pyrazinamide has been researched along with Liver Failure in 7 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present the case of an elderly patient who died of fulminant hepatic failure in the course of receiving 2 months of treatment with pyrazinamide and rifampin for his latent tuberculosis." | 3.71 | Death associated with rifampin and pyrazinamide 2-month treatment of latent mycobacterium tuberculosis. ( Medinger, A, 2002) |
| "Four patients presented hepatic encephalopathy." | 1.29 | [Severe hepatotoxicity of tuberculostatic agents. Increase in the incidence]. ( Bruguera, M; Mas, A; Moitinho, E; Rodés, J; Salmerón, JM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, N | 1 |
| Kedarisetty, CK | 1 |
| Kumar, S | 1 |
| Khillan, V | 1 |
| Sarin, SK | 1 |
| Castro, KG | 1 |
| Jereb, JA | 1 |
| Koppaka, VR | 1 |
| Cohn, DL | 1 |
| Story, RE | 1 |
| Ditto, AM | 1 |
| Toyama, T | 1 |
| Kato, H | 1 |
| Kobayashi, E | 1 |
| Kusakabe, A | 1 |
| Fuziwara, K | 1 |
| Nemoto, A | 1 |
| Hayashi, K | 1 |
| Ogino, M | 1 |
| Tsuzuki, T | 1 |
| Harada, Y | 1 |
| Kawakami, K | 1 |
| Koyama, K | 1 |
| Yamaryo, T | 1 |
| Kimura, Y | 1 |
| Moitinho, E | 1 |
| Salmerón, JM | 1 |
| Mas, A | 1 |
| Bruguera, M | 1 |
| Rodés, J | 1 |
| Medinger, A | 1 |
2 reviews available for pyrazinamide and Liver Failure
| Article | Year |
|---|---|
Antitubercular therapy in patients with cirrhosis: challenges and options.
Topics: Antitubercular Agents; Ethambutol; Humans; Immune System Diseases; Isoniazid; Latent Tuberculosis; L | 2014 |
[A case of fulminant hepatic failure associated with pyrazinamide in a woman with hypoalbuminemia].
Topics: Antitubercular Agents; Female; Humans; Hypoalbuminemia; Liver Failure; Middle Aged; Pyrazinamide; Tu | 2005 |
5 other studies available for pyrazinamide and Liver Failure
| Article | Year |
|---|---|
Fatal liver injury associated with rifampin-pyrazinamide treatment of latent tuberculosis infection.
Topics: Adverse Drug Reaction Reporting Systems; Antitubercular Agents; Centers for Disease Control and Prev | 2003 |
A 32-year-old man with tuberculosis, fever, and rash.
Topics: Adult; Antitubercular Agents; Diagnosis, Differential; Drug Hypersensitivity; Ethambutol; Exanthema; | 2004 |
[Case of fatal liver failure due to anti-tuberculous therapy].
Topics: Aged; Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Fatal Outcome; Female; Humans; I | 2007 |
[Severe hepatotoxicity of tuberculostatic agents. Increase in the incidence].
Topics: Acute Disease; Adult; Antibiotics, Antitubercular; Antitubercular Agents; Chemical and Drug Induced | 1996 |
Death associated with rifampin and pyrazinamide 2-month treatment of latent mycobacterium tuberculosis.
Topics: Aged; Antibiotics, Antitubercular; Antitubercular Agents; Drug Therapy, Combination; Humans; Liver F | 2002 |