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pyrazinamide and Drug Hypersensitivity

pyrazinamide has been researched along with Drug Hypersensitivity in 39 studies

pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.

Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.

Research Excerpts

ExcerptRelevanceReference
" Subjects who experienced hypersensitivity reactions, including maculopapular exanthema (MPE) and drug reaction with eosinophilia and systemic symptoms (DRESS), to first-line anti-tuberculosis medications (isoniazid [INH], ethambutol [EMB], rifampin [RFP], and pyrazinamide [PZA]) were enrolled."3.91Efficacy and tolerability of desensitization in the treatment of delayed drug hypersensitivities to anti-tuberculosis medications. ( Ban, GY; Jeong, YJ; Kim, SH; Lee, SH; Park, HS; Shin, SS; Shin, YS; Ye, YM, 2019)
"A 64-year-old man without a history of drug allergy developed fever and severe headache."1.42[A case of tuberculous meningitis complicated with multiple drug hypersensitivity to antituberculosis agents]. ( Arai, M, 2015)
"Rifampin has been reported to cause acute pancreatitis in up to 2."1.30Pancreatic insufficiency due to antituberculous therapy. ( Cohen, LB; Knowles, SR; Liu, BA; Shear, NH; Werb, MR, 1997)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199021 (53.85)18.7374
1990's9 (23.08)18.2507
2000's4 (10.26)29.6817
2010's5 (12.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nadri, G1
Taneja, S1
Singh, V1
Mittal, P1
Ban, GY1
Jeong, YJ1
Lee, SH1
Shin, SS1
Shin, YS1
Park, HS1
Kim, SH1
Ye, YM1
Arai, M1
Aniked, S1
Bakouh, O1
Bourkadi, JE1
Kuwabara, K1
Ribi, C1
Hauser, C1
CHAVES, AD1
TANI, P1
POPPIUS, H1
GIUNIO, N1
Story, RE1
Ditto, AM1
Marra, F1
Cox, VC1
FitzGerald, JM1
Moadebi, S1
Elwood, RK1
Carrasco, E1
Zierski, M2
Bek, E1
Okwera, A1
Whalen, C1
Byekwaso, F1
Vjecha, M1
Johnson, J1
Huebner, R1
Mugerwa, R1
Ellner, J1
Urban, T1
Maquarre, E1
Housset, C1
Chouaid, C1
Devin, E1
Lebeau, B1
McKeon, J1
Patel, AM1
Corbella, X1
Vadillo, M1
Cabellos, C1
Fernandez-Viladrich, P1
Rufi, G1
Luo, C1
Chintu, C1
Bhat, G1
Raviglione, M1
Diwan, V1
DuPont, HL1
Zumla, A1
Shorr, AF1
Trotta, RF1
Liu, BA1
Knowles, SR1
Cohen, LB1
Werb, MR1
Shear, NH1
Beji, M1
Louzir, B1
Ben Rhomdane, N1
Zouari, M1
Mtimet, B1
Daghfous, J1
Martínez, E1
Collazos, J1
Mayo, J1
Maurya, V1
Panjabi, C1
Shah, A1
Newton, RW1
Rossouw, JE1
Saunders, SJ1
Sifontes, JE1
Holdiness, MR1
Nariman, S1
van Dijke, CP1
Mudde, AH1
Wilson, TM1
Mühlberger, F1
Lester, W1
Burgher, LW1
Kass, I1
Wolinsky, E1
Pregowski, W1
Stańczuk-Holub, A1
Petera, V1
Klapálek, D1
Paichl, P1
Pecený, A1

Reviews

2 reviews available for pyrazinamide and Drug Hypersensitivity

ArticleYear
Adverse cutaneous reactions to antituberculosis drugs.
    International journal of dermatology, 1985, Volume: 24, Issue:5

    Topics: Acne Vulgaris; Adult; Amikacin; Antitubercular Agents; Drug Hypersensitivity; Ethambutol; Ethionamid

1985
Adverse reactions to drugs used in the treatment of tuberculosis.
    Adverse drug reactions and acute poisoning reviews, 1988,Winter, Volume: 7, Issue:4

    Topics: Antitubercular Agents; Drug Hypersensitivity; Humans; Isoniazid; Pyrazinamide; Rifampin; Streptomyci

1988

Trials

3 trials available for pyrazinamide and Drug Hypersensitivity

ArticleYear
Randomised trial of thiacetazone and rifampicin-containing regimens for pulmonary tuberculosis in HIV-infected Ugandans. The Makerere University-Case Western University Research Collaboration.
    Lancet (London, England), 1994, Nov-12, Volume: 344, Issue:8933

    Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Drug Eruptions; Drug Hypersensitivity; Dru

1994
Investigations of allergic status and blood counts in Chinese patients receiving daily or intermittent rifampicin in Hong Kong.
    Clinical allergy, 1975, Volume: 5, Issue:2

    Topics: ABO Blood-Group System; Blood Cell Count; China; Clinical Trials as Topic; Cycloserine; Drug Hyperse

1975
A controlled clinical trial of small daily doses of rifampicin in the prevention of adverse reactions to the drug in a once-weekly regimen of chemotherapy in Hong Kong: second report:-the results at 12 months.
    Tubercle, 1974, Volume: 55, Issue:3

    Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Administration Schedule; Drug Hypersensitivity; Dr

1974

Other Studies

34 other studies available for pyrazinamide and Drug Hypersensitivity

ArticleYear
Anaphylaxis to rifampicin and pyrazinamide in a child with tuberculous meningitis: A case report.
    The Indian journal of tuberculosis, 2017, Volume: 64, Issue:2

    Topics: Anaphylaxis; Antitubercular Agents; Child; Drug Hypersensitivity; Humans; Male; Pyrazinamide; Rifamp

2017
Efficacy and tolerability of desensitization in the treatment of delayed drug hypersensitivities to anti-tuberculosis medications.
    Respiratory medicine, 2019, Volume: 147

    Topics: Adult; Aged; Aged, 80 and over; Antitubercular Agents; Desensitization, Immunologic; Drug Hypersensi

2019
[A case of tuberculous meningitis complicated with multiple drug hypersensitivity to antituberculosis agents].
    Rinsho shinkeigaku = Clinical neurology, 2015, Volume: 55, Issue:2

    Topics: Antitubercular Agents; Drug Hypersensitivity; Drug Therapy, Combination; Ethambutol; Ethionamide; Hu

2015
[The interest of addiction to first line anti-TB drugs].
    The Pan African medical journal, 2014, Volume: 19

    Topics: Antitubercular Agents; Drug Eruptions; Drug Hypersensitivity; Ethambutol; Female; Humans; Isoniazid;

2014
[Anti-tuberculosis chemotherapy and management of adverse reactions].
    Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69, Issue:8

    Topics: Aged, 80 and over; Antitubercular Agents; Child; Drug Administration Schedule; Drug Hypersensitivity

2011
Adverse reactions to pyrazinamide.
    Allergy, 2002, Volume: 57, Issue:10

    Topics: Adult; Antitubercular Agents; Drug Eruptions; Drug Hypersensitivity; Exanthema; Female; Humans; Pyra

2002
DRUG THERAPY FOR TUBERCULOUS PATIENTS OUTSIDE THE HOSPITAL.
    The Medical annals of the District of Columbia, 1963, Volume: 32

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Cycloserine; Drug Hypersensitivity; Drug Resistance; Drug

1963
SIDE EFFECTS OF AN ANTITUBERCULOUS FIVE-DRUG REGIMEN: ETHIONAMIDE, CYCLOSERINE, PYRAZINAMIDE, VIOMYCIN AND ISONIAZID.
    Acta tuberculosea et pneumologica Scandinavica, 1963, Volume: 43

    Topics: Amyloidosis; Antitubercular Agents; Cycloserine; Deafness; Drug Hypersensitivity; Duodenal Ulcer; Et

1963
CHEMOTHERAPY OF PREVIOUSLY TREATED PATIENTS WITH PULMONARY TUBERCULOSIS.
    Tubercle, 1964, Volume: 45

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Cycloserine; Drug Hypersensitivity; Drug Resistance; Drug

1964
A 32-year-old man with tuberculosis, fever, and rash.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 92, Issue:5

    Topics: Adult; Antitubercular Agents; Diagnosis, Differential; Drug Hypersensitivity; Ethambutol; Exanthema;

2004
Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2004, Volume: 8, Issue:7

    Topics: Adult; Anti-Infective Agents; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Ciprofl

2004
[Adverse reactions to short-course anti-tuberculous therapy (author's transl)].
    Revista medica de Chile, 1981, Volume: 109, Issue:6

    Topics: Antitubercular Agents; Drug Hypersensitivity; Drug Tolerance; Humans; Isoniazid; Pyrazinamide; Rifam

1981
[Side effects of various combinations of rifampin and isoniazid with ethambutol or streptomycin and pyrazinamide in short-term chemotherapy of newly-detected pulmonary tuberculosis].
    Pneumonologia polska, 1980, Volume: 48, Issue:7

    Topics: Adolescent; Adult; Aged; Antitubercular Agents; Drug Administration Schedule; Drug Hypersensitivity;

1980
[Allopurinol hypersensitivity. A possible cause of hepatitis and mucocutaneous eruptions in a patient undergoing antitubercular treatment].
    Revue des maladies respiratoires, 1995, Volume: 12, Issue:3

    Topics: Adult; Allopurinol; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; D

1995
Antituberculous therapy and acute liver failure.
    Lancet (London, England), 1995, May-06, Volume: 345, Issue:8958

    Topics: Adult; Antitubercular Agents; Drug Hypersensitivity; Female; Humans; Isoniazid; Liver Failure, Acute

1995
Hypersensitivity hepatitis due to pyrazinamide.
    Scandinavian journal of infectious diseases, 1995, Volume: 27, Issue:1

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypers

1995
Human immunodeficiency virus type-1 infection in Zambian children with tuberculosis: changing seroprevalence and evaluation of a thioacetazone-free regimen.
    Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 1994, Volume: 75, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Drug Hypersensitivity; Drug Therapy, Combination; Female; HIV I

1994
PZA hypersensitivity.
    Chest, 1996, Volume: 109, Issue:3

    Topics: Antitubercular Agents; Drug Hypersensitivity; Humans; Male; Middle Aged; Pyrazinamide

1996
Pancreatic insufficiency due to antituberculous therapy.
    The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6

    Topics: Antitubercular Agents; Chronic Disease; Drug Hypersensitivity; Drug Therapy, Combination; Ethambutol

1997
[Thrombocytopenia following a re-introduction of rifampicin in a daily treatment. Apropos of a case].
    La Tunisie medicale, 1995, Volume: 73, Issue:5

    Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Chemical and Drug Induced Liver Injury; D

1995
Shock and cerebral infarct after rifampin re-exposure in a patient infected with human immunodeficiency virus.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 27, Issue:5

    Topics: Adult; Anaphylaxis; Antibiotics, Antitubercular; Antitubercular Agents; Cerebral Infarction; Drug Hy

1998
Pyrazinamide induced photoallergy.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2001, Volume: 5, Issue:11

    Topics: Adult; Antitubercular Agents; Dermatitis, Photoallergic; Drug Hypersensitivity; Female; Humans; Pyra

2001
Side effects of drugs used to treat tuberculosis.
    Scottish medical journal, 1975, Volume: 20, Issue:2

    Topics: Aminosalicylic Acids; Animals; Antitubercular Agents; Capreomycin; Chemical and Drug Induced Liver I

1975
Hepatic complications of antituberculous therapy.
    The Quarterly journal of medicine, 1975, Volume: 44, Issue:173

    Topics: Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensi

1975
Editorial: Rifampin in tuberculous meningitis.
    The Journal of pediatrics, 1975, Volume: 87, Issue:6 Pt 1

    Topics: Child; Child, Preschool; Drug Hypersensitivity; Drug Interactions; Drug Therapy, Combination; Humans

1975
[Drug-induced fever?].
    Nederlands tijdschrift voor geneeskunde, 1986, Oct-18, Volume: 130, Issue:42

    Topics: Aged; Drug Hypersensitivity; Fever; Humans; Male; Pyrazinamide; Skin Tests; Tuberculosis, Ocular

1986
Clinical experience with ethambutol.
    Antibiotica et chemotherapia. Fortschritte. Advances. Progres, 1970, Volume: 16

    Topics: Aminosalicylic Acids; Blood Chemical Analysis; Capreomycin; Drug Combinations; Drug Hypersensitivity

1970
[Allergy to antitubercular agents; with special reference to new drugs].
    Schweizerische medizinische Wochenschrift, 1973, Jan-27, Volume: 103, Issue:4

    Topics: Adult; Aged; Agranulocytosis; Anaphylaxis; Antitubercular Agents; Capreomycin; Cycloserine; Drug Hyp

1973
Treatment of drug-resistant tuberculosis.
    Disease-a-month : DM, 1971

    Topics: Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cycloserine; Dr

1971
Treatment of tuberculosis today in Nebraska.
    The Nebraska medical journal, 1973, Volume: 58, Issue:5

    Topics: Aminosalicylic Acids; Antitubercular Agents; Cycloserine; Drug Hypersensitivity; Ethambutol; Ethiona

1973
New antituberculosis drugs and concepts of prophylaxis.
    The Medical clinics of North America, 1974, Volume: 58, Issue:3

    Topics: Aminosalicylic Acids; Antitubercular Agents; Arthritis; Chemical and Drug Induced Liver Injury; Chil

1974
[Treatment with pyrazinamide given in increased doses twice a week in combination with other drugs].
    Gruzlica i choroby pluc; tuberculosis et pneumonologia, 1973, Volume: 41, Issue:7

    Topics: Adult; Aged; Antitubercular Agents; Chronic Disease; Drug Hypersensitivity; Drug Synergism; Drug Tol

1973
The use of second line drugs in patients with drug resistance to standard tuberculostatics.
    Diseases of the chest, 1968, Volume: 53, Issue:4

    Topics: Ambulatory Care; Aminosalicylic Acids; Antitubercular Agents; Cycloserine; Drug Hypersensitivity; Dr

1968
[On the problem of chronic liver damage following drug therapy of tuberculosis].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1965, Volume: 25, Issue:4

    Topics: Adult; Aminosalicylic Acids; Antitubercular Agents; Biopsy; Chemical and Drug Induced Liver Injury;

1965
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