pyrazinamide has been researched along with Bile Duct Obstruction in 2 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrazinamide (PZA) is an indispensable first-line drug used for the treatment of tuberculosis which may cause serious hepatotoxicity; however, the mechanisms underlying these toxicities are poorly understood." | 1.43 | Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport. ( Ding, PP; Dong, SZ; Guo, HL; Hassan, HM; Jiang, ZZ; Sun, LX; Wang, T; Zhang, LY; Zhang, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, HL | 1 |
| Hassan, HM | 1 |
| Zhang, Y | 1 |
| Dong, SZ | 1 |
| Ding, PP | 1 |
| Wang, T | 1 |
| Sun, LX | 1 |
| Zhang, LY | 1 |
| Jiang, ZZ | 1 |
| Pilheu, JA | 1 |
| De Salvo, MC | 1 |
| Koch, O | 1 |
2 other studies available for pyrazinamide and Bile Duct Obstruction
| Article | Year |
|---|---|
Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Chemical and Drug Ind | 2016 |
Liver alterations in antituberculosis regimens containing pyrazinamide.
Topics: Adolescent; Adult; Aged; Alcoholism; Antitubercular Agents; Cholestasis; Diabetes Complications; Dia | 1981 |