pyrazinamide has been researched along with Hepatitis in 12 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Hepatitis: INFLAMMATION of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the clinical characteristics, adverse drug reactions, and outcomes of the oldest old patients (aged ≥80 years) with tuberculosis (TB) treated with rifampicin, isoniazid, and pyrazinamide (RIP)-containing regimens." | 7.83 | The clinical outcomes of oldest old patients with tuberculosis treated by regimens containing rifampicin, isoniazid, and pyrazinamide. ( Chang, PJ; Cheng, CW; Chou, YL; Lin, HS; Lin, JC; Lin, MS; Ye, JJ, 2016) |
| "Pyrazinamide (PZA) is an essential antitubercular drug, but little is still known about its hepatotoxicity potential." | 5.43 | Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae. ( Chen, W; Ding, P; Guo, H; Han, L; Hassan, HM; He, Q; Hsiao, CD; Jiang, Z; Liu, K; Zhang, L; Zhang, Y, 2016) |
| "To investigate the clinical characteristics, adverse drug reactions, and outcomes of the oldest old patients (aged ≥80 years) with tuberculosis (TB) treated with rifampicin, isoniazid, and pyrazinamide (RIP)-containing regimens." | 3.83 | The clinical outcomes of oldest old patients with tuberculosis treated by regimens containing rifampicin, isoniazid, and pyrazinamide. ( Chang, PJ; Cheng, CW; Chou, YL; Lin, HS; Lin, JC; Lin, MS; Ye, JJ, 2016) |
| "We prospectively examined the incidence of drug-induced hepatitis in 2070 patients treated for TB with the standard regimen based on 6 months of rifampicin (R, RMP) and isoniazid (H, INH), with 2 months of initial pyrazinamide (Z, PZA) and ethambutol (E, EMB), over a 30-year period from 1981 to 2010, in Blackburn, UK." | 3.83 | Drug-related hepatitis in patients treated with standard anti-tuberculosis chemotherapy over a 30-year period. ( Bright-Thomas, RJ; Gondker, AR; Morris, J; Ormerod, LP, 2016) |
| "Pyrazinamide (PZA) is an essential antitubercular drug, but little is still known about its hepatotoxicity potential." | 1.43 | Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae. ( Chen, W; Ding, P; Guo, H; Han, L; Hassan, HM; He, Q; Hsiao, CD; Jiang, Z; Liu, K; Zhang, L; Zhang, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, HS | 1 |
| Cheng, CW | 1 |
| Lin, MS | 1 |
| Chou, YL | 1 |
| Chang, PJ | 1 |
| Lin, JC | 1 |
| Ye, JJ | 1 |
| Zhang, Y | 1 |
| Liu, K | 1 |
| Hassan, HM | 1 |
| Guo, H | 1 |
| Ding, P | 1 |
| Han, L | 1 |
| He, Q | 1 |
| Chen, W | 1 |
| Hsiao, CD | 1 |
| Zhang, L | 1 |
| Jiang, Z | 1 |
| Bright-Thomas, RJ | 1 |
| Gondker, AR | 1 |
| Morris, J | 1 |
| Ormerod, LP | 1 |
| GILLIS, S | 1 |
| TEXLER, K | 1 |
| BEK, E | 1 |
| COTTIN, S | 1 |
| COZAN, R | 1 |
| VERAN, P | 1 |
| SERI, I | 1 |
| KOLUMBAN, K | 1 |
| BALOGH, Z | 1 |
| ENTZ, A | 1 |
| BARRAS, G | 1 |
| Angel, JH | 1 |
| Pilheu, JA | 1 |
| De Salvo, MC | 1 |
| Koch, O | 1 |
| Schaberg, T | 1 |
| Rebhan, K | 1 |
| Lode, H | 1 |
1 trial available for pyrazinamide and Hepatitis
| Article | Year |
|---|---|
BTA short-course chemotherapy studies.
Topics: Clinical Trials as Topic; Ethambutol; Female; Hepatitis; Humans; Isoniazid; Liver Function Tests; Ma | 1981 |
11 other studies available for pyrazinamide and Hepatitis
| Article | Year |
|---|---|
The clinical outcomes of oldest old patients with tuberculosis treated by regimens containing rifampicin, isoniazid, and pyrazinamide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitubercular Agents; Chemical and Drug Induced Liver I | 2016 |
Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae.
Topics: Animals; Animals, Genetically Modified; Antitubercular Agents; Apoptosis; Fatty Acid-Binding Protein | 2016 |
Drug-related hepatitis in patients treated with standard anti-tuberculosis chemotherapy over a 30-year period.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitubercular Agents; Chemical and Drug Induced Liver I | 2016 |
Unusual reactions to anti-tuberculous chemotherapy.
Topics: Hepatitis; Hepatitis A; Humans; Isoniazid; Pyrazinamide; Tuberculosis; Uric Acid | 1960 |
[INTOLERANCE AND TOXICITY OF SUBSTITUTE ANTIBACTERIAL DRUGS].
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Chemical and Drug Induced Liver In | 1963 |
[APROPOS OF ETHIONAMIDE JAUNDICE].
Topics: Alanine Transaminase; Alcoholism; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransfer | 1964 |
[EFFECT OF PYRAZINAMIDE ON INACTIVE DUODENAL ULCER].
Topics: Chemical and Drug Induced Liver Injury; Drug Therapy; Duodenal Ulcer; Hepatitis; Liver Function Test | 1964 |
[CLINICAL EXPERIENCE WITH THE COMBINED APPEARANCE OF TUBERCULOSIS AND VIRUS HEPATITIS].
Topics: Adrenocorticotropic Hormone; Aminosalicylic Acid; Aminosalicylic Acids; Collapse Therapy; Drug Thera | 1964 |
[STUDY ON LIVER TOLERANCE TO N-(4-MORPHOLINOMETHYL-PYRAZINAMIDE) IN THE TREATMENT OF PULMONARY TUBERCULOSIS].
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Tolerance; Hepatitis; Humans; Py | 1964 |
Liver alterations in antituberculosis regimens containing pyrazinamide.
Topics: Adolescent; Adult; Aged; Alcoholism; Antitubercular Agents; Cholestasis; Diabetes Complications; Dia | 1981 |
Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antitubercular Agents; Arthralgia; Child; C | 1996 |