pyrazinamide has been researched along with Porphyrias in 1 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrazinamide was found to be capable of significantly inducing amino-levulinic acid synthetase activity; the other antituberculous drugs caused either slight or no induction of amino-levulinic acid synthetase." | 1.26 | Exacerbation of porphyria during treatment of pulmonary tuberculosis. ( Magnussen, CR; Patterson, JR; Treece, GL; Tschudy, DP, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Treece, GL | 1 |
| Magnussen, CR | 1 |
| Patterson, JR | 1 |
| Tschudy, DP | 1 |
1 other study available for pyrazinamide and Porphyrias
| Article | Year |
|---|---|
Exacerbation of porphyria during treatment of pulmonary tuberculosis.
Topics: 5-Aminolevulinate Synthetase; Adult; Animals; Diet; Enzyme Induction; Humans; Liver; Male; Porphyria | 1976 |