pyrazinamide has been researched along with Diabetes Mellitus in 16 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to compare plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA) between tuberculosis (TB) patients with and without diabetes mellitus (DM)." | 5.24 | Anti-tuberculosis drug concentrations in tuberculosis patients with and without diabetes mellitus. ( Chandrasekaran, V; Kannan, T; Kumar, AK; Lavanya, J; Murali, AL; Ramachandran, G; Sudha, V; Swaminathan, S, 2017) |
| "This review will introduce pharmacokinetic parameters for key anti-TB drugs, as well as the indications and limitations of measuring these parameters in clinical practice." | 2.50 | Understanding pharmacokinetics to improve tuberculosis treatment outcome. ( Heysell, SK; Reynolds, J, 2014) |
| "There is a need for individualized dosing of isoniazid and rifampicin based on plasma concentration measurements (therapeutic drug monitoring) and for clinical trials on higher doses of these TB drugs in patients with TB and DM." | 1.51 | Effect of diabetes mellitus on TB drug concentrations in Tanzanian patients. ( Aarnoutse, RE; Boeree, MJ; Burger, DM; Colbers, A; Irongo, CF; Kibiki, GS; Mtabho, CM; Semvua, HH; Tostmann, A; van Crevel, R; van den Boogaard, J; van der Ven, AJAM, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Mary Rebecca, Y | 1 |
| Sudha, V | 2 |
| Bharathiraja, T | 1 |
| Kannan, T | 2 |
| Lavanya, J | 2 |
| Hemanth Kumar, AK | 1 |
| Mtabho, CM | 1 |
| Semvua, HH | 1 |
| van den Boogaard, J | 1 |
| Irongo, CF | 1 |
| Boeree, MJ | 1 |
| Colbers, A | 1 |
| Burger, DM | 1 |
| van Crevel, R | 1 |
| van der Ven, AJAM | 1 |
| Kibiki, GS | 1 |
| Tostmann, A | 1 |
| Aarnoutse, RE | 1 |
| Alfarisi, O | 1 |
| Mave, V | 1 |
| Gaikwad, S | 1 |
| Sahasrabudhe, T | 1 |
| Ramachandran, G | 2 |
| Kumar, H | 1 |
| Gupte, N | 1 |
| Kulkarni, V | 1 |
| Deshmukh, S | 1 |
| Atre, S | 1 |
| Raskar, S | 1 |
| Lokhande, R | 1 |
| Barthwal, M | 1 |
| Kakrani, A | 1 |
| Chon, S | 1 |
| Gupta, A | 1 |
| Golub, JE | 1 |
| Dooley, KE | 1 |
| Dekkers, BGJ | 1 |
| Akkerman, OW | 1 |
| Alffenaar, JWC | 1 |
| Reynolds, J | 1 |
| Heysell, SK | 1 |
| Kumar, AK | 1 |
| Chandrasekaran, V | 1 |
| Murali, AL | 1 |
| Swaminathan, S | 1 |
| Sogebi, OA | 1 |
| Adefuye, BO | 1 |
| Adebola, SO | 1 |
| Oladeji, SM | 1 |
| Adedeji, TO | 1 |
| DEENSTRA, H | 1 |
| COTTIN, S | 1 |
| COZAN, R | 1 |
| VERAN, P | 1 |
| FILLA, E | 1 |
| COMENALE, D | 1 |
| ROSSI, F | 1 |
| Pilheu, JA | 1 |
| De Salvo, MC | 1 |
| Koch, O | 1 |
| Hiroshige, K | 1 |
| Yuu, K | 1 |
| Takasugi, M | 1 |
| Soejima, M | 1 |
| Kuroiwa, A | 1 |
| Wada, M | 1 |
| Doi, K | 1 |
| Dulin, WE | 1 |
| Wyse, BM | 1 |
| Onisk, J | 1 |
1 review available for pyrazinamide and Diabetes Mellitus
| Article | Year |
|---|---|
Understanding pharmacokinetics to improve tuberculosis treatment outcome.
Topics: Antitubercular Agents; Diabetes Mellitus; Drug Monitoring; Ethambutol; HIV Infections; Humans; Isoni | 2014 |
2 trials available for pyrazinamide and Diabetes Mellitus
| Article | Year |
|---|---|
Anti-tuberculosis drug concentrations in tuberculosis patients with and without diabetes mellitus.
Topics: Adult; Antitubercular Agents; Diabetes Mellitus; Female; Humans; Isoniazid; Male; Middle Aged; Pyraz | 2017 |
[Clinical studies on the ketogenic effect of certain antitubercular drugs in patients with diabetes and pulmonary tuberculosis].
Topics: Adult; Antitubercular Agents; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; E | 1968 |
13 other studies available for pyrazinamide and Diabetes Mellitus
| Article | Year |
|---|---|
Urinary excretion of metformin in diabetic patients with and without tuberculosis.
Topics: Antitubercular Agents; Diabetes Mellitus; Humans; India; Isoniazid; Metformin; Pyrazinamide; Tubercu | 2023 |
Effect of diabetes mellitus on TB drug concentrations in Tanzanian patients.
Topics: Adult; Aged; Aged, 80 and over; Antitubercular Agents; Diabetes Complications; Diabetes Mellitus; Fe | 2019 |
Effect of Diabetes Mellitus on the Pharmacokinetics and Pharmacodynamics of Tuberculosis Treatment.
Topics: Adult; Antitubercular Agents; Diabetes Mellitus; Female; Glycated Hemoglobin; Humans; Isoniazid; Mal | 2018 |
Role of Therapeutic Drug Monitoring in Treatment Optimization in Tuberculosis and Diabetes Mellitus Comorbidity.
Topics: Comorbidity; Diabetes Mellitus; Drug Monitoring; Humans; Pyrazinamide; Tuberculosis | 2019 |
Clinical predictors of aminoglycoside-induced ototoxicity in drug-resistant Tuberculosis patients on intensive therapy.
Topics: Adult; Age Factors; Aminoglycosides; Antitubercular Agents; Audiometry, Pure-Tone; Body Mass Index; | 2017 |
[TREATMENT OF TUBERCULOSIS AND DIABETES BECOMING SIMILAR].
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Cycloserine; Diabetes Mellitus; Ethionamide; Isoniazid; P | 1964 |
[APROPOS OF ETHIONAMIDE JAUNDICE].
Topics: Alanine Transaminase; Alcoholism; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransfer | 1964 |
[CHEMO-ANTIBIOTIC THERAPY OF TUBERCULOSIS IN DIABETICS AND ITS REPERCUSSIONS ON GLUCIDE METABOLISM].
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Blood Glucose; Carbohydrate Metabo | 1964 |
Liver alterations in antituberculosis regimens containing pyrazinamide.
Topics: Adolescent; Adult; Aged; Alcoholism; Antitubercular Agents; Cholestasis; Diabetes Complications; Dia | 1981 |
[A study on uric acid excretion in patients with hypouricemia].
Topics: Acute Kidney Injury; Benzbromarone; Diabetes Complications; Diabetes Mellitus; Female; Humans; Kidne | 1993 |
[The effectiveness of pyrazinamide-containing six-month short course chemotherapy].
Topics: Adult; Aged; Aged, 80 and over; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Diabe | 2000 |
[Studies on the mechanism of the diabetogenic activity of streptozotocin and on the ability of compounds to block the diabetogenic activity of streptozotocin (author's transl)].
Topics: Adenoma, Islet Cell; Amides; Animals; Blood Glucose; Cats; Cystine; Deoxyglucose; Diabetes Mellitus; | 1975 |
Studies on the ability of compounds to block the diabetogenic activity of streptozotocin.
Topics: Amino Acids; Animals; Diabetes Mellitus; Diaphragm; Diazoxide; Epinephrine; Ethanol; Glucosamine; Gl | 1969 |