pyrantel-pamoate and Ascaridiasis

Topics: Adolescent; Anemia; Antinematodal Agents; Ascaridiasis; Child; Cholangitis; Cholestasis; Humans; Intestinal Obstruction; Liver Abscess; Pyrantel Pamoate; Vietnam

Antinematodal efficacy of Saussurea lappa roots (Qust-e-Shereen) and anticestodal effect of Nigella sativa seeds (Kalonji) was studied in children infected naturally with the respective worms. The activities were judged on the basis of percentage reductions in the faecal eggs per gram (EPG) counts. The 50 mg/kg single dose of S. lappa and equivalent amount of its methanolic extract produced on days 7 and 15 percentage EPG reduction similar to 10 mg/kg of pyrantel pamoate. Similarly, single oral administration of 40 mg/kg of N. sativa, equivalent amount of its ethanolic extract and 50 mg/kg of niclosamide reduced the percentage of EPG counts not significantly different from each other on the days 7 and 15. Therefore, it is conceivable that these indigenous medicinal plants contain active principles effective against nematodes and cestodes. The crude drugs did not produce any adverse side effects in the doses tested.

Topics: Anticestodal Agents; Antinematodal Agents; Ascaridiasis; Child; Feces; Humans; Hymenolepiasis; Medicine, Traditional; Niclosamide; Pakistan; Parasite Egg Count; Plants, Medicinal; Pyrantel Pamoate; Taeniasis

Topics: Adult; Africa, Western; Animals; Ascaridiasis; Cats; Dogs; Feces; Female; Helminthiasis; Hookworm Infections; Humans; Male; Necator; Pyrantel; Pyrantel Pamoate; Rats; Schistosomiasis; Strongyloidiasis