Page last updated: 2024-10-20

pyrazinamide and Aging

pyrazinamide has been researched along with Aging in 4 studies

pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"To determine population pharmacokinetic parameters of pyrazinamide after multiple oral doses given to children and adults with tuberculosis."9.10Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosis. ( Ashkin, D; Berning, SE; Bulpitt, AE; Burman, WJ; Peloquin, CA; Stambaugh, JJ; Starke, JR; Steiner, P; Zhu, M, 2002)
"To determine population pharmacokinetic parameters of pyrazinamide after multiple oral doses given to children and adults with tuberculosis."5.10Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosis. ( Ashkin, D; Berning, SE; Bulpitt, AE; Burman, WJ; Peloquin, CA; Stambaugh, JJ; Starke, JR; Steiner, P; Zhu, M, 2002)
" Elderly patients are more sensitive to antituberculous (anti-TB) drugs; therefore, a modification in the dosage for this patient group should be considered."1.28The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide. ( Chan, HS; Chan, K; Walubo, A; Wong, CL; Woo, J, 1991)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Woo, J3
Cheung, W1
Chan, R1
Chan, HS3
Cheng, A1
Chan, K3
Zhu, M1
Starke, JR1
Burman, WJ1
Steiner, P1
Stambaugh, JJ1
Ashkin, D1
Bulpitt, AE1
Berning, SE1
Peloquin, CA1
Walubo, A2
Wong, CL2

Trials

1 trial available for pyrazinamide and Aging

ArticleYear
Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosis.
    Pharmacotherapy, 2002, Volume: 22, Issue:6

    Topics: Adult; Aging; Antitubercular Agents; Area Under Curve; Child; Chromatography, Gas; Drug Monitoring;

2002

Other Studies

3 other studies available for pyrazinamide and Aging

ArticleYear
In vitro protein binding characteristics of isoniazid, rifampicin, and pyrazinamide to whole plasma, albumin, and alpha-1-acid glycoprotein.
    Clinical biochemistry, 1996, Volume: 29, Issue:2

    Topics: Aging; Blood Proteins; Humans; In Vitro Techniques; Isoniazid; Orosomucoid; Plasma; Protein Binding;

1996
The disposition of antituberculous drugs in plasma of elderly patients. I. Isoniazid and hydrazine metabolite.
    Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:8

    Topics: Acetylation; Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Middle Aged; Py

1991
The disposition of antituberculous drugs in plasma of elderly patients. II. Isoniazid, rifampicin and pyrazinamide.
    Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Isoniazid; Male; Metabolic Clearance Rate; Mi

1991