pyrantel-pamoate and Trichinellosis

Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.

Topics: Animals; Female; Intestinal Diseases, Parasitic; Larva; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Pyrantel Pamoate; Thymus Extracts; Trichinella spiralis; Trichinellosis

Topics: Amebicides; Anti-Inflammatory Agents; Antimalarials; Ascariasis; Benzenesulfonates; Cestode Infections; Echinococcosis; Entamoebiasis; Hookworm Infections; Humans; Malaria; Niclosamide; Niridazole; Oxyuriasis; Parasitic Diseases; Paromomycin; Pyrantel Pamoate; Schistosomiasis; Strongyloidiasis; Tartrates; Tetrachloroethylene; Tetracycline; Thiabendazole; Toxocariasis; Trichinellosis

Topics: Ascariasis; Child; Hookworm Infections; Humans; Intestinal Diseases, Parasitic; Mebendazole; Nematode Infections; Oxyuriasis; Piperazines; Pyrantel Pamoate; Strongyloidiasis; Tetrachloroethylene; Thiabendazole; Trichinellosis; Trichuriasis