pyrazinamide has been researched along with Liver Dysfunction in 21 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cases of severe and fatal liver injury were reported after a 2-month course of rifampin-pyrazinamide therapy was recommended in 2000 as an alternative to isoniazid for treatment of latent tuberculosis infection." | 7.73 | National survey to measure rates of liver injury, hospitalization, and death associated with rifampin and pyrazinamide for latent tuberculosis infection. ( Castro, KG; Iademarco, MF; Ijaz, K; Jereb, JA; Lambert, LA; McElroy, PD; Navin, TR, 2005) |
| "An alternative regimen for the treatment of latent tuberculosis infection is 2 months of rifampin and pyrazinamide, but some patients have died of hepatitis associated with this therapy." | 7.72 | Safety of 2 months of rifampin and pyrazinamide for treatment of latent tuberculosis. ( Cheng, AC; Engemann, JJ; Fortenberry, ER; Hamilton, CD; Stout, JE, 2003) |
| "The cornerstone of tuberculosis management is a 6-month course of isoniazid, rifampicin, pyrazinamide and ethambutol." | 4.84 | Antituberculosis drug-induced hepatotoxicity: concise up-to-date review. ( Aarnoutse, RE; Boeree, MJ; de Lange, WC; Dekhuijzen, R; Tostmann, A; van der Ven, AJ, 2008) |
| "Cases of severe and fatal liver injury were reported after a 2-month course of rifampin-pyrazinamide therapy was recommended in 2000 as an alternative to isoniazid for treatment of latent tuberculosis infection." | 3.73 | National survey to measure rates of liver injury, hospitalization, and death associated with rifampin and pyrazinamide for latent tuberculosis infection. ( Castro, KG; Iademarco, MF; Ijaz, K; Jereb, JA; Lambert, LA; McElroy, PD; Navin, TR, 2005) |
| "An alternative regimen for the treatment of latent tuberculosis infection is 2 months of rifampin and pyrazinamide, but some patients have died of hepatitis associated with this therapy." | 3.72 | Safety of 2 months of rifampin and pyrazinamide for treatment of latent tuberculosis. ( Cheng, AC; Engemann, JJ; Fortenberry, ER; Hamilton, CD; Stout, JE, 2003) |
| "Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats." | 1.35 | Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats. ( Akashi, I; Hirano, T; Kagami, K; Oka, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Bourhia, M | 1 |
| Ullah, R | 1 |
| S Alqahtani, A | 1 |
| Ibenmoussa, S | 1 |
| Kumar, N | 1 |
| Kedarisetty, CK | 1 |
| Kumar, S | 1 |
| Khillan, V | 1 |
| Sarin, SK | 1 |
| Adhvaryu, MR | 1 |
| Reddy, N | 1 |
| Vakharia, BC | 1 |
| Srivastava, RK | 1 |
| Sharma, S | 1 |
| Verma, S | 1 |
| Arora, B | 1 |
| Lal, H | 1 |
| Akashi, I | 1 |
| Kagami, K | 1 |
| Hirano, T | 1 |
| Oka, K | 1 |
| Gulati, K | 1 |
| Ray, A | 1 |
| Vijayan, VK | 1 |
| Stout, JE | 1 |
| Engemann, JJ | 1 |
| Cheng, AC | 1 |
| Fortenberry, ER | 1 |
| Hamilton, CD | 1 |
| TANI, P | 1 |
| POPPIUS, H | 1 |
| Ijaz, K | 2 |
| McElroy, PD | 2 |
| Navin, TR | 2 |
| Lambert, LA | 1 |
| Jereb, JA | 1 |
| Iademarco, MF | 1 |
| Castro, KG | 1 |
| Cook, PP | 1 |
| Tostmann, A | 1 |
| Boeree, MJ | 1 |
| Aarnoutse, RE | 1 |
| de Lange, WC | 1 |
| van der Ven, AJ | 1 |
| Dekhuijzen, R | 1 |
| Panchabhai, TS | 1 |
| Ambarkhane, SV | 1 |
| Joshi, AS | 1 |
| Samant, BD | 1 |
| Rege, NN | 1 |
| Pilheu, JA | 1 |
| De Salvo, MC | 1 |
| Koch, O | 1 |
| Robson, SC | 1 |
| Pillans, P | 1 |
| Willcox, PA | 1 |
| Ali, J | 1 |
| O'Brien, RJ | 1 |
| Donald, PR | 1 |
| Schoeman, JF | 1 |
| O'Kennedy, A | 1 |
| Beckert, W | 1 |
| Pickroth, G | 1 |
2 reviews available for pyrazinamide and Liver Dysfunction
| Article | Year |
|---|---|
Antitubercular therapy in patients with cirrhosis: challenges and options.
Topics: Antitubercular Agents; Ethambutol; Humans; Immune System Diseases; Isoniazid; Latent Tuberculosis; L | 2014 |
Antituberculosis drug-induced hepatotoxicity: concise up-to-date review.
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; In | 2008 |
2 trials available for pyrazinamide and Liver Dysfunction
| Article | Year |
|---|---|
Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach.
Topics: Adult; Antitubercular Agents; Blood Sedimentation; Body Weight; Chemical and Drug Induced Liver Inju | 2008 |
Assessment of protective role of polyherbal preparation, Livina, against anti-tubercular drug induced liver dysfunction.
Topics: Adolescent; Adult; Alanine Transaminase; Antitubercular Agents; Aspartate Aminotransferases; Chemica | 2010 |
17 other studies available for pyrazinamide and Liver Dysfunction
| Article | Year |
|---|---|
Evidence of drug-induced hepatotoxicity in the Maghrebian population.
Topics: Adolescent; Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug-Related Side | 2022 |
Influence of diabetes on liver injury induced by antitubercular drugs and on silymarin hepatoprotection in rats.
Topics: Animals; Antitubercular Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Diabetes Mellitus | 2008 |
Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.
Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug I | 2009 |
Safety of 2 months of rifampin and pyrazinamide for treatment of latent tuberculosis.
Topics: Adolescent; Adult; Aged; Alcoholism; Antibiotics, Antitubercular; Antitubercular Agents; Chemical an | 2003 |
SIDE EFFECTS OF AN ANTITUBERCULOUS FIVE-DRUG REGIMEN: ETHIONAMIDE, CYCLOSERINE, PYRAZINAMIDE, VIOMYCIN AND ISONIAZID.
Topics: Amyloidosis; Antitubercular Agents; Cycloserine; Deafness; Drug Hypersensitivity; Duodenal Ulcer; Et | 1963 |
Short-course rifampin and pyrazinamide compared with isoniazid for latent tuberculosis infection: a cost-effectiveness analysis based on a multicenter clinical trial.
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Pyrazinamide; | 2004 |
National survey to measure rates of liver injury, hospitalization, and death associated with rifampin and pyrazinamide for latent tuberculosis infection.
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Health Surveys; Hospitalization; Huma | 2005 |
Rifampin and pyrazinamide for treatment of latent tuberculosis infection.
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Hospitalization; Humans; Liver Diseas | 2006 |
Protective effect of Tinospora cordifolia, Phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study.
Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; I | 2008 |
Liver alterations in antituberculosis regimens containing pyrazinamide.
Topics: Adolescent; Adult; Aged; Alcoholism; Antitubercular Agents; Cholestasis; Diabetes Complications; Dia | 1981 |
Treatment of tuberculosis in patients with pre-existing liver disease or following hepatotoxic drug reactions.
Topics: Chemical and Drug Induced Liver Injury; Clinical Protocols; Contraindications; Humans; Isoniazid; Li | 1993 |
Hepatotoxic effects of tuberculosis therapy. A practical approach to a tricky management problem.
Topics: Antibiotics, Antitubercular; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Humans; | 1996 |
[First-time standard setting for therapy of pulmonary tuberculosis after revision of the Medical Treatment Standard--special reference to results of questionnaire survey on reality of early stage short-term PZA therapy and occurrence of the adverse effect
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy; Gout; Humans; Japan; Li | 1997 |
Hepatoxic reaction to antituberculous drugs: Adjustments to therapeutic regimen.
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Clinical Protocols; Humans; Isoniazid | 1991 |
Hepatic toxicity during chemotherapy for severe tuberculosis meningitis.
Topics: Alanine Transaminase; Antitubercular Agents; Aspartate Aminotransferases; Chemical and Drug Induced | 1987 |
[Centrilobular liver necrosis following antimycobacterial treatment].
Topics: Antitubercular Agents; Biopsy; Chemical and Drug Induced Liver Injury; Ethionamide; Humans; Liver Di | 1971 |
[Liver damage in tuberculosis].
Topics: Bile Acids and Salts; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Ethionamide; Fatty | 1968 |