Page last updated: 2024-08-21

pyrazines and Acute Disease

pyrazines has been researched along with Acute Disease in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (4.41)	18.7374
1990's	7 (10.29)	18.2507
2000's	18 (26.47)	29.6817
2010's	37 (54.41)	24.3611
2020's	3 (4.41)	2.80

Authors

Authors	Studies
Fu, B; Gao, G; Meng, S	1
Cao, X; Liu, X; Xia, S; Xu, S	1
Li, D; Li, X; Liu, H; Wang, M; Wu, Z; Xie, F; Xu, C; Zhang, X; Zhao, W	1
Li, J; Li, ZF; Zhang, J; Zhang, S; Zhou, R	1
Arrate, MP; Ayers, GD; Boyd, KL; Fesik, SW; Fischer, MA; Fuller, L; Gorska, AE; Hogdal, LJ; Lee, T; Olejniczak, ET; Ramsey, HE; Savona, MR; Sensintaffar, J; Strickland, SA	1
Chen, L; Chen, Y; Jianli, Z; Yun, H	1
Chang, HY; Clark, JM; Richards, TM; Segal, JB; Singh, S; Weiner, JP	1
Gale, EA	1
Cohen, D	1
Cho, YH; Choi, BS; Choi, YJ; Chung, BH; Hong, YA; Kim, YS; Park, CW; Park, GS; Sun, IO; Yang, CW	1
Du, X; Geng, S; Lai, P; Lin, S; Ling, W; Liu, X; Luo, C; Lv, M; Weng, J	1
Abdallah, AO; Bailey, C; Barlogie, B; Chauhan, N; Cottler-Fox, M; Crowley, J; Epstein, J; Heuck, CJ; Hoering, A; Johann, D; Muzaffar, J; Petty, N; Rosenthal, A; Sawyer, J; Sexton, R; Singh, Z; Usmani, SZ; van Rhee, F; Waheed, S; Yaccoby, S	1
McNeil, C	1
Akar, M; Aktan Kosker, T; Buyukasik, S; Ersoy, O; Solakoglu, T	1
Cheng, Q; Jin, Y; Liang, Y; Liu, H; Ma, S; Wang, Y; Wu, D; Wu, Y; Zhang, Y; Zheng, D	1
Rouse, R; Stewart, S; Xu, L; Zhang, J	1
Shah, BK; Sharma, LR; Subedi, A	1
Levy, Y; Maisel, C; Robinson, S; Tong, AW	1
Abedi, M; Blazar, BR; Chen, M; Hagino, T; Hsiao, HH; Mall, C; Monjazeb, A; Murphy, WJ; Pai, CC; Sun, K; Tellez, J	1
Brenner, C; Fischer, C; Franz, WM; Grabmaier, U; Gross, L; Herbach, N; Israel, L; Kränkel, N; Kühlenthal, S; Landmesser, U; Laskowski, A; Remm, F; Speer, T; Theiss, H; Wanke, R	1
Aota, Y; Gotoh, A; Hanyu, N; Honma, T; Kitagawa, N; Komatsu, N; Morisaki, M; Yokoyama, T	1
Abu Jawdeh, BG; Alloway, RR; Cardi, MA; Ejaz, NS; Sadaka, B; Shields, AR; Wadih, G; Witte, D; Woodle, ES	1
Cao, W; Chen, J; Cui, M; Shi, Q; Wang, C; Wang, X; Zhang, B; Zhang, G; Zhao, Y	1
Gonullu, E; Hacihanefioglu, A; Tarkun, P	1
Alloway, RR; Arend, LJ; Brailey, P; Cardi, M; Everly, JJ; Everly, MJ; Govil, A; Mogilishetty, G; Rike, AH; Roy-Chaudhury, P; Susskind, B; Tevar, A; Wadih, G; Woodle, ES	1
Cas, LD; Cotter, G; Gheorghiade, M; Metra, M; Sabbah, HN; Teerlink, JR; Zacà, V	1
Bruserud, O; Hatfield, KJ; Kalland, KH; Kittang, AO; Oyan, AM; Reikvam, H	1
Chaudhary, R; Ghose, A; Taj, A; Tariq, Z	1
Clay, RJ; Engel, SS; Goldstein, BJ; Golm, GT; Kaufman, KD; Machotka, SV; Williams-Herman, DE	1
Ben Salem, C; Biour, M; Bouraoui, K; Elouni, B; Sakhri, J; Zamy, M	1
Basu, A; Lunz, J; Mapara, M; Morgan, C; Randhawa, P; Shapiro, R; Sharma, V; Tan, HP; Zeevi, A	1
Alford, K; Hardinger, KL; Murillo, D	1
Bloom, D; Djamali, A; Lorentzen, D; Mezrich, JD; Miller, KM; Muth, BL; Pirsch, JD; Sollinger, HW; Torrealba, J	1
Ma, ML; Ou, JM; Wang, C; Wu, DJ; Zhang, XP	1
Fang, Y; Tao, Y; Wang, J; Wang, L; Yang, D; Zhang, W; Zhou, H	1
Arfons, LM; Ataergin, SA; Barr, PM; Cooper, BW; Creger, RJ; Fu, P; Gerson, SL; Kaplan, D; Kaye, NM; Kindwall-Keller, TL; Laughlin, MJ; Lazarus, HM; Liu, F; Sommers, SR	1
Everly, MJ	1
Al Meshari, K; Altalhi, M; Alzayer, F; Elgamal, H; Pall, A	1
Cooper, M; Drachenberg, C; Haririan, A; Kukuruga, D; Manitpisitkul, W; Nogueira, J; Philosophe, B; Wilson, NS	1
Alberú, J; Leyva, S; Marino, LA; Morales-Buenrostro, LE	1
Arai, S; Ichikawa, M; Imai, Y; Kataoka, K; Kumano, K; Kurokawa, M; Nakagawa, M; Nannya, Y; Nishimoto, N; Sato, T; Shimabe, M; Shinohara, A; Watanabe-Okochi, N; Yoshimi, A	1
Fehr, T; Gaspert, A	1
Chan, KM; Chou, HS; Eldeen, FZ; Lee, CF; Lee, WC; Soong, RS; Wu, TH; Wu, TJ	1
Huang, K; Li, Y; Ma, L; Nie, D; Wang, X; Wu, Y; Xiao, J; Xie, S; Yin, S	1
Benedetti, E; Jeon, H; Joseph, J; Oberholzer, J; Spaggiari, M; Thielke, J; Tzvetanov, I	1
Giles, FJ	1
Barao, I; Blazar, BR; Liu, H; Murphy, WJ; O'Shaughnessy, MJ; Panoskaltsis-Mortari, A; Riordan, W; Sayers, TJ; Serody, JS; Sitcheran, R; Sun, K; Welniak, LA; Wysocki, C	1
Chen, XL; Han, ZX; Wang, SY; Xu, QL; Zhang, Z; Zheng, H	1
Ahsan, MH; Purchio, AF; West, DB; Zhang, N	1
Anver, MR; Blazar, BR; Murphy, WJ; Panoskaltsis-Mortari, A; Sayers, TJ; Sun, K; Welniak, LA; Wilkins, DE	1
Delaney, TF; Harmon, DC; Mohiuddin, MM	1
Kamada, N; Kikuchi, S; Kobayashi, S; Komatsu, Y; Kusama, H; Mukaiyama, H; Nishimura, T; Oonota, H; Ozawa, T	1
Dang, SC; Qu, JG; Wang, XQ; Zhang, JX	1
Du, ST; Jiang, H; Liu, YK; Niu, CY; Zhang, YP; Zhao, ZG	1
Bruserud, Ø; Gjertsen, BT; Kalland, KH; Olsnes, AM; Ryningen, A; Stordrange, L; Øyan, AM	1
Javaheri, S; Weyne, J	1
Inaba, H; Kishimoto, W; Nakano, M; Nakao, A; Takagi, H; Takahashi, A	1
Sun, R; Wang, D; Xu, J; Zhang, H; Zhang, S	1
Shi, YT; Shi, ZX; Zhang, JL	1
Cao, W; Guo, Z; Luo, W	1
Baron, P; Chavan, SJ; Polsky, B; Prochaska, HJ	1
DiSesa, VJ; Fyfe, BS; Goldstein, C; Mohiuddin, M; Momeni, R; Shen, Z; Whitman, GJ; Yokoyama, H	1
Fesce, E; Iamoni, G; Ideo, G; Lanzani, F; Mondazzi, L; Zavaglia, C	1
Hsiao, G; Lee, YM; Sheu, JR; Yen, MH	1
Lin, CC; Lin, SC; Liu, CF; Ng, LT	1
Beeley, JM; Darke, CS; Weber, JC	1
Canfield, CJ; Hall, WH; MacDonald, BS; Whiting, EG	1

Reviews

8 review(s) available for pyrazines and Acute Disease

Article	Year
Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. World journal of gastroenterology, 2017, May-28, Volume: 23, Issue:20 Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Apigenin; Artemisinins; Drugs, Chinese Herbal; Emodin; Flavanones; Glucuronates; Humans; Medicine, Chinese Traditional; Pancreas; Pancreatitis; Patient Safety; Phytotherapy; Plant Extracts; Pyrazines; Resveratrol; Rheum; Salvia miltiorrhiza; Stilbenes; Sulfates	2017
Bortezomib-induced acute congestive heart failure: a case report and review of literature. Annals of hematology, 2014, Volume: 93, Issue:10 Topics: Acute Disease; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Dexamethasone; Heart Failure; Humans; Male; Multiple Myeloma; Protease Inhibitors; Pyrazines	2014
Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond. Heart failure reviews, 2009, Volume: 14, Issue:4 Topics: Acute Disease; Cardiotonic Agents; Digoxin; Dobutamine; Etiocholanolone; Exercise Test; Heart Failure; Hemodynamics; Hospitals, Group Practice; Humans; Hydrazones; Prognosis; Pyrazines; Pyridazines; Quinolines; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Simendan; Treatment Outcome; Urea; Vasodilator Agents	2009
Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis. International journal of clinical practice, 2010, Volume: 64, Issue:7 Topics: Acute Disease; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglycemic Agents; Pancreatitis; Pyrazines; Randomized Controlled Trials as Topic; Risk Factors; Sitagliptin Phosphate; Triazoles	2010
Antibody-mediated kidney allograft rejection: therapeutic options and their experimental rationale. Transplant international : official journal of the European Society for Organ Transplantation, 2012, Volume: 25, Issue:6 Topics: Acute Disease; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Boronic Acids; Bortezomib; Chronic Disease; Graft Rejection; Graft Survival; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosorbent Techniques; Isoantibodies; Kidney Transplantation; Plasma Exchange; Pyrazines; Rituximab; Splenectomy	2012
The use of bortezomib as a rescue treatment for acute antibody-mediated rejection: report of three cases and review of literature. Transplantation proceedings, 2012, Volume: 44, Issue:10 Topics: Acute Disease; Adult; Boronic Acids; Bortezomib; Drug Substitution; Female; Graft Rejection; Graft Survival; Histocompatibility; HLA Antigens; Humans; Immunity, Humoral; Immunosuppressive Agents; Isoantibodies; Kidney; Kidney Transplantation; Male; Middle Aged; Pyrazines; Time Factors; Treatment Outcome	2012
New drugs in acute myeloid leukemia. Current oncology reports, 2002, Volume: 4, Issue:5 Topics: Acute Disease; Adenine Nucleotides; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinonucleosides; Azacitidine; Bevacizumab; Boronic Acids; Bortezomib; Clofarabine; Cytosine; Decitabine; Dioxolanes; Humans; Indoles; Leukemia, Myeloid; Phthalazines; Pyrazines; Pyridines; Pyrroles; Thionucleotides	2002
Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. Journal of cellular biochemistry. Supplement, 1995, Volume: 22 Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Antiviral Agents; Clinical Trials as Topic; HIV-1; Humans; Pyrazines; Schistosomicides; Thiones; Thiophenes; Virus Replication	1995

Trials

2 trial(s) available for pyrazines and Acute Disease

Article	Year
[Clinical study of naoxin sutong in the treatment of acute cerebral infarction]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1994, Volume: 14, Issue:8 Topics: Acute Disease; Aged; Cerebral Infarction; Disulfides; Female; Humans; Hypolipidemic Agents; Male; Malondialdehyde; Middle Aged; Pyrazines; Sulfinic Acids	1994
Sulfametopyrazine in the prophylaxis of exacerbations of chronic bronchitis. British journal of diseases of the chest, 1972, Volume: 66, Issue:4 Topics: Acute Disease; Ampicillin; Attitude of Health Personnel; Attitude to Health; Bronchitis; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Male; Placebos; Pyrazines; Sputum; Sulfonamides	1972

Article

Year

[Clinical study of naoxin sutong in the treatment of acute cerebral infarction].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1994, Volume: 14, Issue:8

Topics: Acute Disease; Aged; Cerebral Infarction; Disulfides; Female; Humans; Hypolipidemic Agents; Male; Malondialdehyde; Middle Aged; Pyrazines; Sulfinic Acids

1994

Sulfametopyrazine in the prophylaxis of exacerbations of chronic bronchitis.

British journal of diseases of the chest, 1972, Volume: 66, Issue:4

Topics: Acute Disease; Ampicillin; Attitude of Health Personnel; Attitude to Health; Bronchitis; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Male; Placebos; Pyrazines; Sputum; Sulfonamides

1972

Other Studies

58 other study(ies) available for pyrazines and Acute Disease

Article	Year
A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study. Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:3(Special) Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Humans; Pyrazines; Retrospective Studies; S100 Calcium Binding Protein beta Subunit; Stroke	2022
T-cell expression of Bruton's tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia. Cellular & molecular immunology, 2020, Volume: 17, Issue:10 Topics: Acute Disease; Agammaglobulinaemia Tyrosine Kinase; Anemia, Aplastic; Animals; Benzamides; Bone Marrow; Cell Proliferation; Graft vs Host Disease; Lymphocyte Activation; Mice, Inbred BALB C; Mice, Inbred C57BL; Phospholipase C gamma; Phosphorylation; Pyrazines; Receptors, Antigen, T-Cell; T-Lymphocytes	2020
Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1. Journal of cellular physiology, 2021, Volume: 236, Issue:9 Topics: Acute Disease; Adenoviridae; Animals; Carbon Tetrachloride; Cell Line, Tumor; Gene Knockdown Techniques; Histone Acetyltransferases; Imidazoles; Insulin-Like Growth Factor I; Liver; Liver Regeneration; Mice, Inbred C57BL; Promoter Regions, Genetic; Protein Binding; Pyrazines; Signal Transduction; Transcriptional Activation	2021
A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia. Cancer discovery, 2018, Volume: 8, Issue:12 Topics: Acute Disease; Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; HL-60 Cells; Humans; Indoles; K562 Cells; Leukemia, Myeloid; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyrazoles; Sulfonamides; THP-1 Cells; U937 Cells; Xenograft Model Antitumor Assays	2018
Tetramethylpyrazine (TMP) protects rats against acute pancreatitis through NF-κB pathway. Bioengineered, 2019, Volume: 10, Issue:1 Topics: Acute Disease; Animals; Apoptosis; Cytokines; Interleukin-6; Male; Mice; NF-kappa B; Pancreatitis; Pyrazines; Rats; Signal Transduction; Tumor Necrosis Factor-alpha	2019
Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA internal medicine, 2013, Apr-08, Volume: 173, Issue:7 Topics: Acute Disease; Adolescent; Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon-Like Peptide 1; Hospitalization; Humans; Logistic Models; Male; Middle Aged; Pancreatitis; Peptides; Pyrazines; Risk Factors; Sitagliptin Phosphate; Triazoles; Venoms	2013
GLP-1 based agents and acute pancreatitis : drug safety falls victim to the three monkey paradigm. BMJ (Clinical research ed.), 2013, Feb-27, Volume: 346 Topics: Acute Disease; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Metaphor; Pancreatitis; Peptides; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Venoms	2013
Two drugs for type 2 diabetes seem to raise risk of acute pancreatitis, study shows. BMJ (Clinical research ed.), 2013, Feb-27, Volume: 346 Topics: Acute Disease; Animals; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Exenatide; Humans; Hypoglycemic Agents; Pancreatitis; Peptides; Pyrazines; Risk Assessment; Risk Factors; Sitagliptin Phosphate; Triazoles; Venoms	2013
Plasma cell-rich acute rejection with monoclonal gammopathy in a renal transplant recipient. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2013, Volume: 11, Issue:2 Topics: Acute Disease; Adult; Antineoplastic Agents; Boronic Acids; Bortezomib; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Paraproteinemias; Patient Compliance; Plasma Cells; Pyrazines	2013
Bortezomib modulates regulatory T cell subpopulations in the process of acute graft-versus-host disease. Clinical laboratory, 2013, Volume: 59, Issue:1-2 Topics: Acute Disease; Animals; Bone Marrow Transplantation; Boronic Acids; Bortezomib; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Graft vs Host Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrazines; T-Lymphocytes, Regulatory	2013
Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma. Blood, 2013, Jun-06, Volume: 121, Issue:23 Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Chromosome Aberrations; Female; Follow-Up Studies; Humans; Incidence; Lenalidomide; Leukemia; Male; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Prognosis; Pyrazines; Risk Factors; Thalidomide; Young Adult	2013
Preventing graft-versus-host disease: transplanters glimpse hope beyond immunosuppressants. Journal of the National Cancer Institute, 2013, Jul-03, Volume: 105, Issue:13 Topics: Acute Disease; Bone Marrow Transplantation; Boronic Acids; Bortezomib; Chronic Disease; Clinical Trials as Topic; Cyclohexanes; Cyclophosphamide; Cyclosporine; Evidence-Based Medicine; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Hydroxamic Acids; Immunosuppressive Agents; Maraviroc; Methotrexate; Pentostatin; Peripheral Blood Stem Cell Transplantation; Pyrazines; Quality of Life; Tacrolimus; Triazoles; Vorinostat	2013
Is bortezomib a rare cause of acute pancreatitis? JOP : Journal of the pancreas, 2013, Nov-10, Volume: 14, Issue:6 Topics: Abdominal Pain; Acute Disease; Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Male; Middle Aged; Multiple Myeloma; Pancreatitis; Pyrazines	2013
IL-1β and TLR4 signaling are involved in the aggravated murine acute graft-versus-host disease caused by delayed bortezomib administration. Journal of immunology (Baltimore, Md. : 1950), 2014, Feb-01, Volume: 192, Issue:3 Topics: Acute Disease; Animals; Bone Marrow Transplantation; Boronic Acids; Bortezomib; Cell Transplantation; Cyclophosphamide; Cytokines; Dendritic Cells; Gene Expression Regulation; Graft vs Host Disease; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protease Inhibitors; Pyrazines; Signal Transduction; Specific Pathogen-Free Organisms; Spleen; Toll-Like Receptor 4; Transplantation Conditioning; Whole-Body Irradiation	2014
High fat diet and GLP-1 drugs induce pancreatic injury in mice. Toxicology and applied pharmacology, 2014, Apr-15, Volume: 276, Issue:2 Topics: Acute Disease; Animals; Apoptosis; Atrophy; Diet, High-Fat; Exenatide; Glucagon-Like Peptide-1 Receptor; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Necrosis; Pancreas; Pancreatitis; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms	2014
Haematological complete remission by ponatinib and bortezomib in a patient with relapsed, Ph⁺ pre-B acute lymphoblastic leukaemia. BMJ case reports, 2014, Apr-12, Volume: 2014 Topics: Acute Disease; Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Humans; Imidazoles; Male; Philadelphia Chromosome; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Pyrazines; Pyridazines; Recurrence; Remission Induction	2014
Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014, Volume: 20, Issue:12 Topics: Acute Disease; Animals; Antibodies, Neutralizing; Antineoplastic Agents; Boronic Acids; Bortezomib; CD8-Positive T-Lymphocytes; Disease Models, Animal; Female; Graft vs Host Disease; Interleukin-6; Liver Diseases; Mice; Organ Specificity; Pyrazines; Skin Diseases	2014
Short-term inhibition of DPP-4 enhances endothelial regeneration after acute arterial injury via enhanced recruitment of circulating progenitor cells. International journal of cardiology, 2014, Nov-15, Volume: 177, Issue:1 Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Carotid Arteries; Cell Movement; Cell Proliferation; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Pyrazines; Regeneration; Signal Transduction; Sitagliptin Phosphate; Stem Cells; Triazoles; Tunica Intima	2014
[Bortezomib-associated acute congestive heart failure in a patient with multiple myeloma]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2015, Volume: 56, Issue:1 Topics: Acute Disease; Aged, 80 and over; Antineoplastic Agents; Boronic Acids; Bortezomib; Electrocardiography; Female; Heart Failure; Humans; Multiple Myeloma; Pyrazines	2015
A Banff Component Scoring-based Histologic Assessment of Bortezomib-based Antibody-mediated Rejection Therapy. Transplantation, 2015, Volume: 99, Issue:8 Topics: Acute Disease; Adult; Atrophy; Biomarkers; Biopsy; Boronic Acids; Bortezomib; Chi-Square Distribution; Chronic Disease; Complement C4b; Drug Monitoring; Female; Fibrosis; Graft Rejection; Humans; Immunity, Humoral; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Middle Aged; Peptide Fragments; Predictive Value of Tests; Pyrazines; Time Factors; Treatment Outcome	2015
Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 82 Topics: Acinar Cells; Acute Disease; Amylases; Animals; Apoptosis; Cell Line; Cytokines; Disease Models, Animal; Down-Regulation; Inflammation Mediators; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pancreatitis; Peroxidase; Phosphorylation; Pyrazines; Rats, Sprague-Dawley	2016
Acute severe cardiac failure in a myeloma patient due to proteasome inhibitor bortezomib. International journal of hematology, 2008, Volume: 88, Issue:2 Topics: Acute Disease; Antineoplastic Agents; Boronic Acids; Bortezomib; Heart Failure; Humans; Male; Middle Aged; Multiple Myeloma; Protease Inhibitors; Pyrazines	2008
Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection. Transplantation, 2008, Dec-27, Volume: 86, Issue:12 Topics: Acute Disease; Biopsy; Boronic Acids; Bortezomib; Creatinine; Graft Rejection; Humans; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Paresthesia; Protease Inhibitors; Pyrazines; Thrombocytopenia; United States; United States Food and Drug Administration	2008
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. European journal of haematology, 2010, Volume: 84, Issue:3 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Angiopoietin-2; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cells, Cultured; Chemokines; Coculture Techniques; Culture Media, Serum-Free; Cytarabine; Diterpenes; Endothelial Cells; Female; Humans; Imidazoles; Leukemia, Myeloid; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Middle Aged; Neoplasm Proteins; NF-kappa B; Protease Inhibitors; Pyrazines; Quinoxalines; Receptor, TIE-2; Recombinant Proteins; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured	2010
Acute dyspnea from treatment of AL amyloidisis with bortezomib. American journal of therapeutics, 2011, Volume: 18, Issue:4 Topics: Acute Disease; Aged; Amyloidosis; Bone Diseases, Metabolic; Boronic Acids; Bortezomib; Dyspnea; Humans; Kidney Diseases; Male; Middle Aged; Protease Inhibitors; Pyrazines	2011
Bortezomib-induced acute pancreatitis. JOP : Journal of the pancreas, 2010, May-05, Volume: 11, Issue:3 Topics: Acute Disease; Antineoplastic Agents; Boronic Acids; Bortezomib; Female; Humans; Middle Aged; Multiple Myeloma; Pancreatitis; Pyrazines	2010
Bortezomib rescue in refractory acute humoral rejection--report of a case. Clinical transplants, 2009 Topics: Acute Disease; Boronic Acids; Bortezomib; Creatinine; Female; Graft Rejection; Histocompatibility Antigens Class I; HLA-D Antigens; Humans; Immunity, Humoral; Immunoglobulins, Intravenous; Immunologic Factors; Isoantibodies; Kidney Failure, Chronic; Kidney Transplantation; Middle Aged; Plasmapheresis; Protease Inhibitors; Pyrazines	2009
Bortezomib for acute humoral rejection in two repeat transplant recipients. Clinical transplants, 2009 Topics: Acute Disease; Adult; B-Lymphocytes; Boronic Acids; Bortezomib; Creatinine; Female; Flow Cytometry; Graft Rejection; HLA-DQ Antigens; Humans; Immunity, Humoral; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Male; Middle Aged; Pyrazines; Reoperation; T-Lymphocytes	2009
Bortezomib as a rescue therapy for hyperacute and multi-drug resistant mixed acute rejection after kidney transplantation. Clinical transplants, 2009 Topics: Acute Disease; Adult; Boronic Acids; Bortezomib; Creatinine; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diuresis; Drug Resistance, Multiple; Graft Rejection; Humans; Immunization; Kidney Transplantation; Male; Pancreas Transplantation; Protease Inhibitors; Pyrazines	2009
Sitagliptin: too many cases of pancreatitis. Prescrire international, 2010, Volume: 19, Issue:106 Topics: Acute Disease; Humans; Hypoglycemic Agents; Pancreatitis; Pyrazines; Sitagliptin Phosphate; Triazoles	2010
Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis. Methods and findings in experimental and clinical pharmacology, 2010, Volume: 32, Issue:9 Topics: Acute Disease; Animals; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Ginsenosides; Isoflavones; Kidney; Liver; Male; Panax; Pancreas; Pancreatitis; Pyrazines; Rats; Rats, Sprague-Dawley; Saponins; Severity of Illness Index	2010
Bortezomib attenuates acute graft-vs.-host disease through interfering with host immature dendritic cells. Experimental hematology, 2011, Volume: 39, Issue:6 Topics: Acute Disease; Animals; Boronic Acids; Bortezomib; Cytokines; Dendritic Cells; Flow Cytometry; Graft vs Host Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrazines	2011
Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011, Volume: 17, Issue:7 Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Aged; Biomarkers; Boronic Acids; Bortezomib; Case-Control Studies; Cytokine Receptor gp130; Female; GATA2 Transcription Factor; Graft vs Host Disease; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Lenalidomide; Male; Melphalan; Middle Aged; Multiple Myeloma; Peripheral Blood Stem Cell Transplantation; Pyrazines; Receptors, CXCR4; T-Lymphocyte Subsets; Thalidomide; Transplantation, Autologous	2011
An update on antibody reduction and rejection reversal following bortezomib use: a report of 52 cases across 10 centers. Clinical transplants, 2010 Topics: Acute Disease; Boronic Acids; Bortezomib; Chronic Disease; Down-Regulation; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Isoantibodies; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Time Factors; Transplants; Treatment Outcome	2010
Bortezomib as an adjuvant to conventional therapy in the treatment of antibody mediated rejection (AMR): the full spectrum. Clinical transplants, 2010 Topics: Acute Disease; Adjuvants, Immunologic; Adult; Boronic Acids; Bortezomib; Female; Graft Rejection; Graft Survival; HLA Antigens; Humans; Immunity, Humoral; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Male; Middle Aged; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Saudi Arabia; Time Factors; Treatment Outcome	2010
Rescue therapy for acute antibody mediated rejection with a proteosome inhibitor after kidney transplantation. Clinical transplants, 2010 Topics: Acute Disease; Adult; Boronic Acids; Bortezomib; Female; Graft Rejection; Graft Survival; HLA Antigens; Humans; Immunity, Humoral; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Male; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Salvage Therapy; Time Factors; Treatment Outcome	2010
Bortezomib for acute humoral rejection treatment at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán in Mexico City: an update. Clinical transplants, 2010 Topics: Academies and Institutes; Acute Disease; Adult; Boronic Acids; Bortezomib; Drug Administration Schedule; Female; Graft Rejection; Graft Survival; HLA Antigens; Humans; Immunity, Humoral; Immunosuppressive Agents; Isoantibodies; Kidney Transplantation; Male; Mexico; Middle Aged; Plasmapheresis; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Time Factors; Treatment Outcome; Young Adult	2010
AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors. Blood, 2011, Dec-15, Volume: 118, Issue:25 Topics: Acute Disease; Animals; Antineoplastic Agents; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Transformation, Neoplastic; Core Binding Factor Alpha 2 Subunit; Cytoplasm; Female; Gene Expression Regulation, Leukemic; HEK293 Cells; Humans; I-kappa B Kinase; Leukemia, Myeloid; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Mutation; NF-kappa B; Protein Binding; Pyrazines; Signal Transduction; Xenograft Model Antitumor Assays	2011
Bortezomib is effective to treat acute humoral rejection after liver transplantation. Transplantation proceedings, 2012, Volume: 44, Issue:2 Topics: Acute Disease; Aged; Antibodies, Monoclonal, Murine-Derived; Boronic Acids; Bortezomib; Drug Therapy, Combination; Female; Graft Rejection; Graft Survival; Humans; Immunity, Humoral; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Plasmapheresis; Protease Inhibitors; Proteasome Endopeptidase Complex; Pulse Therapy, Drug; Pyrazines; Retrospective Studies; Rituximab; Steroids; Taiwan; Time Factors; Treatment Outcome	2012
Synergistic/additive interaction of valproic acid with bortezomib on proliferation and apoptosis of acute myeloid leukemia cells. Leukemia & lymphoma, 2012, Volume: 53, Issue:12 Topics: Acute Disease; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cell Survival; Cyclin D1; Drug Synergism; Gene Expression; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Myeloid; Proteasome Inhibitors; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Telomerase; Valproic Acid	2012
Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib. Proceedings of the National Academy of Sciences of the United States of America, 2004, May-25, Volume: 101, Issue:21 Topics: Acute Disease; Animals; Bone Marrow Transplantation; Boronic Acids; Bortezomib; Cell Line, Tumor; Female; Graft vs Host Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Protease Inhibitors; Pyrazines; Survival Analysis; T-Lymphocytes, Cytotoxic; Transplantation, Homologous	2004
Ligustrazine attenuates acute lung injury after burn trauma. Burns : journal of the International Society for Burn Injuries, 2005, Volume: 31, Issue:4 Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Capillary Permeability; Interleukin-8; Lung; Male; Models, Animal; Peroxidase; Pyrazines; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome	2005
Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition. Journal of immunology (Baltimore, Md. : 1950), 2005, Jun-15, Volume: 174, Issue:12 Topics: Acute Disease; Animals; Arthritis, Experimental; Boronic Acids; Bortezomib; Dermatitis, Contact; Disease Models, Animal; Enzyme Induction; Female; Genetic Vectors; Lipopolysaccharides; Luciferases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Organ Specificity; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Sepsis; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha	2005
Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity. Blood, 2005, Nov-01, Volume: 106, Issue:9 Topics: Acute Disease; Animals; Bone Marrow Transplantation; Boronic Acids; Bortezomib; Enzyme Inhibitors; Female; Gastrointestinal Tract; Graft vs Host Disease; Mice; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger	2005
Severe acute enteritis in a multiple myeloma patient receiving bortezomib and spinal radiotherapy: case report. Journal of chemotherapy (Florence, Italy), 2005, Volume: 17, Issue:3 Topics: Acute Disease; Adult; Antineoplastic Agents; Boronic Acids; Bortezomib; Combined Modality Therapy; Enteritis; Female; Humans; Multiple Myeloma; Palliative Care; Pyrazines; Radiation Injuries; Spinal Neoplasms	2005
Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke. Bioorganic & medicinal chemistry, 2007, Jan-15, Volume: 15, Issue:2 Topics: Acute Disease; Animals; Brain Ischemia; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Neuroprotective Agents; Pyrazines; Rats; Spectrophotometry, Infrared; src-Family Kinases; Stroke; Structure-Activity Relationship	2007
Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis. World journal of gastroenterology, 2006, Dec-21, Volume: 12, Issue:47 Topics: Acute Disease; Animals; Disease Models, Animal; Kidney Diseases; Pancreatitis, Acute Necrotizing; Pyrazines; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilator Agents	2006
[Effects of ligustrazine injection on lymph circulation in rats with acute microcirculation disturbance]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2006, Volume: 29, Issue:9 Topics: Acute Disease; Animals; Drugs, Chinese Herbal; Injections; Lymphatic System; Lymphocytes; Male; Mesentery; Microcirculation; Monocytes; Plants, Medicinal; Pyrazines; Rats; Rats, Wistar	2006
Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells. Haematologica, 2007, Volume: 92, Issue:3 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Boronic Acids; Bortezomib; Cell Division; Cell Line, Tumor; Chemokines; Chemotaxis; DNA Replication; Female; Hematopoietic Cell Growth Factors; Humans; Leukemia, Myeloid; Male; Middle Aged; Neoplasm Proteins; NF-kappa B; Pyrazines; Receptors, Chemokine; Recombinant Fusion Proteins; T-Lymphocytes; Tumor Stem Cell Assay	2007
Effect of amiloride on cisternal fluid [HCO3-] in acute respiratory acidosis. Respiration physiology, 1984, Volume: 58, Issue:1 Topics: Acidosis, Respiratory; Acute Disease; Amiloride; Animals; Bicarbonates; Carbon Dioxide; Dogs; Electrolytes; Injections, Intraventricular; Ion Exchange; Pyrazines	1984
Detection of superoxide free radicals in rats with acute pancreatitis. Pancreas, 1995, Volume: 11, Issue:2 Topics: Acute Disease; Animals; Ceruletide; Free Radicals; Imidazoles; Kinetics; Luminescent Measurements; Male; Pancreas; Pancreatitis; Pyrazines; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides	1995
[Experimental study on acute hypoxia in newborn rabbits]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1995, Volume: 17, Issue:1 Topics: Acute Disease; Animals; Animals, Newborn; Blood Pressure; Calcium Channel Blockers; Dura Mater; Female; Hypoxia; Male; Microcirculation; Pulmonary Artery; Pyrazines; Rabbits; Solanaceous Alkaloids	1995
[Effects of ligustrazine and nitroglycerine on acute hypoxic pulmonary hypertension in anesthetized dogs]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1994, Volume: 16, Issue:2 Topics: Acute Disease; Animals; Blood Pressure; Calcium Channel Blockers; Dogs; Female; Hypertension, Pulmonary; Hypoxia; Male; Methylene Blue; Nitroglycerin; Pyrazines; Vascular Resistance	1994
Effects of vesnarinone, a novel orally active inotropic agent with an immunosuppressive action, on experimental cardiac transplantation in rats. Transplantation, 1996, Dec-15, Volume: 62, Issue:11 Topics: Acute Disease; Animals; Cardiotonic Agents; Chronic Disease; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Male; Pyrazines; Quinolines; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew	1996
Severe acute hepatitis associated with morphazinamide therapy. Journal of hepatology, 1996, Volume: 25, Issue:6 Topics: Acute Disease; Adult; Antitubercular Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Liver Function Tests; Pyrazines	1996
Antithrombotic effects of tetramethylpyrazine in in vivo experiments. International journal of hematology, 2001, Volume: 73, Issue:3 Topics: Acute Disease; Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Pressure; Drug Evaluation, Preclinical; Fibrinolytic Agents; Injections, Intravenous; Mesenteric Arteries; Mesenteric Veins; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Pyrazines; Radiation Injuries, Experimental; Reproducibility of Results; Thrombolytic Therapy; Vasodilator Agents; Venous Thrombosis	2001
Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury. Planta medica, 2002, Volume: 68, Issue:6 Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Dose-Response Relationship, Drug; Econazole; Ferrous Compounds; Free Radical Scavengers; Lipid Peroxidation; Liver; Liver Diseases; Male; Malondialdehyde; Pyrazines; Rats; Rats, Wistar; Silymarin; Superoxides; Vitamin E	2002
Treatment of acute falciparum malaria from Vietnam with trimethoprim and sulfalene. The American journal of tropical medicine and hygiene, 1971, Volume: 20, Issue:4 Topics: Acute Disease; Administration, Oral; Antimalarials; Folic Acid Antagonists; Humans; Malaria; Military Medicine; Plasmodium falciparum; Pyrazines; Pyrimidines; Sulfonamides; United States; Vietnam	1971