pyrantel-pamoate and Trichostrongylosis

Topics: Animals; Antinematodal Agents; Diagnosis, Differential; Humans; Intestinal Diseases, Parasitic; Prognosis; Pyrantel Pamoate; Trichostrongylosis; Trichostrongylus

This article discusses strongyloidiasis, hookworm infection, trichostrongyliasis, ascariasis, trichuriasis (whipworm infection), and enterobiasis (pinworm infection). For each infection, the author describes the organism, the epidemiology and geographic distribution, symptomatology and pathogenesis, and diagnosis and treatment.

Topics: Adolescent; Adult; Age Factors; Animals; Ascariasis; Child; Child, Preschool; Female; Hookworm Infections; Humans; Infant; Intestinal Diseases, Parasitic; Male; Mebendazole; Nematode Infections; Oxyuriasis; Piperazines; Pyrantel Pamoate; Strongyloides; Strongyloidiasis; Thiabendazole; Trichostrongylosis; Trichuriasis

Topics: Animals; Anthelmintics; Anti-Bacterial Agents; Antinematodal Agents; Equidae; Feces; Female; Horse Diseases; Horses; Intestinal Diseases, Parasitic; Ivermectin; Macrolides; Male; Parasite Egg Count; Pyrantel Pamoate; Strongylida Infections; Trichostrongylosis

The effect of pyrantel pamoate, levamisole, mebendazole, thiabendazole and bephenium hydroxynaphthoate on various intestinal helminths were evaluated among the inhabitants of four villages in the Dezful area southwest of Iran. A total number of 328 persons, all infected simultaneously with Ascaris and hookworm (Ancylostoma duodenale) and 49.2% with Trichostrongylus spp., were randomly divided into six groups. One group was kept as the control and the other five were each treated with one compound. Follow-up examinations showed that all of the drugs used were highly effective on Ascaris, and the differences in the cure rate were not statistically significant except for bephenium hydroxynaphthoate which showed a lower cure rate. For hookworm, cure rates of 100, 90, and 85% were observed with levamisole, pyrantel pamoate and bephenium hydroxynaphthoate, respectively. Cure rates observed with mebendazole and thiabendazole were 35 and 51%, respectively. For Trichostrongylus, the highest cure rate was achieved with levamisole, followed by thiabendazole and mebendazole. While the percentage of people showing side-effects was rather low for all drugs, thiabendazole and bephenium hydroxynaphthoate produced a higher, and levamisole a lower, percentage of side effects.

Topics: Adolescent; Adult; Ancylostomiasis; Anthelmintics; Ascariasis; Bephenium Compounds; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Feces; Follow-Up Studies; Helminthiasis; Humans; Infant; Intestinal Diseases, Parasitic; Iran; Levamisole; Mebendazole; Parasite Egg Count; Pyrantel Pamoate; Thiabendazole; Trichostrongylosis