pyrazinamide has been researched along with Uremia in 5 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The serum half-life (t1/2) of PZG was 1 h." | 1.28 | Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs. ( Beyer, KH; Gelarden, RT; Jeszenka, EV; Passananti, GT; Vesell, ES, 1992) |
| " Bioavailability of pyrazinamide was only slightly increased in patients, its dialysis extraction coefficient being 55." | 1.27 | Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure. ( Farinotti, R; Fessi, H; Kenouch, S; Méry, JP; Montes, C; Stamatakis, G; Trouvin, JH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Passananti, GT | 1 |
| Vesell, ES | 1 |
| Jeszenka, EV | 1 |
| Gelarden, RT | 1 |
| Beyer, KH | 1 |
| Lacroix, C | 1 |
| Hermelin, A | 1 |
| Guiberteau, R | 1 |
| Guyonnaud, C | 1 |
| Nouveau, J | 1 |
| Duwoos, H | 1 |
| Lafont, O | 1 |
| Stamatakis, G | 1 |
| Montes, C | 1 |
| Trouvin, JH | 1 |
| Farinotti, R | 1 |
| Fessi, H | 1 |
| Kenouch, S | 1 |
| Méry, JP | 1 |
| Garyfallos, A | 1 |
| Magoula, I | 1 |
| Tsapas, G | 1 |
| Danovitch, GM | 1 |
| Weinberger, J | 1 |
| Berlyne, GM | 1 |
5 other studies available for pyrazinamide and Uremia
| Article | Year |
|---|---|
Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Drug Stabilit | 1992 |
Haemodialysis of pyrazinamide in uraemic patients.
Topics: Adult; Biotransformation; Chromatography, High Pressure Liquid; Female; Humans; Male; Pyrazinamide; | 1989 |
Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure.
Topics: Adult; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pyrazinamide; Renal Dialysis; Tuberculosi | 1988 |
Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test.
Topics: Absorption; Creatinine; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Kidney Failur | 1987 |
Uric acid in advanced renal failure.
Topics: Absorption; Adult; Allopurinol; Biological Transport; Chronic Disease; Glomerular Filtration Rate; H | 1972 |