pyrazinamide has been researched along with Aging in 4 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine population pharmacokinetic parameters of pyrazinamide after multiple oral doses given to children and adults with tuberculosis." | 9.10 | Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosis. ( Ashkin, D; Berning, SE; Bulpitt, AE; Burman, WJ; Peloquin, CA; Stambaugh, JJ; Starke, JR; Steiner, P; Zhu, M, 2002) |
| "To determine population pharmacokinetic parameters of pyrazinamide after multiple oral doses given to children and adults with tuberculosis." | 5.10 | Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosis. ( Ashkin, D; Berning, SE; Bulpitt, AE; Burman, WJ; Peloquin, CA; Stambaugh, JJ; Starke, JR; Steiner, P; Zhu, M, 2002) |
| " Elderly patients are more sensitive to antituberculous (anti-TB) drugs; therefore, a modification in the dosage for this patient group should be considered." | 1.28 | The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide. ( Chan, HS; Chan, K; Walubo, A; Wong, CL; Woo, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Woo, J | 3 |
| Cheung, W | 1 |
| Chan, R | 1 |
| Chan, HS | 3 |
| Cheng, A | 1 |
| Chan, K | 3 |
| Zhu, M | 1 |
| Starke, JR | 1 |
| Burman, WJ | 1 |
| Steiner, P | 1 |
| Stambaugh, JJ | 1 |
| Ashkin, D | 1 |
| Bulpitt, AE | 1 |
| Berning, SE | 1 |
| Peloquin, CA | 1 |
| Walubo, A | 2 |
| Wong, CL | 2 |
1 trial available for pyrazinamide and Aging
| Article | Year |
|---|---|
Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosis.
Topics: Adult; Aging; Antitubercular Agents; Area Under Curve; Child; Chromatography, Gas; Drug Monitoring; | 2002 |
3 other studies available for pyrazinamide and Aging
| Article | Year |
|---|---|
In vitro protein binding characteristics of isoniazid, rifampicin, and pyrazinamide to whole plasma, albumin, and alpha-1-acid glycoprotein.
Topics: Aging; Blood Proteins; Humans; In Vitro Techniques; Isoniazid; Orosomucoid; Plasma; Protein Binding; | 1996 |
The disposition of antituberculous drugs in plasma of elderly patients. I. Isoniazid and hydrazine metabolite.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Middle Aged; Py | 1991 |
The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Metabolic Clearance Rate; Mi | 1991 |