pyrantel-pamoate and Myasthenia-Gravis

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction that can be triggered by anticholinergic agents.. We present a 4-year-old female patient who was admitted to the outpatient clinic. She complained of drooped eyelids, which first appeared 2 days after taking a 200 mg dose of pyrantel pamoate. Past medical history is negative.. She was hospitalized with a diagnosis of ocular type MG, and pyridostigmine (40 mg/day) treatment was started.. The patient recovered, and subsequently, the treatment dose was tapered.. Pyrantel is an antihelminthic that acts as an agonist of nicotinic acetylcholine receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. Consequently, there may be an association between pyrantel pamoate and MG.

Topics: Administration, Oral; Antinematodal Agents; Child, Preschool; Female; Humans; Myasthenia Gravis; Pyrantel Pamoate

Topics: Aged; Ascariasis; Humans; Male; Myasthenia Gravis; Neurologic Examination; Pyrantel Pamoate