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pyrazinamide and Diarrhea

pyrazinamide has been researched along with Diarrhea in 9 studies

pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"To test the hypothesis that antituberculous drug disposition is altered in patients with AIDS, we studied the steady-state pharmacokinetics of isoniazid (300 mg/d), rifampin (600 mg/d), and pyrazinamide (1,500 mg/d) in 29 adults (14 patients infected with human immunodeficiency virus [HIV] and 15 non-HIV-infected patients) with tuberculosis in Nairobi, Kenya."5.08Pharmacokinetics of antimycobacterial drugs in patients with tuberculosis, AIDS, and diarrhea. ( Aoki, FY; Choudhri, SH; Gathua, S; Hawken, M; Long, R; Minyiri, GO; Sahai, J; Sitar, DS; Watkins, W, 1997)
" Peak drug exposure to isoniazid was lower in patients with diarrhea."3.69Reduced plasma concentrations of antituberculosis drugs in patients with HIV infection. ( Cameron, DW; Gallicano, K; Garber, G; Oliveras, L; Rachlis, A; Sahai, J; Seguin, I; Swick, L; Tailor, S; Walker, S, 1997)
"Pyrazinamide, an antituberculous drug discovered in 1952, was first considered as a toxic drug."2.36[Toxicity of pyrazinamide in antituberculous treatments (author's transl)]. ( Perdrizet, S; Pretet, S, 1980)
"Abstract: Mycobacterium avium paratuberculosis (Map) was cultured from the feces of a wild-caught, female, adult Southern black rhinoceros."1.38Mycobacterium avium subspecies paratuberculosis cultured from the feces of a Southern black rhinoceros (Diceros bicornis minor) with diarrhea and weight loss. ( Blyde, D; Bryant, B; Eamens, G; Whittington, R, 2012)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Li, DF1
Yao, J1
Wang, LS1
Cerezo Lajas, A1
Caminero Luna, JA1
Rodríguez Guzmán, MDC1
de Miguel Díez, J1
Hara, M1
Hatta, T1
Ohtani, M1
Segawa, H1
Ueno, R1
Sawada, K1
Opondo, EA1
Bryant, B1
Blyde, D1
Eamens, G1
Whittington, R1
Pretet, S1
Perdrizet, S1
Choudhri, SH1
Hawken, M1
Gathua, S1
Minyiri, GO1
Watkins, W1
Sahai, J2
Sitar, DS1
Aoki, FY1
Long, R1
Gallicano, K1
Swick, L1
Tailor, S1
Garber, G1
Seguin, I1
Oliveras, L1
Walker, S1
Rachlis, A1
Cameron, DW1
Mwinga, A1
Hosp, M1
Zulu, I1
Farthing, MJ1
Mulambo, S1
Kelly, P1

Reviews

1 review available for pyrazinamide and Diarrhea

ArticleYear
[Toxicity of pyrazinamide in antituberculous treatments (author's transl)].
    Revue francaise des maladies respiratoires, 1980, Volume: 8, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Diarrhea; Drug Eruptions; Gout; Humans; Isoniazid; Nausea; P

1980

Trials

1 trial available for pyrazinamide and Diarrhea

ArticleYear
Pharmacokinetics of antimycobacterial drugs in patients with tuberculosis, AIDS, and diarrhea.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1997, Volume: 25, Issue:1

    Topics: Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Biological Availability; Diarrh

1997

Other Studies

7 other studies available for pyrazinamide and Diarrhea

ArticleYear
Ileal amyloidosis mimicking Crohn´s disease as a cause of chronic diarrhea.
    Revista espanola de enfermedades digestivas, 2021, Volume: 113, Issue:12

    Topics: Amyloidosis; Antitubercular Agents; Crohn Disease; Diarrhea; Drug Therapy, Combination; Female; Huma

2021
Antituberculosis Treatment in a Patient with Celiac Disease.
    Archivos de bronconeumologia, 2018, Volume: 54, Issue:6

    Topics: Aged; Antitubercular Agents; Celiac Disease; Diarrhea; Diet, Gluten-Free; Drug Compounding; Drug Sub

2018
[A case of tuberculous peritonitis in a hemodialysis patient revealed by severe diarrhea and stomachache].
    Nihon Jinzo Gakkai shi, 2013, Volume: 55, Issue:1

    Topics: Abdominal Pain; Antitubercular Agents; Biomarkers; CA-125 Antigen; Diagnosis, Differential; Diarrhea

2013
Diagnostic challenges of intestinal tuberculosis in a patient with chronic diarrhoea: case report.
    East African medical journal, 2008, Volume: 85, Issue:2

    Topics: Adult; Antitubercular Agents; Chronic Disease; Diarrhea; Ethambutol; Humans; Isoniazid; Laparotomy;

2008
Mycobacterium avium subspecies paratuberculosis cultured from the feces of a Southern black rhinoceros (Diceros bicornis minor) with diarrhea and weight loss.
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2012, Volume: 43, Issue:2

    Topics: Animals; Antitubercular Agents; Diarrhea; Feces; Female; Mycobacterium avium subsp. paratuberculosis

2012
Reduced plasma concentrations of antituberculosis drugs in patients with HIV infection.
    Annals of internal medicine, 1997, Aug-15, Volume: 127, Issue:4

    Topics: Adult; Aged; Antitubercular Agents; Case-Control Studies; Diarrhea; Ethambutol; Female; HIV Infectio

1997
Tuberculosis preventative treatment also prevented diarrhoea in HIV-infected patients in Zambia.
    AIDS (London, England), 2002, Mar-29, Volume: 16, Issue:5

    Topics: Antibiotics, Antitubercular; Antitubercular Agents; Diarrhea; Drug Therapy, Combination; Follow-Up S

2002