrazines | 2016 |
Proteasome inhibition improves diaphragm function in an animal model for COPD.
Topics: Animals; Biomechanical Phenomena; Boronic Acids; Bortezomib; Contractile Proteins; Cricetinae; Diaphragm; Disease Models, Animal; Male; Organ Specificity; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pyrazines | 2011 |
[Effect of combination of ligustrazine and nitrendipine on hemodynamics in patients with chronic obstructive pulmonary disease].
Topics: Adult; Aged; Calcium Channel Blockers; Drug Synergism; Drug Therapy, Combination; Female; Hemodynamics; Humans; Male; Middle Aged; Nitrendipine; Pulmonary Disease, Chronic Obstructive; Pyrazines; Vasodilator Agents | 2001 |
[Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease].
Topics: Aged; Drug Therapy, Combination; Endothelin-1; Female; Humans; Male; Middle Aged; Nitrendipine; P-Selectin; Pulmonary Disease, Chronic Obstructive; Pyrazines; Thromboxane B2; Vasodilator Agents | 2001 |