pyrazinamide has been researched along with Acquired Immunodeficiency Syndrome in 18 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mycobacterium tuberculosis infection has been shown to result in increased HIV replication and disease progression in HIV-infected individuals through increased immune activation." | 1.35 | Incomplete immunological recovery following anti-tuberculosis treatment in HIV-infected individuals with active tuberculosis. ( Hanna, LE; Narayanan, PR; Nayak, K; Subramanyam, S; Swaminathan, S; Venkatesan, P, 2009) |
| "He was diagnosed as pulmonary tuberculosis, and started treatment with INH, RFP, EB, and PZA." | 1.34 | [A case of tuberculosis showing immune reconstitution syndrome after the initiation of antiretroviral therapy for HIV infection]. ( Izumi, S; Taniguchi, H, 2007) |
| "Hyponatremia is seen in 40% to 60% of hospitalized acquired immune deficiency syndrome (AIDS) patients." | 1.31 | Normouricemia in the syndrome of inappropriate antidiuretic hormone secretion. ( Akalin, E; Chandrakantan, A; Hamburger, RJ; Keane, J, 2001) |
| "To test whether the bioavailability of antituberculosis drugs is altered in HIV-infected patients with tuberculosis." | 1.30 | Does AIDS impair the absorption of antituberculosis agents? ( Smith, PJ; Taylor, B, 1998) |
| "Pyrazinamide was administered at 1 g once daily for 5 days to 40 adult volunteers (10 men with AIDS, 10 normal men, 10 women with AIDS, and 10 normal women)." | 1.30 | Intrapulmonary concentrations of pyrazinamide. ( Conte, JE; Duncan, S; Golden, JA; McKenna, E; Zurlinden, E, 1999) |
| "There are few reports of children with AIDS and TB." | 1.29 | Clinical manifestation and outcome of tuberculosis in children with acquired immunodeficiency syndrome. ( Birnbaum, J; Chan, SP; Rao, M; Steiner, P, 1996) |
| "Forty-one of our patients had pulmonary tuberculosis, 38 had extra pulmonary and in 61 it was disseminated." | 1.28 | AIDS and tuberculosis in Spain. A report of 140 cases. ( Adrados, M; Díaz, F; García Aguado, C; González Lahoz, JM; Laguna, F; Martínez, R; Puente, S, 1991) |
| "Seven patients received no treatment because tuberculosis was first diagnosed after death." | 1.28 | Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection. ( Chaisson, RE; Goodman, PC; Hopewell, PC; Sande, MA; Schecter, GF; Small, PM, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 11 (61.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hanna, LE | 1 |
| Nayak, K | 1 |
| Subramanyam, S | 1 |
| Venkatesan, P | 1 |
| Narayanan, PR | 1 |
| Swaminathan, S | 1 |
| Taniguchi, H | 1 |
| Izumi, S | 1 |
| Chan, SP | 1 |
| Birnbaum, J | 1 |
| Rao, M | 1 |
| Steiner, P | 1 |
| Brmbolić, BJ | 1 |
| Boricić, I | 1 |
| Salemović, DR | 1 |
| Jevtović, DL | 1 |
| Ranin, JT | 1 |
| Begić-Janeva, A | 1 |
| de Kantor, IN | 1 |
| Latini, O | 1 |
| Barrera, L | 1 |
| Taylor, B | 1 |
| Smith, PJ | 1 |
| Domoua, K | 1 |
| N'Dhatz, M | 1 |
| Coulibaly, G | 1 |
| Traore, F | 1 |
| Koffi, J | 1 |
| Achi, V | 1 |
| Daix, T | 1 |
| Ouattara, Y | 1 |
| Ouedraogo, M | 1 |
| Beugre, LK | 1 |
| Konan, JB | 1 |
| Coulibaly, V | 1 |
| Coulibaly, IM | 1 |
| Yapi, A | 1 |
| Conte, JE | 1 |
| Golden, JA | 1 |
| Duncan, S | 1 |
| McKenna, E | 1 |
| Zurlinden, E | 1 |
| Takahashi, T | 1 |
| Endou, T | 1 |
| Nakamura, T | 1 |
| Asai, S | 1 |
| Yoshikawa, K | 1 |
| Iwamoto, A | 1 |
| Akalin, E | 1 |
| Chandrakantan, A | 1 |
| Keane, J | 1 |
| Hamburger, RJ | 1 |
| Kura, MM | 1 |
| Hira, SK | 1 |
| Rabahi, MF | 1 |
| Rodrigues, AB | 1 |
| Queiroz de Mello, F | 1 |
| de Almeida Netto, JC | 1 |
| Kritski, AL | 1 |
| Pust, RE | 1 |
| Laguna, F | 1 |
| Adrados, M | 1 |
| Díaz, F | 1 |
| Martínez, R | 1 |
| García Aguado, C | 1 |
| Puente, S | 1 |
| González Lahoz, JM | 1 |
| Small, PM | 1 |
| Schecter, GF | 1 |
| Goodman, PC | 1 |
| Sande, MA | 1 |
| Chaisson, RE | 1 |
| Hopewell, PC | 1 |
| Pitchenik, AE | 1 |
| Tournier, G | 1 |
| Gallet, S | 1 |
| Bellon, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Simultaneous Versus Sequential Antiretroviral Therapy and Antituberculosis Treatment in Patients With AIDS and Active Tuberculosis. Open, Randomized and Controlled, Multisite Clinical Trial.[NCT00737724] | 63 participants (Actual) | Interventional | 2008-03-31 | Terminated (stopped due to Other published trials showed definitive expected superiority of Group 1) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyrazinamide and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
[Which treatment for primary tuberculosis?].
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Pyrazi | 1989 |
1 trial available for pyrazinamide and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Reintroducing antituberculosis therapy after Stevens-Johnson syndrome in human immunodeficiency virus-infected patients with tuberculosis: role of desensitization.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antitubercular Age | 2001 |
16 other studies available for pyrazinamide and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Incomplete immunological recovery following anti-tuberculosis treatment in HIV-infected individuals with active tuberculosis.
Topics: Acquired Immunodeficiency Syndrome; Analysis of Variance; beta 2-Microglobulin; Biomarkers; CD4-Posi | 2009 |
[A case of tuberculosis showing immune reconstitution syndrome after the initiation of antiretroviral therapy for HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Antitubercular Agents; Drug Therapy, Com | 2007 |
Clinical manifestation and outcome of tuberculosis in children with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; AIDS-Related Opportunistic Infections; Antibiotics, | 1996 |
Focal tuberculosis of the liver with local hemorrhage in a patient with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Ethambutol; Granuloma; Histocytochemistry; Homosexuality, | 1996 |
[Resistance and multiresistance to antitubercular drugs in Argentina and in other Latin American countries].
Topics: Acquired Immunodeficiency Syndrome; Antitubercular Agents; Argentina; Drug Resistance, Microbial; Dr | 1998 |
Does AIDS impair the absorption of antituberculosis agents?
Topics: Absorption; Acquired Immunodeficiency Syndrome; Adolescent; Adult; Antitubercular Agents; Biological | 1998 |
[Efficacy of a short 6 month therapeutic coursefor HIV infected tuberculosis patients in Abidjan, Côte d'Ivoire].
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Antitubercular Agents; Cohort Studies; Cote d | 1998 |
Intrapulmonary concentrations of pyrazinamide.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antitubercular Agents; Epithelium; Female; Humans; Lung; | 1999 |
Pulmonary nodule mimicking lung cancer in a human immunodeficiency virus type-1 infected patient.
Topics: Acquired Immunodeficiency Syndrome; Adenocarcinoma; Adult; Antitubercular Agents; Diagnosis, Differe | 1999 |
Normouricemia in the syndrome of inappropriate antidiuretic hormone secretion.
Topics: Acquired Immunodeficiency Syndrome; Ethambutol; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lu | 2001 |
Noncompliance with tuberculosis treatment by patients at a tuberculosis and AIDS reference hospital in midwestern Brazil.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Antitubercular Agents; Brazil; Child; C | 2002 |
Tuberculosis in the 1990's: resurgence, regimens, and resources.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Child; Drug Administration Schedule; Drug Interacti | 1992 |
AIDS and tuberculosis in Spain. A report of 140 cases.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Ethambutol; Female; Humans; Incidence | 1991 |
Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Administration Schedule; Drug Therapy, Combination; | 1991 |
Tuberculosis control and the AIDS epidemic in developing countries.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Developing Countries; Diagnosis, Different | 1990 |
[Tuberculosis in children in 1989].
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Age Factors; Anti-Bacterial Agents; BCG Vaccine; Chi | 1989 |