Page last updated: 2024-10-20

pyrazinamide and Chemical Dependence

pyrazinamide has been researched along with Chemical Dependence in 4 studies

pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.

Research Excerpts

ExcerptRelevanceReference
"Severe liver injuries were attributed to the rifampin and pyrazinamide (RZ) regimen after it was recommended for treating latent tuberculosis infection."7.73Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection. ( Bower, WA; Castro, KG; Iademarco, MF; Ijaz, K; Jereb, JA; Lambert, LA; McElroy, PD; Navin, TR; Spradling, PR, 2006)
"Severe liver injuries were attributed to the rifampin and pyrazinamide (RZ) regimen after it was recommended for treating latent tuberculosis infection."3.73Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection. ( Bower, WA; Castro, KG; Iademarco, MF; Ijaz, K; Jereb, JA; Lambert, LA; McElroy, PD; Navin, TR; Spradling, PR, 2006)
" When recommended dosage regiments are followed, the incidence of adverse reactions is low with short-course therapy, and in only 5% or less of patients is it necessary to withdraw one or more drugs."2.36Short-course therapy for tuberculosis. ( Aquinas, M, 1982)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Danna, BJ1
Harvey, AW1
Woc-Colburn, LE1
Ricks, PM1
Hershow, RC1
Rahimian, A1
Huo, D1
Johnson, W1
Prachand, N1
Jimenez, A1
Wiebel, W1
Paul, W1
Ijaz, K1
Jereb, JA1
Lambert, LA1
Bower, WA1
Spradling, PR1
McElroy, PD1
Iademarco, MF1
Navin, TR1
Castro, KG1
Aquinas, M1

Reviews

1 review available for pyrazinamide and Chemical Dependence

ArticleYear
Short-course therapy for tuberculosis.
    Drugs, 1982, Volume: 24, Issue:2

    Topics: Drug Therapy, Combination; Humans; Pyrazinamide; Rifampin; Streptomycin; Substance-Related Disorders

1982

Trials

1 trial available for pyrazinamide and Chemical Dependence

ArticleYear
A randomized trial comparing standard outcomes in two treatment models for substance users with tuberculosis.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015, Volume: 19, Issue:3

    Topics: Adult; Antitubercular Agents; Directly Observed Therapy; Drug Users; Ethambutol; Ethnicity; Female;

2015

Other Studies

2 other studies available for pyrazinamide and Chemical Dependence

ArticleYear
Esophageal Tuberculosis - A Mass of Confusion.
    The American journal of medicine, 2020, Volume: 133, Issue:10

    Topics: Aged; Antitubercular Agents; Deglutition Disorders; Delayed Diagnosis; Diagnosis, Differential; Dire

2020
Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Feb-01, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Aged; Alcohol Drinking; Antitubercular Agents; Chemical and Drug Induced Liver In

2006