pyrazinamide has been researched along with Diarrhea in 9 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypothesis that antituberculous drug disposition is altered in patients with AIDS, we studied the steady-state pharmacokinetics of isoniazid (300 mg/d), rifampin (600 mg/d), and pyrazinamide (1,500 mg/d) in 29 adults (14 patients infected with human immunodeficiency virus [HIV] and 15 non-HIV-infected patients) with tuberculosis in Nairobi, Kenya." | 5.08 | Pharmacokinetics of antimycobacterial drugs in patients with tuberculosis, AIDS, and diarrhea. ( Aoki, FY; Choudhri, SH; Gathua, S; Hawken, M; Long, R; Minyiri, GO; Sahai, J; Sitar, DS; Watkins, W, 1997) |
| " Peak drug exposure to isoniazid was lower in patients with diarrhea." | 3.69 | Reduced plasma concentrations of antituberculosis drugs in patients with HIV infection. ( Cameron, DW; Gallicano, K; Garber, G; Oliveras, L; Rachlis, A; Sahai, J; Seguin, I; Swick, L; Tailor, S; Walker, S, 1997) |
| "Pyrazinamide, an antituberculous drug discovered in 1952, was first considered as a toxic drug." | 2.36 | [Toxicity of pyrazinamide in antituberculous treatments (author's transl)]. ( Perdrizet, S; Pretet, S, 1980) |
| "Abstract: Mycobacterium avium paratuberculosis (Map) was cultured from the feces of a wild-caught, female, adult Southern black rhinoceros." | 1.38 | Mycobacterium avium subspecies paratuberculosis cultured from the feces of a Southern black rhinoceros (Diceros bicornis minor) with diarrhea and weight loss. ( Blyde, D; Bryant, B; Eamens, G; Whittington, R, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Li, DF | 1 |
| Yao, J | 1 |
| Wang, LS | 1 |
| Cerezo Lajas, A | 1 |
| Caminero Luna, JA | 1 |
| Rodríguez Guzmán, MDC | 1 |
| de Miguel Díez, J | 1 |
| Hara, M | 1 |
| Hatta, T | 1 |
| Ohtani, M | 1 |
| Segawa, H | 1 |
| Ueno, R | 1 |
| Sawada, K | 1 |
| Opondo, EA | 1 |
| Bryant, B | 1 |
| Blyde, D | 1 |
| Eamens, G | 1 |
| Whittington, R | 1 |
| Pretet, S | 1 |
| Perdrizet, S | 1 |
| Choudhri, SH | 1 |
| Hawken, M | 1 |
| Gathua, S | 1 |
| Minyiri, GO | 1 |
| Watkins, W | 1 |
| Sahai, J | 2 |
| Sitar, DS | 1 |
| Aoki, FY | 1 |
| Long, R | 1 |
| Gallicano, K | 1 |
| Swick, L | 1 |
| Tailor, S | 1 |
| Garber, G | 1 |
| Seguin, I | 1 |
| Oliveras, L | 1 |
| Walker, S | 1 |
| Rachlis, A | 1 |
| Cameron, DW | 1 |
| Mwinga, A | 1 |
| Hosp, M | 1 |
| Zulu, I | 1 |
| Farthing, MJ | 1 |
| Mulambo, S | 1 |
| Kelly, P | 1 |
1 review available for pyrazinamide and Diarrhea
| Article | Year |
|---|---|
[Toxicity of pyrazinamide in antituberculous treatments (author's transl)].
Topics: Chemical and Drug Induced Liver Injury; Diarrhea; Drug Eruptions; Gout; Humans; Isoniazid; Nausea; P | 1980 |
1 trial available for pyrazinamide and Diarrhea
| Article | Year |
|---|---|
Pharmacokinetics of antimycobacterial drugs in patients with tuberculosis, AIDS, and diarrhea.
Topics: Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Biological Availability; Diarrh | 1997 |
7 other studies available for pyrazinamide and Diarrhea
| Article | Year |
|---|---|
Ileal amyloidosis mimicking Crohn´s disease as a cause of chronic diarrhea.
Topics: Amyloidosis; Antitubercular Agents; Crohn Disease; Diarrhea; Drug Therapy, Combination; Female; Huma | 2021 |
Antituberculosis Treatment in a Patient with Celiac Disease.
Topics: Aged; Antitubercular Agents; Celiac Disease; Diarrhea; Diet, Gluten-Free; Drug Compounding; Drug Sub | 2018 |
[A case of tuberculous peritonitis in a hemodialysis patient revealed by severe diarrhea and stomachache].
Topics: Abdominal Pain; Antitubercular Agents; Biomarkers; CA-125 Antigen; Diagnosis, Differential; Diarrhea | 2013 |
Diagnostic challenges of intestinal tuberculosis in a patient with chronic diarrhoea: case report.
Topics: Adult; Antitubercular Agents; Chronic Disease; Diarrhea; Ethambutol; Humans; Isoniazid; Laparotomy; | 2008 |
Mycobacterium avium subspecies paratuberculosis cultured from the feces of a Southern black rhinoceros (Diceros bicornis minor) with diarrhea and weight loss.
Topics: Animals; Antitubercular Agents; Diarrhea; Feces; Female; Mycobacterium avium subsp. paratuberculosis | 2012 |
Reduced plasma concentrations of antituberculosis drugs in patients with HIV infection.
Topics: Adult; Aged; Antitubercular Agents; Case-Control Studies; Diarrhea; Ethambutol; Female; HIV Infectio | 1997 |
Tuberculosis preventative treatment also prevented diarrhoea in HIV-infected patients in Zambia.
Topics: Antibiotics, Antitubercular; Antitubercular Agents; Diarrhea; Drug Therapy, Combination; Follow-Up S | 2002 |