pyrazinamide has been researched along with Diabetes Mellitus, Type 2 in 9 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (MET) is a potential combination drug to elevate anti-TB efficacy." | 5.51 | Metformin induced autophagy in diabetes mellitus - Tuberculosis co-infection patients: A case study. ( Ali, M; Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2019) |
| "To observe the clinical effect on type 2 diabetes mellitus (T2DM) complicated with pulmonary tuberculosis (TB) of insulin, isoniazid, rifampicin, pyrazinamide and ethambutol (conventional medication) administered together with Qi-boosting and Yin-nourishing decoction derived from Traditional Chinese Medicine (TCM)." | 2.80 | Effects on type 2 diabetes complicated with pulmonary tuberculosis: regiment of insulin, isoniazid, rifampicin, pyrazinamide and ethambutol versus the regiment plus Qi-boosting and Yin-nourishing decoction of Traditional Chinese Medicine. ( Shi, G; Zhang, L, 2015) |
| "Metformin (MET) is a potential combination drug to elevate anti-TB efficacy." | 1.51 | Metformin induced autophagy in diabetes mellitus - Tuberculosis co-infection patients: A case study. ( Ali, M; Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2019) |
| " In this article, a case series is presented to illustrate the value of individualized TB drug dosing in four patients with low TB drug concentrations." | 1.38 | Therapeutic drug monitoring in the treatment of tuberculosis patients. ( Aarnoutse, R; Boeree, M; Ijdema, D; Magis-Escurra, C; van den Boogaard, J, 2012) |
| " Intensive pharmacokinetic sampling was performed for rifampin, pyrazinamide, and ethambutol at steady state." | 1.36 | Pharmacokinetics of antituberculosis drugs in pulmonary tuberculosis patients with type 2 diabetes. ( Aarnoutse, RE; Adhiarta, IG; Alisjahbana, B; Kariadi, SH; Nijland, HM; Ruslami, R; van Crevel, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruslami, R | 1 |
| Nijland, HM | 1 |
| Adhiarta, IG | 1 |
| Kariadi, SH | 1 |
| Alisjahbana, B | 1 |
| Aarnoutse, RE | 1 |
| van Crevel, R | 1 |
| Novita, BD | 1 |
| Ali, M | 1 |
| Pranoto, A | 1 |
| Soediono, EI | 1 |
| Mertaniasih, NM | 1 |
| Babalik, A | 1 |
| Ulus, IH | 1 |
| Bakirci, N | 1 |
| Kuyucu, T | 1 |
| Arpag, H | 1 |
| Dagyildizi, L | 1 |
| Capaner, E | 1 |
| Shi, G | 1 |
| Zhang, L | 1 |
| Magis-Escurra, C | 1 |
| van den Boogaard, J | 1 |
| Ijdema, D | 1 |
| Boeree, M | 1 |
| Aarnoutse, R | 1 |
| Chernykh, NA | 1 |
| Karachunskiĭ, MA | 1 |
| Kaminskaia, GO | 1 |
| Kossiĭ, IuE | 1 |
| Yamamoto, T | 1 |
| Moriwaki, Y | 1 |
| Takahashi, S | 1 |
| Suda, M | 1 |
| Agbedana, EO | 1 |
| Higashino, K | 1 |
| Hisatome, I | 1 |
| Sasaki, N | 1 |
| Yamakawa, M | 1 |
| Kobayashi, M | 1 |
| Tanaka, Y | 1 |
| Kosaka, H | 1 |
| Yoshida, A | 1 |
| Kotake, H | 1 |
| Mashiba, H | 1 |
| Takeda, A | 1 |
| Shichiri, M | 1 |
| Iwamoto, H | 1 |
| Shiigai, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis: A Randomized Controlled Trial[NCT05215990] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2022-01-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pyrazinamide and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effects on type 2 diabetes complicated with pulmonary tuberculosis: regiment of insulin, isoniazid, rifampicin, pyrazinamide and ethambutol versus the regiment plus Qi-boosting and Yin-nourishing decoction of Traditional Chinese Medicine.
Topics: Adult; Aged; Antitubercular Agents; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Drugs, Chi | 2015 |
8 other studies available for pyrazinamide and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Pharmacokinetics of antituberculosis drugs in pulmonary tuberculosis patients with type 2 diabetes.
Topics: Adult; Antitubercular Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Administra | 2010 |
Metformin induced autophagy in diabetes mellitus - Tuberculosis co-infection patients: A case study.
Topics: Adult; Antitubercular Agents; Autophagy; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Etham | 2019 |
Plasma concentrations of isoniazid and rifampin are decreased in adult pulmonary tuberculosis patients with diabetes mellitus.
Topics: Adult; Antitubercular Agents; Biological Availability; Diabetes Mellitus, Type 2; Drug Administratio | 2013 |
Therapeutic drug monitoring in the treatment of tuberculosis patients.
Topics: Adult; Aged; Alcoholism; Antibiotics, Antitubercular; Antitubercular Agents; Chromatography, High Pr | 2012 |
[Effectiveness of an intensive chemotherapy stage in new cases of pulmonary tuberculosis and diabetes mellitus].
Topics: Antibiotics, Antitubercular; Antitubercular Agents; Data Interpretation, Statistical; Diabetes Melli | 2004 |
Two cases in whom pyrazinamide does not inhibit the uricosuric action of benzbromarone.
Topics: Adult; Benzbromarone; Diabetes Mellitus, Type 2; Drug Interactions; Female; Humans; Kidney; Kidney D | 1992 |
Two cases of persistent hypouricemia associated with diabetes mellitus.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Kidney Tubules; Male; Probenecid | 1992 |
Diabetic renal hypouricemia.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Tubules; Male; Midd | 1987 |