pyrazinamide has been researched along with Pott Disease in 36 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results are presented of the incidence of hepatitis, nearly always with jaundice, among 1686 patients in clinical trials of the treatment of spinal tuberculosis, of tuberculosis meningitis and of pulmonary tuberculosis with short-course regimens containing rifampicin, isoniazid, streptomycin and pyrazinamide." | 7.67 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide. ( Janardhanam, B; Parthasarathy, R; Ramachandran, P; Santha, T; Sarma, GR; Sivasubramanian, S; Somasundaram, PR; Tripathy, SP, 1986) |
| "Results are presented of the incidence of hepatitis, nearly always with jaundice, among 1686 patients in clinical trials of the treatment of spinal tuberculosis, of tuberculosis meningitis and of pulmonary tuberculosis with short-course regimens containing rifampicin, isoniazid, streptomycin and pyrazinamide." | 3.67 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide. ( Janardhanam, B; Parthasarathy, R; Ramachandran, P; Santha, T; Sarma, GR; Sivasubramanian, S; Somasundaram, PR; Tripathy, SP, 1986) |
| "Evidences of spinal tuberculosis have been found in Egyptian mummies and the disease is one of the oldest diseases afflicting humans." | 2.42 | Management of spinal tuberculosis--current concepts. ( Agarwal, S; Jain, UK, 2004) |
| "It controls infection, corrects the kyphosis, and maintains correction and neurological improvement over time." | 1.43 | Anterior debridement may not be necessary in the treatment of tuberculous spondylitis of the thoracic and lumbar spine in adults: a retrospective study. ( Chang, MC; Chou, PH; Lin, CP; Liu, CL; Ma, HL; Wang, ST; Yu, WK, 2016) |
| "No other case of spondylodiscitis caused by a mycobacterial coinfection pathogen has been reported so far." | 1.33 | [Cervical spondylodiscitis: one pathogen may hide another]. ( Ader, F; Bernard, L; Carlier, R; Perronne, C; Salomon, J; Toubiana, J, 2006) |
| "The characteristic syndrome, Pott's disease, reflects the consequence of infection of the lower thoracic and lumbar spine, the most common site of tuberculous vertebral osteomyelitis." | 1.29 | Cervical tuberculous vertebral osteomyelitis: case report and discussion of the literature. ( Langer, B; Quader, Z; Simon, D; Wurtz, R, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (16.67) | 18.7374 |
| 1990's | 7 (19.44) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 9 (25.00) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, X | 1 |
| Che, X | 1 |
| Qiu, Z | 1 |
| Chao, J | 1 |
| Kong, Z | 1 |
| Li, H | 1 |
| Marcos-Pinto, A | 1 |
| Marques, T | 1 |
| Machado, AP | 1 |
| Soares-de-Almeida, L | 1 |
| Filipe, P | 1 |
| Bozzola, E | 1 |
| Bozzola, M | 1 |
| Magistrelli, A | 1 |
| Calcaterra, V | 1 |
| Larizza, D | 1 |
| Lancella, L | 1 |
| Villani, A | 1 |
| Alawad, AAM | 1 |
| Khalifa, AFM | 1 |
| Avcu, G | 1 |
| Sahbudak Bal, Z | 1 |
| Duyu, M | 1 |
| Akkus, E | 1 |
| Karapinar, B | 1 |
| Vardar, F | 1 |
| Zhang, Z | 1 |
| Luo, F | 1 |
| Zhou, Q | 1 |
| Dai, F | 1 |
| Sun, D | 1 |
| Xu, J | 1 |
| Wang, ST | 1 |
| Ma, HL | 1 |
| Lin, CP | 1 |
| Chou, PH | 1 |
| Liu, CL | 1 |
| Yu, WK | 1 |
| Chang, MC | 1 |
| Ge, Z | 1 |
| Wang, Z | 1 |
| Wei, M | 1 |
| Thwaites, G | 1 |
| Fisher, M | 1 |
| Hemingway, C | 1 |
| Scott, G | 1 |
| Solomon, T | 1 |
| Innes, J | 1 |
| Ermertcan, AT | 1 |
| Öztürk, F | 1 |
| Gençoğlan, G | 1 |
| İnanir, I | 1 |
| Özkütük, N | 1 |
| Temiz, P | 1 |
| Liu, P | 1 |
| Zhu, Q | 1 |
| Jiang, J | 1 |
| Rigotti, S | 1 |
| Boriani, L | 1 |
| Luzi, CA | 1 |
| Marocco, S | 1 |
| Angheben, A | 1 |
| Gasbarrini, A | 1 |
| Zorzi, C | 1 |
| CHOFNAS, I | 1 |
| SURRETT, NE | 1 |
| SEVERN, HD | 1 |
| Islam, N | 1 |
| Ahmedani, MY | 1 |
| Agarwal, S | 1 |
| Jain, UK | 1 |
| Chacko, AG | 1 |
| Moorthy, RK | 1 |
| Chandy, MJ | 1 |
| Toubiana, J | 1 |
| Salomon, J | 1 |
| Ader, F | 1 |
| Perronne, C | 1 |
| Carlier, R | 1 |
| Bernard, L | 1 |
| Listernick, R | 1 |
| Ribeiro, MA | 1 |
| Barouni, AS | 1 |
| Augusto, CJ | 1 |
| Augusto, MV | 1 |
| Lopes, MT | 1 |
| Salas, CE | 1 |
| Meurice, JC | 1 |
| Dore, P | 1 |
| Lamotte, F | 1 |
| Bataille, B | 1 |
| Levard, G | 1 |
| Castets, M | 1 |
| Patte, F | 1 |
| Wurtz, R | 1 |
| Quader, Z | 1 |
| Simon, D | 1 |
| Langer, B | 1 |
| Sánchez Pernaute, R | 1 |
| Berciano, J | 1 |
| Rebollo, M | 1 |
| Pascual, J | 1 |
| el Khader, K | 1 |
| el Fassi, J | 1 |
| Karmouni, T | 1 |
| Tazi, K | 1 |
| Ibnattya, A | 1 |
| Hachimi, M | 1 |
| Lakrissa, A | 1 |
| Choonhakarn, C | 1 |
| Janma, J | 1 |
| Aljada, IS | 1 |
| Crane, JK | 1 |
| Corriere, N | 1 |
| Wagle, DG | 1 |
| Amsterdam, D | 1 |
| Barrière, V | 1 |
| Gepner, P | 1 |
| Bricaire, F | 1 |
| Blétry, O | 1 |
| Caumes, E | 1 |
| Allali, F | 1 |
| Benomar, A | 1 |
| El Yahyaoui, M | 1 |
| Chkili, T | 1 |
| Hajjaj-Hassouni, N | 1 |
| Loembe, PM | 1 |
| Mwanyombet-Ompounga, L | 1 |
| Assengone-Zeh, Y | 1 |
| Kengue-Lechiombeka, PR | 1 |
| Turgut, M | 1 |
| van Loenhout-Rooyackers, JH | 1 |
| Verbeek, AL | 1 |
| Jutte, PC | 1 |
| Nanda, S | 1 |
| Agarwal, U | 1 |
| Sangwan, K | 1 |
| Adendorff, JJ | 1 |
| Boeke, EJ | 1 |
| Lazarus, C | 1 |
| van Aalderen, WM | 1 |
| Knoester, H | 1 |
| Knol, K | 1 |
| Parthasarathy, R | 1 |
| Sarma, GR | 1 |
| Janardhanam, B | 1 |
| Ramachandran, P | 1 |
| Santha, T | 1 |
| Sivasubramanian, S | 1 |
| Somasundaram, PR | 1 |
| Tripathy, SP | 1 |
| Jackson, JW | 1 |
| Cressman, MR | 1 |
| Hoppenfeld, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis[NCT03092817] | Phase 3 | 520 participants (Actual) | Interventional | 2017-05-25 | Active, not recruiting | ||
| A Randomized Double Blind Placebo Controlled Non-inferiority Trial of Adjunctive Dexamethasone for the Treatment of HIV-uninfected Adults With Tuberculous Meningitis Stratified by Leukotriene A4 Hydrolase Genotype[NCT03100786] | Phase 3 | 640 participants (Anticipated) | Interventional | 2018-02-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyrazinamide and Pott Disease
| Article | Year |
|---|---|
Management of spinal tuberculosis--current concepts.
Topics: Antitubercular Agents; Ethambutol; Humans; Isoniazid; Pyrazinamide; Tuberculosis, Spinal | 2004 |
Chemotherapeutic treatment for spinal tuberculosis.
Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Child; Drug Administration Schedule; Fema | 2002 |
34 other studies available for pyrazinamide and Pott Disease
| Article | Year |
|---|---|
Simultaneous determination of three antituberculosis drugs in the serum of patients with spinal tuberculosis by capillary electrophoresis.
Topics: Antitubercular Agents; Electrophoresis, Capillary; Humans; Isoniazid; Pyrazinamide; Tuberculosis, Sp | 2021 |
Concomitant metastatic cutaneous tuberculous abscesses and Pott disease in an immunocompetent patient.
Topics: Abscess; Adult; Antitubercular Agents; Arthrodesis; Debridement; Ethambutol; Humans; Immunocompetenc | 2016 |
Paediatric tubercular spinal abscess involving the dorsal, lumbar and sacral regions and causing spinal cord compression.
Topics: Adolescent; Antitubercular Agents; Drug Therapy, Combination; Epidural Abscess; Humans; Isoniazid; L | 2013 |
A Rare Cause of Retropharyngeal Abscess: Cervical Pott's Disease.
Topics: Antitubercular Agents; Biopsy, Fine-Needle; Cervical Vertebrae; Child; Diagnosis, Differential; Drug | 2015 |
Thanks to Trauma: A Delayed Diagnosis of Pott Disease.
Topics: Accidental Falls; Antitubercular Agents; Child, Preschool; Delayed Diagnosis; Diagnosis, Differentia | 2015 |
The outcomes of chemotherapy only treatment on mild spinal tuberculosis.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Drug Administration Schedule; Drug Therapy, Combinat | 2016 |
Anterior debridement may not be necessary in the treatment of tuberculous spondylitis of the thoracic and lumbar spine in adults: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Antitubercular Agents; Decompression, Surgical; Drug Therapy, Combin | 2016 |
Measurement of the concentration of three antituberculosis drugs in the focus of spinal tuberculosis.
Topics: Adult; Antitubercular Agents; Biopsy; Chromatography, High Pressure Liquid; Dose-Response Relationsh | 2008 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Topics: Adenosine Deaminase; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Cerebrospinal Fluid; | 2009 |
Pott's disease with scrofuloderma and psoas abscess misdiagnosed and treated as hidradenitis suppurativa.
Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Diagnosis, Differential; Diagnostic Error | 2011 |
Distribution of three antituberculous drugs and their metabolites in different parts of pathological vertebrae with spinal tuberculosis.
Topics: Adult; Aged; Antitubercular Agents; Female; Humans; Isoniazid; Male; Middle Aged; Orthopedic Procedu | 2011 |
Minimally invasive posterior stabilization for treating spinal tuberculosis.
Topics: Adult; Antitubercular Agents; Bed Rest; Casts, Surgical; Combined Modality Therapy; Ethambutol; Huma | 2013 |
POTT'S DISEASE TREATED WITHOUT SPINAL FUSION.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Drug Therapy; Humans; Isoniazid; P | 1964 |
Cervical spine tuberculosis.
Topics: Adolescent; Antitubercular Agents; Cervical Vertebrae; Ethambutol; Humans; Isoniazid; Male; Pyrazina | 2004 |
The transpedicular approach in the management of thoracic spine tuberculosis: a short-term follow up study.
Topics: Abscess; Adolescent; Adult; Aged; Antitubercular Agents; Braces; Combined Modality Therapy; Curettag | 2004 |
[Cervical spondylodiscitis: one pathogen may hide another].
Topics: Anti-Bacterial Agents; Antitubercular Agents; Aza Compounds; Cervical Vertebrae; Cholecystitis; Disc | 2006 |
A 2-year-old girl with an abnormal gait.
Topics: Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Ethambu | 2005 |
PCR identification of Mycobacterium tuberculosis complex in a clinical sample from a patient with symptoms of tuberculous spondylodiscitis.
Topics: Adult; Antitubercular Agents; Biopsy; Discitis; Drug Therapy, Combination; Humans; Isoniazid; Male; | 2007 |
[Sacral tuberculous osteitis].
Topics: Child, Preschool; Drug Therapy, Combination; Humans; Isoniazid; Magnetic Resonance Imaging; Male; Os | 1994 |
Cervical tuberculous vertebral osteomyelitis: case report and discussion of the literature.
Topics: Adult; Cervical Vertebrae; Drug Therapy, Combination; Humans; Isoniazid; Male; Pyrazinamide; Rifampi | 1993 |
Intramedullary tuberculoma of the spinal cord with syringomyelia.
Topics: Adult; Antitubercular Agents; Drug Therapy, Combination; Follow-Up Studies; Humans; Isoniazid; Magne | 1996 |
[Urogenital tuberculosis. Apropos of 40 cases].
Topics: Adolescent; Adult; Aged; Antibiotics, Antitubercular; Antitubercular Agents; Biopsy; Combined Modali | 1997 |
Pyrazinamide-induced lichenoid photodermatitis.
Topics: Antitubercular Agents; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Drug Eruptions; Dru | 1999 |
Mycobacterium bovis BCG causing vertebral osteomyelitis (Pott's disease) following intravesical BCG therapy.
Topics: Administration, Intravesical; Aged; Antitubercular Agents; BCG Vaccine; Drug Therapy, Combination; E | 1999 |
[Current aspects of spinal tuberculosis: apropos of 16 case reports].
Topics: Adult; Aged; Antibiotics, Antitubercular; Antitubercular Agents; Drug Therapy, Combination; Ethambut | 1999 |
Atlantoaxial tuberculosis: three cases.
Topics: Adult; Aged; Antitubercular Agents; Atlanto-Axial Joint; Drug Therapy, Combination; Female; Humans; | 2000 |
[Early anterolateral surgery for tuberculosis of the lower cervical spine with neurological complications in adult. Our experience in Gabon].
Topics: Adult; Antitubercular Agents; Cervical Vertebrae; Combined Modality Therapy; Debridement; Emergencie | 2000 |
Multifocal extensive spinal tuberculosis (Pott's disease) involving cervical, thoracic and lumbar vertebrae.
Topics: Antitubercular Agents; Cervical Vertebrae; Ethambutol; Female; Humans; Isoniazid; Lumbar Vertebrae; | 2001 |
Complete resolution of cervical spinal tuberculosis with paraplegia in pregnancy.
Topics: Adult; Antitubercular Agents; Cervical Vertebrae; Diagnosis, Differential; Female; Humans; Infant, N | 2002 |
Pott's paraplegia.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Isoniazid; Male; Middle Ag | 1987 |
Fulminant hepatitis during treatment with rifampicin, pyrazinamid and ethambutol.
Topics: Cervical Vertebrae; Chemical and Drug Induced Liver Injury; Child; Drug Therapy, Combination; Ethamb | 1987 |
Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide.
Topics: Adolescent; Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 1986 |
Surgical appraoches to the anterior aspect of the spinal column.
Topics: Abscess; Adult; Aged; Aminosalicylic Acids; Bronchial Neoplasms; Carcinoma; Child; Female; Humans; I | 1971 |
Treatment of an unusual case of tuberculosis of the cervical spine. Case report.
Topics: Cervical Vertebrae; Child; Female; Humans; Kyphosis; Pyrazinamide; Radiography; Spinal Fusion; Strep | 1969 |