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pyrazinamide and Jaundice

pyrazinamide has been researched along with Jaundice in 9 studies

pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.

Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.

Research Excerpts

ExcerptRelevanceReference
"Results are presented of the incidence of hepatitis, nearly always with jaundice, among 1686 patients in clinical trials of the treatment of spinal tuberculosis, of tuberculosis meningitis and of pulmonary tuberculosis with short-course regimens containing rifampicin, isoniazid, streptomycin and pyrazinamide."7.67Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide. ( Janardhanam, B; Parthasarathy, R; Ramachandran, P; Santha, T; Sarma, GR; Sivasubramanian, S; Somasundaram, PR; Tripathy, SP, 1986)
"Results are presented of the incidence of hepatitis, nearly always with jaundice, among 1686 patients in clinical trials of the treatment of spinal tuberculosis, of tuberculosis meningitis and of pulmonary tuberculosis with short-course regimens containing rifampicin, isoniazid, streptomycin and pyrazinamide."3.67Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide. ( Janardhanam, B; Parthasarathy, R; Ramachandran, P; Santha, T; Sarma, GR; Sivasubramanian, S; Somasundaram, PR; Tripathy, SP, 1986)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19907 (77.78)18.7374
1990's2 (22.22)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
COTTIN, S1
COZAN, R1
VERAN, P1
Somner, AR1
Brace, AA1
Døssing, M1
Wilcke, JT1
Askgaard, DS1
Nybo, B1
Rossouw, JE1
Saunders, SJ1
Campbell, IA1
Parthasarathy, R1
Sarma, GR1
Janardhanam, B1
Ramachandran, P1
Santha, T1
Sivasubramanian, S1
Somasundaram, PR1
Tripathy, SP1
Petera, V1
Klapálek, D1
Paichl, P1
Pecený, A1

Trials

1 trial available for pyrazinamide and Jaundice

ArticleYear
A controlled clinical trial of small daily doses of rifampicin in the prevention of adverse reactions to the drug in a once-weekly regimen of chemotherapy. A Hong Kong Tuberculosis Treatment Services-British Medical Research Council Investigation.
    Clinical allergy, 1974, Volume: 4, Issue:1

    Topics: Adult; Alanine Transaminase; Antibodies; Ethambutol; Female; Fever; Humans; Jaundice; Male; Middle A

1974

Other Studies

8 other studies available for pyrazinamide and Jaundice

ArticleYear
[APROPOS OF ETHIONAMIDE JAUNDICE].
    Le Poumon et le coeur, 1964, Volume: 20

    Topics: Alanine Transaminase; Alcoholism; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransfer

1964
REACTIONS TO ANTITUBERCULOSIS DRUGS AMONG CHINESE IN HONG KONG.
    Tubercle, 1964, Volume: 45

    Topics: Alcoholism; Alopecia; Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Asian People

1964
Changes in serum transaminase due to prothionamide.
    Tubercle, 1967, Volume: 48, Issue:2

    Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Resistance, Microbial; Ethionamide; Female; Huma

1967
Liver injury during antituberculosis treatment: an 11-year study.
    Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 1996, Volume: 77, Issue:4

    Topics: Adolescent; Adult; Aged; Alcohol Drinking; Antitubercular Agents; Aspartate Aminotransferases; Bilir

1996
Hepatic complications of antituberculous therapy.
    The Quarterly journal of medicine, 1975, Volume: 44, Issue:173

    Topics: Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensi

1975
Any questions? How should a patient be managed who is being treated for sputum positive pulmonary tuberculosis and becomes jaundiced in the third week of chemotherapy?
    Tubercle, 1990, Volume: 71, Issue:2

    Topics: Antitubercular Agents; Drug Therapy, Combination; Humans; Isoniazid; Jaundice; Pyrazinamide; Rifampi

1990
Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid, rifampicin and pyrazinamide.
    Tubercle, 1986, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child; Child, Pres

1986
[On the problem of chronic liver damage following drug therapy of tuberculosis].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1965, Volume: 25, Issue:4

    Topics: Adult; Aminosalicylic Acids; Antitubercular Agents; Biopsy; Chemical and Drug Induced Liver Injury;

1965