pyrazinamide has been researched along with Renal Insufficiency in 1 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Marked increases in metabolites of the L-tryptophan-kynurenine pathway, L-kynurenine and quinolinic acid (Quin), were observed in serum and cerebrospinal fluid (CSF) of both the rat and human with renal insufficiency." | 7.70 | Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. ( Fujigaki, S; Fujii, H; Heyes, MP; Noma, A; Saito, K; Seishima, M; Shibata, K; Takemura, M; Wada, H, 2000) |
| "Marked increases in metabolites of the L-tryptophan-kynurenine pathway, L-kynurenine and quinolinic acid (Quin), were observed in serum and cerebrospinal fluid (CSF) of both the rat and human with renal insufficiency." | 3.70 | Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. ( Fujigaki, S; Fujii, H; Heyes, MP; Noma, A; Saito, K; Seishima, M; Shibata, K; Takemura, M; Wada, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, K | 1 |
| Fujigaki, S | 1 |
| Heyes, MP | 1 |
| Shibata, K | 1 |
| Takemura, M | 1 |
| Fujii, H | 1 |
| Wada, H | 1 |
| Noma, A | 1 |
| Seishima, M | 1 |
1 other study available for pyrazinamide and Renal Insufficiency
| Article | Year |
|---|---|
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
Topics: Adult; Albuminuria; Animals; Carboxy-Lyases; Enzyme Inhibitors; Female; Humans; Hydrolases; Kynureni | 2000 |