pyrazinamide has been researched along with Tuberculosis, Meningeal in 82 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Tuberculosis, Meningeal: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results are presented of the incidence of hepatitis, nearly always with jaundice, among 1686 patients in clinical trials of the treatment of spinal tuberculosis, of tuberculosis meningitis and of pulmonary tuberculosis with short-course regimens containing rifampicin, isoniazid, streptomycin and pyrazinamide." | 7.67 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide. ( Janardhanam, B; Parthasarathy, R; Ramachandran, P; Santha, T; Sarma, GR; Sivasubramanian, S; Somasundaram, PR; Tripathy, SP, 1986) |
| "Results are presented of the incidence of hepatitis, nearly always with jaundice, among 1686 patients in clinical trials of the treatment of spinal tuberculosis, of tuberculosis meningitis and of pulmonary tuberculosis with short-course regimens containing rifampicin, isoniazid, streptomycin and pyrazinamide." | 3.67 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide. ( Janardhanam, B; Parthasarathy, R; Ramachandran, P; Santha, T; Sarma, GR; Sivasubramanian, S; Somasundaram, PR; Tripathy, SP, 1986) |
| "Levofloxacin is an effective bactericidal category III antitubercular drug." | 2.82 | Safety and efficacy of additional levofloxacin in tuberculous meningitis: A randomized controlled pilot study. ( Betai, S; Bhoi, SK; Kalita, J; Misra, UK, 2016) |
| "Levofloxacin was discontinued more frequently than rifampicin due to SAEs (16 versus 4, P = 0." | 2.79 | Safety and efficacy of levofloxacin versus rifampicin in tuberculous meningitis: an open-label randomized controlled trial. ( Bhoi, SK; Kalita, J; Misra, UK; Prasad, S, 2014) |
| " In the first study, when isoniazid was prescribed daily in a dosage of 20 mg/kg, 39% of the patients developed jaundice; however, when the dosage was reduced to 12 mg/kg, the incidence fell to 16%." | 2.66 | Three chemotherapy studies of tuberculous meningitis in children. ( Duraipandian, M; Nagarajan, M; Prabhakar, R; Ramachandran, P; Ramakrishnan, CV; Tripathy, SP, 1986) |
| "Pyrazinamide also has good CSF penetration and in children receiving dosages of 40 mg/kg the CSF C(max) exceeds the proposed minimal inhibitory concentration of 20 μg/ml." | 2.46 | Cerebrospinal fluid concentrations of antituberculosis agents in adults and children. ( Donald, PR, 2010) |
| "Diffuse pachymeningitis is an uncommon presentation of tuberculous meningitis (TBM)." | 2.44 | Diffuse pachymeningitis due to Mycobacterium tuberculosis: a case report and review of the literature. ( Apisarnthanarak, A; Apisarnthanarak, P; Khawcharoenporn, T; Kiratisin, P; Mundy, LM; Rakskul, P; Warnnissorn, N, 2008) |
| "Pyrazinamide has emerged as a useful drug." | 2.37 | Appearance of tuberculoma during treatment of tuberculous meningitis. ( Behari, M; Maheshwari, MC; Pauranik, A, 1987) |
| "Tuberculomas are best treated medically." | 2.37 | CNS tuberculosis. ( Des Prez, RM; Sheller, JR, 1986) |
| "There has been reports on pediatric TB meningitis manifesting with fever and seizures, altered sensorium or focal deficits." | 1.56 | Tuberculous meningitis manifesting with neuroregression in a eleven month child. ( Kasinathan, A; Palanisamy, S; Serane, VK, 2020) |
| " Nonlinear mixed-effects modeling was used to evaluate the pharmacokinetic properties of the four drugs and to simulate different dosing strategies." | 1.56 | Population Pharmacokinetic Properties of Antituberculosis Drugs in Vietnamese Children with Tuberculous Meningitis. ( Bang, ND; Day, JN; Hoglund, RM; Ngo, VN; Nosoongnoen, W; Panjasawatwong, N; Pouplin, T; Tarning, J; Wattanakul, T, 2020) |
| " A naïve-pooled non-compartmental data analysis was used to describe the pharmacokinetic properties of drugs in the two-age groups of children ≤ 4 years or > 4 years of age." | 1.43 | Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis. ( Bang, ND; Caws, M; Day, JN; Dung, NH; Duong, TN; Phuong, PN; Pouplin, T; Tarning, J; Thwaites, GE; Toi, PV, 2016) |
| "BACKGROUND Tuberculous meningitis is very rare in the United States in immunocompetent hosts." | 1.43 | Tuberculous Meningitis in an Immunocompetent Host: A Case Report. ( Khanna, SR; Kralovic, SM; Prakash, R, 2016) |
| "A 64-year-old man without a history of drug allergy developed fever and severe headache." | 1.42 | [A case of tuberculous meningitis complicated with multiple drug hypersensitivity to antituberculosis agents]. ( Arai, M, 2015) |
| "Intracranial tuberculoma is a possible complication of meningeal, miliary or pulmonary tuberculosis." | 1.33 | [Tuberculoma complicating tuberculous meningitis: description of one paediatric case]. ( Alosi, MM; Ruggeri, C; Scibilia, G; Valenzise, M; Wasniewska, M, 2005) |
| "Patients with non-communicating hydrocephalus received ventriculo-peritoneal shunts shortly after admission while communicating hydrocephalus was treated with oral acetazolamide (100 mg/kg/day) and furosemide (1 mg/kg/day) in 3-4 divided doses." | 1.31 | Long-term follow up of childhood tuberculous meningitis. ( Burger, M; Donald, P; Fertig, G; Schoeman, J; Springer, P; van Rensburg, AJ; van Zyl, F; Wait, J, 2002) |
| "Intracranial tuberculomas are a rare manifestation of neurotuberculosis and are due to hematogenous dissemination of distant focuses of Mycobacterium tuberculosis infection." | 1.31 | [Intracranial tuberculomas developing during treatment of pulmonary tuberculosis: case report]. ( Alves, SM; Belo Neto, E; Brandão, RZ; Novis, SA; Pimentel, ML, 2000) |
| "Tuberculous Meningitis is associated with a high morbidity and mortality if there is a delay in diagnosis." | 1.31 | Diagnostic criteria for Tuberculous Meningitis. ( Seth, R; Sharma, U, 2002) |
| "A prospective, observational study of isoniazid (INH), rifampicin (RMP) and ethionamide (ETH) in a dosage of 20 mg/kg, and pyrazinamide (PZA) 40 mg/kg, all given once daily in hospital for 6 months." | 1.30 | Intensive short course chemotherapy in the management of tuberculous meningitis. ( De Villiers, JN; Donald, PR; Pretorius, M; Schoeman, JF; Springer, P; Van Zyl, LE, 1998) |
| " appropriate dosage of corticosteroids and, 3." | 1.28 | [Evaluation of the treatment of adult tuberculous meningitis]. ( Yu, BZ, 1992) |
| "A patient with tuberculous meningitis is described, who developed brainstem tuberculoma after 7 months of adequate drug therapy and while improving satisfactorily." | 1.27 | Appearance of tuberculoma during the course of TB meningitis. ( Borah, NC; Goulatia, RK; Maheshwari, MC; Mishra, NK, 1984) |
| " Current dosage recommendations are based on total body weight (TBW); drug toxicity might result in obese patients receiving TBW doses." | 1.27 | Dosage of antituberculous drugs in obese patients. ( Geiseler, PJ; Maddux, MS; Manis, RD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (32.93) | 18.7374 |
| 1990's | 16 (19.51) | 18.2507 |
| 2000's | 16 (19.51) | 29.6817 |
| 2010's | 18 (21.95) | 24.3611 |
| 2020's | 5 (6.10) | 2.80 |
| Authors | Studies |
|---|---|
| Kasinathan, A | 1 |
| Serane, VK | 1 |
| Palanisamy, S | 1 |
| Chesdachai, S | 1 |
| Katz, B | 1 |
| Sapkota, S | 1 |
| Bongomin, F | 1 |
| Khan, SA | 1 |
| Oravec, T | 1 |
| Kalita, J | 3 |
| Misra, UK | 3 |
| Singh, VK | 1 |
| Pandey, PC | 1 |
| Thomas, J | 1 |
| Panjasawatwong, N | 1 |
| Wattanakul, T | 1 |
| Hoglund, RM | 1 |
| Bang, ND | 2 |
| Pouplin, T | 2 |
| Nosoongnoen, W | 1 |
| Ngo, VN | 1 |
| Day, JN | 2 |
| Tarning, J | 2 |
| Nadri, G | 1 |
| Taneja, S | 1 |
| Singh, V | 1 |
| Mittal, P | 1 |
| Soto-Cabrera, E | 1 |
| Villamil-Osorio, LV | 1 |
| Garcia-Luna, RC | 1 |
| Carrera-Pineda, R | 1 |
| Vibha, D | 1 |
| Prasad, K | 1 |
| Andriescu, EC | 1 |
| Khetan, NG | 1 |
| Mazur, L | 1 |
| Smith, KC | 1 |
| Benson, SM | 1 |
| Narasimhamurthy, R | 1 |
| Prasad, S | 1 |
| Bhoi, SK | 2 |
| Molton, JS | 1 |
| Huggan, PJ | 1 |
| Archuleta, S | 1 |
| Török, ME | 2 |
| Arai, M | 1 |
| Toi, PV | 1 |
| Phuong, PN | 1 |
| Dung, NH | 1 |
| Duong, TN | 1 |
| Caws, M | 2 |
| Thwaites, GE | 2 |
| Betai, S | 1 |
| Khanna, SR | 1 |
| Kralovic, SM | 1 |
| Prakash, R | 1 |
| Khawcharoenporn, T | 1 |
| Apisarnthanarak, A | 1 |
| Apisarnthanarak, P | 1 |
| Rakskul, P | 1 |
| Warnnissorn, N | 1 |
| Kiratisin, P | 1 |
| Mundy, LM | 1 |
| Moon, S | 1 |
| Son, J | 1 |
| Chang, W | 1 |
| Cecchini, D | 1 |
| Ambrosioni, J | 1 |
| Brezzo, C | 1 |
| Corti, M | 1 |
| Rybko, A | 1 |
| Perez, M | 1 |
| Poggi, S | 1 |
| Ambroggi, M | 1 |
| Thwaites, G | 1 |
| Fisher, M | 2 |
| Hemingway, C | 1 |
| Scott, G | 1 |
| Solomon, T | 1 |
| Innes, J | 1 |
| Laktaoui, A | 1 |
| Naoumi, A | 1 |
| Reda, K | 1 |
| Kriet, M | 1 |
| Elouarsani, A | 1 |
| Khayati, A | 1 |
| Elharradi, A | 1 |
| Rouimi, A | 1 |
| Douhal, A | 1 |
| Mounahc, J | 1 |
| Houmadi, A | 1 |
| Arquinio, L | 1 |
| García-Gasalla, M | 1 |
| Losada, I | 1 |
| Sarasibar, H | 1 |
| Donald, PR | 6 |
| Morales, S | 1 |
| Ramos, W | 1 |
| Vílchez, R | 1 |
| Pérez, J | 1 |
| Alvarado, M | 1 |
| Bhavnani, SM | 1 |
| Chau, TT | 1 |
| Hammel, JP | 1 |
| Van Wart, SA | 1 |
| Mai, PP | 1 |
| Reynolds, DK | 1 |
| Dung, NT | 1 |
| Hien, TT | 1 |
| Kulawy, R | 1 |
| Farrar, J | 1 |
| Ambrose, PG | 1 |
| Takahashi, I | 1 |
| Yamada, M | 1 |
| Matsushima, M | 1 |
| Sato, K | 1 |
| Kano, T | 1 |
| Yabe, I | 1 |
| Sasaki, H | 1 |
| Schoeman, J | 1 |
| Wait, J | 1 |
| Burger, M | 1 |
| van Zyl, F | 1 |
| Fertig, G | 1 |
| van Rensburg, AJ | 1 |
| Springer, P | 2 |
| Donald, P | 1 |
| Wang, JT | 1 |
| Hung, CC | 1 |
| Sheng, WH | 1 |
| Wang, JY | 1 |
| Chang, SC | 1 |
| Luh, KT | 1 |
| DEGLI ESPOSTI, A | 2 |
| CORSINI, F | 1 |
| SANTOPADRE, I | 1 |
| PFUETZE, KH | 1 |
| PYLE, MM | 1 |
| GRAZIA, G | 1 |
| FOUQUET, J | 1 |
| CORNU, P | 1 |
| Ruggeri, C | 1 |
| Valenzise, M | 1 |
| Alosi, MM | 1 |
| Scibilia, G | 1 |
| Wasniewska, M | 1 |
| Kumar, R | 1 |
| Dwivedi, A | 1 |
| Kumar, P | 1 |
| Kohli, N | 1 |
| Maree, F | 1 |
| Hesseling, AC | 1 |
| Schaaf, HS | 2 |
| Marais, BJ | 1 |
| Beyers, N | 1 |
| van Helden, P | 1 |
| Warren, RM | 1 |
| Schoeman, JF | 3 |
| Borah, NC | 1 |
| Maheshwari, MC | 3 |
| Mishra, NK | 1 |
| Goulatia, RK | 1 |
| Stone, MM | 1 |
| Vannier, AM | 1 |
| Storch, SK | 1 |
| Peterson, C | 1 |
| Nitta, AT | 1 |
| Zhang, Y | 1 |
| Fortún, J | 1 |
| Gómez-Mampaso, E | 1 |
| Navas, E | 1 |
| Hermida, JM | 1 |
| Antela, A | 1 |
| Guerrero, A | 1 |
| Seth, V | 1 |
| Beotra, A | 1 |
| Seth, SD | 1 |
| Semwal, OP | 1 |
| Kabra, S | 1 |
| Jain, Y | 1 |
| Mukhopadhya, S | 1 |
| Seifart, HI | 2 |
| Kruger, PB | 1 |
| Parkin, DP | 1 |
| van Jaarsveld, PP | 1 |
| de Gans, J | 1 |
| Palacios, PT | 1 |
| Méndez Ramos, MJ | 1 |
| Negreira Cepeda, S | 1 |
| Tomlinson, DR | 1 |
| Coker, RJ | 1 |
| Pozniak, A | 1 |
| Garavelli, PL | 1 |
| Chang, AB | 1 |
| Grimwood, K | 1 |
| Harvey, AS | 1 |
| Rosenfeld, JV | 1 |
| Olinsky, A | 1 |
| Van Zyl, LE | 1 |
| De Villiers, JN | 1 |
| Pretorius, M | 1 |
| Rao, GP | 1 |
| Pimentel, ML | 1 |
| Alves, SM | 1 |
| Novis, SA | 1 |
| Brandão, RZ | 1 |
| Belo Neto, E | 1 |
| Gie, RP | 1 |
| van Rie, A | 1 |
| van Helden, PD | 1 |
| Cotton, MF | 1 |
| van Loenhout-Rooyackers, JH | 1 |
| Keyser, A | 1 |
| Laheij, RJ | 1 |
| Verbeek, AL | 1 |
| van der Meer, JW | 1 |
| Kassubek, J | 1 |
| Zucker, B | 1 |
| Oehm, E | 1 |
| Serr, A | 1 |
| Arnold, SM | 1 |
| Lücking, CH | 1 |
| Els, T | 1 |
| Seth, R | 1 |
| Sharma, U | 1 |
| Clarke, PD | 1 |
| Fallon, RJ | 1 |
| Sifontes, JE | 1 |
| Yu, BZ | 1 |
| Jacobs, RF | 1 |
| Sunakorn, P | 1 |
| Chotpitayasunonah, T | 1 |
| Pope, S | 1 |
| Kelleher, K | 1 |
| Kaojarern, S | 2 |
| Supmonchai, K | 2 |
| Phuapradit, P | 3 |
| Mokkhavesa, C | 2 |
| Krittiyanunt, S | 1 |
| Alarcón, F | 1 |
| Escalante, L | 1 |
| Pérez, Y | 1 |
| Banda, H | 1 |
| Chacón, G | 1 |
| Dueñas, G | 1 |
| Teoh, R | 3 |
| Humphries, MJ | 2 |
| Chan, JC | 1 |
| Ng, HK | 1 |
| O'Mahony, G | 1 |
| O'Kennedy, A | 1 |
| Ellard, GA | 2 |
| Gabriel, M | 1 |
| Pauranik, A | 2 |
| Behari, M | 2 |
| Seifart, H | 1 |
| Sheller, JR | 1 |
| Des Prez, RM | 1 |
| Vejjajiva, A | 1 |
| Woo, J | 1 |
| Wong, CL | 1 |
| Chan, K | 1 |
| Ramachandran, P | 2 |
| Duraipandian, M | 1 |
| Nagarajan, M | 1 |
| Prabhakar, R | 1 |
| Ramakrishnan, CV | 1 |
| Tripathy, SP | 2 |
| Parthasarathy, R | 1 |
| Sarma, GR | 1 |
| Janardhanam, B | 1 |
| Santha, T | 1 |
| Sivasubramanian, S | 1 |
| Somasundaram, PR | 1 |
| Geiseler, PJ | 1 |
| Manis, RD | 1 |
| Maddux, MS | 1 |
| Acharya, VN | 1 |
| Kudva, BT | 1 |
| Retnam, VJ | 1 |
| Mehta, PJ | 1 |
| Forgan-Smith, R | 1 |
| Newton, D | 1 |
| Mitchison, DA | 1 |
| Bartsocas, CS | 1 |
| Pantelakis, SN | 1 |
| Tauchnitz, C | 1 |
| Storch, W | 1 |
| Ellorhaoui, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis[NCT03092817] | Phase 3 | 520 participants (Actual) | Interventional | 2017-05-25 | Active, not recruiting | ||
| A Randomized Double Blind Placebo Controlled Non-inferiority Trial of Adjunctive Dexamethasone for the Treatment of HIV-uninfected Adults With Tuberculous Meningitis Stratified by Leukotriene A4 Hydrolase Genotype[NCT03100786] | Phase 3 | 640 participants (Anticipated) | Interventional | 2018-02-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for pyrazinamide and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Diagnostic Challenges and Dilemmas in Tuberculous Meningitis.
Topics: Adult; Antitubercular Agents; Asthma; Ethambutol; Female; Headache; Hospitalization; Humans; Hydroce | 2020 |
Tuberculous meningitis: advances in diagnosis and treatment.
Topics: Antitubercular Agents; Drug Therapy, Combination; Host-Pathogen Interactions; Humans; Isoniazid; Myc | 2015 |
Diffuse pachymeningitis due to Mycobacterium tuberculosis: a case report and review of the literature.
Topics: Adrenal Cortex Hormones; Aged; Antibiotics, Antitubercular; Antitubercular Agents; Ethambutol; Femal | 2008 |
Cerebrospinal fluid concentrations of antituberculosis agents in adults and children.
Topics: Adult; Antitubercular Agents; Child; Dose-Response Relationship, Drug; Female; Humans; Isoniazid; Ma | 2010 |
The chemotherapy of tuberculous meningitis in children and adults.
Topics: Adult; Aminosalicylic Acid; Antibiotics, Antitubercular; Antitubercular Agents; Child; Dose-Response | 2010 |
[Fulminant hepatitis during the therapy for tuberculous meningitis].
Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Drug Therapy, Combination; Female; Hepati | 1996 |
Tuberculous meningitis: is a 6-month treatment regimen sufficient?
Topics: Adult; Antitubercular Agents; Child; Drug Administration Schedule; Drug Therapy, Combination; Humans | 2001 |
Advances in the treatment of tuberculosis.
Topics: Aminosalicylic Acids; Drug Therapy, Combination; Ethambutol; Female; Humans; Isoniazid; Pyrazinamide | 1976 |
Appearance of tuberculoma during treatment of tuberculous meningitis.
Topics: Adult; Child; Female; Humans; Pyrazinamide; Tomography, X-Ray Computed; Tuberculoma; Tuberculosis, M | 1987 |
CNS tuberculosis.
Topics: Biopsy; Cerebral Ventricles; Cerebrospinal Fluid; Ethambutol; Humans; Hyaluronoglucosaminidase; Ison | 1986 |
5 trials available for pyrazinamide and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Safety and efficacy of levofloxacin versus rifampicin in tuberculous meningitis: an open-label randomized controlled trial.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Aspirin; Drug Therapy, Combination; Ethambutol; Fema | 2014 |
Safety and efficacy of additional levofloxacin in tuberculous meningitis: A randomized controlled pilot study.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Disability Evaluation; Drug Therapy, Combination; Et | 2016 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
Penetration of pyrazinamide into the cerebrospinal fluid in tuberculous meningitis.
Topics: Adolescent; Adult; Aged; Humans; Middle Aged; Pyrazinamide; Tuberculosis, Meningeal | 1987 |
Three chemotherapy studies of tuberculous meningitis in children.
Topics: Antitubercular Agents; Child; Child, Preschool; Drug Therapy, Combination; Ethambutol; Female; Human | 1986 |
67 other studies available for pyrazinamide and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Tuberculous meningitis manifesting with neuroregression in a eleven month child.
Topics: Acetazolamide; Antitubercular Agents; Carbonic Anhydrase Inhibitors; Cerebrospinal Fluid; Early Medi | 2020 |
A Complete Triad: Horner's Syndrome in Tuberculous Meningitis.
Topics: Antitubercular Agents; Brain; Ethambutol; Horner Syndrome; Humans; Immunocompetence; Isoniazid; Male | 2020 |
Inclusion of Mechanical Ventilation in Severity Staging of Tuberculous Meningitis Improves Outcome Prediction.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antitubercular Agents; Child; Child, Preschool; Consciousn | 2020 |
Population Pharmacokinetic Properties of Antituberculosis Drugs in Vietnamese Children with Tuberculous Meningitis.
Topics: Adult; Antitubercular Agents; Asian People; Child; Ethambutol; Humans; Isoniazid; Pyrazinamide; Tube | 2020 |
Anaphylaxis to rifampicin and pyrazinamide in a child with tuberculous meningitis: A case report.
Topics: Anaphylaxis; Antitubercular Agents; Child; Drug Hypersensitivity; Humans; Male; Pyrazinamide; Rifamp | 2017 |
[Optochiasmatic tuberculomas as a paradoxical reaction to treatment for meningeal tuberculosis].
Topics: Adult; Antitubercular Agents; Brain Infarction; Diagnostic Errors; Disease Progression; Drug Resista | 2018 |
Prevailing practices in the treatment of tuberculous meningitis (TBM): a cross-sectional study.
Topics: Anticonvulsants; Antitubercular Agents; Cross-Sectional Studies; Disease Management; Drug Therapy, C | 2019 |
Tuberculosis Meningitis in a 10-Month-Old Living in an Immigrant Township.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Brain; Diagnosis, Differential; Electroencephalography | 2019 |
Severe hyponatremia and MRI point to diagnosis of tuberculous meningitis in the Southwest USA.
Topics: Adult; Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Female; Humans; Hyponatremia; I | 2013 |
Infliximab therapy in two cases of severe neurotuberculosis paradoxical reaction.
Topics: Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antitubercular Agents; Dexamethasone; Etham | 2015 |
[A case of tuberculous meningitis complicated with multiple drug hypersensitivity to antituberculosis agents].
Topics: Antitubercular Agents; Drug Hypersensitivity; Drug Therapy, Combination; Ethambutol; Ethionamide; Hu | 2015 |
Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis.
Topics: Adolescent; Antitubercular Agents; Arylamine N-Acetyltransferase; Asian People; Child; Child, Presch | 2016 |
Tuberculous Meningitis in an Immunocompetent Host: A Case Report.
Topics: Antitubercular Agents; Cerebrospinal Fluid; Drug Therapy, Combination; Emigrants and Immigrants; Hum | 2016 |
A case of oculomotor nerve palsy and choroidal tuberculous granuloma associated with tuberculous meningoencephalitis.
Topics: Adolescent; Antitubercular Agents; Blepharoptosis; Choroid Diseases; Dexamethasone; Drug Therapy, Co | 2008 |
Tuberculous meningitis in HIV-infected and non-infected patients: comparison of cerebrospinal fluid findings.
Topics: Adult; Antitubercular Agents; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Drug Resistance, Mu | 2009 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
[Macular tuberculoma and optic neuritis: rare association with tuberculosis meningoencephalitis].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antitubercular Agents; Calcinosis; Confusion; Dip | 2009 |
[Onset of neurological symptoms during tuberculosis treatment: description of two cases].
Topics: Adult; Aged, 80 and over; Antitubercular Agents; Aphasia; Child, Preschool; Drug Therapy, Combinatio | 2010 |
Effectiveness and safety of the schedules of short and long term treatment for tuberculous meningoencephalitis at two hospitals of Lima--Peru.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Drug Administration Schedule; Drug Therapy, Combinat | 2011 |
[Treatment of intractable tuberculous meningitis using intrathecal isoniazid administration and steroid pulse therapy; a report of two cases].
Topics: Adult; Antitubercular Agents; Dexamethasone; Drug Therapy, Combination; Ethambutol; Female; Humans; | 2012 |
Long-term follow up of childhood tuberculous meningitis.
Topics: Acetazolamide; Anti-Inflammatory Agents; Antitubercular Agents; Brain; Child; Cognition Disorders; D | 2002 |
Prognosis of tuberculous meningitis in adults in the era of modern antituberculous chemotherapy.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Female; Human | 2002 |
[First results in the treatment of tuberculous meningitis with the use of pyrazinamide and the first studies on its action on isoniazid-resistant strains].
Topics: Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pyrazinamide; Pyrimidines; Tuberculosis; Tuberculosis | 1956 |
[Use of pyrazinamide in acute tuberculous disseminations; 1 year's experience in the Centro Meningitic di Bologna].
Topics: Child; Humans; Infant; Meningitis; Niacin; Nicotinic Acids; Pyrazinamide; Tuberculosis; Tuberculosis | 1957 |
[Tests of liver function during pyrazinamide therapy].
Topics: Child; Humans; Infant; Isoniazid; Liver; Niacin; Nicotinic Acids; Pyrazinamide; Tuberculosis; Tuberc | 1959 |
RECENT ADVANCES IN TREATMENT OF ORGAN TUBERCULOSIS.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Child; Cycloserine; Ethionamide; I | 1964 |
[INDICATIONS AND UTILITY OF INTRATHECAL AND INTRAVENTRICULAR TREATMENT IN THE THERAPY OF TUBERCULAR MENINGITIS].
Topics: Child; Chlorpromazine; Humans; Injections; Injections, Spinal; Isoniazid; Prednisolone; Pyrazinamide | 1963 |
[TUBERCULOUS MENINGITIS WITH RESISTANT KOCH BACILLI; RECOVERY OWING TO CYCLOSERINE-PYRAZINAMIDE COMBINATION].
Topics: Adolescent; Aminosalicylic Acid; Aminosalicylic Acids; Cycloserine; Drug Resistance; Drug Resistance | 1964 |
[Tuberculoma complicating tuberculous meningitis: description of one paediatric case].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibiotics, Antitubercular; Antitubercular Agents; | 2005 |
Tuberculous meningitis in BCG vaccinated and unvaccinated children.
Topics: Antitubercular Agents; BCG Vaccine; Child, Preschool; Female; Humans; Injections, Intramuscular; Iso | 2005 |
Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis.
Topics: Adolescent; Antibiotics, Antitubercular; Antitubercular Agents; Child; Child, Preschool; Ethionamide | 2007 |
Appearance of tuberculoma during the course of TB meningitis.
Topics: Adolescent; Brain Stem; Female; Humans; Isoniazid; Prednisolone; Pyrazinamide; Rifampin; Tomography, | 1984 |
Brief report: meningitis due to iatrogenic BCG infection in two immunocompromised children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antitubercular Agents; Child, Preschool; Drug Contam | 1995 |
[Tuberculous meningitis caused by resistant microorganisms. Therapeuticfailure in 2 patients with HIV infection and disseminated tuberculosis].
Topics: Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Drug Resistance, Microbial; Dru | 1994 |
Serum concentrations of rifampicin and isoniazid in tuberculosis.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Female; Half-Life; Humans; Infant; I | 1993 |
Therapeutic monitoring of antituberculosis drugs by direct in-line extraction on a high-performance liquid chromatography system.
Topics: Antitubercular Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Ethionamide; Humans; I | 1993 |
[The many aspects pf the acid-fast rods].
Topics: Drug Resistance, Microbial; Humans; Pyrazinamide; Tuberculosis, Meningeal | 1993 |
Ocular lesions of tuberculosis.
Topics: Adolescent; Choroid Diseases; Drug Combinations; Female; Humans; Infant; Isoniazid; Male; Pyrazinami | 1993 |
The management of mycobacterial infections in HIV seropositive individuals. Jefferiss Wing Therapeutics and Protocols Group.
Topics: Adrenal Cortex Hormones; Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitu | 1996 |
Tuberculous meningitis.
Topics: Antitubercular Agents; Humans; Isoniazid; Pyrazinamide; Rifampin; Streptomycin; Tuberculosis, Mening | 1997 |
Central nervous system tuberculosis after resolution of miliary tuberculosis.
Topics: Antitubercular Agents; Central Nervous System Infections; Dexamethasone; Drug Therapy, Combination; | 1998 |
Intensive short course chemotherapy in the management of tuberculous meningitis.
Topics: Antibiotics, Antitubercular; Antitubercular Agents; Child; Child, Preschool; Drug Therapy, Combinati | 1998 |
Spinal intramedullary tuberculous lesion: medical management. Report of four cases.
Topics: Adolescent; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Clinical Protocols; Female; F | 2000 |
[Intracranial tuberculomas developing during treatment of pulmonary tuberculosis: case report].
Topics: Adult; Antitubercular Agents; Humans; Isoniazid; Magnetic Resonance Imaging; Male; Pyrazinamide; Rif | 2000 |
Second episode of tuberculosis in an HIV-infected child: relapse or reinfection?
Topics: AIDS-Related Opportunistic Infections; Amoxicillin-Potassium Clavulanate Combination; Antibiotics, A | 2000 |
Tuberculous meningoencephalitis in HIV-seronegative patients: variety of clinical presentation and impact on diagnostics and treatment.
Topics: Adult; Aged; Antitubercular Agents; Brain; Drug Therapy, Combination; Ethambutol; Female; HIV Serone | 2001 |
Diagnostic criteria for Tuberculous Meningitis.
Topics: Antitubercular Agents; Child; Child, Preschool; Humans; Isoniazid; Mycobacterium tuberculosis; Progn | 2002 |
Editorial: Treatment of tuberculous meningitis.
Topics: Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Pyrazinamide; Rifampin; Streptomycin; Tube | 1976 |
The treatment of tuberculous meningitis.
Topics: Aminosalicylic Acid; Antitubercular Agents; Drug Evaluation; Drug Therapy, Combination; Ethambutol; | 1978 |
Editorial: Rifampin in tuberculous meningitis.
Topics: Child; Child, Preschool; Drug Hypersensitivity; Drug Interactions; Drug Therapy, Combination; Humans | 1975 |
[Evaluation of the treatment of adult tuberculous meningitis].
Topics: Adolescent; Adult; Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Intracranial Pr | 1992 |
Intensive short course chemotherapy for tuberculous meningitis.
Topics: Antitubercular Agents; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combinat | 1992 |
Effect of steroids on cerebrospinal fluid penetration of antituberculous drugs in tuberculous meningitis.
Topics: Adult; Aged; Antitubercular Agents; Female; Humans; Isoniazid; Male; Middle Aged; Pyrazinamide; Rifa | 1991 |
Tuberculous meningitis. Short course of chemotherapy.
Topics: Adolescent; Adult; Aged; Child; Drug Combinations; Female; Humans; Infant; Isoniazid; Male; Middle A | 1990 |
The blood/cerebrospinal fluid partitioning of pyrazinamide: a study during the course of treatment of tuberculous meningitis.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Blood-Brain Barrier; Drug Therapy, Combination; Fema | 1990 |
Internuclear ophthalmoplegia in tuberculous meningitis.
Topics: Adult; Brain Stem; Cerebral Infarction; Dexamethasone; Drug Therapy, Combination; Endarteritis; Huma | 1989 |
Hepatic toxicity during chemotherapy for severe tuberculosis meningitis.
Topics: Alanine Transaminase; Antitubercular Agents; Aspartate Aminotransferases; Chemical and Drug Induced | 1987 |
Cerebrospinal fluid pyrazinamide concentrations in children with tuberculous meningitis.
Topics: Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Intracranial Pressure; Pyraz | 1988 |
Treatment of tuberculous meningitis: role of short-course chemotherapy.
Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination; Humans; Isoniazid; | 1987 |
Liquid chromatographic assay for the simultaneous determination of pyrazinamide and rifampicin in serum samples from patients with tuberculous meningitis.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Pyrazinamide; Rifampin; Tuberculosis, Men | 1987 |
Pyrazinamide in treatment of tuberculous meningitis.
Topics: Drug Therapy, Combination; Humans; Isoniazid; Pyrazinamide; Rifampin; Tuberculosis, Meningeal | 1986 |
Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide.
Topics: Adolescent; Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 1986 |
Dosage of antituberculous drugs in obese patients.
Topics: Adult; Antitubercular Agents; Ethambutol; Humans; Male; Obesity; Pyrazinamide; Rifampin; Streptomyci | 1985 |
Adult tuberculous meningitis: comparative study of different chemotherapeutic regimens.
Topics: Adolescent; Adult; Aminosalicylic Acid; Antitubercular Agents; Drug Therapy, Combination; Ethambutol | 1985 |
Pyrazinamide and other drugs in tuberculous meningitis.
Topics: Adult; Blood-Brain Barrier; Humans; Isoniazid; Male; Pyrazinamide; Rifampin; Streptomycin; Tuberculo | 1973 |
Human growth hormone therapy in hypopituitarism due to tuberculous meningitis.
Topics: Adolescent; Aminosalicylic Acids; Blood Glucose; Body Height; Calcinosis; Child; Child, Preschool; D | 1973 |
[Chronic tuberculous meningitis in a case of known Mycobacterium kansasii infection].
Topics: Adult; Burns; Cell Count; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Drug Therapy, Combinati | 1974 |