pyrazines has been researched along with Adjuvant Arthritis in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Alhassan, AB; Anand, R; Babu Boga, S; Bennett, C; Brandish, PE; Cai, J; Duffy, JL; Fischmann, TO; Gao, X; Gao, YD; Garlisi, CG; Guiadeen, D; Hicks, A; Kelly, J; Kim, R; Knemeyer, I; Kozlowski, JA; Krikorian, A; Leccese, E; Liu, J; Liu, S; Maloney, KM; Mansueto, M; Presland, J; Selyutin, O; Stivers, P; Tyagarajan, S; Wang, J; Wu, H; Xu, J; Xu, Z; Yang, C; Yu, W; Yu, Y; Zhang-Hoover, J | 1 |
| Chen, L; Liu, J; Liu, T; Wang, Q | 1 |
| Li, Y; Zhang, T; Zhou, Y; Zhu, Z | 1 |
| Huang, YL; Li, YC; Liu, GL; Mu, CX; Tian, H | 1 |
| Bian, YQ; Guo, HT; He, XJ; Lu, C; Luo, D; Xiao, C; Xu, SH; Zhao, HY | 1 |
| Acosta, YY; Aragoneses-Fenoll, L; Blanco-Aparicio, C; Criado, G; Dianzani, U; Herranz, J; Martínez, S; Montes-Casado, M; Ojeda, G; Pastor, J; Portolés, P; Rojo, JM | 1 |
| Kim, JH; Lee, SK; Lee, SW; Park, YB | 1 |
| Chen, G; Feng, B; Ma, Q; Xu, X; Zhang, J | 1 |
| Anagnostopoulos, A; Athanasiou, E; Bougiouklis, D; Kaloyannidis, P; Palladas, P; Papadopoulou, A; Paraskeva, A; Yannaki, E; Yiangou, M | 1 |
| Anagnostopoulos, A; Athanasiou, E; Batsis, I; Fassas, A; Kaloyannidis, P; Papadopoulou, A; Yannaki, E; Yiangou, M; Zogas, N | 1 |
| Cao, YL; Ma, T; Xu, BB; Zhou, XM | 1 |
| Ahsan, MH; Purchio, AF; West, DB; Zhang, N | 1 |
| Blum, E; Buhl, T; Di Padova, FE; Feifel, R; Gram, H; Hiestand, P; Manning, U; Neumann, U; Revesz, L; Rucklin, G | 1 |
| Barbera, R; Grasso, S; Monforte, MT; Ottanà, R; Trovato, A; Vigorita, MG; Zappalà, M | 1 |
14 other study(ies) available for pyrazines and Adjuvant Arthritis
| Article | Year |
|---|---|
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental; Binding Sites; Bridged Bicyclo Compounds; Crystallography, X-Ray; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Half-Life; Humans; Imidazoles; Molecular Dynamics Simulation; Protein Kinase Inhibitors; Pyrazines; Rats; Rats, Wistar; src-Family Kinases; Structure-Activity Relationship | 2020 |
Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspartate Aminotransferases; Cartilage; Curcumin; Cytokines; Drug Combinations; Edema; Female; Inflammation; Joints; Kidney; Liver; Male; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Pyrazines; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2017 |
Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-κB and Nrf-2/HO-1 pathways.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Heme Oxygenase (Decyclizing); Inflammation; Injections, Subcutaneous; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Sirtuin 1; Structure-Activity Relationship | 2019 |
[Effect of Tetramethyl pyrazine on serum levels of IL-1beta, IL-6, and IL-2, and NO and PGE2 in the synovial fluid of CIA rats: an experimental research].
Topics: Animals; Arthritis, Experimental; Dinoprostone; Female; Interleukin-1beta; Interleukin-2; Interleukin-6; Male; Nitric Oxide; Pyrazines; Rats; Rats, Sprague-Dawley; Synovial Fluid | 2014 |
[Effect of Combination Therapy of Tetramethylpyrazine with Methotrexate on Inflammatory Reac- tions and Hemorheology in Collagen-induced Arthritis Rats].
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cattle; Collagen Type II; Drug Therapy, Combination; Drugs, Chinese Herbal; Hemorheology; Interleukin-17; Interleukin-1beta; Interleukin-6; Male; Methotrexate; Pyrazines; Rats; Rats, Sprague-Dawley; Synovial Membrane | 2015 |
ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.
Topics: Animals; Antibodies; Arthritis, Experimental; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Class Ia Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Imidazoles; Interferon-gamma; Interleukin-10; Interleukin-2; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Phosphoinositide-3 Kinase Inhibitors; Protein Subunits; Proto-Oncogene Proteins c-akt; Pyrazines; T-Box Domain Proteins | 2016 |
Bortezomib attenuates murine collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Boronic Acids; Bortezomib; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Inflammation Mediators; Male; Mice; Mice, Inbred DBA; Protease Inhibitors; Pyrazines; Severity of Illness Index; Treatment Outcome; X-Ray Microtomography | 2009 |
[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Gene Expression; Humans; Male; Pyrazines; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A | 2009 |
The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant-induced arthritis in rats.
Topics: Analysis of Variance; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Diseases; Boronic Acids; Bortezomib; Cell Proliferation; Cytokines; Flow Cytometry; Immunohistochemistry; Inflammation; Joints; Pyrazines; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Synovial Membrane; Toll-Like Receptors; Treatment Outcome | 2010 |
Mesenchymal stem cells are conditionally therapeutic in preclinical models of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Boronic Acids; Bortezomib; Disease Models, Animal; Flow Cytometry; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrazines; Rats; Rats, Inbred F344; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; T-Lymphocytes | 2012 |
Effect of (3,5,6-trimethylpyrazin-2-yl)methyl 2-[4-(2-methylpropyl)phenyl]propanoate (ITE), a newly developed anti-inflammatory drug, on type II collagen-induced arthritis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Collagen Type II; Dose-Response Relationship, Drug; Male; Mice; Propionates; Pyrazines | 2004 |
Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition.
Topics: Acute Disease; Animals; Arthritis, Experimental; Boronic Acids; Bortezomib; Dermatitis, Contact; Disease Models, Animal; Enzyme Induction; Female; Genetic Vectors; Lipopolysaccharides; Luciferases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Organ Specificity; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Sepsis; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha | 2005 |
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Disease Models, Animal; Enzyme Inhibitors; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinase 14; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2006 |
Aminopyrazinyl derivatives: synthesis and evaluation of antiinflammatory and related activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Edema; Female; Indomethacin; Lethal Dose 50; Male; Mice; Pain Measurement; Phenylbutazone; Pyrazines; Rats; Rats, Wistar; Reaction Time; Stomach Ulcer | 1994 |